Explanipedia

The efficacy and safety of peripheral nerve blocks for postoperative analgesia following total hip arthroplasty: a network meta-analysis Open

Yanyan Yang, Yan Xu, Hong Tang, Y. Hu, Fuhai Bai · 2025

CRD42025639677.

Blue Light as an Anti-inflammatory and Analgesic Strategy in Thoracic Trauma (BLAASTT): protocol for a randomised controlled trial in adult trauma inpatients with painful rib fractures Open

Rebecca E. Kotcher, Matthew R. Rosengart, Luca La Colla, Hsing‐Hua Sylvia Lin, Keith M. Vogt , et al. · 2025

Introduction Blue light (peak wavelength 442 nm) has been shown to modulate the immune response in preclinical models of intra-abdominal sepsis and pneumonia. In vivo pathways involve optic nerve stimulation with transmission to the centra…

A Study of the Narrative Structure and Action Logic of 〈Squid Game 2〉. -Analysis Based on Grimes and Propp Theory- Open

Yan Xu · 2025

Activation of the α7 nicotinic acetylcholine receptor mitigates cognitive deficits in mice with sepsis-associated encephalopathy by inhibiting microglial pyroptosis Open

Qiaosheng Wang, Qiong Luo, Zhiwei Su, Yan Xu, Liangshan Peng , et al. · 2025

The activation of α7 nAChR reduces pyroptosis by enhancing microglial mitophagy, thereby mitigating SAE.

Competitive Antagonism of Xylazine on α7 Nicotinic Acetylcholine Receptors and Reversal by Curcuminoids Open

Qiang Chen, Yan Xu, Pei Tang · 2024

Co-use of xylazine with opioids is a major health threat in the United States. However, a critical knowledge gap exists in the understanding of xylazine-induced pharmacological and pathological impact. Xylazine is mostly known as an agonis…

Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes Open

Vasyl Bondarenko, Qiang Chen, Tommy S. Tillman, Yan Xu, Pei Tang · 2024

PDZ domains are modular domains that conventionally bind to C terminal or internal motifs of target proteins to control cellular functions through the regulation of protein complex assemblies. Almost all reported structures of PDZ-target p…

Fingerprint of Circulating Immunocytes as Biomarkers for the Prognosis of Brain Inflammation and Neuronal Injury after Cardiac Arrest Open

Huanyu Dou, Nicole R. Brandon, Kerryann Koper, Yan Xu · 2023

Cardiac arrest is one of the most dangerous health problems in the world. Outcome prognosis is largely based on cerebral performance categories determined by neurological evaluations. Few systemic tests are currently available to predict s…

EXPRESSION OF AN ENGINEERED CHLORIDE CHANNEL AS A POSSIBLE GENE THERAPY TREATMENT FOR PAINFUL BLADDER SYNDROME / INTERSTITIAL CYSTITIS Open

Jean Beckel, Geraldine Ward, Jessica J. Connelly, Kevin D. Healy, Sarah E. Daugherty , et al. · 2023

Urothelial Knock-in of the Engineered Chloride Channel EG3RF as a Potential Treatment for Cystitis-Induced Bladder Inflammation Open

Grace Ward, Jonathan M. Beckel, Yan Xu, Keara Healy, Stephanie L. Daugherty · 2023

Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization Open

Vasyl Bondarenko, Qiang Chen, Kevin Singewald, Nandan Haloi, Tommy S. Tillman , et al. · 2023

[Image: see text] The α7 nicotinic acetylcholine receptor (α7nAChR) mediates signaling in the central nervous system and cholinergic anti-inflammatory pathways. Ivermectin is a positive allosteric modulator of a full-length α7nAChR and an …

SARS-CoV-2 Spike Protein Downregulates Cell Surface α7nAChR through a Helical Motif in the Spike Neck Open

Tommy S. Tillman, Qiang Chen, Vasyl Bondarenko, Jonathan A. Coleman, Yan Xu , et al. · 2023

A deficiency of the functional α7 nicotinic acetylcholine receptor (α7nAChR) impairs neuronal and immune systems. The SARS-CoV-2 spike protein (S12) facilitates virus cell entry during COVID-19 infection and can also independently disrupt …

Structure and mechanism of human cystine exporter cystinosin Open

Xue Guo, Philip Schmiege, Tufa E. Assafa, Rong Wang, Yan Xu , et al. · 2022

Protective Effects of Oviductus Ranae Mediated HPA Axis Regulation on Depressive Model of Mice Open

Xiaowei Huang, Chao Ma, Lin He, Yuchen Wang, Yan Xu , et al. · 2022

Authors' Contribution GL, ZL and XH designed the study, acquired of the financial support and managed the project.CM created models and wrote the initial draft.HL, YW and YX performed the experiment and analysed the data.

The Influence of H2SO4●●●H2O and (H2SO4)2 on hydrolysis of formaldehyde: a potential source of methanediol in troposphere Open

Yongqi Zhang, Longjie Huang, Yang Cheng, Teng Ye, Yan Xu , et al. · 2022

The hydrolysis of formaldehyde (HCHO) assisted by bimolecular acidic catalysts of H2SO4●●●H2O and (H2SO4)2 under different concentrations of H2SO4 and H2O were performed by quantum chemical calculations and the Master Equation method. The …

35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope Open

Xiaofei Wang, Xiangyu Chen, Jiaxing Tan, Shuai Yue, Runhong Zhou , et al. · 2022

Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor Open

Vasyl Bondarenko, Marta M. Wells, Qiang Chen, Tommy S. Tillman, Kevin Singewald , et al. · 2022

Impact of SARS-CoV-2 spike protein on α7 nicotinic acetylcholine receptor in cells Open

Tommy S. Tillman, Yan Xu, Pei Tang · 2022

An Observational Study of Team-Based Learning (TBL) and Problem-Based Learning (PBL) in the Teaching of Neuromuscular Disease Open

Jingwen Niu, Jun Zhao, Ying Xin Tan, Yangyu Huang, Yan Xu , et al. · 2021

Background To explore the practicability of team-based learning (TBL) and problem-based learning (PBL) in the teaching of neuromuscular disease in the Department of Neurology. Methods During 2012 and 2015, eighty-eight interns from Peking …

Gastroprotective effect of cirsilineol against hydrochloric acid/ethanol-induced gastric ulcer in rats Open

Guojin Gong, Rigetu Zhao, Yuhui Zhu, Jinfeng Yu, Bin Wei , et al. · 2021

This study was designed to evaluate the gastroprotective activity of cirsilineol in hydrochloric acid (HCl)/ethanol-induced gastric ulcer model. Cirsilineol was administered at the doses of 20 and 40 mg/kg in HCl/ethanol-induced rats. The …

Joint Interactions of Graphene and Benzo[a]pyrene With Pulmonary Surfactant Open

Tongtao Yue, Rujie Lv, Dongfang Xu, Yan Xu, Lu Liu , et al. · 2021

Background: Airborne nanoparticles can be ^{inhaled and deposit in human alveoli, where pulmonary surfactant (PS) molecules line at the alveolar air-water interface to act as the first barrier against inhaled nanoparticles entering th…}

Regulation and drug modulation of a voltage-gated sodium channel: Pivotal role of the S4–S5 linker in activation and slow inactivation Open

Jinglei Xiao, Vasyl Bondarenko, Yali Wang, Antonio Suma, Marta M. Wells , et al. · 2021

Significance Voltage-gated sodium channels initiate electric signals in cell communications. The S4–S5 linker between the voltage-sensing and pore modules transmits depolarization signals to trigger channel activation. The mechanisms of th…

Combined mass spectrometry-guided genome mining and virtual screening for acaricidal activity in secondary metabolites of <i>Bacillus velezensis</i> W1 Open

Xingyu Li, Shahzad Munir, Yan Xu, Yue‐Hu Wang, Yueqiu He · 2021

A comprehensive analytic strategy was performed to study the acaricidal activity ingredients of Bacillus velezensis W1, a strain for biological control of Tetranychus urticae.

Membrane cholesterol dependence of cannabinoid modulation of glycine receptor Open

Lei Yao, Marta M. Wells, Xiongwu Wu, Yan Xu, Li Zhang , et al. · 2020

Cannabinoids exert therapeutic effects on several diseases such as chronic pain and startle disease by targeting glycine receptors (GlyRs). Our previous studies have shown that cannabinoids target a serine residue at position 296 in the th…

A Thermal Place Preference Test for Discovery of Neuropathic Pain Drugs Open

Joel Caporoso, Mark Moses, Kerryann Koper, Tommy S. Tillman, Lingling Jiang , et al. · 2020

Developing potent non-opioid pain medications is an integral part of the battle to conquer both chronic pain and the current opioid crisis. Although most screening approaches use in vitro surrogate targets, in vivo screening …

Optimizing the Extraction of Polysaccharides from Bletilla ochracea Schltr. Using Response Surface Methodology (RSM) and Evaluating their Antioxidant Activity Open

Bulei Wang, Yan Xu, Lijun Chen, Guangming Zhao, Zeyuan Mi , et al. · 2020

Bletilla ochracea Schltr. polysaccharides (BOP) have a similar structure to Bletilla striata (Thunb.) Reichb.f. (Orchidaceae) polysaccharides (BSP). Therefore, BOP can be considered as a substitute for BSP in the food, pharmaceuticals and …

Functional Tolerance to Cysteine Mutations in Human α7 Nicotinic Acetylcholine Receptors Open

Tommy S. Tillman, Zachary Choi, Yan Xu, Pei Tang · 2020

The α7 nicotinic acetylcholine receptor (α7 nAChR) is involved in various intracellular signaling pathways that mediate addiction, chronic pain, and other diseases, but its intracellular domain structures remain undetermined. The presence …

<sup>19</sup>F Paramagnetic Relaxation-Based NMR for Quaternary Structural Restraints of Ion Channels Open

Vasyl Bondarenko, Marta M. Wells, Qiang Chen, Kevin Singewald, Sunil Saxena , et al. · 2019

Quaternary distance restraints are essential to define the three-dimensional structures of protein assemblies. These distances often fall within a range of 10-18 Å, which challenges the high and low measurement limits of conventional nucle…

Quality Control Measures and Validation in Gene Association Studies: Lessons for Acute Illness Open

Maria Cohen, Ashley J. Lamparello, Lukas Schimunek, Fayten El-Dehaibi, Rami A. Namas , et al. · 2019

Acute illness is a complex constellation of responses involving dysregulated inflammatory and immune responses, which are ultimately associated with multiple organ dysfunction. Gene association studies have associated single-nucleotide pol…

Delays in Cardiopulmonary Resuscitation, Defibrillation, and Epinephrine Administration All Decrease Survival in In-hospital Cardiac Arrest Open

Nicholas G. Bircher, Paul S. Chan, Yan Xu · 2019

Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Because the extent to which delays in initiating cardiopulmonary resuscitation (CPR) versus the time from CPR to defibrillation or…

Functional Tolerance of Human α7 Nicotinic Acetylcholine Receptor to Cysteine Labeling Open

Tommy S. Tillman, Yan Xu, Pei Tang · 2019

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