Yuji Yokozeki
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View article: Fresh Platelet-Rich Plasma Gel Reduces Sciatic Nerve-Associated Neuropathic Pain in Rats by Suppressing Tumor Necrosis Factor-α and Interleukin-6 Expression
Fresh Platelet-Rich Plasma Gel Reduces Sciatic Nerve-Associated Neuropathic Pain in Rats by Suppressing Tumor Necrosis Factor-α and Interleukin-6 Expression Open
PRP gel wrapping has a substantial long-term suppression effect on neuropathic pain, possibly involving suppression of Tnf-α and Il-6 expression in the nerves. This study suggests that PRP gel wrapping may be clinically appli…
View article: Malnutrition and Spinal Sagittal Malalignment Are Risk Factors for Incidence of New Vertebral Fractures in Patients with Osteoporosis
Malnutrition and Spinal Sagittal Malalignment Are Risk Factors for Incidence of New Vertebral Fractures in Patients with Osteoporosis Open
The 1-year incidence of new VFs was 10.1% among patients with osteoporosis, despite appropriate osteoporosis treatment. These patients also exhibited malnutrition and spinal sagittal malalignment at baseline. Our findings suggest that maln…
View article: P41. Muscle strength but not muscle mass might be associated with spinal sagittal alignment and low back pain in patients with osteoporosis
P41. Muscle strength but not muscle mass might be associated with spinal sagittal alignment and low back pain in patients with osteoporosis Open
View article: Muscle strength rather than appendicular skeletal muscle mass might affect spinal sagittal alignment, low back pain, and health-related quality of life
Muscle strength rather than appendicular skeletal muscle mass might affect spinal sagittal alignment, low back pain, and health-related quality of life Open
Sarcopenia is defined as decreasing in muscle strength and mass, and dynapenia is defined as decreasing in muscle strength and maintained muscle mass. This study elucidated the prevalence and characteristics of sarcopenia and dynapenia and…
View article: Posterior Spinal Fusion Surgery for Neuromuscular Disease Patients with Severe Scoliosis Whose Cobb Angle Was over 100 Degrees
Posterior Spinal Fusion Surgery for Neuromuscular Disease Patients with Severe Scoliosis Whose Cobb Angle Was over 100 Degrees Open
Background and objectives: Patients with neuromuscular diseases usually have progressive neuromuscular scoliosis (NMS), requiring invasive surgery. Some patients present with severe scoliosis at the time of consultation and are difficult t…
View article: Posterior Spinal Fusion Surgery for Neuromuscular Disease Patients With Severe Scoliosis Whose Cobb Angle was Over 100 Degrees
Posterior Spinal Fusion Surgery for Neuromuscular Disease Patients With Severe Scoliosis Whose Cobb Angle was Over 100 Degrees Open
Patients with neuromuscular diseases usually have progressive neuromuscular scoliosis (NMS), requiring invasive surgery. Some patients present with severe scoliosis at the time of consultation and are difficult to treat. Posterior spinal f…
View article: Intraoperative Blood Loss at Different Surgical-Procedure Stages during Posterior Spinal Fusion for Idiopathic Scoliosis
Intraoperative Blood Loss at Different Surgical-Procedure Stages during Posterior Spinal Fusion for Idiopathic Scoliosis Open
Background and Objectives: Several predictive factors have been reportedly associated with intraoperative total blood loss (TBL) during posterior spinal fusion (PSF) for idiopathic scoliosis (IS). To reduce TBL, preoperative factors and in…
View article: COL1A1 and COL3A1 elevation and regulation by β2-microglobulin in subsynovial connective tissues of patients undergoing hemodialysis with carpal tunnel syndrome
COL1A1 and COL3A1 elevation and regulation by β2-microglobulin in subsynovial connective tissues of patients undergoing hemodialysis with carpal tunnel syndrome Open
Purpose: Carpal tunnel syndrome (CTS) constitutes a typical complication of patients receiving long-term hemodialysis (HD). However, the mechanisms underlying the manifestation of CTS in patients receiving long-term hemodialysis remain to …
View article: Origin of M2 Mϕ and its macrophage polarization by TGF-β in a mice intervertebral injury model
Origin of M2 Mϕ and its macrophage polarization by TGF-β in a mice intervertebral injury model Open
Introduction Studies have identified the presence of M1 and M2 macrophages (Mϕ) in injured intervertebral discs (IVDs). However, the origin and polarization-regulatory factor of M2 Mϕ are not fully understood. TGF-β is a regulatory factor …
View article: A High Body Mass Index and the Vacuum Phenomenon Upregulate Pain-Related Molecules in Human Degenerated Intervertebral Discs
A High Body Mass Index and the Vacuum Phenomenon Upregulate Pain-Related Molecules in Human Degenerated Intervertebral Discs Open
Animal studies suggest that pain-related-molecule upregulation in degenerated intervertebral discs (IVDs) potentially leads to low back pain (LBP). We hypothesized that IVD mechanical stress and axial loading contribute to discogenic LBP’s…
View article: Prevalence and location of endplate fracture and subsidence after oblique lumbar interbody fusion for adult spinal deformity
Prevalence and location of endplate fracture and subsidence after oblique lumbar interbody fusion for adult spinal deformity Open
View article: TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model
TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model Open
Background Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP). Following disc injury, nerve growth factor (NGF) concentrations rise in IVDs, and anti-NGF therapy has been shown to attenuate LBP in humans. Increa…
View article: Prevalence and Characteristics of Spinal Sagittal Malalignment in Patients with Osteoporosis
Prevalence and Characteristics of Spinal Sagittal Malalignment in Patients with Osteoporosis Open
Spinal sagittal malalignment due to vertebral fractures (VFs) induces low back pain (LBP) in patients with osteoporosis. This study aimed to elucidate spinal sagittal malalignment prevalence based on VF number and patient characteristics i…
View article: Prevalence and Location of Endplate Fracture and Subsidence after Oblique Lumbar Interbody Fusion for Adult Spinal Deformity
Prevalence and Location of Endplate Fracture and Subsidence after Oblique Lumbar Interbody Fusion for Adult Spinal Deformity Open
Background: Recently, Oblique lumbar interbody fusion (OLIF) is commonly indicated to correct the sagittal and coronal alignment in adult spinal deformity (ASD). Endplate fracture during surgery is one of major complication of OLIF, but th…
View article: Reduced TGF‐<i>β</i> Expression and CD206‐Positive Resident Macrophages in the Intervertebral Discs of Aged Mice
Reduced TGF‐<i>β</i> Expression and CD206‐Positive Resident Macrophages in the Intervertebral Discs of Aged Mice Open
Age is a key factor in intervertebral disc (IVD) degeneration; however, the changes that occur in IVDs with age are not fully understood. Tissue‐resident macrophages are critical for tissue homeostasis and are regulated by transforming gro…
View article: Incidence of Unintentional Intraoperative Hypothermia in Pediatric Scoliosis Surgery and Associated Preoperative Risk Factors
Incidence of Unintentional Intraoperative Hypothermia in Pediatric Scoliosis Surgery and Associated Preoperative Risk Factors Open
The incidence of hypothermia in pediatric posterior scoliosis surgery is 38.8%. Diagnosis of non-AIS, lower body mass index, and lower core body temperature at the time of anesthesia induction are preoperative risk factors for intraoperati…
View article: Acceleration of bone union by in situ-formed hydrogel containing bone morphogenetic protein-2 in a mouse refractory fracture model
Acceleration of bone union by in situ-formed hydrogel containing bone morphogenetic protein-2 in a mouse refractory fracture model Open
View article: Short-Term Impact of Staying Home on Bone Health in Patients With Osteoporosis During a State of Emergency Declaration Due to COVID-19 in Kanagawa, Japan
Short-Term Impact of Staying Home on Bone Health in Patients With Osteoporosis During a State of Emergency Declaration Due to COVID-19 in Kanagawa, Japan Open
Background On April 16, 2020, the Japanese government declared a state of emergency due to the spread of COVID-19 infection, leading prefectural governors to announce a stay-at-home order for 39 days until May 25, 2020. As physical inactiv…
View article: Posterior Spinal Correction and Fusion Surgery in Patients with Spinal Muscular Atrophy-Associated Scoliosis for Whom Treatment with Nusinersen Was Planned
Posterior Spinal Correction and Fusion Surgery in Patients with Spinal Muscular Atrophy-Associated Scoliosis for Whom Treatment with Nusinersen Was Planned Open
Our findings show that additional lumbar laminectomy during surgery for spinal scoliosis has effectively allowed for intrathecal injection of Nusinersen.
View article: Loop-Mediated Isothermal Amplification Screening for COVID-19 in Asymptomatic Preoperative Orthopedic Patients in a General Hospital in Kanagawa, Japan
Loop-Mediated Isothermal Amplification Screening for COVID-19 in Asymptomatic Preoperative Orthopedic Patients in a General Hospital in Kanagawa, Japan Open
The global coronavirus disease 2019 (COVID-19) pandemic has caused several million infections and hundreds of thousands of deaths. A large number of healthcare workers have died as a result of infection with this virus. Therefore, elective…
View article: Investigation of resident and recruited macrophages following disc injury in mice
Investigation of resident and recruited macrophages following disc injury in mice Open
Macrophages, particularly M1 macrophages, produce proinflammatory cytokines and contribute to the degenerative process in injured intervertebral discs (IVDs). We previously showed that macrophages in both intact and injured IVDs increased …
View article: <p>Osteoarthritis patients with high haemoglobin A1c have increased Toll-like receptor 4 and matrix metalloprotease-13 expression in the synovium</p>
Osteoarthritis patients with high haemoglobin A1c have increased Toll-like receptor 4 and matrix metalloprotease-13 expression in the synovium Open
TLR4 and MMP13 expression were elevated in the synovium of osteoarthritis patients with high HbA1c concentrations. Our results may provide insight into the pathology of OA patients with DM.
View article: Osteoarthritis patients with high haemoglobin A1c have increased Toll-like receptor 4 and matrix metalloprotease-13 expression in the synovium
Osteoarthritis patients with high haemoglobin A1c have increased Toll-like receptor 4 and matrix metalloprotease-13 expression in the synovium Open
Kosuke Murata,1 Kentaro Uchida,1 Shotaro Takano,1 Shintaro Shoji,1 Dai Iwase,1 Gen Inoue,1 Jun Aikawa,1 Yuji Yokozeki,1 Hiroyuki Sekiguchi,2 Masashi Takaso11Department of Orthopedic Surgery, Kitasato University School of Medicine, Sagamiha…