Yi Yang
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View article: Comparative Analysis of Volatile Organic Compounds in Freshwater-Cultured and Saline–Alkaline Selectively Bred Tilapia Using Electronic Nose, GC-IMS, and HS-SPME-GC-MS
Comparative Analysis of Volatile Organic Compounds in Freshwater-Cultured and Saline–Alkaline Selectively Bred Tilapia Using Electronic Nose, GC-IMS, and HS-SPME-GC-MS Open
Tilapia is a cornerstone species in global aquaculture, yet the impact of saline-alkaline adaptive breeding on its flavor-related volatile organic compounds (VOCs) remains unclear. Herein, we compared VOCs in freshwater-cultured tilapia (F…
View article: Causal Relationship Between Serum Zinc Levels and Diabetic Kidney Disease (DKD): A Plasma Proteomics Mediation Study
Causal Relationship Between Serum Zinc Levels and Diabetic Kidney Disease (DKD): A Plasma Proteomics Mediation Study Open
The association between serum zinc levels and diabetic kidney disease (DKD) has been a focus of considerable scientific interest. Lower serum zinc has been observed to be involved in the progression of DKD, and zinc supplementation can imp…
View article: State Medical Cannabis Policy Implementation and Racial Disparities in Opioid Prescribing Among Medicare Beneficiaries: A Policy Impact Analysis
State Medical Cannabis Policy Implementation and Racial Disparities in Opioid Prescribing Among Medicare Beneficiaries: A Policy Impact Analysis Open
The study found no clear indication of racial disparities in the impact of medical cannabis policies on opioid prescribing. Future research should focus on access to medical cannabis and prescriber attitudes toward treating racial minority…
View article: Machine learning-based diagnostic model for neonatal intestinal diseases in multiple centres: a cross-sectional study protocol
Machine learning-based diagnostic model for neonatal intestinal diseases in multiple centres: a cross-sectional study protocol Open
Background Neonatal intestinal diseases often have an insidious onset and can lead to poor outcomes if not identified early. Early assessment of abnormal bowel function is critical for timely intervention and improving prognosis, underscor…
View article: Single Cell‐Pair Proteomics for Decoding Immune‐Cancer Cell Interactions
Single Cell‐Pair Proteomics for Decoding Immune‐Cancer Cell Interactions Open
The efficacy of cancer immunotherapy is significantly influenced by the heterogeneity of individual tumors and immune responses. To investigate this phenomenon, a microfluidic platform is constructed for profiling immune‐cancer cell intera…
View article: Quantitative site-specific glycoproteomics by ZenoTOF reveals glyco-signatures for breast cancer diagnosis
Quantitative site-specific glycoproteomics by ZenoTOF reveals glyco-signatures for breast cancer diagnosis Open
Intact glycopeptide characterization by mass spectrometry has proven a versatile tool for site-specific glycoproteomics analysis and biomarker screening. Here, we present a method using the ZenoTOF instrument with optimized fragmentation f…
View article: Pantothenate-encapsulated liposomes combined with exercise for effective inhibition of CRM1-mediated PKM2 translocation in Alzheimer's therapy
Pantothenate-encapsulated liposomes combined with exercise for effective inhibition of CRM1-mediated PKM2 translocation in Alzheimer's therapy Open
Alzheimer's disease (AD) is a complex neurodegenerative condition characterized by metabolic imbalances and neuroinflammation, posing a formidable challenge in medicine due to the lack of effective treatments. Despite considerable research…
View article: Pathogen-specific alterations in intestinal microbiota precede urinary tract infections in preterm infants: a longitudinal case-control study
Pathogen-specific alterations in intestinal microbiota precede urinary tract infections in preterm infants: a longitudinal case-control study Open
Urinary tract infections (UTIs) are among the most common late-onset infections in preterm infants, characterized by nonspecific symptoms and a pathogenic spectrum that diverges from that of term infants and older children, which present u…
View article: Prediction of glycopeptide fragment mass spectra by deep learning
Prediction of glycopeptide fragment mass spectra by deep learning Open
Deep learning has achieved a notable success in mass spectrometry-based proteomics and is now emerging in glycoproteomics. While various deep learning models can predict fragment mass spectra of peptides with good accuracy, they cannot cop…
View article: Pick-up single-cell proteomic analysis for quantifying up to 3000 proteins in a Mammalian cell
Pick-up single-cell proteomic analysis for quantifying up to 3000 proteins in a Mammalian cell Open
The shotgun proteomic analysis is currently the most promising single-cell protein sequencing technology, however its identification level of ~1000 proteins per cell is still insufficient for practical applications. Here, we develop a pick…
View article: Dynamics and Crosstalk between Gut Microbiota, Metabolome, and Fecal Calprotectin in Very Preterm Infants: Insights into Feeding Intolerance
Dynamics and Crosstalk between Gut Microbiota, Metabolome, and Fecal Calprotectin in Very Preterm Infants: Insights into Feeding Intolerance Open
Background: Feeding intolerance (FI) is a significant concern in the care of preterm infants, impacting their growth and development. We previously reported that FI is linked to lower fecal calprotectin (FC) levels. This study aims to expl…
View article: Salidroside regulates tumor microenvironment of non-small cell lung cancer via Hsp70/Stub1/Foxp3 pathway in Tregs
Salidroside regulates tumor microenvironment of non-small cell lung cancer via Hsp70/Stub1/Foxp3 pathway in Tregs Open
Background The treatment of non-small cell lung cancer (NSCLC) is challenging due to immune tolerance and evasion. Salidroside (SAL) is an extract in traditional Chinese medicine and has a potential antitumor effect. However, the mechanism…
View article: Metaproteomics profiling of the microbial communities in fermentation starters (Daqu) during multi-round production of Chinese liquor
Metaproteomics profiling of the microbial communities in fermentation starters (Daqu) during multi-round production of Chinese liquor Open
Introduction The special flavor and fragrance of Chinese liquor are closely related to microorganisms in the fermentation starter Daqu . The changes of microbial community can affect the stability of liquor yield and quality. Methods In th…
View article: DeepFLR facilitates false localization rate control in phosphoproteomics
DeepFLR facilitates false localization rate control in phosphoproteomics Open
Protein phosphorylation is a post-translational modification crucial for many cellular processes and protein functions. Accurate identification and quantification of protein phosphosites at the proteome-wide level are challenging, not leas…
View article: Salidroside regulates tumor microenvironment of non-small cell lung cancer via Hsp70/Stub1/Foxp3 pathway in Tregs
Salidroside regulates tumor microenvironment of non-small cell lung cancer via Hsp70/Stub1/Foxp3 pathway in Tregs Open
Background: The treatment of non-small cell lung cancer (NSCLC) is challenging due to immune tolerance and evasion. Salidroside (SAL) is an extract in traditional Chinese medicine and has a potential antitumor effect. However, the mechanis…
View article: Data-independent acquisition boosts quantitative metaproteomics for deep characterization of gut microbiota
Data-independent acquisition boosts quantitative metaproteomics for deep characterization of gut microbiota Open
Metaproteomics can provide valuable insights into the functions of human gut microbiota (GM), but is challenging due to the extreme complexity and heterogeneity of GM. Data-independent acquisition (DIA) mass spectrometry (MS) has been an e…
View article: Quantitative metaproteomics reveals composition and metabolism characteristics of microbial communities in Chinese liquor fermentation starters
Quantitative metaproteomics reveals composition and metabolism characteristics of microbial communities in Chinese liquor fermentation starters Open
Introduction Daqu , the Chinese liquor fermentation starter, contains complex microbial communities that are important for the yield, quality, and unique flavor of produced liquor. However, the composition and metabolism of microbial commu…
View article: Dynamics and Crosstalk between Gut Microbiota, Metabolome, and Fecal Calprotectin in Very Preterm Infants: Insights into Feeding Intolerance
Dynamics and Crosstalk between Gut Microbiota, Metabolome, and Fecal Calprotectin in Very Preterm Infants: Insights into Feeding Intolerance Open
Untargeted metabolome data of 1908 metabolites with HMDB annotations in feces 118 very preterm infants with and without feeding intolerance
View article: Changes in pathogens of neonatal bacterial meningitis over the past 12 years: a single-center retrospective study
Changes in pathogens of neonatal bacterial meningitis over the past 12 years: a single-center retrospective study Open
GBS and E. coli are the most common pathogens of neonatal bacterial meningitis in our hospital, and both have shown an upward trend over the past 12 years.
View article: Non‐hemodynamic effects: Repurposing of nonselective beta‐blockers in cirrhosis?
Non‐hemodynamic effects: Repurposing of nonselective beta‐blockers in cirrhosis? Open
To the Editor: Liver cirrhosis (LC), the end-stage condition of chronic liver disease, results in >1,300,000 annual deaths worldwide. Meanwhile, the global incidence of decompensated cirrhosis is rising yearly.1 Following clinically signif…
View article: Study on Pathophysiology of Gastric Function in Patients with Reflux Esophagitis
Study on Pathophysiology of Gastric Function in Patients with Reflux Esophagitis Open
Background Reflux esophagitis (RE) is a type of gastroesophageal reflux disease (GERD) which shows endoscopic injuries. Gastric function has been known as a part of mechanisms of GERD. However, there is still no comprehensive understanding…