Yong‐Qiang Deng
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View article: Compensatory Activation of PI3K/AKT Signaling Protects Against Cardiomyocyte Apoptosis in Pulmonary Hypertension–Induced Right Ventricular Dysfunction
Compensatory Activation of PI3K/AKT Signaling Protects Against Cardiomyocyte Apoptosis in Pulmonary Hypertension–Induced Right Ventricular Dysfunction Open
Background Pulmonary hypertension (PH) is a progressive cardiopulmonary disorder marked by increased pulmonary vascular resistance and poor prognosis. Right ventricular (RV) dysfunction, rather than pulmonary vascular pathology, is the pri…
View article: Knowledge, attitudes, and practices regarding temporomandibular joint disorder among patients
Knowledge, attitudes, and practices regarding temporomandibular joint disorder among patients Open
This study investigates the knowledge, attitudes, and practices (KAP) of patients diagnosed with temporomandibular joint disorder (TMD). Conducted at Shenzhen University General Hospital from October to November 2024, the cross-sectional a…
View article: Correction: Identification of novel lipid metabolism-related biomarkers of aortic dissection by integrating single-cell RNA sequencing analysis and machine learning algorithms
Correction: Identification of novel lipid metabolism-related biomarkers of aortic dissection by integrating single-cell RNA sequencing analysis and machine learning algorithms Open
View article: Identification of novel lipid metabolism-related biomarkers of aortic dissection by integrating single-cell RNA sequencing analysis and machine learning algorithms
Identification of novel lipid metabolism-related biomarkers of aortic dissection by integrating single-cell RNA sequencing analysis and machine learning algorithms Open
Introduction Aortic dissection (AD) is a lethal disease with increasing incidence and limited preventive options, characterized by aortic media degeneration and inflammatory cell infiltration. Dysregulation of lipid metabolism is increasin…
View article: Development and characterization of a bivalent mRNA vaccine targeting the Delta and Omicron variants of SARS-CoV-2
Development and characterization of a bivalent mRNA vaccine targeting the Delta and Omicron variants of SARS-CoV-2 Open
The emergence of the Omicron variant of SARS-CoV-2 has led to a decrease in vaccine efficacy and contributed to the ongoing epidemic of COVID-19. Consequently, there is an urgent need to develop new vaccines targeting the emerging SARS-CoV…
View article: Histopathological Characteristics and Multi-Omics Analysis of Ocular Pigmentation Defects in Albino Percocypris pingi
Histopathological Characteristics and Multi-Omics Analysis of Ocular Pigmentation Defects in Albino Percocypris pingi Open
Percocypris pingi was listed in the China Vertebrate Red List in 2015, and albino P. pingi exhibits remarkable ocular phenotypes due to melanin synthesis defects, including the deficiency of melanin granules in the iris and retinal pigment…
View article: Recapitulating dengue virus infection with human pluripotent stem cell-derived liver organoids for antiviral screening
Recapitulating dengue virus infection with human pluripotent stem cell-derived liver organoids for antiviral screening Open
Dengue virus (DENV) poses a major global health threat, affecting an estimated 100 to 400 million people annually. The infection and pathogenesis remain incompletely understood, and no antiviral drug is currently approved for DENV treatmen…
View article: RNA-Seq Revealed the Effects of Cold Stress on Different Brain Regions of Leiocassis longirostris
RNA-Seq Revealed the Effects of Cold Stress on Different Brain Regions of Leiocassis longirostris Open
Cold shock represents a prevalent but harmful environmental stress factor that poses significant threats to fish survival and reproductive success. In fish, the brain acts as a central regulator of thermoregulatory processes. Nevertheless,…
View article: Author Correction: ARF4-mediated intracellular transport as a broad-spectrum antiviral target
Author Correction: ARF4-mediated intracellular transport as a broad-spectrum antiviral target Open
View article: RNA-seq revealed the effects of heat stress on different brain regions of Leiocassis longirostris
RNA-seq revealed the effects of heat stress on different brain regions of Leiocassis longirostris Open
Understanding how distinct brain regions of Leiocassis longirostris molecularly adapt to heat stress is vital for improving aquaculture sustainability and guiding conservation strategies in a warming climate. To elucidate the region-specif…
View article: Early brain gene network alterations and growth disruptions in juvenile Chinese longsnout catfish (Leiocassis longirostris) induced by 17β-estradiol and 17α-methyltestosterone
Early brain gene network alterations and growth disruptions in juvenile Chinese longsnout catfish (Leiocassis longirostris) induced by 17β-estradiol and 17α-methyltestosterone Open
Endocrine-disrupting chemicals (EDCs) 17β-estradiol (E2β) and 17α-methyltestosterone (MT) have been detected in aquatic environments at concentrations capable of perturbing neuroendocrine systems, yet their molecular mechanisms of action r…
View article: Safety and Immunogenicity of the Tetravalent Recombinant COVID-19 Protein Vaccine SCTV01E in Children and Adolescents Aged 3 to 17 Years: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial
Safety and Immunogenicity of the Tetravalent Recombinant COVID-19 Protein Vaccine SCTV01E in Children and Adolescents Aged 3 to 17 Years: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial Open
Background: SCTV01E is a tetravalent recombinant COVID-19 vaccine authorized for emergency use in China for adults 18 years and older but not for those under 18. Objective: This Phase 2 trial assessed the safety and immunogenicity of SCTV0…
View article: Case Report: A missed diagnosis of cardiac amyloidosis using echocardiography due to immunoglobulin light chain amyloidosis with normal wall thickness in the early stage
Case Report: A missed diagnosis of cardiac amyloidosis using echocardiography due to immunoglobulin light chain amyloidosis with normal wall thickness in the early stage Open
Background Cardiac amyloidosis (CA) is a challenging diagnosis, particularly when the classic signs, such as increased wall thickness in a non-dilated left ventricle (LV), are absent. This makes the diagnosis more difficult in patients wit…
View article: Integrating enzyme-nanoparticles bring new prospects for the diagnosis and treatment of immune dysregulation in periodontitis
Integrating enzyme-nanoparticles bring new prospects for the diagnosis and treatment of immune dysregulation in periodontitis Open
Enzymes play a significant role in mediating inflammatory and immune responses in periodontitis. Effective diagnosis, timely treatment, and continuous management of periodontal enzymes are essential to prevent undesirable consequences; how…
View article: Rational design of a DNA-launched live attenuated vaccine against human enterovirus 71
Rational design of a DNA-launched live attenuated vaccine against human enterovirus 71 Open
View article: Immunogenicity and Protective Efficacy of Aerosolized Live-Attenuated Yellow Fever 17D Vaccine in Mice
Immunogenicity and Protective Efficacy of Aerosolized Live-Attenuated Yellow Fever 17D Vaccine in Mice Open
Yellow fever (YF), caused by the yellow fever virus (YFV), continually spreads and causes epidemics worldwide, posing a great threat to human health. The live-attenuated YF 17D vaccine (YF-17D) has been licensed for preventing YFV infectio…
View article: Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses
Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses Open
The Orthopoxvirus genus, especially variola virus (VARV), monkeypox virus (MPXV), remains a significant public health threat worldwide. The development of therapeutic antibodies against orthopoxviruses is largely hampered by the high cost …
View article: Targeting ARF4-mediated intracellular transport as broad-spectrum antivirals
Targeting ARF4-mediated intracellular transport as broad-spectrum antivirals Open
Host factors that regulate cellular vesicular trafficking also contribute to progeny virions’ destination, thus representing as potential antiviral drug targets. Here we demonstrate that genetic deletion of ARF4, a regulator in vesicle tra…
View article: The infection kinetics and transmission potential of two Guaico Culex viruses in Culex quinquefasciatus mosquitoes
The infection kinetics and transmission potential of two Guaico Culex viruses in Culex quinquefasciatus mosquitoes Open
View article: Immune Activation and Inflammatory Response Mediated by the NOD/Toll-like Receptor Signaling Pathway—The Potential Mechanism of Bullfrog (Lithobates catesbeiana) Meningitis Caused by Elizabethkingia miricola
Immune Activation and Inflammatory Response Mediated by the NOD/Toll-like Receptor Signaling Pathway—The Potential Mechanism of Bullfrog (Lithobates catesbeiana) Meningitis Caused by Elizabethkingia miricola Open
Elizabethkingia miricola is an emerging opportunistic pathogen that is highly pathogenic in both immunocompromised humans and animals. Once the disease occurs, treatment can be very difficult. Therefore, a deep understanding of the patholo…
View article: Ammonia nitrogen stress damages the intestinal mucosal barrier of yellow catfish (Pelteobagrus fulvidraco) and induces intestinal inflammation
Ammonia nitrogen stress damages the intestinal mucosal barrier of yellow catfish (Pelteobagrus fulvidraco) and induces intestinal inflammation Open
Nitrogen from ammonia is one of the most common pollutants toxics to aquatic species in aquatic environment. The intestinal mucosa is one of the key mucosal defenses of aquatic species, and the accumulation of ammonia nitrogen in water env…
View article: Competitive fitness and homologous recombination of SARS-CoV-2 variants of concern
Competitive fitness and homologous recombination of SARS-CoV-2 variants of concern Open
SARS-CoV-2 variants continue to emerge and cocirculate in humans and wild animals. The factors driving the emergence and replacement of novel variants and recombinants remain incompletely understood. Herein, we comprehensively characterize…
View article: A pangolin-origin SARS-CoV-2-related coronavirus: infectivity, pathogenicity, and cross-protection by preexisting immunity
A pangolin-origin SARS-CoV-2-related coronavirus: infectivity, pathogenicity, and cross-protection by preexisting immunity Open
Virus spillover remains a major challenge to public health. A panel of SARS-CoV-2-related coronaviruses have been identified in pangolins, while the infectivity and pathogenicity of these pangolin-origin coronaviruses (pCoV) in humans rema…
View article: Oral administration of D-glucosamine confers broad-spectrum protection against human coronaviruses including SARS-CoV-2
Oral administration of D-glucosamine confers broad-spectrum protection against human coronaviruses including SARS-CoV-2 Open
View article: PA-E18G substitution in influenza A virus confers resistance to ZX-7101, a cap-dependent endonuclease inhibitor
PA-E18G substitution in influenza A virus confers resistance to ZX-7101, a cap-dependent endonuclease inhibitor Open
View article: Rational development of multicomponent mRNA vaccine candidates against mpox
Rational development of multicomponent mRNA vaccine candidates against mpox Open
The re-emerging mpox (formerly monkeypox) virus (MPXV), a member of Orthopoxvirus genus together with variola virus (VARV) and vaccinia virus (VACV), has led to public health emergency of international concern since July 2022. Inspi…
View article: Development of neutralizing antibodies against SARS-CoV-2, using a high-throughput single-B-cell cloning method
Development of neutralizing antibodies against SARS-CoV-2, using a high-throughput single-B-cell cloning method Open
Background Rapid and efficient strategies are needed to discover neutralizing antibodies (nAbs) from B cells derived from virus-infected patients. Methods Here, we report a high-throughput single-B-cell cloning method for high-throughput i…
View article: Zika virus leads to olfactory disorders in mice by targeting olfactory ensheathing cells
Zika virus leads to olfactory disorders in mice by targeting olfactory ensheathing cells Open
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View article: Pathogenicity and Structural Basis of Zika Variants with Glycan Loop Deletions in the Envelope Protein
Pathogenicity and Structural Basis of Zika Variants with Glycan Loop Deletions in the Envelope Protein Open
Zika virus (ZIKV) has been identified as a cause of microcephaly and acquired evolutionary mutations since its discovery. Previously deletions in the E glycan loop were recorded in African ZIKV strains, which have re-emerged in the contemp…
View article: An Engineered IgG–VHH Bispecific Antibody against SARS‐CoV‐2 and Its Variants
An Engineered IgG–VHH Bispecific Antibody against SARS‐CoV‐2 and Its Variants Open
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) neutralizing antibodies are shown to be effective therapeutics for providing coronavirus disease 2019 (COVID‐19) protection. However, recurrent variants arise and facilitate sign…