Yuki Taya
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View article: Late-onset radiation-induced brain necrosis following allogeneic transplantation for CNS-involved acute myeloid leukemia after whole brain irradiation: two case reports
Late-onset radiation-induced brain necrosis following allogeneic transplantation for CNS-involved acute myeloid leukemia after whole brain irradiation: two case reports Open
View article: Single-unit cord blood transplantation reduces the risk of relapse and improves leukemia-free survival compared to other donor sources in allo-HSCT for patients with high-risk acute myeloid leukemia
Single-unit cord blood transplantation reduces the risk of relapse and improves leukemia-free survival compared to other donor sources in allo-HSCT for patients with high-risk acute myeloid leukemia Open
Background: Outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with high-risk acute myeloid leukemia (AML), including those with adverse disease biology or chemotherapy-refractory disease, remain subopti…
View article: Therapy-related Trilineage Mixed Phenotype Acute Leukemia Treated with Venetoclax and Azacitidine
Therapy-related Trilineage Mixed Phenotype Acute Leukemia Treated with Venetoclax and Azacitidine Open
This is the first report of therapy-related mixed-phenotype acute leukemia (MPAL) characterized by B-cell, T-cell, and myeloid lineage phenotypes. A 68-year-old man, who was in complete remission after chemoradiotherapy for recurrent esoph…
View article: Discordant lymphoma characterized by the coexistence of diffuse large B-cell lymphoma in the brain and mantle cell lymphoma in the colon, rectum, and bone marrow.
Discordant lymphoma characterized by the coexistence of diffuse large B-cell lymphoma in the brain and mantle cell lymphoma in the colon, rectum, and bone marrow. Open
We describe a rare case of discordant lymphoma characterized by the coexistence of diffuse large B-cell lymphoma (DLBCL) in the brain and mantle cell lymphoma (MCL) in the colon, rectum, and bone marrow. A 63-year-old male patient with con…
View article: Food Development through Co-creation with AI: bread with a "taste of love"
Food Development through Co-creation with AI: bread with a "taste of love" Open
This study explores a new method in food development by utilizing AI including generative AI, aiming to craft products that delight the senses and resonate with consumers' emotions. The food ingredient recommendation approach used in this …
View article: Natto consumption suppresses atherosclerotic plaque progression in LDL receptor-deficient mice transplanted with iRFP-expressing hematopoietic cells
Natto consumption suppresses atherosclerotic plaque progression in LDL receptor-deficient mice transplanted with iRFP-expressing hematopoietic cells Open
Natto, known for its high vitamin K content, has been demonstrated to suppress atherosclerosis in large-scale clinical trials through a yet-unknown mechanism. In this study, we used a previously reported mouse model, transplanting the bone…
View article: PROPHYLACTIC EFFICACY OF WASHED CORD BLOOD AGAINST ANAPHYLAXIS ASSOCIATED WITH CORD BLOOD TRANSPLANTATION: A CASE REPORT
PROPHYLACTIC EFFICACY OF WASHED CORD BLOOD AGAINST ANAPHYLAXIS ASSOCIATED WITH CORD BLOOD TRANSPLANTATION: A CASE REPORT Open
治療抵抗性急性骨髄性白血病（AML）の30代女性患者に対して初回の臍帯血移植（CBT，有核細胞数1.72×107個/kg）を行ったところ，輸注時に呼吸困難，SpO2低下，血圧低下を伴うアナフィラキシーを認めた．直ちに輸注を中止し，エピネフリン筋注＋補液で対処した．輸注は80%以上が完了していたため再開しなかった．移植後25日目に生着を確認した．その後AMLの再発を認め，移植後18カ月の時点で2回目のCBTを検討，実施にあたりアナフィラキシー予防として臍帯血の洗浄を実施した．…
View article: Incidence of breakthrough COVID-19 in patients with hematological disorders who received pre-exposure prophylaxis with tixagevimab-cilgavimab: a retrospective study in Japan
Incidence of breakthrough COVID-19 in patients with hematological disorders who received pre-exposure prophylaxis with tixagevimab-cilgavimab: a retrospective study in Japan Open
View article: Rituximab/bendamustine/cytarabine for transplant‐eligible patients with mantle cell lymphoma: A retrospective study
Rituximab/bendamustine/cytarabine for transplant‐eligible patients with mantle cell lymphoma: A retrospective study Open
Background Mantle cell lymphoma is considered an aggressive B‐cell lymphoma. The optimal induction regimen remains controversial as no randomized controlled trial has compared the efficacy of different induction therapies. Method Herein, w…
View article: Clinical Evaluation Based on a New Approach to Improve the Accuracy of 4β-Hydroxycholesterol Measurement as a Biomarker of CYP3A4 Activity
Clinical Evaluation Based on a New Approach to Improve the Accuracy of 4β-Hydroxycholesterol Measurement as a Biomarker of CYP3A4 Activity Open
This study examines 4β-Hydroxycholesterol (4β-HC), which is considered to be a potential marker for the CYP3A4 induction of new chemical entities (NCEs) in drug development. To ensure the use of 4β-HC as a practical biomarker, it is necess…
View article: Factors Associated with Breakthrough Fungemia Caused by <i>Candida</i> , <i>Trichosporon</i> , or Fusarium Species in Patients with Hematological Disorders
Factors Associated with Breakthrough Fungemia Caused by <i>Candida</i> , <i>Trichosporon</i> , or Fusarium Species in Patients with Hematological Disorders Open
Limited data are available on breakthrough fungemia, defined as fungemia that develops on administration of antifungal agents, in patients with hematological disorders. We reviewed the medical and microbiological records of adult patients …
View article: A case of late-onset hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic stem cell transplantation: usefulness of ultrasonography (liver stiffness measurement) for diagnosis and follow-up
A case of late-onset hepatic sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic stem cell transplantation: usefulness of ultrasonography (liver stiffness measurement) for diagnosis and follow-up Open
症例は32歳女性，急性骨髄性白血病の治療のため同種造血幹細胞移植が施行された．入院時の肝硬度（liver stiffness: LS）は3.5 KPaであった．移植後，第67 病日から体重増加，腹痛，血清ビリルビン値の上昇を認め，腹部超音波検査（Ultrasonography: US），肝硬度測定を実施した．LSは42.2 KPaと著明に上昇，US検査では肝腫大，腹水貯留，門脈血流低下を認め，遅発性の肝類洞閉塞症候群／中心静脈閉塞症（sinusoidal obstructi…
View article: Effects of Genetic Polymorphisms of Cathepsin A on Metabolism of Tenofovir Alafenamide
Effects of Genetic Polymorphisms of Cathepsin A on Metabolism of Tenofovir Alafenamide Open
Cathepsin A (CatA) is important as a drug-metabolizing enzyme responsible for the activation of prodrugs, such as the anti-human immunodeficiency virus drug Tenofovir Alafenamide (TAF). The present study was undertaken to clarify the prese…
View article: Clinical and Microbiological Characteristics of Proven Invasive Aspergillosis Due to Rare/Cryptic Species in Allogeneic Hematopoietic Stem Cell Transplant Recipients
Clinical and Microbiological Characteristics of Proven Invasive Aspergillosis Due to Rare/Cryptic Species in Allogeneic Hematopoietic Stem Cell Transplant Recipients Open
There are few reports on the clinical course of proven invasive aspergillosis (IA) due to rare/cryptic species in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. We retrospectively reviewed the electronic medical reco…
View article: Retrospective analyses of other iatrogenic immunodeficiency‐associated lymphoproliferative disorders in patients with rheumatic diseases
Retrospective analyses of other iatrogenic immunodeficiency‐associated lymphoproliferative disorders in patients with rheumatic diseases Open
Summary Other iatrogenic immunodeficiency‐associated lymphoproliferative disorders (OIIA‐LPDs) occur in patients receiving immunosuppressive drugs for autoimmune diseases; however, their clinicopathological and genetic features remain unkn…
View article: Investigation of nesting distribution of Kentish plover by simultaneous shooting of visible and infrared images using UAV.
Investigation of nesting distribution of Kentish plover by simultaneous shooting of visible and infrared images using UAV. Open
View article: Prognostic Impact of Cytogenetic Evolution on the Outcome of Allogeneic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia in Nonremission: A Single-Institute Analysis of 212 Recipients
Prognostic Impact of Cytogenetic Evolution on the Outcome of Allogeneic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia in Nonremission: A Single-Institute Analysis of 212 Recipients Open
Recent progress in genetic analysis technology has helped researchers understand the pathogenesis of acute myeloid leukemia (AML). Considering this progress, AML karyotype is still one of the most significant prognostic factors that provid…
View article: Real-Time Model Predictive Control of Rigid Body Motion via Discretization Using the Cayley Map
Real-Time Model Predictive Control of Rigid Body Motion via Discretization Using the Cayley Map Open
This paper presents a fast nonlinear model predictive control method for rigid body dynamical systems such as spacecraft or aerial vehicles on the special Euclidean group SE(3). The focus of this research is on the real-time execution of t…
View article: Micafungin Breakthrough Fungemia in Patients with Hematological Disorders
Micafungin Breakthrough Fungemia in Patients with Hematological Disorders Open
Limited data are available on micafungin breakthrough fungemia (MBF), fungemia that develops on administration of micafungin, in patients with hematological disorders. We reviewed medical and microbiological records of patients with hemato…
View article: CD34 + CD38- Leukemia Stem Cell and Karyotype Predicts Relapse after Cord Blood Transplantation for Acute Myeloid Leukemia with Myelodysplasia-Related Changes
CD34 + CD38- Leukemia Stem Cell and Karyotype Predicts Relapse after Cord Blood Transplantation for Acute Myeloid Leukemia with Myelodysplasia-Related Changes Open
Background: In acute myeloid leukemia (AML), leukemia stem cells (LSCs) are enriched within CD34 + CD38- fraction. Although several groups reported that LSCs contributed to relapse after chemotherapy, relapse after allogeneic hematopoietic…
View article: Micafungin Breakthrough Fungemia in Patients with Hematological Disorders: A Retrospective Study to Determine Therapeutic Strategy
Micafungin Breakthrough Fungemia in Patients with Hematological Disorders: A Retrospective Study to Determine Therapeutic Strategy Open