Explanipedia

Body Composition Changes in Hospitalized Patients with Community-Acquired Pneumonia Open

Ryuji Sugiya, Osamu Nishiyama, Masashi Shiraishi, Kazuya Yoshikawa, Kyuya Gose , et al. · 2025

Background: The influence of hospitalization owing to pneumonia on changes in body composition has not been specifically reported. We conducted a prospective cohort study of patients with community-acquired pneumonia (CAP) requiring hospit…

Non-coding repeat analyses in patients with Parkinson’s disease Open

Makito Hirano, Makoto Samukawa, Satoko Miyatake, Yuko Yamagishi, Chiharu Isono , et al. · 2025

Introduction The genetic etiology of Parkinson’s disease (PD) is complex; approximately 10% of patients with PD have various gene mutations that lead to familial forms of the disease. Recent analyses of non-coding repeat regions revealed t…

Aging-related changes of miR-23b-3p expression in extracellular vesicles from mesenchymal stromal cells affect TGFBR3 signaling Open

Maki Itokazu, Toshiyuki Takehara, Kensuke Toriumi, Natsumi Iwawaki, Tatsufumi Mori , et al. · 2025

Extracellular vesicles (EVs), which carry biological mediators such as microRNAs (miRNAs) and cytokines, play a crucial role in regulating recipient tissues and are considered a key mechanism of action in cell therapy. However, it has been…

Preoperative inspiratory muscle training preserved diaphragmatic excursion after esophagectomy: a randomized-controlled trial Open

Hiroki Mizusawa, Yuji Higashimoto, Osamu Shiraishi, Masashi Shiraishi, Ryuji Sugiya , et al. · 2025

Predictive Value of Preoperative Peak Oxygen Uptake for Postoperative Pulmonary Complications in Lung Cancer Patients with Chronic Obstructive Pulmonary Disease: A Single-Center Retrospective Cohort Study Open

Masaya Noguchi, Toshiki Takemoto, Masashi Shiraishi, Ryuji Sugiya, Hiroki Mizusawa , et al. · 2025

Introduction: The relationship between preoperative peak oxygen uptake/weight (VO₂/W) and postoperative pulmonary complications (PPC) in lobectomies, including video-assisted thoracoscopic surgery, remains unclear. Traditional p…

Effects of the continuous subcutaneous infusion of foslevodopa-foscarbidopa on swallowing in patients with Parkinson’s disease Open

Makito Hirano, Makoto Samukawa, Chiharu Isono, Rino Inada, Yuta Fukumoto , et al. · 2025

This study provides preliminary evidence that CSCI-FF may partially improve swallowing function in patients with advanced PD. Further research with larger cohorts is warranted.

Enhanced diaphragm excursion and exercise tolerance in COPD patients through inspiratory muscle training after standardised pulmonary rehabilitation: randomised controlled trial Open

Masashi Shiraishi, Yuji Higashimoto, Ryuji Sugiya, Hiroki Mizusawa, Yu Takeda , et al. · 2024

Objective Inspiratory muscle training (IMT) is used to improve inspiratory muscle strength in patients with COPD. However, the effect of IMT on diaphragmatic function has not yet been thoroughly evaluated. This study aimed to evaluate the …

Association of tissue oxygen saturation levels with skeletal muscle injury in the critically ill Open

Ryuji Sugiya, Shinichi Arizono, Yuji Higashimoto, Y Kimoto, Masashi Shiraishi , et al. · 2024

This study aimed to investigate the association between the level of tissue oxygen saturation (StO 2 ) and quadriceps/skeletal muscle dysfunction, measured using the Medical Research Council (MRC) scale and ultrasonography, in critically i…

Improvement of diaphragmatic excursion in the supine position in a patient with idiopathic pleuroparenchymal fibroelastosis: A case report Open

Masashi Shiraishi, Yuji Higashimoto, Osamu Nishiyama, Ryo Yamazaki, Ryuji Sugiya , et al. · 2024

Idiopathic pleuroparenchymal fibroelastosis (iPPFE) is a rare form of idiopathic interstitial pneumonia. We report a case of a patient with iPPFE in whom postural changes improved diaphragmatic excursion (DE) and exercise tolerance. Chest …

Quantitative emphysema on computed tomography imaging of chest is a risk factor for prognosis of esophagectomy: A retrospective cohort study Open

Hiroki Mizusawa, Osamu Shiraishi, Masashi Shiraishi, Ryuji Sugiya, Tamotsu Kimura , et al. · 2023

The low attenuation area percentage (LAA%) is gaining popularity. LAA% is an index of quantitative emphysema on computed tomography (CT) imaging of the chest. This study aims to retrospectively investigate whether preoperative LAA% is asso…

Association of tissue oxygen saturation levels with skeletal muscle injury in the critically ill Open

Ryuji Sugiya, Shinichi Arizono, Yuji Higashimoto, Y Kimoto, Masashi Shiraishi , et al. · 2023

Objectives: This study aimed to investigate the association between the level of tissue oxygen saturation (StO 2 ) and quadriceps/skeletal muscle dysfunction, measured using the Medical Research Council (MRC) scale and ultrasonography, in …

Diaphragm dome height on chest radiography as a predictor of dynamic lung hyperinflation in COPD Open

Masashi Shiraishi, Yuji Higashimoto, Ryuji Sugiya, Hiroki Mizusawa, Yu Takeda , et al. · 2023

Background and objective Dynamic lung hyperinflation (DLH) can play a central role in exertional dyspnoea in patients with COPD. Chest radiography is the basic tool for assessing static lung hyperinflation in COPD. However, the predictive …

Nationwide survey of refractory asthma with bronchiectasis by inflammatory subtypes Open

Natsuko Nomura, Hisako Matsumoto, Akihito Yokoyama, Yoshihiro Nishimura, Koichiro Asano , et al. · 2022

Sternocleidomastoid Muscle Thickness Correlates with Exercise Tolerance in Patients with COPD Open

Masashi Shiraishi, Yuji Higashimoto, Ryuji Sugiya, Hiroki Mizusawa, Yu Takeda , et al. · 2022

Background: Patients with chronic obstructive pulmonary disease (COPD) have difficulties inhaling as the diaphragm becomes flattened and weakened due to lung hyperinflation. This weakened respiratory function is compensated for by the incr…

Adipose-derived exosomes block muscular stem cell proliferation in aged mouse by delivering miRNA Let-7d-3p that targets transcription factor HMGA2 Open

Maki Itokazu, Yuta Onodera, Tatsufumi Mori, Shinji Inoue, Kotaro Yamagishi , et al. · 2022

Effectiveness of Rehabilitation for Cancer Patients with Bone Metastasis Open

Maki Itokazu, Yuji Higashimoto, Masami Ueda, Kazushi Hanada, Saori Murakami , et al. · 2022

Rehabilitation improved ADL status to a greater extent in patients with pelvic metastases than in those with other metastasis sites. Patients with pelvic metastases may fear fractures, limiting their ADL, but rehabilitation could eliminate…

Supplementary Material for: Sternocleidomastoid Muscle Thickness Correlates with Exercise Tolerance in Patients with COPD Open

Michael Shiraishi, Yuji Higashimoto, Ryuji Sugiya, H. Mizusawa, Yu Takeda , et al. · 2022

Background: Patients with chronic obstructive pulmonary disease (COPD) have difficulties inhaling as the diaphragm becomes flattened and weakened due to lung hyperinflation. This weakened respiratory function is compensated f…

Diaphragmatic excursion is correlated with the improvement in exercise tolerance after pulmonary rehabilitation in patients with chronic obstructive pulmonary disease Open

Masashi Shiraishi, Yuji Higashimoto, Ryuji Sugiya, Hiroki Mizusawa, Yu Takeda , et al. · 2021

Background In patients with chronic obstructive pulmonary disease (COPD), the maximum level of diaphragm excursion (DE max ) is correlated with dynamic lung hyperinflation and exercise tolerance. This study aimed to elucidate the utility o…

Diaphragmatic Excursion is Correlated With the Improvement in Exercise Tolerance After Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease Open

Masashi Shiraishi, Yuji Higashimoto, Ryuji Sugiya, Hiroki Mizusawa, Yu Takeda , et al. · 2021

Background: In patients with chronic obstructive pulmonary disease (COPD), the maximum level of diaphragm excursion (DE max ) is correlated with dynamic lung hyperinflation and exercise tolerance. This study aims to clarify the utility of …

Effect of Pulmonary Rehabilitation on Erector Spinae Muscles in Individuals With COPD Open

Yuji Higashimoto, Masashi Shiraishi, Ryuji Sugiya, Hiroki Mizusawa, Osamu Nishiyama , et al. · 2021

ESM mass was shown to decline yearly in subjects with COPD. The annual decline in muscle mass was reduced by PR.

Decreased Tongue Strength is Related to Skeletal Muscle Mass in COPD Patients Open

Ryuji Sugiya, Yuji Higashimoto, Masashi Shiraishi, Tomomi Tamura, Tamotsu Kimura , et al. · 2021

Diaphragmatic excursion correlates with exercise capacity and dynamic hyperinflation in COPD patients Open

Masashi Shiraishi, Yuji Higashimoto, Ryuji Sugiya, Hiroki Mizusawa, Yu Takeda , et al. · 2020

Background Although the pathophysiological mechanisms involved in the development of dyspnoea and poor exercise tolerance in patients with COPD are complex, dynamic lung hyperinflation (DLH) plays a central role. Diaphragmatic excursions c…

Prefrontal cortex activation is associated with dyspnea during methacholine bronchial provocation tests in patients with bronchial asthma Open

Yuji Higashimoto, Akiko Sano, Osamu Nishiyama, Hiroyuki Sano, Takashi Iwanaga , et al. · 2020

Ability to categorize end-feel joint movement according to years of clinical experience: an experiment with an end-feel simulator Open

Hiroyuki Kawamura, Shimon Tasaka, Atsutoshi Ikeda, Takashi Harada, Yuji Higashimoto , et al. · 2020

[Purpose] Discrimination between end-feel types is difficult, and years of clinical experience is considered a factor for improving the accuracy of the discrimination. The present study investigated whether the accuracy of classification o…

Involvement of Allosteric Effect and KCa Channels in Crosstalk between β2-Adrenergic and Muscarinic M2 Receptors in Airway Smooth Muscle Open

Hiroaki Kume, Osamu Nishiyama, Takaaki Isoya, Yuji Higashimoto, Yuji Tohda , et al. · 2018

To advance the development of bronchodilators for asthma and chronic obstructive pulmonary disease (COPD), this study was designed to investigate the mechanism of functional antagonism between β2-adrenergic and muscarinic M2 receptors, foc…

Mechanisms of Dyspnea and the Effect of Pulmonary Rehabilitation to Exertional Dyspnea in COPD Open

Yuji Higashimoto · 2017

慢性閉塞性肺疾患（COPD）の罹患者は年々増加しており，肺の生活習慣病といわれている．労作時呼吸困難はCOPDの主要な症状の1つで，このために日常生活に支障をきたすことが多い．COPDにおける呼吸困難の機序はまだ十分に解明されていないが，低酸素血症以外にも，肺の動的過膨張やうつ・不安症状なども関連していることがわかっている．呼吸困難に対する薬物治療としては気管支拡張薬の吸入薬が第一選択であるが，症状改善が十分でないことが多く，呼吸リハビリテーション，栄養指導，心理的サポート…

Clinical Features and Outcomes of IPF Patients Hospitalized for Pulmonary Infection: A Japanese Cohort Study Open

Ryo Yamazaki, Osamu Nishiyama, Hiroyuki Sano, Takashi Iwanaga, Yuji Higashimoto , et al. · 2016

Many patients with idiopathic pulmonary fibrosis (IPF) undergo hospitalizations due to pulmonary infections. We retrospectively investigated the characteristics of hospitalizations due to pulmonary infection in patients with IPF to elucida…

Characteristics of phenotypes of elderly patients with asthma Open

Hiroyuki Sano, Takashi Iwanaga, Osamu Nishiyama, Akiko Sano, Yuji Higashimoto , et al. · 2016

Half of elderly patients with asthma are characterized by asthma-emphysema overlap. Our results showed that elderly patients with asthma who are smokers and have moderate or severe OAD are also likely to have emphysema.

Pulmonary Hemodynamics and Six-Minute Walk Test Outcomes in Patients with Interstitial Lung Disease Open

Osamu Nishiyama, Ryo Yamazaki, Hiroyuki Sano, Takashi Iwanaga, Yuji Higashimoto , et al. · 2016

Background . Six-minute walk test (6MWT) has 3 measurement outcomes, which are walk distance, desaturation, and symptom. The aim of this study was to examine whether routinely measured right-heart catheter (RHC) data correlate with 6MWT ou…

Exertional dyspnoea and cortical oxygenation in patients with COPD Open

Yuji Higashimoto, Noritsugu Honda, Toshiyuki Yamagata, Akiko Sano, Osamu Nishiyama , et al. · 2015

This study was designed to investigate the association of perceived dyspnoea intensity with cortical oxygenation and cortical activation during exercise in patients with chronic obstructive pulmonary disease (COPD) and exertional hypoxaemi…

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