Yukiko Okazaki
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View article: Effect of a Multifactorial Intervention on Retinopathy in People With Type 2 Diabetes
Effect of a Multifactorial Intervention on Retinopathy in People With Type 2 Diabetes Open
Importance Prevention of diabetic retinopathy is important to keep vision and quality of life. Objective To examine the effects of an intensive multifactorial intervention and hypoglycemia on retinopathy in people with type 2 diabetes. Des…
View article: Severe and Prolonged Hypoglycemia Following Adrenalectomy for Pheochromocytoma: A Case Report
Severe and Prolonged Hypoglycemia Following Adrenalectomy for Pheochromocytoma: A Case Report Open
We report a case of a 64-year-old woman with poorly controlled diabetes mellitus who was found to have a left adrenal pheochromocytoma. Despite standard preoperative management including alpha-blockade with doxazosin, the patient developed…
View article: Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance
Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance Open
Orchestrated hormonal interactions in response to feeding and fasting play a pivotal role in regulating glucose homeostasis. Here, we show that in obesity, the production of follistatin-like 3 (FSTL3), an endogenous inhibitor of Activin B,…
View article: Elucidation of the clinical traits of diabetic chorea through a questionnaire survey of people with diabetic chorea from 59 Japanese hospitals
Elucidation of the clinical traits of diabetic chorea through a questionnaire survey of people with diabetic chorea from 59 Japanese hospitals Open
Aims Diabetic chorea refers to sudden involuntary movements developing in people with diabetes mellitus and is known to occur mainly in those with severe hyperglycemia. We conducted a questionnaire survey of case‐reporting facilities in Ja…
View article: Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance
Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance Open
Orchestrated hormonal interacts in response to feeding and fasting play a pivotal role in regulating glucose homeostasis. Here, we show that in obesity, the production of follistatin-like 3 (FSTL3), an endogenous inhibitor of Activin B, in…
View article: Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice
Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice Open
View article: Effect of a Multifactorial Intervention on Fracture in Patients With Type 2 Diabetes: Subanalysis of the J-DOIT3 Study
Effect of a Multifactorial Intervention on Fracture in Patients With Type 2 Diabetes: Subanalysis of the J-DOIT3 Study Open
Aims To evaluate the effects of an intensified multifactorial intervention and patient characteristics on the incidence of fractures comorbid with type 2 diabetes. Methods Fracture events were identified and analyzed among adverse events r…
View article: Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation
Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation Open
View article: Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism Open
View article: Effect of Multifactorial Intervention on Diabetic Kidney Disease in Patients with Type 2 Diabetes
Effect of Multifactorial Intervention on Diabetic Kidney Disease in Patients with Type 2 Diabetes Open
View article: The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis
The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis Open
Adipocyte differentiation is regulated by various mechanisms, of which mitotic clonal expansion (MCE) is a key step. Although this process is known to be regulated by cell cycle modulators, the precise mechanism remains unclear. N
View article: CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors
CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors Open
View article: Design of and rationale for the Japan Diabetes Optimal Integrated Treatment study for 3 major risk factors of cardiovascular diseases (J-DOIT3): a multicenter, open-label, randomized, parallel-group trial
Design of and rationale for the Japan Diabetes Optimal Integrated Treatment study for 3 major risk factors of cardiovascular diseases (J-DOIT3): a multicenter, open-label, randomized, parallel-group trial Open
Objective Multifactorial intervention including the management of levels of blood glucose (BG), blood pressure (BP), and lipids has been suggested to decrease cardiovascular disease (CVD) risk. However, the target ideal and feasible levels…