Explanipedia

Proteinase 3 is involved in presepsin production through neutrophil extracellular trap phagocytosis by macrophages Open

Akishige Ikegame, Akihiro Kondo, Tatsuya Morinishi, Yusuke Yamaguchi, Yukihiro Okutani , et al. · 2025

Presepsin (P-SEP), a soluble subtype of CD14, has been widely reported as a useful biomarker for sepsis in clinical studies. However, the cytological mechanism underlying its production remains poorly understood. Previous research has demo…

Endoscopic findings of gallbladder lesions evaluated with image‐enhanced endoscopy: A preliminary study using resected gallbladders Open

Kiyoyuki Kobayashi, Maki Ayaki, Takako Nomura, Kaho Nakatani, Masaki Tokumo , et al. · 2025

The diagnosis of gallbladder (GB) lesions relies on imaging findings. Transpapillary cholangioscopy can potentially be used to diagnose GB lesions; however, the images obtained remain unclear. This study aimed to characterize the endoscopi…

Additional Stem Resection for Control of Massive Bleeding After Polypectomy for a Pedunculated Colonic Polyp Open

Shima Mimura, Kazuhiro Kozuka, Yoshitaka Kinouchi, Yukiko Koyama, Toshiharu Funaki , et al. · 2025

Background Polypectomy‐associated bleeding is the most frequent complication of colorectal polypectomy. Case Presentation An 82‐year‐old woman underwent polypectomy after an endoloop was placed in a pedunculated polyp in the sigmoid colon.…

Intravenous D‑allose administration improves blood glucose control by maintaining insulin secretion in diabetic mice with transplanted islets Open

Seiji Noge, Kensuke Kumamoto, Hiroyuki Matsukawa, Yukio Ando, Hironobu Suto , et al. · 2025

Although pancreatic islet transplantation outcomes have improved, further refinements are required to extend the insulin withdrawal period. The present study examined whether intravenous D-allose administration improves insulin secretion w…

Fenofibrate, a PPAR-α Agonist, Modulates Signaling Pathways to Suppress Proliferation in Colorectal Cancer Cells Open

Tatsuya Morinishi, Yasunori Tokuhara, Futoshi Suizu, Akishige Ikegame, Akihiro Kondo , et al. · 2025

577. OUTCOMES OF SIMULTANEOUS RESECTION AND RECONSTRUCTION OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA SYNCHRONOUSLY ASSOCIATED WITH HEAD AND NECK CANCER Open

Takayoshi Kishino, Dongping Feng, Hiroyuki Mastukawa, Bunpei Nishiura, Akihiro Kondo , et al. · 2024

In 1953, a study by Slaughter et al. on oral cancer proposed that field cancerization is the phenomenon of widespread carcinogenesis across multiple regions due to long-term exposure to common cancer-causing factors. Esophageal squamous ce…

Identification of organs of origin of macrophages that produce presepsin via neutrophil extracellular trap phagocytosis Open

Akihiro Kondo, Tatsuya Morinishi, Yusuke Yamaguchi, Akishige Ikegame · 2024

A case of chronic expanding hematoma mimicking a cystic pancreatic tumor Open

Asuna Sakamoto, Yukio Ando, Dongping Feng, Mina Nagao, Hiroyuki Matsukawa , et al. · 2024

Background A chronic expanding hematoma is an uncommon entity described as an organized blood collection that increases in size after the initial hemorrhagic event without histological neoplastic features. The standard treatment is complet…

Disease Activity and Progression of Disability in Multiple Sclerosis Patients Aged Over 50 With or Without Disease-Modifying Drug Treatment: A Retrospective Cohort Study Open

Akihiro Kondo, Ryotaro Ikeguchi, Kazuo Kitagawa, Yuko Shimizu · 2023

Background This study aimed to clarify the need for disease-modifying drug (DMD) treatment in elderly patients with multiple sclerosis (MS) aged 50 years or older. MS is an autoimmune, demyelinating disease of the central nervous system th…

Terahertz radiation by quantum interference of excitons in a one-dimensional Mott insulator Open

Tatsuya Miyamoto, Akihiro Kondo, Takeshi Inaba, Takeshi Morimoto, S You , et al. · 2023

Outcomes of Endoscopic Intervention Using Over-the-Scope Clips for Anastomotic Leakage Involving Secondary Fistula after Gastrointestinal Surgery: A Japanese Multicenter Case Series Open

Naoya TADA, Hideki Kobara, Tomoaki Tashima, Hayato Fukui, Satoshi Asai , et al. · 2023

Background: The over-the-scope clip (OTSC) is a highly effective clipping device for refractory gastrointestinal disease. However, Japanese data from multicenter studies for anastomotic leakage (AL) involving a secondary fistula after gast…

Hairy cell leukaemia with an IGH–BRAF fusion gene Open

Kensuke Matsumoto, Naoki Kakazu, Osamu Imataki, Akihiro Kondo, Nobuhiro Kanaji , et al. · 2023

Data S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the …

Author Correction: Identification of microbes coexisting with Legionella spp. in bathwaters Open

Masaki Okunaga, Kenta Kushiro, Ryohei Horie, Akihiro Kondo, Takashi Abe · 2023

and "MDS".The Figures should have appeared as shown below.

Novel endoscopic duodenal observation protocol based on Seven Pictures Rule for detecting duodenal neoplasms during esophagogastroduodenoscopy: Prospective observational study Open

Kazuhiro Kozuka, Hideki Kobara, Takanori Matsui, Akihiko Fujisawa, Miwa Tatsuta , et al. · 2023

Objectives No protocol for esophagogastroduodenoscopic examination of the duodenum has been established. We examined the feasibility and ability to detect neoplasms of a novel duodenal examination protocol. Methods This was a two‐facility,…

Autopsy Findings of Severe COVID-19 Pneumonia Combined with Pulmonary Aspergillosis, Pneumothorax, and Pulmonary Thromboembolisms Open

Nobuhiro Kanaji, Nachino Kimura, Akihiro Kondo, Naoki Watanabe, Takuya Inoue , et al. · 2023

BACKGROUND COVID-19-associated pulmonary aspergillosis (CAPA), acute respiratory distress syndrome (ARDS), pulmonary thromboembolism (PTE), and pneumothorax are complications in severe COVID-19 patients. CASE REPORT A 64-year-old Japanese …

Newly developed endoscopic retrieval device: funnel-shaped overtube formed by air inflation-deflation Open

Nobuya Kobayashi, Hideki Kobara, Noriko Nishiyama, Kazuhiro Kozuka, Naoya TADA , et al. · 2023

Techniques for endoscopic retrieval require further development. Traditional measures using nets, grasping forceps, and overtubes [1] are sometimes inadequate for retrieval of large, endoscopically resected specimens or sharp foreign bodie…

Comparison of Needle Knife versus Scissors Forceps for Colorectal Endoscopic Submucosal Dissection: A Prospective Randomized Study Open

Tatsuo Yachida, Hideki Kobara, Kazuhiro Kozuka, Kaho Nakatani, Naoya TADA , et al. · 2023

Background and Aim: To evaluate the efficacy and safety of a grasping-type knife, called Clutch Cutter (CC), for colorectal endoscopic submucosal dissection (C-ESD). Methods: This was a randomized prospective study. Patients who underwent …

EARTHQUAKE RESPONSE EVALUATION OF SEISMICALLY ISOLATED BUILDINGS CONSIDERING THERMAL-MECHANICAL COUPLED BEHAVIOR OF LEAD RUBBER BEARINGS Open

Akihiro Kondo, Masaru KIKUCHI · 2023

It is known that when lead rubber bearings (LRB) are subjected to cyclic and large deformation under long period earthquake input, the temperature of lead plug rises up, resulting in deterioration of yield stress of LRB. The change in the …

Comparison of purse-string suture versus over-the-scope clip for gastric endoscopic full-thickness closure: traction and leak pressure testing in ex vivo porcine model Open

Takanori Matsui, Hideki Kobara, Noriko Nishiyama, Kaho Nakatani, Tingting Shi , et al. · 2023

Background The recently developed endoscopic full-thickness resection technique requires reliable closure. The main closure methods are the purse-string suture (PSS) technique and over-the-scope clip (OTSC) technique; however, basic data o…

A Quantum Chemical Study on the Anti-SARS-CoV-2 Activity of TMPRSS2 Inhibitors Open

Akihiro Kondo, Kazuhiro J. Fujimoto, Takeshi Yanai · 2023

Nafamostat and camostat are known to inhibit the spike protein-mediated fusion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by forming a covalent bond with the human transmembrane serine protease 2 (TMPRSS2) enzyme. Prev…

A quantum chemical study on the anti-SARS-CoV-2 activity of TMPRSS2 inhibitors Open

Akihiro Kondo, Kazuhiro J. Fujimoto, Takeshi Yanai · 2023

Nafamostat and camostat are known to inhibit the spike protein-mediated fusion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by forming a covalent bond with the human transmembrane serine protease 2 (TMPRSS2) enzyme.

Identification of microbes coexisting with Legionella spp. in bathwaters Open

Masaki Okunaga, Kenta Kushiro, Ryohei Horie, Akihiro Kondo, Takashi Abe · 2022

Indocyanine green fluorescence imaging during laparoscopic rectal cancer surgery could reduce the incidence of anastomotic leakage: a single institutional retrospective cohort study Open

Akihiro Kondo, Kensuke Kumamoto, Eisuke Asano, Dongping Feng, Hideki Kobara , et al. · 2022

Indocyanine green fluorescence imaging during laparoscopic rectal cancer surgery could reduce the incidence of anastomotic leakage: A single institutional retrospective cohort study Open

Akihiro Kondo, Kensuke Kumamoto, Eisuke Asano, Dongping Feng, Hideki Kobara , et al. · 2022

Background : There is insufficient evidence on whether indocyanine green (ICG) fluorescence angiography can reduce the incidence of anastomotic leakage (AL). This retrospective cohort study aimed to evaluate the effect of ICG fluorescence …

Comparison of purse-string suture versus over-the-scope clip for gastric endoscopic full-thickness closure: traction and leak pressure testing in ex vivo porcine model Open

Takanori Matsui, Hideki Kobara, Noriko Nishiyama, Kaho Nakatani, Tingting Shi , et al. · 2022

Background The recently developed endoscopic full-thickness resection technique requires reliable closure. The main closure methods are the purse-string suture (PSS) technique and over-the-scope clip (OTSC) technique; however, basic data o…

Tumor metabolic alterations after neoadjuvant chemoradiotherapy predict postoperative recurrence in patients with pancreatic cancer Open

Yukiko Wada, Keiichi Okano, Kiyotoshi Sato, Masahiro Sugimoto, Ayaka Shimomura , et al. · 2022

Objective We investigated the metabolic changes in pancreatic ductal adenocarcinoma to identify the mechanisms of treatment response of neoadjuvant chemoradiation therapy. Methods Frozen tumor and non-neoplastic pancreas tissues were prosp…

Presepsin production in monocyte/macrophage-mediated phagocytosis of neutrophil extracellular traps Open

Akishige Ikegame, Akihiro Kondo, Ken Kitaguchi, Kanami Sasa, Masashi Miyoshi · 2022

Constrictive pericarditis caused by pericardial metastasis from esophageal squamous cell carcinoma: a case report Open

Takayoshi Kishino, Kensuke Kumamoto, Hiroyuki Matsukawa, Akihiro Kondo, Yasuhisa Ando , et al. · 2022

Elucidation of a Novel Mechanism of Presepsin Production by Monocyte/macrophage Phagocytosis of Neutrophil Extracellular Traps Open

Akishige Ikegame, Akihiro Kondo, Ken Kitaguchi, Kanami Sasa, Masashi Miyoshi · 2022

Presepsin, a biomarker discovered in Japan, has been clinically applied as a diagnostic aid for sepsis. Recently, however, it has been reported that presepsin levels are elevated in patients with severe systemic lupus erythematosus without…

Supplementary Material for: Outcomes of patients with left-sided obstructive colorectal cancer: Comparison between self-expandable metallic stent and other treatment methods Open

Akihiro Kondo, Kensuke Kumamoto, Hideki Kobara, Toshihiro Nagahara, Masaki Wato , et al. · 2022

Introduction: The aim of this multi-institutional retrospective study was to evaluate the efficacy of preoperative self-expandable metallic stent (SEMS) placement for patients with left-sided obstructive colorectal cancer (OCRC). Methods: …

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