Yukiko Hayashi
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View article: Cytokine adsorption properties of a polymethylmethacrylate (PMMA) hollow-fiber membrane: an in vitro study
Cytokine adsorption properties of a polymethylmethacrylate (PMMA) hollow-fiber membrane: an in vitro study Open
Background The aims of this study were to analyze the relationship between the membrane surface area and cytokine adsorption performance of polymethylmethacrylate (PMMA) hemofilters as well as the distribution of cytokines inside the membr…
View article: Microinjection of angiotensin <scp>II</scp> into zebrafish embryos induces transient dilation and elastin disruption of the dorsal aorta
Microinjection of angiotensin <span>II</span> into zebrafish embryos induces transient dilation and elastin disruption of the dorsal aorta Open
The effects of angiotensin II (AngII) on blood vessel development and remodeling have been extensively investigated in mice and humans. However, its action on the vessels in the zebrafish remains largely unknown. To investigate whether Ang…
View article: Profiling of pathogenic variants in Japanese patients with sarcoglycanopathy
Profiling of pathogenic variants in Japanese patients with sarcoglycanopathy Open
Background Sarcoglycanopathies (SGPs) are limb-girdle muscular dystrophies (LGMDs) that can be classified into four types, LGMDR3, LGMDR4, LGMDR5, and LGMDR6, caused by mutations in the genes, SGCA, SGCB, SGCG, and SGCD, respectively. SGPs…
View article: Intestinal butyric acid-mediated disruption of gut hormone secretion and lipid metabolism in vasopressin receptor-deficient mice
Intestinal butyric acid-mediated disruption of gut hormone secretion and lipid metabolism in vasopressin receptor-deficient mice Open
The deficiency in V1 receptor genes may increase gut butyric acid levels and impair the function of L cells, thus dysregulating lipid homeostasis in the brown adipose tissue and skeletal muscle. This study highlights the importance of appr…
View article: Corrigendum: Metabolic dysregulation and decreased capillarization in skeletal muscles of male adolescent offspring rats exposed to gestational intermittent hypoxia
Corrigendum: Metabolic dysregulation and decreased capillarization in skeletal muscles of male adolescent offspring rats exposed to gestational intermittent hypoxia Open
[This corrects the article DOI: 10.3389/fphys.2023.1067683.].
View article: Optimized simple culture protocol for inducing mature myotubes from MYOD1-overexpressed human iPS cells
Optimized simple culture protocol for inducing mature myotubes from MYOD1-overexpressed human iPS cells Open
The forced expression system of MYOD1, a master gene for myogenic differentiation, can efficiently and rapidly reproduce muscle differentiation of human induced pluripotent stem cells (hiPSCs). Despite these advantages of the MYOD1 overexp…
View article: Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorder
Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorder Open
Nonalcoholic steatohepatitis (NASH) is a progressive fibrotic disease associated with an increased risk of developing hepatocellular carcinoma; at present, no efficient therapeutic strategy has been established. Herein, we examined the eff…
View article: Metabolic dysregulation and decreased capillarization in skeletal muscles of male adolescent offspring rats exposed to gestational intermittent hypoxia
Metabolic dysregulation and decreased capillarization in skeletal muscles of male adolescent offspring rats exposed to gestational intermittent hypoxia Open
Gestational intermittent hypoxia (IH) is a hallmark of obstructive sleep apnea that occurs frequently during pregnancy, and effects caused by this environmental change during pregnancy may be transmitted to the offspring. In this study, we…
View article: Emerin deficiency does not exacerbate cardiomyopathy in a murine model of Emery–Dreifuss muscular dystrophy caused by an LMNA gene mutation
Emerin deficiency does not exacerbate cardiomyopathy in a murine model of Emery–Dreifuss muscular dystrophy caused by an LMNA gene mutation Open
Emery-Dreifuss muscular dystrophy (EDMD), caused by mutations in genes encoding nuclear envelope proteins, is clinically characterized by muscular dystrophy, early joint contracture, and life-threatening cardiac abnormalities. To elucidate…
View article: α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish
α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish Open
Glycosylation is an important mechanism regulating various biological processes, including intercellular signaling and adhesion. α-1,6-fucosyltransferase (Fut8) belongs to a family of enzymes that determine the terminal structure of glycan…
View article: Exploration and Stratification of Factors Contributing to the Improvement of Physicians’ and Nurses’ Satisfaction with Pharmacists’ Ward Pharmacy Services
Exploration and Stratification of Factors Contributing to the Improvement of Physicians’ and Nurses’ Satisfaction with Pharmacists’ Ward Pharmacy Services Open
This study was conducted based on a questionnaire survey addressed to physicians and nurses, who were in direct contact with pharmacists on their wards, in order to explore and stratify the factors contributing to the improvement of physic…
View article: CD70 in Thymic Squamous Cell Carcinoma: Potential Diagnostic Markers and Immunotherapeutic Targets
CD70 in Thymic Squamous Cell Carcinoma: Potential Diagnostic Markers and Immunotherapeutic Targets Open
CD70 – a ligand protein of CD27 on lymphocytes – is expressed in a large spectrum of malignancies. It is an attractive target for antibody-based therapy and several clinical trials are currently being conducted. However, there is no eviden…
View article: Drug screening using transgenic zebrafish model.
Drug screening using transgenic zebrafish model. Open
Zebrafish is an excellent animal model for human diseases due to its high genetic homology to human, and easy genetic manipulation. To monitor the expression of Muscle RING-finger protein-1 (MuRF1) gene, which is one of marker molecules of…
View article: Cerebral Infarction and Myalgia in a 75-year-old Man with Eosinophilic Granulomatosis with Polyangiitis
Cerebral Infarction and Myalgia in a 75-year-old Man with Eosinophilic Granulomatosis with Polyangiitis Open
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare condition of systemic vasculitis of small to medium-sized blood vessels. We herein report the case of a 75-year-old man who presented with hemiplegia on his right side due to c…
View article: Homozygous nonsense variant in <i>LRIF1</i> associated with facioscapulohumeral muscular dystrophy
Homozygous nonsense variant in <i>LRIF1</i> associated with facioscapulohumeral muscular dystrophy Open
ObjectiveFacioscapulohumeral muscular dystrophy (FSHD) is a heterogenetic disorder predominantly characterized by progressive facial and scapular muscle weakness. Patients with FSHD either have a contraction of the D4Z4 repeat on chromosom…
View article: Deficiency of emerin contributes differently to the pathogenesis of skeletal and cardiac muscles in LmnaH222P/H222P mutant mice
Deficiency of emerin contributes differently to the pathogenesis of skeletal and cardiac muscles in LmnaH222P/H222P mutant mice Open
Laminopathies are tissue-selective diseases that affect differently in organ systems. Mutations in nuclear envelopes, emerin (Emd) and lamin A/C (Lmna) genes, cause clinically indistinguishable myopathy called Emery-Dreifuss muscular dystr…
View article: Renal involvement in the pathogenesis of mineral and bone disorder in dystrophin-deficient mdx mouse
Renal involvement in the pathogenesis of mineral and bone disorder in dystrophin-deficient mdx mouse Open
Duchenne muscular dystrophy is a severe muscular disorder, often complicated with osteoporosis, and impaired renal function has recently been featured. We aimed to clarify the involvement of renal function in the pathogenesis of mineral an…
View article: AB007. OA01.07: CD70 in thymic carcinoma: a promising diagnostic marker
AB007. OA01.07: CD70 in thymic carcinoma: a promising diagnostic marker Open
Background: CD70, one of tumor necrosis factor family protein, is reported to be expressed in a large spectrum of solid tumors and hematological malignancies. CD70 is an attractive target for antibody-based therapy and several clinical tri…
View article: Characteristics of Japanese Patients with Becker Muscular Dystrophy and Intermediate Muscular Dystrophy in a Japanese National Registry of Muscular Dystrophy (Remudy): Heterogeneity and Clinical Variation
Characteristics of Japanese Patients with Becker Muscular Dystrophy and Intermediate Muscular Dystrophy in a Japanese National Registry of Muscular Dystrophy (Remudy): Heterogeneity and Clinical Variation Open
Background: Obtaining an adequate number of patients to conduct a natural history study for rare diseases such as Becker muscular dystrophy (BMD) is difficult. Objectives: The present study used data from Remudy, a national registry for ne…
View article: Tumor necrosis factor‐α‐mediated hepatocyte apoptosis stimulates fibrosis in the steatotic liver in mice
Tumor necrosis factor‐α‐mediated hepatocyte apoptosis stimulates fibrosis in the steatotic liver in mice Open
Hepatocyte apoptosis has been implicated in the progression of nonalcoholic steatohepatitis. However, it is unclear whether the induction of tumor necrosis factor (TNF)‐α‐mediated hepatocyte apoptosis in the simple fatty liver triggers liv…
View article: Aberrant Myokine Signaling in Congenital Myotonic Dystrophy
Aberrant Myokine Signaling in Congenital Myotonic Dystrophy Open
Myotonic dystrophy types 1 (DM1) and 2 (DM2) are dominantly inherited neuromuscular disorders caused by a toxic gain of function of expanded CUG and CCUG repeats, respectively. Although both disorders are clinically similar, congenital myo…