Yukinobu Ito
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View article: PRDX4 Can Potentially Serve as an Independent Prognostic Marker for Early Recurrence of Oral Squamous Cell Carcinoma
PRDX4 Can Potentially Serve as an Independent Prognostic Marker for Early Recurrence of Oral Squamous Cell Carcinoma Open
Oral squamous cell carcinoma (OSCC), a main histological subtype of oral cavity cancer, remains one of the most prevailing tumors worldwide with the increasing incidence and mortality. Since a high rate of early local recurrence is one of …
View article: Pathological Angiogenesis Precedes the Onset of Aortic Dissection
Pathological Angiogenesis Precedes the Onset of Aortic Dissection Open
Summary Aortic dissection (AD) is a severe, life-threatening disease that occurs abruptly 1 . Although remodeling and inherent vulnerability of the aortic media, as observed in heritable connective tissue disorders such as Marfan syndrome,…
View article: Characteristic <scp>miRNA</scp> profiles represent clinicopathological diversity of small cell lung cancer
Characteristic <span>miRNA</span> profiles represent clinicopathological diversity of small cell lung cancer Open
Small cell lung cancer (SCLC) is classified into distinct molecular subtypes based on the expression patterns of four transcription regulators: achaete–scute homolog 1 (ASCL1), neuronal differentiation 1 (NEUROD1), POU class 2 homeobox 3 (…
View article: Clinicopathological significance of loss of Y chromosome in male meningiomas
Clinicopathological significance of loss of Y chromosome in male meningiomas Open
Male meningiomas, comprising approximately 30% of all meningiomas, are more frequently high-grade and associated with poorer clinical outcomes compared to their female counterparts. Although Y chromosome alterations have been studied in va…
View article: Ligand-dependent Wnt signaling promotes gastric cancer metastasis through hyaluronan expression in microenvironment
Ligand-dependent Wnt signaling promotes gastric cancer metastasis through hyaluronan expression in microenvironment Open
The majority of gastric cancer cells proliferate in a Wnt ligand-dependent manner. In this study, we examined the role of ligand-dependent Wnt signaling in the development and metastasis of gastric cancer. We generated mice with mutations …
View article: <scp>APRIL</scp> / <scp>BAFF</scp> upregulation is associated with clonal B‐cell expansion in Hunner‐type interstitial cystitis
<span>APRIL</span> / <span>BAFF</span> upregulation is associated with clonal B‐cell expansion in Hunner‐type interstitial cystitis Open
Hunner‐type interstitial cystitis (HIC) is a chronic inflammatory disease of the urinary bladder with an unknown etiology. We conducted comprehensive immunogenomic profiling of bladder specimens obtained by biopsy and cystectomy from 37 pa…
View article: Comprehensive genomic analysis reveals clonal origin and subtype-specific evolution in a case of sporadic multiple meningiomas
Comprehensive genomic analysis reveals clonal origin and subtype-specific evolution in a case of sporadic multiple meningiomas Open
Meningioma is the most common primary intracranial tumor in adults, with up to 10% manifesting as multiple tumors. Data on the genomic and molecular changes in sporadic multiple meningiomas are scarce, leading to ongoing debates regarding …
View article: Comprehensive genomic analysis of sporadic multiple meningiomas reveals clonal origin and histotype-specific evolution: a case report
Comprehensive genomic analysis of sporadic multiple meningiomas reveals clonal origin and histotype-specific evolution: a case report Open
Meningioma is the most common primary intracranial tumor in adults, with up to 10% manifesting as multiple tumors. Data on the genomic and molecular changes in sporadic multiple meningiomas are scarce, leading to ongoing debates regarding …
View article: Recurrence of an extracranial internal carotid artery aneurysm treated with STA-MCA bypass and trapping due to neovascularization from an ascending pharyngeal artery: illustrative case
Recurrence of an extracranial internal carotid artery aneurysm treated with STA-MCA bypass and trapping due to neovascularization from an ascending pharyngeal artery: illustrative case Open
BACKGROUND Extracranial internal carotid artery aneurysms (EICAs) are rare. Although a high mortality risk has been reported in nonoperated cases, the optimal treatment for EICAs remains unknown. OBSERVATIONS A 79-year-old female presented…
View article: Identification of Uromodulin Deposition in the Stroma of Perinephric Fibromyxoid Nephrogenic Adenoma by Mass Spectrometry
Identification of Uromodulin Deposition in the Stroma of Perinephric Fibromyxoid Nephrogenic Adenoma by Mass Spectrometry Open
Background Nephrogenic adenoma (NA) is an epithelial lesion that usually occurs in the mucosa of the urinary tract. Rare cases of deep infiltrative or perinephric lesions have also been reported. Recently, NA with characteristic fibromyxoi…
View article: Macrophage numbers in the marginal area of sarcomas predict clinical prognosis
Macrophage numbers in the marginal area of sarcomas predict clinical prognosis Open
Even when treated comprehensively by surgery, chemotherapy, and radiotherapy, soft-tissue sarcoma has an unfavorable outcome. Because soft-tissue sarcoma is rare, it is the subject of fewer clinicopathological studies, which are important …
View article: A New Chemotactic Mechanism Governs Long-Range Angiogenesis Induced by Patching an Arterial Graft into a Vein
A New Chemotactic Mechanism Governs Long-Range Angiogenesis Induced by Patching an Arterial Graft into a Vein Open
Chemotaxis, the migration of cells in response to chemical stimulus, is an important concept in the angiogenesis model. In most angiogenesis models, chemotaxis is defined as the migration of a sprout tip in response to the upgradient of th…
View article: Disorganization of intercalated discs in dilated cardiomyopathy
Disorganization of intercalated discs in dilated cardiomyopathy Open
View article: Collision of Epstein–Barr virus-positive and -negative gastric cancer, diagnosed by molecular analysis: a case report
Collision of Epstein–Barr virus-positive and -negative gastric cancer, diagnosed by molecular analysis: a case report Open
Background Epstein–Barr virus (EBV)-positive gastric carcinoma (GC) is defined by the proliferation of GC cells with EBV infection. The co-existence of EBV-positive and -negative components in a single GC is rare. We report a case of GC wi…
View article: Chronic contained rupture of abdominal aortic aneurysm that developed from chronic abdominal aortic dissection
Chronic contained rupture of abdominal aortic aneurysm that developed from chronic abdominal aortic dissection Open
View article: Disorganization of Intercalated Discs in Dilated Cardiomyopathy
Disorganization of Intercalated Discs in Dilated Cardiomyopathy Open
Dilated cardiomyopathy (DCM) is a primary myocardial disease, the pathology of which is left ventricular or biventricular dilation and impaired myocardial contractility. The clinical and pathological diagnosis of DCM is difficult, and othe…
View article: Post-mortem Plasma Cell-Free DNA Sequencing: Proof-of-Concept Study for the “Liquid Autopsy”
Post-mortem Plasma Cell-Free DNA Sequencing: Proof-of-Concept Study for the “Liquid Autopsy” Open
Recent genomic studies on cancer tissues obtained during rapid autopsy have provided insights into the clonal evolution and heterogeneity of cancer. However, post-mortem blood has not been subjected to genetic analyses in relation to cance…
View article: A case of Russell body gastritis with multifocal lesions
A case of Russell body gastritis with multifocal lesions Open
Russell body gastritis is an extremely rare gastritis characterized by abundant infiltration of plasma cells with Russell body and eccentric nuclei, known as Mott cells. An 81-year-old Japanese woman with Helicobacter pylori and hepatitis …
View article: Multiple ulcerations and perforation in the small intestine after steroid treatment in eosinophilic granulomatosis with polyangiitis: a case report and literature review
Multiple ulcerations and perforation in the small intestine after steroid treatment in eosinophilic granulomatosis with polyangiitis: a case report and literature review Open
Eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is an uncommon disease with pathological features consisting of systemic necrotizing vasculitis, eosinophilic infiltration, and granulomatous or …
View article: Neovasculature can be induced by patching an arterial graft into a vein: A novel in vivo model of spontaneous arteriovenous fistula formation
Neovasculature can be induced by patching an arterial graft into a vein: A novel in vivo model of spontaneous arteriovenous fistula formation Open