Yukako HARA
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View article: Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm Mirna Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring
Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm Mirna Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring Open
View article: Effects of low-dose subchronic exposure to the phenylpyrazole insecticide fipronil in juvenile mice
Effects of low-dose subchronic exposure to the phenylpyrazole insecticide fipronil in juvenile mice Open
Fipronil (FPN) inhibits gamma-aminobutyric acid type A receptors and exhibits strong insecticidal effects. Although FPN's adverse effects on mammals have been reported recently, few studies have examined subchronic exposure to low doses. W…
View article: Effect of the neonicotinoid pesticide clothianidin at a no-observed-adverse-effect-level (NOAEL) dose on maternal behavior in pregnant mice and their female offspring
Effect of the neonicotinoid pesticide clothianidin at a no-observed-adverse-effect-level (NOAEL) dose on maternal behavior in pregnant mice and their female offspring Open
Our previous reports showed that exposure to the neonicotinoid pesticide clothianidin (CLO) at a no-observed-adverse-effect-level (NOAEL) dose during fetal development and lactation in mice led to higher rates of maternal neglect and infan…
View article: Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis
Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis Open
The effects of exposure to clothianidin (CLO), a neonicotinoid pesticide (NN), on the thymus and intestinal microbiota were recently revealed. Immune cells express nicotinic acetylcholine receptors (nAChRs), an NN target, suggesting CLO ma…
View article: Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice
Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice Open
The mechanism by which the neonicotinoid pesticide clothianidin (CLO) disrupts the intestinal microbiota of experimental animals is unknown. We focused on α-defensins, which are regulators of the intestinal microbiota. Subchronic exposure …
View article: No-observed-adverse-effect-level (NOAEL) clothianidin, a neonicotinoid pesticide, impairs hippocampal memory and motor learning associated with alteration of gene expression in cerebellum
No-observed-adverse-effect-level (NOAEL) clothianidin, a neonicotinoid pesticide, impairs hippocampal memory and motor learning associated with alteration of gene expression in cerebellum Open
Neonicotinoid pesticides (NNs) have been associated with numerous neurobehavioral effects in rodents, raising concerns about their impact on cognitive function. Clothianidin (CLO), a type of NN, was orally administered to male mice (10 wee…
View article: Next-generation effects of fetal and lactational exposure to the neonicotinoid pesticide clothianidin on the immune system and gut microbiota
Next-generation effects of fetal and lactational exposure to the neonicotinoid pesticide clothianidin on the immune system and gut microbiota Open
Recently, the effects of exposure to clothianidin (CLO) on the thymus and gut microbiota have become clear, but no report has examined its next-generation impacts. Pregnant C57BL/6N mice were administered a no-observed-adverse-effect-level…
View article: Neurotoxicity and behavioral disorders induced in mice by acute exposure to the diamide insecticide chlorantraniliprole
Neurotoxicity and behavioral disorders induced in mice by acute exposure to the diamide insecticide chlorantraniliprole Open
Diamide insecticides activate ryanodine receptors expressed in lepidopteran skeletal muscle and promote Ca2+ release in the sarcoplasmic reticulum, causing abnormal contractions and paralysis, leading to death of the pest. Altho…
View article: Transgenerational effects of developmental neurotoxicity induced by exposure to a no-observed-adverse-effect level (NOAEL) of neonicotinoid pesticide clothianidin
Transgenerational effects of developmental neurotoxicity induced by exposure to a no-observed-adverse-effect level (NOAEL) of neonicotinoid pesticide clothianidin Open
Neonicotinoid pesticides (NNs) transfer rapidly from mother to offspring, which exhibit neurobehavioral effects. However, no studies have investigated NNs' transgenerational effects. We exposed F0 generation mice (mothers) to a no-observed…
View article: Developmental stage-specific exposure and neurotoxicity evaluation of low-dose clothianidin during neuronal circuit formation
Developmental stage-specific exposure and neurotoxicity evaluation of low-dose clothianidin during neuronal circuit formation Open
Neonicotinoid pesticides (NN) were recently reported to exhibit adverse effects in higher vertebrates. Moreover, NNs are routinely transferred from mother to offspring, raising concerns about their effects on future generations. The fetal …