Explanipedia

Long-term hydrophilic PDMS surfaces using Brij L4: A simple and robust approach for biomedical applications Open

Diana Pinho, Andréa Zille, Yuji Nashimoto, Hirokazu Kaji, Ana Moita , et al. · 2025

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes Open

Serge Ostrovidov, Hongkai Wu, Toshinori Fujie, Yutaka Nakamura, Yuji Nashimoto , et al. · 2025

Chronic diseases require regular medication intake over a long period of time, which induce a poor adherence to treatment by patients. To overcome this limitation, new implantable drug delivery systems (IDDS) are being developed to allow o…

Directed Navigation of Magnetotactic Bacteria via Magnetotaxis in a 3D Vasculature‐On‐A‐Chip Open

Brianna Bradley, Yuji Nashimoto, Adrián González-López, Takeshi Hori, Hirokazu Kaji , et al. · 2025

Magnetotactic bacteria (MTB), inherently motile and self‐powered, are promising biorobotic candidates for targeted anti‐cancer drug delivery since they can actively deliver the therapeutic agent to the tumor, decreasing adverse side effect…

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening Open

Yuki Nakao, Makiko Mori, Yuta Sekiguchi, I. Morita, Ryota Shindoh , et al. · 2025

In advancing pathophysiological models to assess renal drug responses, kidney organoids derived from human pluripotent stem cells mark notable progress. However, replicating aging‐ and senescence‐related pathologies remains a challenge. In…

Long-Term Hydrophilic Polydimethylsiloxane (Pdms) Surfaces Using Brij L4: A Simple and Robust Approach for Biomedical Applications Open

Inês M. Gonçalves, Diana Pinho, Joel Borges, F. Vaz, Andréa Zille , et al. · 2025

Placental microphysiological systems: new advances on promising platforms that mimic the microenvironment of the human placenta Open

Inês M. Gonçalves, Muhammad Afzal, Nithil Kennedy, Ana Moita, Rui Lima , et al. · 2024

This review presents new advancements in placental MPS models for toxicological screening, preeclampsia assessment, and embryo uterine implantation and an overview of bioprinting technology and current advances in endometrial MPSs.

Editorial: Modelling and sensing platform for cancer and tumour microenvironment Open

Yuji Nashimoto, Yusuke Kanno, Hidenori Ito, Mustafa Şen · 2024

EDITORIAL article Front. Bioeng. Biotechnol., 04 June 2024Sec. Tissue Engineering and Regenerative Medicine Volume 12 - 2024 | https://doi.org/10.3389/fbioe.2024.1432352

Osteogenic differentiation of mesenchymal stem cell spheroids: A microfluidic device and electrochemiluminescence imaging study Open

Kaoru Hiramoto, An Konno, Yuji Nashimoto, Ayumi Hirano‐Iwata, Kosuke Ino , et al. · 2024

Human mesenchymal stem cells (MSCs) have attracted attention as a major cellular source for regenerative medicine and preclinical studies. Three-dimensional (3D) cell culture systems can be used to construct physiologically relevant MSC sp…

Development of Tumor Models Using Microphysiological System Open

Yuji Nashimoto · 2024

1.はじめに

Modeling embryo-endometrial interface recapitulating human embryo implantation Open

Shun Shibata, Shun Endo, Luís Augusto Eijy Nagai, Eri Kobayashi, Akira Oike , et al. · 2024

The initiation of human pregnancy is marked by the implantation of an embryo into the uterine environment; however, the underlying mechanisms remain largely elusive. To address this knowledge gap, we developed hormone-responsive endometria…

Microfluidic vascular formation model for assessing angiogenic capacities of single islets Open

Yuji Nashimoto, An Konno, Takuto Imaizumi, Kaori Nishikawa, Kosuke Ino , et al. · 2023

Pancreatic islet transplantation presents a promising therapy for individuals suffering from type 1 diabetes. To maintain the function of transplanted islets in vivo, it is imperative to induce angiogenesis. However, the mechanisms underly…

Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes Open

Serge Ostrovidov, Murugan Ramalingam, Hojae Bae, Gorka Orive, Toshinori Fujie , et al. · 2023

Molecularly imprinted polymers (MIPs) are synthetic polymers with specific binding sites that present high affinity and spatial and chemical complementarities to a targeted analyte. They mimic the molecular recognition seen naturally in th…

Oxygen metabolism analysis of a single organoid for non-invasive discrimination of cancer subpopulations with different growth capabilities Open

Yuji Nashimoto, Shotaro Shishido, Kunishige Onuma, Kosuke Ino, Masahiro Inoue , et al. · 2023

Heterogeneous nature is a pivotal aspect of cancer, rendering treatment problematic and frequently resulting in recurrence. Therefore, advanced techniques for identifying subpopulations of a tumour in an intact state are essential to devel…

Engineering Oral Microenvironments Using Microphysiological Systems Open

Yuji Nashimoto, Takeshi Hori, Serge Ostrovidov, Sayaka Katagiri, Hirokazu Kaji · 2023

A deeper understanding of oral homeostasis and a precise evaluation of the effects of foreign materials are crucial for the oral health and total quality of life.Microphysiological systems (MPSs) or organs-on-chips have emerged over the pa…

Three-dimensional-printed Refillable Drug Delivery Device for Long-term Sustained Drug Delivery to Retina Open

Takeshi Hori, Yuya Ito, Bibek Raut, Serge Ostrovidov, Yuji Nashimoto , et al. · 2023

As the aging population increases worldwide, the number of patients with retinal diseases requiring long-term treatment, such as for age-related macular degeneration (AMD), is expected to increase.Intravitreal injection is the most common …

Effects of Ion Concentration on Ion Current Rectification Using a Glass Nanocapillary Open

Chisato Ito, Kosuke Ino, Kaoru Hiramoto, Yuji Nashimoto, Hitoshi Shiku · 2023

先端開口径がナノスケールのガラスナノキャピラリーにイオン濃度の低い溶液を入れた場合,先端のナノポアにはそのイオン濃度から予想されるよりも過剰なイオンが存在している.これは,イオンが内壁で電気二重層を形成しているからである.この条件でキャピラリー内に電極を設置して,ナノポアを介してイオン電流を計測すると,正と負の電圧をかけたときで得られるイオン電流値が大きく異なる.この現象をイオン電流整流作用(ion current rectification, ICR)と呼ぶ.ICRの大き…

Minimally Invasive Sub-Retinal Transplantation of RPE-J Cells on a Biodegradable Composite PCL/Collagen Nanosheet Open

Kazuya Yamashita, Serge Ostrovidov, Bibek Raut, Takeshi Hori, Yuji Nashimoto , et al. · 2023

Retinal cells are irreparably damaged by diseases such as age-related macular degeneration (AMD). A promising method to restore partial or whole vision is through cell-based transplantation to the damaged location. However, cell transplant…

Electrochemiluminescence Imaging Based on Bipolar Electrochemistry Using Commercially Available Anisotropic Conductive Films Open

Rise Akasaka, Kosuke Ino, Tomoki Iwama, Kumi Y. Inoue, Yuji Nashimoto , et al. · 2022

Electrochemical Glue for Binding Chitosan–Alginate Hydrogel Fibers for Cell Culture Open

Yoshinobu Utagawa, Kosuke Ino, Tatsuki Kumagai, Kaoru Hiramoto, Masahiro Takinoue , et al. · 2022

Three-dimensional organs and tissues can be constructed using hydrogels as support matrices for cells. For the assembly of these gels, chemical and physical reactions that induce gluing should be induced locally in target areas without cau…

Electrochemical Substrates and Systems for Enzyme-Based Bioassays Open

Yoshinobu Utagawa, Kentaro Ito, Kumi Y. Inoue, Yuji Nashimoto, Kosuke Ino , et al. · 2022

バイオ分析において基質が果たす役割は大きい.例えば,イムノアッセイでは酵素標識された抗体が用いられ,さらに酵素に特異的に反応する基質を添加して,酵素生成物を検出することで目的の測定物を定量できる.健康診断における検体サンプルや培養細胞における抗原の検出では,酵素を用いた免疫染色法が幅広く用いられており,基質からの酵素生成物の着色により可視化されている.多くの場合は,生成物の光学特性を生かし,着色したり,吸光度測定したりするが,装置の簡便さや優れた定量性を生かし,電気化学計測…

Electrochemical Imaging of Endothelial Permeability Using a Large-Scale Integration-Based Device Open

Kosuke Ino, Hao-Jen Pai, Kaoru Hiramoto, Yoshinobu Utagawa, Yuji Nashimoto , et al. · 2021

It is important to clarify the transport of biomolecules and chemicals to tissues. Herein, we present an electrochemical imaging method for evaluating the endothelial permeability. In this method, the diffusion of electrochemical tracers, …

Ion Conductance-Based Perfusability Assay of Vascular Vessel Models in Microfluidic Devices Open

Rise Akasaka, Masashi Ozawa, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku · 2021

We present a novel methodology based on ion conductance to evaluate the perfusability of vascular vessels in microfluidic devices without microscopic imaging. The devices consisted of five channels, with the center channel filled with fibr…

In vitro electrochemical assays for vascular cells and organs Open

Yoshinobu Utagawa, Kaoru Hiramoto, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku · 2021

Vascular form vascular organs and the walls of blood vessels play a crucial role in transporting nutritive compounds and drugs. Vascular cells also release factors required to maintain the homeostasis of the organs. Since cancer cells trav…

Bipolar Electrode‐based Electrochromic Devices for Analytical Applications – A Review Open

Siti Masturah binti Fakhruddin, Kosuke Ino, Kumi Y. Inoue, Yuji Nashimoto, Hitoshi Shiku · 2021

Bipolar electrode‐based (BPE‐based) electrochromic devices have garnered increasing attention in the past decade. These BPE‐based electrochromic devices have been used for analytical health monitoring, point‐of‐care (POC) diagnostics, and …

A Droplet Array Device for Electrochemical Detection of Methylene Blue Based on Local Redox Cycling Open

Kaoru Hiramoto, Keika Komatsu, Yuta Yamada, Yuji Nashimoto, Tomokazu Matsue , et al. · 2021

Methylene blue is widely utilized as an indicator and dye in bioassays. For the simultaneous detection of many samples in bioassays, a multiple assay device is desired. Here, we present an array device based on local redox cycling for the …

Announcements Open

Nobuaki Soh, Kai Kamada, Kotoe Nakasha, Gaku Fukuhara, Shota Takahashi , et al. · 2021

A new perfusion culture method with a self-organized capillary network Open

Kei Sugihara, Yoshimi Yamaguchi, Shiori Usui, Yuji Nashimoto, Sanshiro Hanada , et al. · 2020

A lack of perfusion has been one of the most significant obstacles for three-dimensional culture systems of organoids and embryonic tissues. Here, we developed a simple and reliable method to implement a perfusable capillary network in vit…

Recent activities of the TOHOKU Branch Open

Yuji Nashimoto · 2020

Recent Advances in Electrochemiluminescence-Based Systems for Mammalian Cell Analysis Open

Kaoru Hiramoto, Elena Villani, Tomoki Iwama, Keika Komatsu, Shinsuke Inagi , et al. · 2020

Mammalian cell analysis is essential in the context of both fundamental studies and clinical applications. Among the various techniques available for cell analysis, electrochemiluminescence (ECL) has attracted significant attention due to …

A new microcirculation culture method with a self-organized capillary network Open

Kei Sugihara, Yoshimi Yamaguchi, Shiori Usui, Yuji Nashimoto, Sanshiro Hanada , et al. · 2020

A lack of microcirculation has been one of the most significant obstacles for three-dimensional culture systems of organoids and embryonic tissues. Here, we developed a simple and reliable method to implement a perfusable capillary network…

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