Yuji Ishida
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View article: Modeling of hepatitis B virus infection spread in primary human hepatocytes
Modeling of hepatitis B virus infection spread in primary human hepatocytes Open
Chronic hepatitis B virus (HBV) infection poses a significant global health threat, causing severe liver diseases including cirrhosis and hepatocellular carcinoma. We characterized HBV DNA kinetics in primary human hepatocytes (PHHs) over …
View article: Development of human growth hormone-treated chimeric mice with humanized livers for an evaluation model of drug-induced fatty liver disease
Development of human growth hormone-treated chimeric mice with humanized livers for an evaluation model of drug-induced fatty liver disease Open
View article: Modeling of hepatitis B virus infection spread in primary human hepatocytes
Modeling of hepatitis B virus infection spread in primary human hepatocytes Open
Chronic hepatitis B virus (HBV) infection poses a significant global health threat, causing severe liver diseases including cirrhosis and hepatocellular carcinoma. We characterized HBV DNA kinetics in primary human hepatocytes (PHH) over 3…
View article: Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies
Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies Open
Designing and carrying out a controlled human infection (CHI) model for hepatitis C virus (HCV) is critical for vaccine development. However, key considerations for a CHI model protocol include understanding of the earliest viral-host kine…
View article: Modeling of hepatitis B virus kinetics and accumulation of cccDNA in primary human hepatocytes
Modeling of hepatitis B virus kinetics and accumulation of cccDNA in primary human hepatocytes Open
View article: Evaluation of whole genome sequencing utility in identifying driver alterations in cancer genome
Evaluation of whole genome sequencing utility in identifying driver alterations in cancer genome Open
View article: Multi-omics analysis of a fatty liver model using human hepatocyte chimeric mice
Multi-omics analysis of a fatty liver model using human hepatocyte chimeric mice Open
We developed a fatty liver mouse model using human hepatocyte chimeric mice. As transplanted human hepatocytes do not respond to mouse growth hormone (GH) and tend to accumulate fat, we hypothesized that addition of human GH would alter li…
View article: Anomaly detection of robot arm using autoencoder
Anomaly detection of robot arm using autoencoder Open
View article: Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics
Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics Open
Hepatitis B virus (HBV) infection kinetics in immunodeficient mice reconstituted with humanized livers from inoculation to steady state is highly dynamic despite the absence of an adaptive immune response. To recapitulate the multiphasic v…
View article: Guiding Hepatic Differentiation of Pluripotent Stem Cells Using 3D Microfluidic Co-Cultures with Human Hepatocytes
Guiding Hepatic Differentiation of Pluripotent Stem Cells Using 3D Microfluidic Co-Cultures with Human Hepatocytes Open
Human pluripotent stem cells (hPSCs) are capable of unlimited proliferation and can undergo differentiation to give rise to cells and tissues of the three primary germ layers. While directing lineage selection of hPSCs has been an active a…
View article: Function of hepatocyte spheroids in bioactive microcapsules is enhanced by endogenous and exogenous hepatocyte growth factor
Function of hepatocyte spheroids in bioactive microcapsules is enhanced by endogenous and exogenous hepatocyte growth factor Open
View article: Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response
Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response Open
Hepatitis delta virus (HDV), a satellite virus of HBV, is regarded as the most severe type of hepatitis virus because of the substantial morbidity and mortality. The IFN system is the first line of defense against viral infections and an e…
View article: HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice
HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice Open
Background and Aims: Mutations within the precore (PC) and basal core promoter (BCP) regions of the HBV genome are associated with fulminant hepatitis and HBV reactivation. These mutations may enhance viral replication, but little is known…
View article: Feasibility and preliminary effectiveness of a psychosocial support program for adolescent and young adult cancer patients in clinical practice: a retrospective observational study
Feasibility and preliminary effectiveness of a psychosocial support program for adolescent and young adult cancer patients in clinical practice: a retrospective observational study Open
View article: <scp>Long‐term</scp> cell fate and functional maintenance of human hepatocyte through stepwise culture configuration
<span>Long‐term</span> cell fate and functional maintenance of human hepatocyte through stepwise culture configuration Open
Human hepatocyte culture system represents by far the most physiologically relevant model for our understanding of liver biology and diseases; however, its versatility has been limited due to the rapid and progressive loss of genuine chara…
View article: Hemiplegic Hand Rehabilitation Robot for Home Use That Deforms Housing According to Spasticity to Regain Independent Finger Movement
Hemiplegic Hand Rehabilitation Robot for Home Use That Deforms Housing According to Spasticity to Regain Independent Finger Movement Open
We have proposed finger rehabilitation robot for in-home hemiplegic patient. In previous study, there remained the problem of not being able to complete treatment in one robot according to degree of recovery due to the housing. This proble…
View article: Cooperation with Therapist Towards Realization of Home Rehabilitation Robots
Cooperation with Therapist Towards Realization of Home Rehabilitation Robots Open
View article: Current methods of preventing infectious disease and managing febrile neutropenia in childhood cancer patients: a nationwide survey in Japan
Current methods of preventing infectious disease and managing febrile neutropenia in childhood cancer patients: a nationwide survey in Japan Open
View article: Head pleomorphic sarcoma showing murine double minute 2 amplification without a well‐differentiated liposarcoma component in a pediatric patient
Head pleomorphic sarcoma showing murine double minute 2 amplification without a well‐differentiated liposarcoma component in a pediatric patient Open
Background Murine double minute 2 (MDM2) is an oncogene that inhibits p53, leading to decreased apoptosis. Sarcomas showing MDM2 amplification are rare among pediatric patients. Case A 14‐year‐old boy presented with pleomorphic sarcoma of …
View article: Development and characterization of secondary standards for nucleic acid amplification technology (NAAT) assays for detection of hepatitis E virus
Development and characterization of secondary standards for nucleic acid amplification technology (NAAT) assays for detection of hepatitis E virus Open
View article: Downregulation of SOCS1 increases interferon-induced ISGylation during differentiation of induced-pluripotent stem cells to hepatocytes
Downregulation of SOCS1 increases interferon-induced ISGylation during differentiation of induced-pluripotent stem cells to hepatocytes Open
To elucidate the mechanism underlying regulation of ISGylation, a key process in the innate immune response, we studied changes in ISGylation-associated genes at the different stages of differentiation from iPSCs to hepatocytes. We found t…
View article: Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release
Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release Open
Hepatitis B virus (HBV) DNA replication takes place inside the viral core particle and is dependent on autophagy. Here we show that HBV core particles are associated with autophagosomes and phagophores in cells that productively replicate …
View article: Loss of mitochondrial ATPase ATAD3A contributes to nonalcoholic fatty liver disease through accumulation of lipids and damaged mitochondria
Loss of mitochondrial ATPase ATAD3A contributes to nonalcoholic fatty liver disease through accumulation of lipids and damaged mitochondria Open
View article: Multiphasic hepatitis B virus kinetic patterns in humanized chimeric mice can be explained via stochastic agent-based modeling of intracellular virion production cycles
Multiphasic hepatitis B virus kinetic patterns in humanized chimeric mice can be explained via stochastic agent-based modeling of intracellular virion production cycles Open
Serum hepatitis B virus (HBV) kinetics in urokinase-type plasminogen activator/severe combined immunodeficient (uPA-SCID) mice reconstituted with humanized livers from inoculation to steady state is highly dynamic despite the absence of an…
View article: Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with <i>in vitro</i> metabolic assays
Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with <i>in vitro</i> metabolic assays Open
Felbamate (FBM) is an antiepileptic drug that has minimal toxicity in preclinical toxicological species but has a serious idiosyncratic drug toxicity (IDT) in humans. The formation of reactive metabolites is common among most drugs associa…
View article: Home Finger Rehabilitation Device with Small Air Actuator for Facilitation of Independent Finger Movement
Home Finger Rehabilitation Device with Small Air Actuator for Facilitation of Independent Finger Movement Open
Although continuous hand rehabilitation even at home is needed for hemiplegic patient to use him/her hand in daily life, a patient cannot be intervened by therapist compared with in clinic. In this study, we have been trying to solve these…
View article: Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3
Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3 Open
Macrophages display phenotypic plasticity and can be induced by hepatitis B virus (HBV) to undergo either M1-like pro-inflammatory or M2-like anti-inflammatory polarization. Here, we report that M1-like macrophages stimulated by HBV exhibi…
View article: New mimic of relapse or regional lymph node metastasis in a cancer survivor: a case of mRNA COVID-19 vaccine-induced lymphadenitis with high FDG uptake
New mimic of relapse or regional lymph node metastasis in a cancer survivor: a case of mRNA COVID-19 vaccine-induced lymphadenitis with high FDG uptake Open
Western countries that were first to administer the COVID-19 vaccination report cases of vaccine-induced axillary lymphadenitis with high FDG uptake. However, no such findings have been reported from any Asian countries. We report here a c…
View article: Estimating Drug Efficacy with a Diet-Induced NASH Model in Chimeric Mice with Humanized Livers
Estimating Drug Efficacy with a Diet-Induced NASH Model in Chimeric Mice with Humanized Livers Open
Nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) is the most common liver disorder in developed countries. Although many new therapeutics for NASH are present in the drug development pipeline, there are still no approved drugs…
View article: Hypoechoic mass in the pancreatic head: pancreatic ganglioneuroma diagnosed by EUS-FNB
Hypoechoic mass in the pancreatic head: pancreatic ganglioneuroma diagnosed by EUS-FNB Open
症例は15歳,男性.健診で指摘された胸部レントゲン異常陰影の精査目的に受診した.胸腹部造影CTで右胸腔内後縦郭および膵頭部内に境界明瞭で造影効果の乏しい腫瘍を認めた.後縦郭腫瘍に経皮的CTガイド下針生検を施行した.紡錘形細胞が索状に増殖し,内部に好塩基性胞体を示す神経節細胞が混在する組織像を呈し,病理組織学的にganglioneuroma(GN)と診断した.膵腫瘍の画像所見は 後縦郭腫瘍と酷似していたが,膵内発生のGNは極めて稀であることから,endoscopic ultr…