Yu‐Kai Lin
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View article: Neutrophil to high-density lipoprotein cholesterol ratio as a potential inflammatory marker for predicting all-cause mortality in out-of-hospital cardiac arrest survivors
Neutrophil to high-density lipoprotein cholesterol ratio as a potential inflammatory marker for predicting all-cause mortality in out-of-hospital cardiac arrest survivors Open
View article: Neutrophil to High-Density Lipoprotein Cholesterol Ratio as a Potential Inflammatory Marker for Predicting All-cause Mortality in Cardiac Arrest Survivors
Neutrophil to High-Density Lipoprotein Cholesterol Ratio as a Potential Inflammatory Marker for Predicting All-cause Mortality in Cardiac Arrest Survivors Open
Background Out-of-hospital cardiac arrest (OHCA) survivors have more than one-third mortality rate. Numerous inflammatory indicators are available, and it should be feasible to identify a fast and accurate way to aid medical decisions. Met…
View article: Effect of Levosimendan Use on All-Cause Mortality in Out-of-Hospital Cardiac Arrest Survivors After Extracorporeal Cardiopulmonary Resuscitation
Effect of Levosimendan Use on All-Cause Mortality in Out-of-Hospital Cardiac Arrest Survivors After Extracorporeal Cardiopulmonary Resuscitation Open
Background: Survivors of out-of-hospital cardiac arrest (OHCA) after external cardiopulmonary resuscitation (ECPR) have a mortality rate as high as 50–70%. The use of vasoactive inotropes worsen the mortality rate at admission. The adminis…
View article: Effect of Levosimendan Use on All-Cause Mortality in Out-of-Hospital Cardiac Arrest Survivors After Extracorporeal Cardiopulmonary Resuscitation
Effect of Levosimendan Use on All-Cause Mortality in Out-of-Hospital Cardiac Arrest Survivors After Extracorporeal Cardiopulmonary Resuscitation Open
Background: Out-of-hospital cardiac arrest (OHCA) survivors after extracorporeal cardiopulmonary resuscitation (ECPR) have a 50-70% mortality rate. However, the use of vasoactive inotropes during the first 24 h worsened the mortality rate.…
View article: SRA-MCTS: Self-driven Reasoning Augmentation with Monte Carlo Tree Search for Code Generation
SRA-MCTS: Self-driven Reasoning Augmentation with Monte Carlo Tree Search for Code Generation Open
Large language models demonstrate exceptional performance in simple code generation tasks but still face challenges in tackling complex problems. These challenges may stem from insufficient reasoning and problem decomposition capabilities.…
View article: Impact of mechanical circulatory support on out-of-hospital cardiac arrest outcomes stratified by vasoactive-inotropic score: A retrospective cohort study
Impact of mechanical circulatory support on out-of-hospital cardiac arrest outcomes stratified by vasoactive-inotropic score: A retrospective cohort study Open
ECMO with or without IABP therapy may improve post-OHCA neurological outcomes and survival in patients with an expected VIS-24 h > 100 (e.g., epinephrine dose reaches 3 mg during CPR).
View article: Utilizing left atrial venoarterial extracorporeal membrane oxygenation to unload the left ventricle prior to angioplasty in acute myocardial infarction: a case series
Utilizing left atrial venoarterial extracorporeal membrane oxygenation to unload the left ventricle prior to angioplasty in acute myocardial infarction: a case series Open
Background Left ventricular (LV) unloading prior to primary angioplasty in patients experiencing acute myocardial infarction holds promise for mitigating reperfusion injury and minimizing infarct size. Case summary This report delves into …
View article: Longitudinal assessment of plasma biomarkers for early detection of cognitive changes in subjective cognitive decline
Longitudinal assessment of plasma biomarkers for early detection of cognitive changes in subjective cognitive decline Open
Background Individuals experiencing subjective cognitive decline (SCD) are at an increased risk of developing mild cognitive impairment and dementia. Early identification of SCD and neurodegenerative diseases using biomarkers may help clin…
View article: Extreme Delta Brush Electroencephalography Pattern in Anti-yo Encephalitis: A Case Report
Extreme Delta Brush Electroencephalography Pattern in Anti-yo Encephalitis: A Case Report Open
Autoimmune encephalitis is complex and gradually being recognized. Anti-N-methyl-D-aspartate Receptor (Anti-NMDAR) encephalitis was the most well-known and its unique electroencephalography (EEG) pattern is extreme delta brush (EDB). Anti-…
View article: Non-alcoholic fatty liver disease causally affects the brain cortical structure: a Mendelian randomization study
Non-alcoholic fatty liver disease causally affects the brain cortical structure: a Mendelian randomization study Open
Background Reduced brain volume, impaired cognition, and possibly a range of psychoneurological disorders have been reported in patients with non-alcoholic fatty liver disease (NAFLD); however, no underlying cause has been specified. Here,…
View article: Case report: Hemophagocytic lymphohistiocytosis complicated by multiple organ dysfunction syndrome following aseptic encephalitis
Case report: Hemophagocytic lymphohistiocytosis complicated by multiple organ dysfunction syndrome following aseptic encephalitis Open
Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially life-threatening condition caused by excessive immune activation. Secondary HLH is usually triggered by infection, most often from viral infection or malignancy. Here, we p…
View article: Bupropion Associated Immunomodulatory Effects on Peripheral Cytokines in Male with Major Depressive Disorder
Bupropion Associated Immunomodulatory Effects on Peripheral Cytokines in Male with Major Depressive Disorder Open
Background: Experimental and clinical studies have reported increased levels of pro-inflammatory cytokines in patients with major depressive disorder (MDD), suggesting that immune system dysregulation may contribute to MDD pathophysiology.…
View article: Shared alterations in hippocampal structural covariance in subjective cognitive decline and migraine
Shared alterations in hippocampal structural covariance in subjective cognitive decline and migraine Open
Introduction Subjective cognitive decline (SCD) and migraine are often comorbid. Hippocampal structural abnormalities have been observed in individuals with both SCD and migraine. Given the known structural and functional heterogeneity alo…
View article: The optimal pulse pressures for healthy adults with different ages and sexes correlate with cardiovascular health metrics
The optimal pulse pressures for healthy adults with different ages and sexes correlate with cardiovascular health metrics Open
Background Pulse pressure (PP) may play a role in the development of cardiovascular disease, and the optimal PP for different ages and sexes is unknown. In a prospective cohort, we studied subjects with favorable cardiovascular health (CVH…
View article: Identification of Novel Genetic Variants Associated with Insomnia and Migraine Comorbidity
Identification of Novel Genetic Variants Associated with Insomnia and Migraine Comorbidity Open
In this GWAS, we identified several novel loci associated with insomnia in migraineurs in a Han Chinese population in Taiwan. These results provide insights into the possible genetic basis of insomnia and migraine comorbidity.
View article: Association of a Common NOS1AP Variant with Attenuation of QTc Prolongation in Men with Heroin Dependence Undergoing Methadone Treatment
Association of a Common NOS1AP Variant with Attenuation of QTc Prolongation in Men with Heroin Dependence Undergoing Methadone Treatment Open
Background: The effects of methadone-induced severe prolongation of the corrected QT interval (QTc) and sudden cardiac death appear unpredictable and sex-dependent. Genetic polymorphisms in the nitric oxide synthase 1 adaptor protein (NOS1…
View article: Athlete's Heart Assessed by Sit-Up Strength Exercises in Military Men and Women: The CHIEF Heart Study
Athlete's Heart Assessed by Sit-Up Strength Exercises in Military Men and Women: The CHIEF Heart Study Open
Background Greater changes in cardiac structure and function in response to physical training have been observed more often in male athletes than in female athletes compared with their sedentary controls. However, studies for the sex-speci…
View article: Obesity Phenotypes and Electrocardiographic Characteristics in Physically Active Males: CHIEF Study
Obesity Phenotypes and Electrocardiographic Characteristics in Physically Active Males: CHIEF Study Open
Background: Metabolically unhealthy obesity (MUO) has been associated with surface electrocardiographic (ECG) left ventricular hypertrophy (LVH), left atrial enlargement (LAE), and inferior T wave inversions (TWI) in the middle- and old-ag…
View article: Cerebral Venous Sinus Thrombosis, Pulmonary Embolism, and Thrombocytopenia After COVID-19 Vaccination in a Taiwanese Man: A Case Report and Literature Review
Cerebral Venous Sinus Thrombosis, Pulmonary Embolism, and Thrombocytopenia After COVID-19 Vaccination in a Taiwanese Man: A Case Report and Literature Review Open
Objective: Coronavirus disease (COVID-19) vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but fatal complication observed within 2 weeks of adenovirus-vectored vaccination. Case Report: A 52-year-old male patient, with …
View article: Middle-age Asian male with cerebral venous thrombosis after COVID-19 AstraZeneca vaccination
Middle-age Asian male with cerebral venous thrombosis after COVID-19 AstraZeneca vaccination Open
View article: Better Identification of Cognitive Decline With Interleukin-2 Than With Amyloid and Tau Protein Biomarkers in Amnestic Mild Cognitive Impairment
Better Identification of Cognitive Decline With Interleukin-2 Than With Amyloid and Tau Protein Biomarkers in Amnestic Mild Cognitive Impairment Open
The rate of cognitive decline among patients with amnestic mild cognitive impairment (aMCI) varies, and it is thus crucial to accurately predict the probability of cognitive deterioration in patients with MCI. We compared the potential of …
View article: A Metallomic Approach to Assess the Associations between Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: A Cross-sectional and Longitudinal Study
A Metallomic Approach to Assess the Associations between Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: A Cross-sectional and Longitudinal Study Open
BACKGROUND Alzheimer’s disease (AD) involves the abnormal activity of transition metals and metal ion dyshomeostasis. The present study aimed to assess the potential of 36 trace elements in predicting cognitive decline in patients with amn…
View article: Metabolically Healthy Obesity and Physical Fitness in Military Males in the CHIEF Study
Metabolically Healthy Obesity and Physical Fitness in Military Males in the CHIEF Study Open
The metabolically healthy obese (MHO) characterized by the absence of abdominal obesity have been reported to have superior cardiorespiratory fitness (CRF) than the metabolically unhealthy obese (MUO). However, this finding might be biased…
View article: Clinical Outcomes of Patients with Intermediate-to-High-Risk Pulmonary Embolism Undergoing Ultrasound-Assisted Catheter-Based Fibrinolysis Therapy in a Mid-Term Follow-Up Period - A Retrospective Observational Study.
Clinical Outcomes of Patients with Intermediate-to-High-Risk Pulmonary Embolism Undergoing Ultrasound-Assisted Catheter-Based Fibrinolysis Therapy in a Mid-Term Follow-Up Period - A Retrospective Observational Study. Open
UACDT exhibited high efficacy, but resulted in a higher-than-expected bleeding rate in this real-world study of an Asian population. The lowest fibrinogen level during thrombolysis was an independent risk factor associated with procedure-r…
View article: Association of Liver Transaminase Levels and Long-Term Blood Pressure Variability in Military Young Males: The CHIEF Study
Association of Liver Transaminase Levels and Long-Term Blood Pressure Variability in Military Young Males: The CHIEF Study Open
Background: An inverse relationship of serum liver transaminases and mortality might be due to better blood pressure control in hypertensive patients. Whether it holds true regarding such an association for long-term blood pressure variabi…
View article: Association of Single Measurement of dipstick proteinuria with physical performance of military males: the CHIEF study
Association of Single Measurement of dipstick proteinuria with physical performance of military males: the CHIEF study Open
View article: The role of Interleukin-33 in patients with mild cognitive impairment and Alzheimer’s disease
The role of Interleukin-33 in patients with mild cognitive impairment and Alzheimer’s disease Open
Background: The neuroprotective role of interleukin (IL)-33 is supported by numerous pre-clinical studies, but it remains uninvestigated in clinical studies of Alzheimer’s disease (AD). We aimed to examine the association between human blo…
View article: Metabolic biomarkers and long-term blood pressure variability in military young male adults
Metabolic biomarkers and long-term blood pressure variability in military young male adults Open
Our findings showed that of traditional metabolic biomarkers, SUA had the strongest positive correlation with long-term systolic and diastolic BPV in young male adults, and the clinical relevance needs further investigation.
View article: The role of Interleukin-33 in patients with mild cognitive impairment and Alzheimer’s disease
The role of Interleukin-33 in patients with mild cognitive impairment and Alzheimer’s disease Open
Background: The neuroprotective role of Interleukin (IL)-33 is supported in numerous pre-clinical studies but remains mostly uninvestigated in clinical studies of Alzheimer’s disease (AD). We aimed to examine the association between human …
View article: The role of Interleukin-33 in patients with mild cognitive impairment and Alzheimer’s disease
The role of Interleukin-33 in patients with mild cognitive impairment and Alzheimer’s disease Open
Background: The neuroprotective role of Interleukin (IL)-33 is supported in numerous pre-clinical studies but remains mostly uninvestigated in clinical studies of Alzheimer’s disease (AD). We aimed to examine the association between human …