Yuki Nakashima
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View article: Glycoliposomes target lymphatic dendritic cells in a size-dependent manner to activate natural killer T cells against breast tumors
Glycoliposomes target lymphatic dendritic cells in a size-dependent manner to activate natural killer T cells against breast tumors Open
Glycolipids have high potential for activating natural killer T (NKT) cells to mediate robust antitumor responses. However, critical challenges, such as low baseline NKT cell counts and the risk of unintentionally engaging immunosuppressiv…
View article: Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor‐Targeted Therapy
Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor‐Targeted Therapy Open
Spatiotemporal control of protein expression remains a critical challenge in messenger RNA (mRNA) therapeutics, particularly for tumor‐targeted therapy. Here, we introduce a Light‐Induced Transfection System (LITS) leveraging photosensitiz…
View article: Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor‐Targeted Therapy
Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor‐Targeted Therapy Open
Spatiotemporal control of protein expression remains a critical challenge in messenger RNA (mRNA) therapeutics, particularly for tumor‐targeted therapy. Here, we introduce a Light‐Induced Transfection System (LITS) leveraging photosensitiz…
View article: Real‐World Outcomes of the Initial Clip Selection for Transcatheter Edge‐to‐Edge Repair Using the MitraClip G4 From the Optimized Catheter Valvular Intervention‐Mitral Registry
Real‐World Outcomes of the Initial Clip Selection for Transcatheter Edge‐to‐Edge Repair Using the MitraClip G4 From the Optimized Catheter Valvular Intervention‐Mitral Registry Open
Background The association of outcomes with initial clip selection has not been investigated in patients undergoing transcatheter edge‐to‐edge repair with the MitraClip G4. Methods We analyzed 2257 patients receiving the MitraClip G4 accor…
View article: Effects of rare‐earth oxides on microstructure, thermal conductivity, and mechanical properties of silicon nitride
Effects of rare‐earth oxides on microstructure, thermal conductivity, and mechanical properties of silicon nitride Open
For the purpose of systematically studying the effects of rare‐earth (RE) oxide additives on the microstructure and properties of silicon nitride ceramics, all the 16 members of the RE family (RE = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Y…
View article: Effect of Solvent on Pulverization and Surface Properties of Powders in Wet Planetary Ball Milling
Effect of Solvent on Pulverization and Surface Properties of Powders in Wet Planetary Ball Milling Open
View article: Effects of packing powder on densification and properties of pressureless sintered silicon nitride ceramics
Effects of packing powder on densification and properties of pressureless sintered silicon nitride ceramics Open
Pressureless sintering of Si 3 N 4 doped with 2 mol% Y 2 O 3 and 5 mol% MgO was carried out at temperatures ranging from 1700°C to 1770°C in three kinds of packing powders consisting of Si 3 N 4 and BN coupled with or without addition of Y…
View article: Dielectric breakdown behavior of oxynitride glass
Dielectric breakdown behavior of oxynitride glass Open
View article: Development of Artificial Intelligence for Predicting Multiple Properties from Microstructure Images of Silicon Nitride Ceramics
Development of Artificial Intelligence for Predicting Multiple Properties from Microstructure Images of Silicon Nitride Ceramics Open
View article: Optically Stimulated Luminescence Properties of Eu-doped BaAl2S4
Optically Stimulated Luminescence Properties of Eu-doped BaAl2S4 Open
View article: Impact of Preoperative Chemotherapy on Physical Function in Patients With Borderline Resectable Pancreatic Cancer: A Retrospective Study
Impact of Preoperative Chemotherapy on Physical Function in Patients With Borderline Resectable Pancreatic Cancer: A Retrospective Study Open
Purpose: Preoperative chemotherapy in borderline resectable pancreatic cancer (BRPC) reduces tumor size to enable surgery but may cause physical function decline. This study aimed to examine changes in physical function before and after pr…
View article: Association Between Direct Oral Anticoagulant Score and Bleeding Events in Patients With Atrial Fibrillation Following Transcatheter Aortic Valve Replacement: A Retrospective Multicenter Cohort Study
Association Between Direct Oral Anticoagulant Score and Bleeding Events in Patients With Atrial Fibrillation Following Transcatheter Aortic Valve Replacement: A Retrospective Multicenter Cohort Study Open
Background The Direct Oral Anticoagulant (DOAC) Score can predict bleeding risk in patients with atrial fibrillation taking DOACs; however, it lacks external validation. Therefore, this study aimed to assess the association between the DOA…
View article: Microstructural basis of AI predictions for material properties: A case study of silicon nitride ceramics using <i>t</i> ‐SNE
Microstructural basis of AI predictions for material properties: A case study of silicon nitride ceramics using <i>t</i> ‐SNE Open
Artificial intelligence (AI) models such as a convolutional neural network (CNN) are powerful tools for predicting the properties of materials from their microstructural images, etc. It is, however, critically essential to understand how t…
View article: Importance of Initial Ambulation as a Factor Influencing Length of Hospital Stay after Surgery for Colorectal Cancer
Importance of Initial Ambulation as a Factor Influencing Length of Hospital Stay after Surgery for Colorectal Cancer Open
View article: Nitridation optimization, electrical reliability assessment, and AI-driven property determination of silicon nitride ceramics
Nitridation optimization, electrical reliability assessment, and AI-driven property determination of silicon nitride ceramics Open
View article: Polymer Coating Technique Using Surface-Forming Radicals
Polymer Coating Technique Using Surface-Forming Radicals Open
セラミック粒子へのポリマー被覆は,粉体の均一・高分散性に寄与し,その特性向上を可能とする.現行のポリマー被覆技術は,精緻な構造・組成制御ができるものの,その工程が煩雑であることが課題となっている.そこで,粒子の破壊や昇温を伴わない機械的処理(摩砕)が引き起こす粒子極表面のラジカルを最大限利用した粒子表面での選択的なポリマー形成技術を開発した.本研究では,モデル材料としてシリカを母粒子として表面ラジカルとスチレンとを反応させることで,ポリスチレンの被覆を行った.パラメータとし…
View article: Dielectric breakdown strength measurement of silicon nitride ceramics by McKewon electrode
Dielectric breakdown strength measurement of silicon nitride ceramics by McKewon electrode Open
Dielectric breakdown strength (DBS) of silicon nitride substrates with thicknesses of 0.25, 0.15, and 0.07 mm was measured by four types of electrodes: 10 mm spherical, 6 mm circular column shape, and 10-and 15-mm gold-coated film.In addit…
View article: Preparation of hollow silica particles by template method via chemical vapor deposition
Preparation of hollow silica particles by template method via chemical vapor deposition Open
Hollow silica particles (HSPs) were prepared using calcium carbonate (CaCO3) templates coated with silica layers via chemical vapor deposition (CVD), and the effects of the deposition duration on the microstructure and pore structure of th…
View article: Tryptophan intercalation in siRNA drives the formation of polymeric micelles with enhanced delivery efficiency
Tryptophan intercalation in siRNA drives the formation of polymeric micelles with enhanced delivery efficiency Open
A robust delivery system for siRNA was developed based on tryptophan-intercalated polymeric micelles. These micelles enhance intracellular delivery and gene knockdown, leveraging tryptophan's role in stability and endosomal escape.
View article: Sintered reaction-bonded silicon nitride ceramics for power-device substrates -review-
Sintered reaction-bonded silicon nitride ceramics for power-device substrates -review- Open
This review addressed the recent progress of sintered reaction‐bonded Si3N4 (SRBSN) ceramics which are expected to be used as ceramic substrates of the next-generation power devices. Following an overview of thermal conductivities of Si3N4…
View article: Effects of heating rate on microstructure and property of sintered reaction bonded silicon nitrides
Effects of heating rate on microstructure and property of sintered reaction bonded silicon nitrides Open
We prepared sintered reaction-bonded silicon nitride (SRBSN) ceramics using yttria and magnesia as sintering additives and evaluated the effects of heating rates of nitridation on their microstructure, bending strength, fracture toughness,…
View article: Multimodality imaging to identify lipid-rich coronary plaques and predict periprocedural myocardial injury: Association between near-infrared spectroscopy and coronary computed tomography angiography
Multimodality imaging to identify lipid-rich coronary plaques and predict periprocedural myocardial injury: Association between near-infrared spectroscopy and coronary computed tomography angiography Open
Background This study compares the efficacy of coronary computed tomography angiography (CCTA) and near-infrared spectroscopy intravascular ultrasound (NIRS–IVUS) in patients with significant coronary stenosis for predicting periprocedural…
View article: Block catiomers with flanking hydrolyzable tyrosinate groups enhance <i>in vivo</i> mRNA delivery <i>via</i> π–π stacking-assisted micellar assembly
Block catiomers with flanking hydrolyzable tyrosinate groups enhance <i>in vivo</i> mRNA delivery <i>via</i> π–π stacking-assisted micellar assembly Open
Messenger RNA (mRNA) therapeutics have recently demonstrated high clinical potential with the accelerated approval of SARS-CoV-2 vaccines. To fulfill the promise of unprecedented mRNA-based treatments, the development of safe and efficient…
View article: High-efficiency Synthesis of Non-oxide Powder Using a Self-propagating High-temperature
High-efficiency Synthesis of Non-oxide Powder Using a Self-propagating High-temperature Open
Self-propagating high-temperature synthesis (SHS) is a promising technique for rapid synthesis of high-purity powder. It can be used to synthesize an objective material using heat generated by the reaction of raw materials, and the reactio…
View article: β-Carotene enhances the expression of inflammation-related genes and histone H3 K9 acetylation, K4 dimethylation, and K36 trimethylation around these genes in juvenile macrophage-like THP-1 cells
β-Carotene enhances the expression of inflammation-related genes and histone H3 K9 acetylation, K4 dimethylation, and K36 trimethylation around these genes in juvenile macrophage-like THP-1 cells Open
View article: Effects of powder–liquid states on the grinding efficiency of silica particles by rotating ball milling
Effects of powder–liquid states on the grinding efficiency of silica particles by rotating ball milling Open
Grinding is an important and widely applied industrial process for decreasing the size of particles, and it has been most frequently carried out together with liquid medium to improve the efficiency. In this study, the relationship among v…
View article: Intraocular Pressure Fluctuation during Aerobic Exercise at Different Exercise Intensities
Intraocular Pressure Fluctuation during Aerobic Exercise at Different Exercise Intensities Open
Few studies have examined the effects of different aerobic-exercise intensities on intraocular-pressure (IOP) changes. This may be important for eye diseases that are impacted by IOP or its fluctuation, including glaucoma, and diabetes tha…
View article: Thickness dependence of dielectric breakdown strength for silicon nitride substrate
Thickness dependence of dielectric breakdown strength for silicon nitride substrate Open
Silicon nitride ceramics have attracted increasing attention as insulated heat-dissipating substrates for power modules due to their high thermal conductivity and mechanical strength. However, there are very few reports on their dielectric…
View article: Selective Transfer of Si Thin-Film Microchips by SiO2 Terraces on Host Chips for Fluidic Self-Assembly
Selective Transfer of Si Thin-Film Microchips by SiO2 Terraces on Host Chips for Fluidic Self-Assembly Open
Fluidic self-assembly is a versatile on-chip integration method. In this scheme, a large number of semiconductor microchips are spontaneously deposited onto a host chip. The host chip typically comprises a Si substrate with an array of poc…
View article: Thermoelectric properties of sorted semiconducting single-walled carbon nanotube sheets
Thermoelectric properties of sorted semiconducting single-walled carbon nanotube sheets Open
Single-walled carbon nanotubes (SWNTs), especially their semiconducting type, are promising thermoelectric (TE) materials due to their high Seebeck coefficient. In this study, the in-plane Seebeck coefficient (S), electrical conduct…