Yuki Numakura
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View article: Evaluation of Diagnostic Performance of Circulating microRNAs as Biomarkers of Retinal Toxicity in the Rat
Evaluation of Diagnostic Performance of Circulating microRNAs as Biomarkers of Retinal Toxicity in the Rat Open
Retinal toxicity is of great concern during drug development due to the irreversibility. Circulating microRNA (miRNA) is reported to be useful for detecting retinal toxicity in rats, although there has been no assessment of the diagnostic …
View article: PHF24 is expressed in the inhibitory interneurons in rats
PHF24 is expressed in the inhibitory interneurons in rats Open
Noda epileptic rat (NER) is a mutant model for epilepsy that exhibits spontaneous generalized tonic-clonic seizure. Epileptogenesis of NER remains to be elucidated; but it is detected an insertion of an endogenous retrovirus sequence in in…
View article: The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats
The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats Open
Pulmonary arterial hypertension (PAH) is a lethal disease characterized by a progressive increase in pulmonary artery pressure due to an increase in vessel tone and occlusion of vessels. The endogenous vasodilator prostacyclin and its anal…
View article: A case of spontaneous nephroblastoma characterized by two distinct morphologies in a Slc:CD(SD)IGS rat
A case of spontaneous nephroblastoma characterized by two distinct morphologies in a Slc:CD(SD)IGS rat Open
We report a spontaneous case of nephroblastoma in a 26-week-old female Slc:CD(SD) rat. Macroscopically, there was a yellow mass in the left kidney that included another small yellowish-white mass. Histologically, the mass was located mainl…
View article: Disperse Orange 3 as a resonance Raman probe for measuring membrane order
Disperse Orange 3 as a resonance Raman probe for measuring membrane order Open
Resonance Raman spectra of azobenzene derivatives were examined in the presence of lipid membranes to find a probe that can distinguish different membrane phases. The NO 2 symmetric stretching band of 4‐(4‐nitrophenylazo)aniline, also know…