Yuki Yoshizaki
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View article: Development of a machine learning tool to predict the risk of incident chronic kidney disease using health examination data
Development of a machine learning tool to predict the risk of incident chronic kidney disease using health examination data Open
Background Chronic kidney disease (CKD) is characterized by a decreased glomerular filtration rate or renal injury (especially proteinuria) for at least 3 months. The early detection and treatment of CKD, a major global public health conce…
View article: Urinary liver-type fatty acid–binding protein level as a prognostic indicator of acute kidney injury secondary to severe falciparum malaria
Urinary liver-type fatty acid–binding protein level as a prognostic indicator of acute kidney injury secondary to severe falciparum malaria Open
View article: A case of severe generalized pustular psoriasis successfully treated with IL-17A monoclonal antibody and granulocyte removal therapy
A case of severe generalized pustular psoriasis successfully treated with IL-17A monoclonal antibody and granulocyte removal therapy Open
View article: 多様性と深い学びを保障する授業の開発 : 音楽・身体をてがかりに
多様性と深い学びを保障する授業の開発 : 音楽・身体をてがかりに Open
In this study, the authors aimed to develop lessons in which diversity, collaboration, and authentic learning are ensured through children’s cooperative involvement in a special class for students with intellectual disabilities. The author…
View article: Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy
Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy Open
View article: Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy
Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy Open
Muscle wasting or sarcopenia contributes to morbidity and mortality in patients with cancer, renal failure, or heart failure, and in elderly individuals. Na + -K + -2Cl − cotransporter 1 (NKCC1) is highly expressed in mammalian skeletal mu…
View article: <i>KLHL3</i> Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3
<i>KLHL3</i> Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3 Open
Mutations in the with-no-lysine kinase 1 (WNK1), WNK4, kelch-like 3 (KLHL3), and cullin3 (CUL3) genes are known to cause the hereditary disease pseudohypoaldosteronism type II (PHAII). It was recently demonstrat…
View article: Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3
Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3 Open
Mutations in with-no-lysine kinase (WNK) 1, WNK4, Kelch-like 3 (KLHL3), and Cullin3 result in an inherited hypertensive disease, pseudohypoaldosteronism type II. WNK activates the Na-Cl cotransporter (NCC), increasing sodium reabsorption i…
View article: Kelch-Like Protein 2 Mediates Angiotensin II–With No Lysine 3 Signaling in the Regulation of Vascular Tonus
Kelch-Like Protein 2 Mediates Angiotensin II–With No Lysine 3 Signaling in the Regulation of Vascular Tonus Open
Recently, the kelch-like protein 3 (KLHL3)-Cullin3 complex was identified as an E3 ubiquitin ligase for with no lysine (WNK) kinases, and the impaired ubiquitination of WNK4 causes pseudohypoaldosteronism type II (PHAII), a hereditary hype…
View article: Retroperitoneal Fibrosis in Chronic Kidney Disease
Retroperitoneal Fibrosis in Chronic Kidney Disease Open
We report two cases of retroperitoneal fibrosis that emerged during a clinical course of moderate chronic kidney disease. In both cases, we observed an elevation in the serum CRP and IgG4 levels without an increase in the white blood cell …