Yuki Takai
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View article: Metabolic landscape of clear cell renal cell carcinoma and search for metabolites predictive of drug response
Metabolic landscape of clear cell renal cell carcinoma and search for metabolites predictive of drug response Open
We validated the landscape of the ccRCC metabolome and identified some metabolites as potential biomarkers for predicting therapeutic response in RCC.
View article: Reassessing prognostic markers in metastatic renal cell carcinoma in the era of immune checkpoint inhibitors: The enduring value of body composition, nutritional, and inflammatory indices
Reassessing prognostic markers in metastatic renal cell carcinoma in the era of immune checkpoint inhibitors: The enduring value of body composition, nutritional, and inflammatory indices Open
Background Immune checkpoint inhibitors (ICIs) are now the standard first-line treatment for metastatic renal cell carcinoma (mRCC), yet many risk factors identified during the tyrosine kinase inhibitor era remain unvalidated in current pr…
View article: Real-world short-term outcomes and treatment regimen comparisons in patients with metastatic renal cell carcinoma treated with first-line immune combinations
Real-world short-term outcomes and treatment regimen comparisons in patients with metastatic renal cell carcinoma treated with first-line immune combinations Open
View article: Can Wharf Roach (Ligia Spp.) Feces Be a New Bioindicator for Non-Invasive Environmental Monitoring to Assess Microplastics Pollution in Coastal Areas?
Can Wharf Roach (Ligia Spp.) Feces Be a New Bioindicator for Non-Invasive Environmental Monitoring to Assess Microplastics Pollution in Coastal Areas? Open
View article: A Case of Metachronous Bilateral Breast Cancer in a Patient with Bloom Syndrome
A Case of Metachronous Bilateral Breast Cancer in a Patient with Bloom Syndrome Open
View article: Changes in dysbiosis and gene expression in the gut of wharf roach (Ligia Spp.) fed with expanded polystyrene
Changes in dysbiosis and gene expression in the gut of wharf roach (Ligia Spp.) fed with expanded polystyrene Open
View article: Impacts of Diazepam on the Locomotor Activity and Brain Gene Expression of Female Japanese Medaka (Oryzias latipes)
Impacts of Diazepam on the Locomotor Activity and Brain Gene Expression of Female Japanese Medaka (Oryzias latipes) Open
Due to its extensive use and high stability in water–sediment systems, diazepam (DZP) has become an emerging pollutant of great concern. The adverse effects of DZP on fish have been well documented, but information on the molecular mechani…
View article: Methods for detection and cell abundance estimation of harmful dinoflagellate <i>Karenia mikimotoi</i> using peak shifts of chlorophyll fluorescence spectra
Methods for detection and cell abundance estimation of harmful dinoflagellate <i>Karenia mikimotoi</i> using peak shifts of chlorophyll fluorescence spectra Open
View article: Urinary continence outcomes after robot‐assisted laparoscopic radical prostatectomy: Significance of anterior reconstruction
Urinary continence outcomes after robot‐assisted laparoscopic radical prostatectomy: Significance of anterior reconstruction Open
Objective Urinary continence after radical prostatectomy is a crucial aspect of patient quality of life. The aim of this study was to identify the factors influencing urinary continence after robot‐assisted laparoscopic radical prostatecto…
View article: Accumulation of Heavy Metals in Tissues of Oreochromis Mossambicus from the uMgeni River and Human Health Risk Assessment
Accumulation of Heavy Metals in Tissues of Oreochromis Mossambicus from the uMgeni River and Human Health Risk Assessment Open
Metal enrichment in aquatic ecosystems has compromised the potential of fish to enhance food security. The uMgeni River drains urban and industrialized catchment and flows through economically disadvantaged rural communities that opt for f…
View article: Metal distribution in three organs and edibility assessment on Coptodon rendalli from the Umgeni River impacted by metallurgic industrial activities
Metal distribution in three organs and edibility assessment on Coptodon rendalli from the Umgeni River impacted by metallurgic industrial activities Open
Fish is among the most affordable and readily available protein sources for communities residing near water bodies. However, the recent pollution status of aquatic ecosystems has rendered fish consumption risky for human health. The study …
View article: Diurnal-Rhythmic Relationships between Physiological Parameters and Photosynthesis- and Antioxidant-Enzyme Genes Expression in the Raphidophyte Chattonella marina Complex
Diurnal-Rhythmic Relationships between Physiological Parameters and Photosynthesis- and Antioxidant-Enzyme Genes Expression in the Raphidophyte Chattonella marina Complex Open
Diurnal rhythms in physiological functions contribute to homeostasis in many organisms. Although relationships between molecular biology and diurnal rhythms have been well studied in model organisms like higher plants, those in harmful alg…
View article: Metabolic landscape of clear cell renal cell carcinoma and search for metabolites predictive of drug response
Metabolic landscape of clear cell renal cell carcinoma and search for metabolites predictive of drug response Open
Background. Clear cell renal cell carcinoma (ccRCC) commonly exhibits biallelic inactivation of VHL genes, profoundly impacting intracellular metabolic pathways and utilization of metabolic substrates. The aims of this study were to valida…
View article: First application of one‐class support vector machine algorithms for detecting abnormal behavior of marine medaka <scp><i>Oryzias javanicus</i></scp> exposed to the harmful alga <scp><i>Karenia mikimotoi</i></scp>
First application of one‐class support vector machine algorithms for detecting abnormal behavior of marine medaka <span><i>Oryzias javanicus</i></span> exposed to the harmful alga <span><i>Karenia mikimotoi</i></span> Open
It is empirically known that fish exposed to harmful algal blooms (HABs) exhibit abnormal behavior. This might serve as a method for early detection of HABs. There has been no report of the detection of behavioral abnormalities of fish exp…
View article: Fragmentation of Expanded Polystyrene to Microplastics by Wharf Roach Ligia Spp
Fragmentation of Expanded Polystyrene to Microplastics by Wharf Roach Ligia Spp Open
View article: No Vector Effects of Polystyrene Microplastics on the Accumulation of Chlorobenzenes in Japanese Medaka (Oryzias Latipes)
No Vector Effects of Polystyrene Microplastics on the Accumulation of Chlorobenzenes in Japanese Medaka (Oryzias Latipes) Open
View article: Intracellular Major Histocompatibility Complex Class II and C-X-C Motif Chemokine Ligand 10-Expressing Neutrophils Indicate the State of Anti-Tumor Activity Induced by Bacillus Calmette–Guérin
Intracellular Major Histocompatibility Complex Class II and C-X-C Motif Chemokine Ligand 10-Expressing Neutrophils Indicate the State of Anti-Tumor Activity Induced by Bacillus Calmette–Guérin Open
(1) Background: Inflammatory responses induce the formation of both anti-tumor and pro-tumor neutrophils known as myeloid-derived suppressor cells (MDSCs). Intermittent intravesical infusion of Bacillus Calmette–Guérin (BCG) is an establis…
View article: Bioconcentration and Behavioral Interference Effect of Diazepam on Adult Japanese Medaka (Oryzias latipes)
Bioconcentration and Behavioral Interference Effect of Diazepam on Adult Japanese Medaka (Oryzias latipes) Open
As one of the most commonly detected polluting drugs in the environment, diazepam (DZP) has been widely detected in rivers, soil, and organisms.To better understand the bioconcentration of DZP in fish and its impact on fish behaviors, we e…
View article: Initial Myeloid Cell Status Is Associated with Clinical Outcomes of Renal Cell Carcinoma
Initial Myeloid Cell Status Is Associated with Clinical Outcomes of Renal Cell Carcinoma Open
The therapeutic outcome of immune checkpoint inhibition (ICI) can be improved through combination treatments with ICI therapy. Myeloid-derived suppressor cells (MDSCs) strongly suppress tumor immunity. MDSCs are a heterogeneous cell popula…
View article: Long term anti-vascular endothelial growth factor receptor treatment impairs renal function in renal cell carcinoma
Long term anti-vascular endothelial growth factor receptor treatment impairs renal function in renal cell carcinoma Open
Background: The overall survival has been dramatically improving in metastatic renal cell carcinoma (mRCC) patients. Although anti-vascular endothelial growth factor receptor (VEGFR) treatment is one of essential therapeutic strategies for…
View article: Body composition changes following chemotherapy for testicular germ cell tumor: obesity is the long-term problem
Body composition changes following chemotherapy for testicular germ cell tumor: obesity is the long-term problem Open
Metabolic syndrome is a long-term complication of systemic chemotherapy for testicular germ cell tumor (TGCT). It is believed to be caused by secondary hypogonadism or toxic medicines because of orchidectomy followed by systemic chemothera…
View article: Uptake and depuration kinetics of microplastics with different polymer types and particle sizes in Japanese medaka (Oryzias latipes)
Uptake and depuration kinetics of microplastics with different polymer types and particle sizes in Japanese medaka (Oryzias latipes) Open
View article: Recent Progress in the Study of Peroxiredoxin in the Harmful Algal Bloom Species Chattonella marina
Recent Progress in the Study of Peroxiredoxin in the Harmful Algal Bloom Species Chattonella marina Open
Peroxiredoxin (Prx) is a relatively recently discovered antioxidant enzyme family that scavenges peroxides and is known to be present in organisms from biological taxa ranging from bacteria to multicellular eukaryotes, including photosynth…
View article: Adipogenesis of Perfluorooctanesulfonate (PFOS) on Japanese Medaka (Oryzias Latipes) Embryo Using Ovo–nanoinjection–mRNA Seq Analysis
Adipogenesis of Perfluorooctanesulfonate (PFOS) on Japanese Medaka (Oryzias Latipes) Embryo Using Ovo–nanoinjection–mRNA Seq Analysis Open
Perfluorooctanesulfonate (PFOS) is a worldwide persistent organic pollutant and suspected to have effects on animals. The present study used in ovo–nanoinjection to simulate the maternal bioaccumulation and biotransformation of PFOS from p…
View article: Effects of Tributyltin and Diazinon on the Intertidal Marine Harpacticoid Copepod Tigriopus japonicus
Effects of Tributyltin and Diazinon on the Intertidal Marine Harpacticoid Copepod Tigriopus japonicus Open
The intertidal zone plays an important role in the ecology of coastal waters by providing marine organisms a place to feed, grow, and spawn. Because the organisms that inhabit these areas may be contaminated and adversely affected by pollu…
View article: Production of a tributyltin-binding protein 2 knockout mutant strain of Japanese medaka,<i>Oryzias latipes</i>
Production of a tributyltin-binding protein 2 knockout mutant strain of Japanese medaka,<i>Oryzias latipes</i> Open
Tributyltin-binding proteins (TBT-bps), members of the lipocalin family, bind TBT in fish blood and are presumed to contribute to detoxification of TBT. Recent studies have shown that many fish species have TBT-bp genes, and that these gen…
View article: Maternal Transcriptome Analysis of Medaka (Oryzias latipes) Embryos by Use of mRNA–seq
Maternal Transcriptome Analysis of Medaka (Oryzias latipes) Embryos by Use of mRNA–seq Open
In this study, we investigated the transfer of maternal transcripts to embryos during the early stages of development in medaka (Oryzias latipes). Using mRNA–Seq, we analyzed gene expression levels in medaka embryos, focusing on maternal t…
View article: PHEOCHROMOCYTOMA CRISIS WITH MIBG SCINTIGRAPHY NEGATIVE: A CASE REPORT
PHEOCHROMOCYTOMA CRISIS WITH MIBG SCINTIGRAPHY NEGATIVE: A CASE REPORT Open
We report a case of pheochromocytoma crisis with negative MIBG scintigraphy. A 48-year-old man was admitted for hypertension crisis. Computed tomographic scan revealed a 60 mm right adrenal mass. The MIBG scintigraphy was negative, but we …
View article: Intraoperative hypothermia is a significant prognostic predictor of radical cystectomy especially for stage II muscle-invasive bladder cancer
Intraoperative hypothermia is a significant prognostic predictor of radical cystectomy especially for stage II muscle-invasive bladder cancer Open
The objective of this study was to evaluate intraoperative hypothermia as a predictor of complication and prognosis in patients with muscle-invasive bladder cancer treated with radical cystectomy. The data of 124 patients treated with radi…
View article: CEREBRAL VENOUS SINUS THROMBOSIS IN PATIENTS WITH METASTATIC TESTICULAR CANCER DURING CHEMOTHERAPY: REPORTS OF TWO CASES
CEREBRAL VENOUS SINUS THROMBOSIS IN PATIENTS WITH METASTATIC TESTICULAR CANCER DURING CHEMOTHERAPY: REPORTS OF TWO CASES Open
Cerebral venous sinus thrombosis (CVT) is rare but sometimes develops in association with malignant neoplasm. We report two cases of CVT that occurred during cisplatin-based chemotherapy for testicular cancer. A 46-year-old man with stage …