Yukiko Onishi
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View article: Long‐term safety and efficacy of imeglimin in Japanese individuals with type 2 diabetes and chronic kidney disease: A 52‐week postmarketing clinical study ( <scp>TWINKLE</scp> )
Long‐term safety and efficacy of imeglimin in Japanese individuals with type 2 diabetes and chronic kidney disease: A 52‐week postmarketing clinical study ( <span>TWINKLE</span> ) Open
Aim To evaluate the long‐term safety and efficacy of imeglimin in Japanese individuals with type 2 diabetes (T2D) and advanced chronic kidney disease (CKD). Materials and Methods This open‐label, single‐arm, multicenter, phase 4 study (TWI…
View article: Sex Differences in Fasting Glucose Levels among Non-diabetic Japanese: Men Exhibit Higher Levels Than Women
Sex Differences in Fasting Glucose Levels among Non-diabetic Japanese: Men Exhibit Higher Levels Than Women Open
Objective Sex differences in fasting glucose levels or the prevalence of impaired fasting glucose (IFG) have been observed in various populations and ethnic groups, suggesting potential variations in the pathophysiology of diabetes between…
View article: Efficacy of Save Medical Corporation (SMC)–01, a Smartphone App Designed to Support Type 2 Diabetes Self-Management Based on Established Guidelines: Randomized Controlled Trial
Efficacy of Save Medical Corporation (SMC)–01, a Smartphone App Designed to Support Type 2 Diabetes Self-Management Based on Established Guidelines: Randomized Controlled Trial Open
Background Lifestyle modifications are a key part of type 2 diabetes mellitus treatment. Many patients find long-term self-management difficult, and mobile apps could be a solution. In 2010, in the United States, a mobile app was approved …
View article: Metabolic Abnormalities Following Tirzepatide Monotherapy in Japanese Patients with Type 2 Diabetes: A Phase 3 SURPASS J-mono Post Hoc Analysis
Metabolic Abnormalities Following Tirzepatide Monotherapy in Japanese Patients with Type 2 Diabetes: A Phase 3 SURPASS J-mono Post Hoc Analysis Open
View article: Efficacy of Save Medical Corporation (SMC)–01, a Smartphone App Designed to Support Type 2 Diabetes Self-Management Based on Established Guidelines: Randomized Controlled Trial (Preprint)
Efficacy of Save Medical Corporation (SMC)–01, a Smartphone App Designed to Support Type 2 Diabetes Self-Management Based on Established Guidelines: Randomized Controlled Trial (Preprint) Open
BACKGROUND Lifestyle modifications are a key part of type 2 diabetes mellitus treatment. Many patients find long-term self-management difficult, and mobile apps could be a solution. In 2010, in the United States, a mobile app was approved…
View article: Efficacy of SMC-01, a Smartphone Application Designed to Support Type 2 Diabetes Self-Management Based on Established Guidelines: Protocol for a Randomized Controlled Trial (Preprint)
Efficacy of SMC-01, a Smartphone Application Designed to Support Type 2 Diabetes Self-Management Based on Established Guidelines: Protocol for a Randomized Controlled Trial (Preprint) Open
BACKGROUND Diabetes is an illness that requires not only accurate medical treatment, but also self-management to promote a healthier lifestyle. A system that supports self-management could be effective and efficient. In Japan, self-manage…
View article: Use of diabetes medications in adults with T2D and CVD in Japan: secondary analysis of the CAPTURE study
Use of diabetes medications in adults with T2D and CVD in Japan: secondary analysis of the CAPTURE study Open
View article: Association of <scp>glucagon‐like peptide</scp>‐1 receptor agonist treatment with gastric residue in an esophagogastroduodenoscopy
Association of <span>glucagon‐like peptide</span>‐1 receptor agonist treatment with gastric residue in an esophagogastroduodenoscopy Open
Aims/Introduction Previous studies have reported that the glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) delays gastric emptying, and gastric emptying was assessed by the 13 C breath test or paracetamol absorption technique. However, n…
View article: Association of self‐stigma with glycated hemoglobin: A single‐center, cross‐sectional study of adults with type 1 diabetes in Japan
Association of self‐stigma with glycated hemoglobin: A single‐center, cross‐sectional study of adults with type 1 diabetes in Japan Open
Aims/Introduction There has been an increase in research on diabetes‐related stigma and its association with glycated hemoglobin (HbA1c) over the past years. However, little is known about the association of self‐stigma with HbA1c in perso…
View article: Cardiovascular disease prevalence in adults with type 2 diabetes in Japan: results from the Japanese centers in the CAPTURE study
Cardiovascular disease prevalence in adults with type 2 diabetes in Japan: results from the Japanese centers in the CAPTURE study Open
View article: Clinical features and sulfonylurea usage among outpatients with diabetes aged ≥90 years in an urban diabetes clinic in Tokyo
Clinical features and sulfonylurea usage among outpatients with diabetes aged ≥90 years in an urban diabetes clinic in Tokyo Open
Aims/Introduction Aging of society is accelerating in many countries. The purpose of this study was to describe the clinical features and sulfonylurea usage among diabetes outpatients aged ≥90 years (nonagenarians). Materials and Methods T…
View article: Quantification of synthetic errors during chemical synthesis of DNA and its suppression by non-canonical nucleosides
Quantification of synthetic errors during chemical synthesis of DNA and its suppression by non-canonical nucleosides Open
View article: Substitution of telemedicine for clinic visit during the <scp>COVID</scp>‐19 pandemic of 2020: Comparison of telemedicine and clinic visit
Substitution of telemedicine for clinic visit during the <span>COVID</span>‐19 pandemic of 2020: Comparison of telemedicine and clinic visit Open
Aims/Introduction The purpose of this retrospective observational cohort study was to compare outpatient diabetes care and glycated hemoglobin (HbA1c) level during the coronavirus disease 2019 pandemic in 2020 with 2019, and to compare the…
View article: IDF21-0140 Higher derived time in range with insulin degludec/insulin aspart vs insulin glargine U100 in Japanese adults with T2D
IDF21-0140 Higher derived time in range with insulin degludec/insulin aspart vs insulin glargine U100 in Japanese adults with T2D Open
View article: Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes
Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes Open
ClinicalTrials.gov Identifier: NCT04039503.
View article: Associations between diabetes duration and self-stigma development in Japanese people with type 2 diabetes: a secondary analysis of cross-sectional data
Associations between diabetes duration and self-stigma development in Japanese people with type 2 diabetes: a secondary analysis of cross-sectional data Open
Objectives To examine the associations between self-stigma and diabetes duration in a sample of Japanese people with type 2 diabetes. Design A secondary analysis of a cross-sectional study. Setting Two university hospitals, one general hos…
View article: Synergistic association of the copper/zinc ratio under inflammatory conditions with diabetic kidney disease in patients with type 2 diabetes: The Asahi Diabetes Complications Study
Synergistic association of the copper/zinc ratio under inflammatory conditions with diabetic kidney disease in patients with type 2 diabetes: The Asahi Diabetes Complications Study Open
Aims/Introduction We aimed to study the relationships among the copper (Cu)/zinc (Zn) ratio, inflammatory biomarkers, and the prevalence of diabetic kidney disease (DKD) in patients with type 2 diabetes. Materials and Methods A cross‐secti…
View article: Association of insulin treatment with gastric residue during an esophagogastroduodenoscopy
Association of insulin treatment with gastric residue during an esophagogastroduodenoscopy Open
The purpose of this study was to investigate the association of glycemic control and diabetes treatment to gastric residue observed during an esophagogastroduodenoscopy. Among 6,592 individuals who had esophagogastroduodenoscopy at our cli…
View article: Diabetes management by either telemedicine or clinic visit improved glycemic control during the coronavirus disease 2019 pandemic state of emergency in Japan
Diabetes management by either telemedicine or clinic visit improved glycemic control during the coronavirus disease 2019 pandemic state of emergency in Japan Open
The purpose of this retrospective cohort study at a Tokyo diabetes clinic was to evaluate the effect of telemedicine and clinic visit on glycated hemoglobin (HbA1c) during the coronavirus disease 2019 state of emergency. The effect of tele…
View article: How self-stigma affects patient activation in persons with type 2 diabetes: a cross-sectional study
How self-stigma affects patient activation in persons with type 2 diabetes: a cross-sectional study Open
Objectives Self-stigma is associated with lower patient activation levels for self-care in persons with type 2 diabetes mellitus (T2DM). However, the causal pathway linking self-stigma with patient activation for self-care has not been sho…
View article: Efficacy and Safety of Once-Weekly Dulaglutide in Type 2 Diabetes Patients Using Insulin: Exploratory Subgroup Analysis by Insulin Regimen
Efficacy and Safety of Once-Weekly Dulaglutide in Type 2 Diabetes Patients Using Insulin: Exploratory Subgroup Analysis by Insulin Regimen Open
View article: Effect of postprandial hyperglycemia at clinic visits on the incidence of retinopathy in patients with type 2 diabetes: An analysis using real‐world long‐term follow‐up data
Effect of postprandial hyperglycemia at clinic visits on the incidence of retinopathy in patients with type 2 diabetes: An analysis using real‐world long‐term follow‐up data Open
Aims/Introduction There is little evidence on the role of postprandial glycemia in the incidence of diabetic retinopathy (DR) in a real‐world setting. We aimed to assess the effect of postprandial hyperglycemia at clinic visits on the inci…
View article: Once-Weekly Dulaglutide with Insulin Therapy for Type 2 Diabetes: Efficacy and Safety Results from a Phase 4, Randomized, Placebo-Controlled Study
Once-Weekly Dulaglutide with Insulin Therapy for Type 2 Diabetes: Efficacy and Safety Results from a Phase 4, Randomized, Placebo-Controlled Study Open
Eli Lilly and Company.
View article: Efficacy, Safety, and Tolerability of Oral Semaglutide Versus Placebo Added to Insulin With or Without Metformin in Patients With Type 2 Diabetes: The PIONEER 8 Trial
Efficacy, Safety, and Tolerability of Oral Semaglutide Versus Placebo Added to Insulin With or Without Metformin in Patients With Type 2 Diabetes: The PIONEER 8 Trial Open
OBJECTIVE To investigate the efficacy, safety, and tolerability of oral semaglutide added to insulin with or without metformin. RESEARCH DESIGN AND METHODS Patients with type 2 diabetes uncontrolled on insulin with or without metformin wer…
View article: Psychological and behavioural patterns of stigma among patients with type 2 diabetes: a cross-sectional study
Psychological and behavioural patterns of stigma among patients with type 2 diabetes: a cross-sectional study Open
Objectives The aim of this study was to test the psychological and behavioural patterns of stigma (self-esteem and social participation) and their relationship to self-stigma, patient activation for engaging in self-care and glycaemic cont…
View article: Analysis of efficacy and safety of dulaglutide 0.75 mg stratified by sex in patients with type 2 diabetes in 2 randomized, controlled phase 3 studies in Japan
Analysis of efficacy and safety of dulaglutide 0.75 mg stratified by sex in patients with type 2 diabetes in 2 randomized, controlled phase 3 studies in Japan Open
We analyzed the efficacy and safety of once weekly dulaglutide 0.75 mg by sex in 2 randomized, controlled phase 3 studies in Japanese patients with type 2 diabetes (a 52-week monotherapy study [comparator liraglutide 0.9 mg] and a 26-week …
View article: Insulin degludec/insulin aspart vs biphasic insulin aspart 30 twice daily in Japanese patients with type 2 diabetes: A randomized controlled trial
Insulin degludec/insulin aspart vs biphasic insulin aspart 30 twice daily in Japanese patients with type 2 diabetes: A randomized controlled trial Open
Aims/Introduction Insulin degludec/insulin aspart ( ID egAsp) is a soluble combination of insulin degludec (70%) and insulin aspart (30%). The present exploratory trial investigated the safety of switching unit‐to‐unit from twice‐daily bas…
View article: Lixisenatide improves glycemic outcomes of Japanese patients with type 2 diabetes: a meta-analysis
Lixisenatide improves glycemic outcomes of Japanese patients with type 2 diabetes: a meta-analysis Open
View article: C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus
C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus Open
In this study, we investigate how measures of insulin secretion and other clinical information affect long-term glycemic control in patients with type 2 diabetes mellitus. Between October 2012 and June 2014, we monitored 202 diabetes patie…
View article: Association between self-stigma and self-care behaviors in patients with type 2 diabetes: a cross-sectional study
Association between self-stigma and self-care behaviors in patients with type 2 diabetes: a cross-sectional study Open
Objective Growing qualitative evidence reveals that many patients with chronic illnesses struggle to rebuild a positive self-image after diagnosis while attempting to find a balance between their current physical status and their ongoing s…