Explanipedia

Targeting glial dysfunction in Alzheimer’s disease: insights into pathogenesis and emerging therapeutics Open

Qing Zhu, Yu Song, Yuanyuan Qian, Ru Zhang, Jianhuang Xue , et al. · 2025

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, amyloid-β (Aβ) plaques, and neurofibrillary tangles. Despite extensive research, its pathogenesis remains incompletely understood and …

Genome-wide investigation of transcription factor footprints and dynamics using cFOOT-seq Open

Heng Wang, Ang Wu, Mengchen Yang, Di Zhou, Xiyang Chen , et al. · 2025

Gene regulation relies on the precise binding of transcription factors (TFs) at regulatory elements, but simultaneously detecting hundreds of TFs on chromatin is challenging. We developed cFOOT-seq, a cytosine deaminase-based TF footprinti…

Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease Open

Zixin Wang, Fengmao Chen, Bin He, Fei Wang, Jiaxue Cha , et al. · 2025

Alzheimer's disease (AD) is associated with genetic risk factors and widespread epigenetic alterations. 5‐Hydroxymethylcytosine (5hmC), an oxidized derivative of 5‐methylcytosine (5mC), constitutes up to 20% of 5mC in neuronal DNA and is i…

The crucial role of neutrophil extracellular traps and IL-17 signaling in indomethacin-induced gastric injury in mice Open

Yujun Hou, Wen Wang, Jiangnan Ye, Luqiang Sun, Siyuan Zhou , et al. · 2025

The homeostasis of gastric mucosa is extremely delicate. Neutrophils, the most abundant immune cells in human circulation, are regarded crutial in the regulation of gastric mucosal immune response. Non-steroidal anti-inflammatory drugs (NS…

Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials Open

Pengfei Jiang, Yan Dai, Yujun Hou, Joshua S. Stein, Siqi Lin , et al. · 2025

Smart biomaterials that can self‐adapt or respond to microenvironmental factors or external signals hold excellent potential for a variety of biomedical applications, from biosensing, drug delivery, and cell therapy to tissue engineering. …

Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions Open

Yujun Hou, Xixia Chu, Jae Hyeon Park, Qing Zhu, Mansoor Hussain , et al. · 2024

BACKGROUND Compromised autophagy, including impaired mitophagy and lysosomal function, plays pivotal roles in Alzheimer's disease (AD). Urolithin A (UA) is a gut microbial metabolite of ellagic acid that stimulates mitophagy. The effects o…

Epigenetic marks or not? The discovery of novel DNA modifications in eukaryotes Open

Wei‐Ying Meng, Zixin Wang, Yunfang Zhang, Yujun Hou, Jianhuang Xue · 2024

DNA modifications add another layer of complexity to the eukaryotic genome to regulate gene expression, playing critical roles as epigenetic marks. In eukaryotes, the study of DNA epigenetic modifications has been confined to 5mC and its d…

Alzheimer’s Amyloid-β Accelerates Cell Senescence and Suppresses SIRT1 in Human Neural Stem Cells Open

Rongyao Li, Yi Li, Haowei Zuo, Gang Pei, Shichao Huang , et al. · 2024

As a lifelong source of neurons, neural stem cells (NSCs) serve multiple crucial functions in the brain. The senescence of NSCs may be associated with the onset and progression of Alzheimer’s disease (AD). Our study reveals a noteworthy fi…

Urolithin A improves Alzheimer’s disease cognition and restores mitophagy and lysosomal functions Open

Yujun Hou, Xixia Chu, Jae Hyeon Park, Qing Zhu, Mansoor Hussain , et al. · 2024

Background Compromised autophagy, including impaired mitophagy and lysosomal function, is thought to play a pivotal role in Alzheimer’s disease (AD). Urolithin A (UA) is a gut microbial metabolite of ellagic acid that stimulates mitophagy.…

The cGAS-STING signaling pathway is modulated by urolithin A Open

Helena Borland Madsen, Jae Hyeon Park, Xia Chu, Yujun Hou, Zaiwang Li , et al. · 2023

During aging, general cellular processes, including autophagic clearance and immunological responses become compromised; therefore, identifying compounds that target these cellular processes is an important approach to improve our health s…

RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice Open

Yujun Hou, Jae Hyeon Park, Xiuli Dan, Xixia Chu, Beimeng Yang , et al. · 2023

Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer’s mouse model Open

Xixia Chu, Yujun Hou, Qiong Meng, Deborah L. Croteau, Yong Wei , et al. · 2022

Alzheimer’s disease (AD) is the most common neurodegenerative disease. Growing evidence suggests an important role for gut dysbiosis and gut microbiota-host interactions in aging and neurodegeneration. Our previous works have demonstrated …

Alzheimer’s Amyloid-β Accelerates Human Neuronal Cell Senescence Which Could Be Rescued by Sirtuin-1 and Aspirin Open

Yi Li, Juan Lü, Yujun Hou, Shichao Huang, Gang Pei · 2022

Cellular senescence is a major biological process related to aging. Neuronal cell senescence contributes to the pathogenesis of many aging-related neurodegenerative diseases including Alzheimer’s disease (AD). In this study, we showed that…

Alzheimer’s Amyloid‐β Accelerates Cell Senescence and Suppresses the SIRT1/NRF2 Pathway in Human Microglial Cells Open

Yuqian An, Yi Li, Yujun Hou, Shichao Huang, Gang Pei · 2022

Microglia play important roles in maintenance of brain homeostasis, while due to some pathological stimuli in aging‐related neurodegenerative diseases including Alzheimer’s disease, they are malfunctioning. Here, we demonstrated that amylo…

NAD + supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING Open

Yujun Hou, Yong Wei, Sofie Lautrup, Beimeng Yang, Yue Wang , et al. · 2021

Significance Impaired neuronal bioenergetics and neuroinflammation are thought to play key roles in the progression of Alzheimer's disease (AD), but their interplay is not clear. AD mouse brains showed lower nicotinamide adenine dinucleoti…

NAD+ supplementation prevents STING‐induced senescence in ataxia telangiectasia by improving mitophagy Open

Beimeng Yang, Xiuli Dan, Yujun Hou, Jong‐Hyuk Lee, Noah Wechter , et al. · 2021

Senescence phenotypes and mitochondrial dysfunction are implicated in aging and in premature aging diseases, including ataxia telangiectasia (A‐T). Loss of mitochondrial function can drive age‐related decline in the brain, but little is kn…

Correction: Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits Open

Yujun Hou, Ying Wang, Jian Zhao, Xiaohang Li, Jin Cui , et al. · 2020

[This corrects the article DOI: 10.1371/journal.pone.0111215.].

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome Open

Evandro Fei Fang, Yujun Hou, Sofie Lautrup, Martin Borch Jensen, Beimeng Yang , et al. · 2019

NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress Open

Beimeng Yang, David M. Figueroa, Yujun Hou, Mansi Babbar, Stephanie L. Baringer , et al. · 2019

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease Open

Evandro Fei Fang, Yujun Hou, Konstantinos Palikaras, Bryan A. Adriaanse, Jesse S. Kerr , et al. · 2019

Toward understanding genomic instability, mitochondrial dysfunction and aging Open

Nima Borhan Fakouri, Yujun Hou, Tyler G. Demarest, Louise Slot Christiansen, Mustafa Nazir Okur , et al. · 2018

The biology of aging is an area of intense research, and many questions remain about how and why cell and organismal functions decline over time. In mammalian cells, genomic instability and mitochondrial dysfunction are thought to be among…

NAD + supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency Open

Yujun Hou, Sofie Lautrup, Stephanie A. Cordonnier, Yue Wang, Deborah L. Croteau , et al. · 2018

Emerging findings suggest that compromised cellular bioenergetics and DNA repair contribute to the pathogenesis of Alzheimer’s disease (AD), but their role in disease-defining pathology is unclear. We developed a DNA repair-deficient 3xTgA…

In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice Open

Evandro Fei Fang, Konstantinos Palikaras, Nuo Sun, Elayne M. Fivenson, Ryan D. Spangler , et al. · 2017

Mitochondria are the powerhouses of cells and produce cellular energy in the form of ATP. Mitochondrial dysfunction contributes to biological aging and a wide variety of disorders including metabolic diseases, premature aging syndromes, an…

NAD + in Aging: Molecular Mechanisms and Translational Implications Open

Evandro Fei Fang, Sofie Lautrup, Yujun Hou, Tyler G. Demarest, Deborah L. Croteau , et al. · 2017

Genome instability in Alzheimer disease Open

Yujun Hou, Hyundong Song, Deborah L. Croteau, Mansour Akbari, Vilhelm A. Bohr · 2016

Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments Open

Xiaohang Li, Jin Cui, Yang Yu, Wěi Li, Yujun Hou , et al. · 2016

Decline of cognitive function is the hallmark of Alzheimer's disease (AD), regardless of the pathological mechanism. Traditional Chinese medicine has been used to combat cognitive impairments and has been shown to improve learning and memo…

SS treatment alleviates Aβ levels and amyloid plaque burden, reduces gliosis and neuron loss in APP/PS1 mice. Open

Yujun Hou, Ying Wang, Jian Zhao, Xiaohang Li, Jin Cui , et al. · 2015

(A–C) Representative half brain sections of WT mice, vehicle or SS-treated APP/PS1 mice stained with antibody against Aβ (6E10) and double staining of GFAP and 6E10 are shown. Scale bar, 1 mm. (B and C) Quantitative an…

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