Yujing Zou
YOU?
Author Swipe
View article: Engineering HSV-1 for oncolytic therapy: From molecular entry mechanisms to retargeting strategies
Engineering HSV-1 for oncolytic therapy: From molecular entry mechanisms to retargeting strategies Open
View article: Tumour nuclear size heterogeneity as a biomarker for post-radiotherapy outcomes in gynecological malignancies
Tumour nuclear size heterogeneity as a biomarker for post-radiotherapy outcomes in gynecological malignancies Open
View article: Comparative evaluation of immunomodulatory cytokines for oncolytic therapy based on a high-efficient platform for oHSV1 reconstruction
Comparative evaluation of immunomodulatory cytokines for oncolytic therapy based on a high-efficient platform for oHSV1 reconstruction Open
Our findings underscore the need for rational cytokine selection in oHSV1-based immunotherapy. While IFN-γ increased immunogenic markers, its systemic toxicity and myeloid effects may limit benefit. GM-CSF exacerbated immune suppression in…
View article: BnLPAT2 gene regulates oil accumulation in Brassica napus by modulating linoleic and linolenic acid levels in seeds
BnLPAT2 gene regulates oil accumulation in Brassica napus by modulating linoleic and linolenic acid levels in seeds Open
Lysophosphatidate acyltransferase (LPAT) catalyzes the conversion of lysophosphatidic acid to phosphatidic acid, a key step in lipid biosynthesis. This study cloned four LPAT2 genes from Brassica napus : BnLPAT2-A04, A07, A09, and C08 . Fu…
View article: Generative Style Transfer for MRI Image Segmentation: A Case of Glioma Segmentation in Sub-Saharan Africa
Generative Style Transfer for MRI Image Segmentation: A Case of Glioma Segmentation in Sub-Saharan Africa Open
In Sub-Saharan Africa (SSA), the utilization of lower-quality Magnetic Resonance Imaging (MRI) technology raises questions about the applicability of machine learning methods for clinical tasks. This study aims to provide a robust deep lea…
View article: Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect
Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect Open
Alloreactive donor T cells undergo extensive metabolic reprogramming to become activated and induce graft-versus-host disease (GVHD) upon alloantigen encounter. It is generally thought that glycolysis, which promotes T cell growth and clon…
View article: Arid1a promotes thymocyte development through β‐selection‐dependent and β‐selection‐independent mechanisms
Arid1a promotes thymocyte development through β‐selection‐dependent and β‐selection‐independent mechanisms Open
Early T‐cell development from CD4 − CD8 − double‐negative (DN) stage to CD4 + CD8 + double‐positive (DP) stage in the thymus is regulated through multiple steps involving a batch of sequentially expressed factors. Our preliminary data and …
View article: Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells
Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells Open
Myeloid-derived suppressor cells (MDSCs) are a hetero geneous group of cells, which can suppress the immune response, promote tumor progression and impair the efficacy of immunotherapies. Consequently, the pharmacological targeting of MDSC…
View article: Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice
Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice Open
Background Aging has long been thought to be a major risk factor for various types of cancers. However, accumulating evidence indicates increased resistance of old animals to tumor growth. An in-depth understanding of how old individuals d…
View article: Med1 controls CD8 T cell maintenance through IL‐7R‐mediated cell survival signalling
Med1 controls CD8 T cell maintenance through IL‐7R‐mediated cell survival signalling Open
Under steady‐state conditions, the pool size of peripheral CD8 + T cells is maintained through turnover and survival. Beyond TCR and IL‐7R signals, the underlying mechanisms are less well understood. In the present study, we found a signif…
View article: A Genetic Model Reveals Biological Features of Neonatal CD4 Helper Cells Undergone Homeostasis in Mice
A Genetic Model Reveals Biological Features of Neonatal CD4 Helper Cells Undergone Homeostasis in Mice Open
CD4 + T cells are essential for regulating effective immune response to pathogens and immune balance. Recent studies have demonstrated the unique features of T cells in neonate mice, such as more sensitive to antigen response and preferenc…
View article: Single-cell sequencing characterizes intratumoral profile of immune cells in old mice
Single-cell sequencing characterizes intratumoral profile of immune cells in old mice Open
It has long been thought that aging is a major risk factor for cancer incidence. However, accumulating evidence indicates increased resistance of old animals to tumor growth. A systematic understanding of how old individuals defend against…
View article: Comparison of Complexity and Predictability of a Cellular Automaton Model in Excitable Media Cardiac Wave Propagation Compared with a FitzHugh-Nagumo Model
Comparison of Complexity and Predictability of a Cellular Automaton Model in Excitable Media Cardiac Wave Propagation Compared with a FitzHugh-Nagumo Model Open
Background: Excitable media are spatially distributed systems that propagate signals without damping. Examples include fire propagating through a forest, the Belousov-Zhabotinsky reaction, and cardiac tissue. (1) Excitable media generate w…
View article: T cell metabolism in graft-versus-host disease
T cell metabolism in graft-versus-host disease Open
Graft-versus-host disease (GVHD) is a major source of morbidity and mortality following allogeneic hematopoietic stem cell transplant (allo-HSCT), one of the most effective approaches to treat hematopoietic malignancies. 1 However, current…
View article: NK cell predicts the severity of acute graft-versus-host disease in patients after allogeneic stem cell transplantation using antithymocyte globulin (ATG) in pretreatment scheme
NK cell predicts the severity of acute graft-versus-host disease in patients after allogeneic stem cell transplantation using antithymocyte globulin (ATG) in pretreatment scheme Open
Background Graft-versus-host disease (GVHD) is one of the most complex complications after allogeneic stem cell transplantation. Current standard of grading system is based on clinical symptoms in skin, liver and intestinal. However, it’s …