Explanipedia

Reply to Liu et al., Zhou et al., and Dong et al. Open

Mohsen Sadatsafavi, Trung N. Tran, Ghislaine Scélo, Ming‐Ju Tsai, John Busby , et al. · 2025

International audience

Independent association of a 17q21 variant with exacerbations in type 2–low adult asthma Open

Yumi Ishiyama, Hisako Matsumoto, Hironobu Sunadome, Yuji Tohda, Takahiko Horiguchi , et al. · 2025

The rs7216389 TT variant on 17q21 may be an independent risk factor for exacerbations in adults with type 2-low asthma, highlighting the role of GSDMB in its pathophysiology.

Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data Open

Wenjia Chen, Trung N. Tran, John Townend, George Christoff, Ming-Ju Tsai , et al. · 2025

Biologic initiation in patients with SA led to substantial reduction in TOCS exposure, particularly in the first year. Future analyses will explore the impact on OCS-related adverse health events.

Practical Guidelines for Asthma Management (PGAM): Digest edition Open

Jun Tamaoki, Hiroyuki Nagase, Hiroyuki Sano, Takeshi Kaneko, Yasuhiro Gon , et al. · 2025

The international and national guidelines for asthma management are typically comprehensive and designed for respiratory specialists, making them less practical for primary care physicians who handle most asthma cases. Recognizing the need…

A Case Report of Smear-positive Pulmonary Tuberculosis with False-negative Loop-mediated Isothermal Amplification and T-SPOT.TB Assays Open

Yuki Tsutsumi, Tadao Nagasaki, Masato Muraki, Soichiro Hanada, Hiroshi Teraguchi , et al. · 2025

Rapid molecular and immunological assays for tuberculosis, including loop-mediated isothermal amplification (LAMP) and T-SPOT. TB assays, may yield false-negative results. We herein report a 62-year-old immunocompetent man with a productiv…

Dupilumab sustains lung function improvements in patients with moderate-to-severe asthma Open

Alberto Papi, Mario Castro, Jonathan Corren, Ian Pavord, Yuji Tohda , et al. · 2024

Dupilumab demonstrated sustained improvements across multiple spirometric lung function measurements for up to 3 years; patients who received placebo in QUEST experienced rapid lung function improvement upon initiation of dupilumab in TRAV…

Real-World Safety and Effectiveness of Benralizumab in Japanese Patients with Severe Asthma: A Multicenter Prospective Observational Study Open

Masao Yamaguchi, Yoshihiro Nishimura, Y Takumi, Nobuya Hayashi, Kei Sakamoto , et al. · 2024

No new safety concerns were raised, and patients experienced benefits consistent with previous studies of benralizumab, thus supporting the use of benralizumab for the add-on maintenance treatment of patients with eosinophilic severe uncon…

Role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma-like symptoms Open

Akiko Sano, Takenori Kozuka, Nanase Watatani, Yuuki Kunita, Yoshiyuki Kawabata , et al. · 2023

Background: Obstructive sleep apnea (OSA) is one of the major co-morbidities and aggravating factors of asthma. In OSA-complicated asthma, obesity, visceral fat, and systemic inflammation are associated with its severity, but the role of b…

Significance of Self-Injectable Biologics in Japanese Patients with Severe Allergic Diseases: Focusing on Pen-Type Devices and Copayment Open

Soichiro Hanada, Masato Muraki, Yoshiyuki Kawabata, Kazuya Yoshikawa, Toshiyuki Yamagata , et al. · 2023

Administration of biologics using pen-type devices is easier, and the introduction of home self-injection leads to a reduction in outpatient visits and copayment.

Construction of a Diagnostic Algorithm for Diagnosis of Adult Asthma Using Machine Learning with Random Forest and XGBoost Open

Katsuyuki Tomita, Akira Yamasaki, Ryohei Katou, Tomoyuki Ikeuchi, Hirokazu Touge , et al. · 2023

An evidence-based diagnostic algorithm for adult asthma is necessary for effective treatment and management. We present a diagnostic algorithm that utilizes a random forest (RF) and an optimized eXtreme Gradient Boosting (XGBoost) classifi…

Characterization of Severe Uncontrolled Asthma in Japan: Analysis of Baseline Data from the PROSPECT Study Open

Toshiyuki Koya, Kazuhisa Asai, Takashi Iwanaga, Yu Hara, Mai Takahashi , et al. · 2023

This analysis of baseline data from the PROSPECT study is the first to clarify the characteristics of Japanese patients with severe uncontrolled asthma. BIOs were not necessarily prescribed to patients in whom they were indicated; however,…

Diaphragm dome height on chest radiography as a predictor of dynamic lung hyperinflation in COPD Open

Masashi Shiraishi, Yuji Higashimoto, Ryuji Sugiya, Hiroki Mizusawa, Yu Takeda , et al. · 2023

Background and objective Dynamic lung hyperinflation (DLH) can play a central role in exertional dyspnoea in patients with COPD. Chest radiography is the basic tool for assessing static lung hyperinflation in COPD. However, the predictive …

Intervention to Prevent Aspiration Pneumonia in the Elderly Open

Tomoaki Iwanaga, Yoshiki Takeyama, Aicha Sano, H. Sano, Yuji Tohda · 2023

Comparative effectiveness of anti‐IL5 and anti‐IgE biologic classes in patients with severe asthma eligible for both Open

Paul Pfeffer, Nasloon Ali, Ruth Murray, Charlotte Suppli Ulrik, Trung N. Tran , et al. · 2023

Background Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of adult patients with severe asthma…

Nationwide survey of refractory asthma with bronchiectasis by inflammatory subtypes Open

Natsuko Nomura, Hisako Matsumoto, Akihito Yokoyama, Yoshihiro Nishimura, Koichiro Asano , et al. · 2022

Systemic corticosteroids in asthma: A call to action from World Allergy Organization and Respiratory Effectiveness Group Open

Eugene R. Bleecker, Mona Al‐Ahmad, Leif Bjermer, Marco Caminati, Giorgio Walter Canonica , et al. · 2022

Sternocleidomastoid Muscle Thickness Correlates with Exercise Tolerance in Patients with COPD Open

Masashi Shiraishi, Yuji Higashimoto, Ryuji Sugiya, Hiroki Mizusawa, Yu Takeda , et al. · 2022

Background: Patients with chronic obstructive pulmonary disease (COPD) have difficulties inhaling as the diaphragm becomes flattened and weakened due to lung hyperinflation. This weakened respiratory function is compensated for by the incr…

Efficacy of dupilumab in patients with uncontrolled, moderate-to-severe asthma recruited from Japanese centers in the phase 3 LIBERTY ASTHMA TRAVERSE study Open

Yuji Tohda, Yoichi Nakamura, Takao Fujisawa, Motohiro Ebisawa, Jérôme Msihid , et al. · 2022

Long-term dupilumab treatment was well tolerated and efficacious in patients with non-OCS-dependent, moderate-to-severe asthma recruited from Japan. (Funded by Sanofi and Regeneron Pharmaceuticals, Inc.; ClinicalTrials.gov identifier, NCT0…

Supplementary Material for: Sternocleidomastoid Muscle Thickness Correlates with Exercise Tolerance in Patients with COPD Open

Michael Shiraishi, Yuji Higashimoto, Ryuji Sugiya, H. Mizusawa, Yu Takeda , et al. · 2022

Background: Patients with chronic obstructive pulmonary disease (COPD) have difficulties inhaling as the diaphragm becomes flattened and weakened due to lung hyperinflation. This weakened respiratory function is compensated f…

Cost-effectiveness analysis of dupilumab among patients with oral corticosteroid-dependent uncontrolled severe asthma in Japan Open

Yuji Tohda, Hisako Matsumoto, Masanori Miyata, Yurie Taguchi, Maki Ueyama , et al. · 2021

In Japan, dupilumab, as an add-on to background therapy, is economically dominant compared with benralizumab, and cost-effective versus mepolizumab.

P16‐60: Post COVID‐19 organizing pneumonia treated with mycophenolate mofetil Open

Ryo Yamazaki, Osamu Nishiyama, Kazuya Yosikawa, Hisako Matsumoto, Yuji Tohda , et al. · 2021

Background: Many patients with IPF typically visit a hospital with chronic respiratory symptoms and then the diagnosis is made.However, some patients are incidentally diagnosed with IPF.Aims: This study was planned to investigate the clini…

S86 Long-term assessment of exacerbations and lung function in the LIBERTY ASTHMA TRAVERSE study, stratified by lung function improvements at the end of the phase 3 LIBERTY ASTHMA QUEST parent study Open

Arnaud Bourdin, NA Hanania, Del Dorscheid, Xavier Muñoz, Yuji Tohda , et al. · 2021

Introduction and Objectives Low pre-bronchodilator FEV₁ in asthma patients is associated with increased exacerbations and lung function decline. Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component …

P16‐4: Therapeutic effect of oligonucleotide therapeutics PK‐7010 in mouse model of bleomycin‐induced lung fibrosis Open

Akihisa Saito, Kojin Murakami, Naoki Takahashi, Seidai Sato, Takeshi Imakura , et al. · 2021

in lung epithelial cells.These results suggested the possibility that ANGPTL4 secreted from lung epithelial cells might act on the fibroblasts and be involved in fibrotic processes.The levels of serum ANGPTL4 of AE-IPF were significantly e…

Diaphragmatic excursion is correlated with the improvement in exercise tolerance after pulmonary rehabilitation in patients with chronic obstructive pulmonary disease Open

Masashi Shiraishi, Yuji Higashimoto, Ryuji Sugiya, Hiroki Mizusawa, Yu Takeda , et al. · 2021

Background In patients with chronic obstructive pulmonary disease (COPD), the maximum level of diaphragm excursion (DE max ) is correlated with dynamic lung hyperinflation and exercise tolerance. This study aimed to elucidate the utility o…

EFFECT OF DUPILUMAB ON LUNG FUNCTION PARAMETERS IN ORAL CORTICOSTEROID-DEPENDENT PATIENTS WITH ASTHMA ENROLLED IN LIBERTY ASTHMA TRAVERSE Open

Mario Castro, Alberto Papi, Jonathan Corren, Ian Pavord, Yuji Tohda , et al. · 2021

LONG-TERM EFFECT OF DUPILUMAB ON LUNG FUNCTION IN PATIENTS WITH TYPE 2 ASTHMA: LIBERTY ASTHMA TRAVERSE STUDY Open

Alberto Papi, Mario Castro, Jonathan Corren, Ian Pavord, Yuji Tohda , et al. · 2021

Development of allergic rhinitis in early life: A prospective cohort study in high-risk infants Open

Sawako Masuda, Mizuho Nagao, Satoko Usui, Kazutaka Nogami, Yuji Tohda , et al. · 2021

Background: Allergic rhinitis (AR) is the most common allergic disease in children and is closely associated with asthma in the context of atopic march. The development process of AR in early childhood, however, is not well understood due …

The phosphodiesterase 4 inhibitor AA6216 suppresses activity of fibrosis-specific macrophages Open

Takashi Matsuhira, Osamu Nishiyama, Yuji Tabata, Shinji Kurashimo, Hiroyuki Sano , et al. · 2021

Impact of baseline patient characteristics on dupilumab efficacy in type 2 asthma Open

William W. Busse, Pierluigi Paggiaro, Xavier Muñoz, Thomas B. Casale, Mario Castro , et al. · 2021

Dupilumab treatment versus placebo improved exacerbation rate and lung function outcomes in patients with uncontrolled moderate-to-severe asthma and high type 2 biomarkers at baseline, regardless of baseline characteristics in the phase 3 …

Effect of Pulmonary Rehabilitation on Erector Spinae Muscles in Individuals With COPD Open

Yuji Higashimoto, Masashi Shiraishi, Ryuji Sugiya, Hiroki Mizusawa, Osamu Nishiyama , et al. · 2021

ESM mass was shown to decline yearly in subjects with COPD. The annual decline in muscle mass was reduced by PR.

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