Yuki Nishida
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View article: Association of SARC-F with muscle mass, strength, and quality derived from bioelectrical impedance spectroscopy for sarcopenia assessment
Association of SARC-F with muscle mass, strength, and quality derived from bioelectrical impedance spectroscopy for sarcopenia assessment Open
The SARC-F is a 5-item questionnaire screening for patients at risk of sarcopenia. The electrical properties of tissues derived from bioelectrical impedance spectroscopy (BIS), including phase angle (PhA) and intracellular-extracellular wa…
View article: Protein degradation of MYC/GSPT1 combined with menin inhibition overcomes resistance to menin inhibition in KMT2A-rearranged Acute Myeloid Leukemia
Protein degradation of MYC/GSPT1 combined with menin inhibition overcomes resistance to menin inhibition in KMT2A-rearranged Acute Myeloid Leukemia Open
BACKGROUND KMT2A rearranged (KMT2Ar) leukemias are an aggressive subset of acute leukemias with poor outcomes. Pharmacological inhibition of the menin-KMT2A interaction using revumenib and ziftomenib has shown encouraging efficacy in clini…
View article: MYC/GSPT1 protein degradation in refractory/relapsed T-cell prolymphocytic leukemias
MYC/GSPT1 protein degradation in refractory/relapsed T-cell prolymphocytic leukemias Open
Background: T-cell prolymphocytic leukemia (T-PLLs) is a rare, mature T-cell-derived, aggressive hematologic malignancy. T-PLLs are one of the most challenging hematologic malignancies based on refractoriness to conventional chemotherapy a…
View article: ABS0302 The NEUTROPHIL/LYMPHOCYTE RATIO (NLR) CAN GUIDE THE OPTIMAL TIMING OF REBIOPSY BY PREDICTING REBIOPSY PROVEN FLARE OF LUPUS NEPHRITIS
ABS0302 The NEUTROPHIL/LYMPHOCYTE RATIO (NLR) CAN GUIDE THE OPTIMAL TIMING OF REBIOPSY BY PREDICTING REBIOPSY PROVEN FLARE OF LUPUS NEPHRITIS Open
View article: Somatic TP53 Mutations Drive T and NK Cell Dysfunction in AML and Can be Rescued by Reactivating Wild Type p53
Somatic TP53 Mutations Drive T and NK Cell Dysfunction in AML and Can be Rescued by Reactivating Wild Type p53 Open
TP53-mutant acute myeloid leukemia (AML) is associated with particularly poor clinical outcomes and resistance to current therapies. While immunotherapy has revolutionized treatment for other hematologic malignancies, its efficacy in TP53-…
View article: Primary Cutaneous CD8-positive Aggressive Epidermotropic Cytotoxic T-cell Lymphoma Complicated by Paraneoplastic Encephalitis
Primary Cutaneous CD8-positive Aggressive Epidermotropic Cytotoxic T-cell Lymphoma Complicated by Paraneoplastic Encephalitis Open
Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma (PCAE-CTL) is a rare subtype of cutaneous T-cell lymphoma with a poor prognosis. We herein report a case of PCAE-CTL accompanied by anti-Ma2 antibody-positi…
View article: Magnetic Resonance Imaging-negative Encephalomyeloradiculopathy Diagnosed by Anti-lactosylceramide Antibody Positivity and Electrophysiological Findings: A Case Report and Review of the Literature
Magnetic Resonance Imaging-negative Encephalomyeloradiculopathy Diagnosed by Anti-lactosylceramide Antibody Positivity and Electrophysiological Findings: A Case Report and Review of the Literature Open
A 71-year-old woman developed progressive limb weakness and sensory disturbances below the thoracic level. Although myelopathy was initially considered, spinal magnetic resonance imaging (MRI) showed no abnormalities. Conversely, electroph…
View article: Non-exercise Activity Thermogenesis Correlated With Clinical Parameters in Patients With or At-Risk for Chronic Obstructive Pulmonary Disease (COPD): A Pilot Study
Non-exercise Activity Thermogenesis Correlated With Clinical Parameters in Patients With or At-Risk for Chronic Obstructive Pulmonary Disease (COPD): A Pilot Study Open
Our study revealed the significance of NEAT as a valuable indicator in assessing the health status of patients with or at risk for COPD. The NEAT score was correlated with various clinical traits, suggesting that incorporating NEAT assessm…
View article: Web-Based Content on Diet and Nutrition Written in Japanese: Infodemiology Study Based on Google Trends and Google Search
Web-Based Content on Diet and Nutrition Written in Japanese: Infodemiology Study Based on Google Trends and Google Search Open
Background The increased availability of content of uncertain integrity obtained through the internet is a major concern. To date, however, there has been no comprehensive scrutiny of the fitness-for-purpose of web-based content on diet an…
View article: Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation
Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation Open
Differentiation therapy has been proposed as a promising therapeutic strategy for acute myeloid leukemia (AML); thus, the development of more versatile methodologies that are applicable to a wide range of AML subtypes is desired. Although …
View article: Multimorbidity patterns in the working age population with the top 10% medical cost from exhaustive insurance claims data of Japan Health Insurance Association
Multimorbidity patterns in the working age population with the top 10% medical cost from exhaustive insurance claims data of Japan Health Insurance Association Open
Although the economic burden of multimorbidity is a growing global challenge, the contribution of multimorbidity in patients with high medical expenses remains unclear. We aimed to clarify multimorbidity patterns that have a large impact o…
View article: Effect of overweight/obesity and metabolic syndrome on frailty in middle‐aged and older Japanese adults
Effect of overweight/obesity and metabolic syndrome on frailty in middle‐aged and older Japanese adults Open
Background The potential for developing frailty exists in middle‐aged and older adults. While obesity and metabolic syndrome (MetS) increase the risk of frailty in older adults, this relationship remains unclear in middle‐aged adults, who …
View article: Epichaperome inhibition targets <i>TP53-</i>mutant AML and AML stem/progenitor cells
Epichaperome inhibition targets <i>TP53-</i>mutant AML and AML stem/progenitor cells Open
TP 53-mutant acute myeloid leukemia (AML) remains the ultimate therapeutic challenge. Epichaperomes, formed in malignant cells, consist of heat shock protein 90 (HSP90) and associated proteins that support the maturation, activity, and sta…
View article: Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics
Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics Open
View article: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics Open
TP53 -mutant acute myeloid leukemia (AML) respond poorly to currently available treatments, including venetoclax-based drug combinations and pose a major therapeutic challenge. Analyses of RNA sequencing and reverse phase protein array dat…
View article: Web-Based Content on Diet and Nutrition Written in Japanese: Infodemiology Study Based on Google Trends and Google Search (Preprint)
Web-Based Content on Diet and Nutrition Written in Japanese: Infodemiology Study Based on Google Trends and Google Search (Preprint) Open
BACKGROUND The increased availability of content of uncertain integrity obtained through the internet is a major concern. To date, however, there has been no comprehensive scrutiny of the fitness-for-purpose of web-based content on diet a…
View article: Possible association of high-density lipoprotein cholesterol levels with trunk muscle deficits and decrease in energy expenditure in patients with or at risk for COPD: A pilot study
Possible association of high-density lipoprotein cholesterol levels with trunk muscle deficits and decrease in energy expenditure in patients with or at risk for COPD: A pilot study Open
HDL-C level was a potential biomarker for trunk muscle volumes and functions, as well as total energy expenditure in COPD.
View article: Impact of non-exercise activity thermogenesis on physical activity in patients with COPD
Impact of non-exercise activity thermogenesis on physical activity in patients with COPD Open
Physical inactivity is associated with comorbidities and mortality in chronic obstructive pulmonary disease (COPD) patients. Although non-exercise activity thermogenesis (NEAT) is important for evaluating the physical activity level (PAL) …
View article: Evaluation of energy intake by brief-type self-administered diet history questionnaire among male patients with stable/at risk for chronic obstructive pulmonary disease
Evaluation of energy intake by brief-type self-administered diet history questionnaire among male patients with stable/at risk for chronic obstructive pulmonary disease Open
Background and objective Weight loss and reduced fat-free mass are independent risk factors for mortality among patients with chronic obstructive pulmonary disease (COPD). These factors are important for determining diet therapy and examin…
View article: Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML
Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML Open
View article: DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia
DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia Open
View article: Impact of walking aids on estimating physical activity using a tri-axial accelerometer in frail older adults
Impact of walking aids on estimating physical activity using a tri-axial accelerometer in frail older adults Open
Objectives This study aimed to compare the estimation error of physical activity level (PAL) estimated using a tri-axial accelerometer between an independent walking group and an assisted walking group with walking aids. Methods Subjects w…
View article: Determinants of Total Energy Expenditure and Physical Activity Level in Patients with COPD
Determinants of Total Energy Expenditure and Physical Activity Level in Patients with COPD Open
View article: Energy expenditure and physical activity in COPD by doubly labelled water method and an accelerometer
Energy expenditure and physical activity in COPD by doubly labelled water method and an accelerometer Open
Although weight loss suggests poor prognosis of COPD, only a few studies have examined total energy expenditure (TEE) or physical activity level (PAL) using the doubly labelled water (DLW) method. We evaluated TEE and PAL using the DLW met…
View article: The product of trunk muscle area and density on the CT image is a good indicator of energy expenditure in patients with or at risk for COPD
The product of trunk muscle area and density on the CT image is a good indicator of energy expenditure in patients with or at risk for COPD Open
View article: Energy Gap between Doubly Labeled Water-Based Energy Expenditure and Calculated Energy Intake from Recipes and Plate Waste, and Subsequent Weight Changes in Elderly Residents in Japanese Long-Term Care Facilities: CLEVER Study
Energy Gap between Doubly Labeled Water-Based Energy Expenditure and Calculated Energy Intake from Recipes and Plate Waste, and Subsequent Weight Changes in Elderly Residents in Japanese Long-Term Care Facilities: CLEVER Study Open
Unintentional weight loss is a major frailty component; thus, assessing energy imbalance is essential for institutionalized elderly residents. This study examined prediction errors of the observed energy intake (OEI) against the actual ene…
View article: Usefulness of Quantitative CT Measures of Muscle Areas in Patients with COPD: Relationship to Energy Expenditure and Physical Activity
Usefulness of Quantitative CT Measures of Muscle Areas in Patients with COPD: Relationship to Energy Expenditure and Physical Activity Open
View article: Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality
Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality Open
View article: Validity of One-Day Physical Activity Recall for Estimating Total Energy Expenditure in Elderly Residents at Long-Term Care Facilities: CLinical EValuation of Energy Requirements Study (CLEVER Study)
Validity of One-Day Physical Activity Recall for Estimating Total Energy Expenditure in Elderly Residents at Long-Term Care Facilities: CLinical EValuation of Energy Requirements Study (CLEVER Study) Open
Malnutrition is a severe problem among elderly residents living in long-term care facilities. A simple and accurate estimation for total daily energy expenditure (TEE) is required in order to provide them with an adequate amount of food. T…
View article: Total energy expenditure is comparable between patients with and without diabetes mellitus: Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) Study
Total energy expenditure is comparable between patients with and without diabetes mellitus: Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) Study Open
Objective Assessment of total energy expenditure (TEE) is essential for appropriate recommendations regarding dietary intake and physical activity in patients with and without diabetes mellitus (DM). However, few reports have focused on TE…