Explanipedia

Effectiveness of the serum ratio of L-cysteine to glutathione for the prediction of cardiovascular events Open

Yuki Ishinoda, Nobuyuki Masaki, Yasuhiro Hitomi, Ryota Nakazawa, Akira Taruoka , et al. · 2025

Aminothiols play an important role in the antioxidant defense system. Their serum profile may be a predictor of prognosis and cardiovascular events. This study followed-up 262 patients (202 men; age, 65 ± 13 years) who had been treated for…

Unveiling catecholaminergic polymorphic ventricular tachycardia: A case of type 2 ryanodine receptor exon 3 deletion mimicking long QT syndrome type 1 Open

Kazuhiko Kuinose, Takumi Toya, Mitsuki Yamaga, Yuji Nagatomo, Takeshi Adachi , et al. · 2024

Sex Differences in Cardiac and Clinical Phenotypes and Their Relation to Outcomes in Patients with Heart Failure Open

Akane Kawai, Yuji Nagatomo, Midori Yukino-Iwashita, Ryota Nakazawa, Yusuke Yumita , et al. · 2024

Biological sex is one of the major factors characterizing the heart failure (HF) patient phenotype. Understanding sex-related differences in HF is crucial to implement personalized care for HF patients with various phenotypes. There are se…

The Safety and Efficacy of Sodium-Glucose Cotransporter-2 Inhibitors for Patients with Sarcopenia or Frailty: Double Edged Sword? Open

Ayami Naito, Yuji Nagatomo, Akane Kawai, Midori Yukino-Iwashita, Ryota Nakazawa , et al. · 2024

Sodium-glucose cotransporter-2 inhibitors (SGLT-2is) show cardiovascular protective effects, regardless of the patient’s history of diabetes mellitus (DM). SGLT2is suppressed cardiovascular adverse events in patients with type 2 DM, and fu…

Sex-Related Differences in Long-term Outcomes across the Spectrum of Ejection Fraction in Heart Failure Patients Open

Akane Kawai, Yuji Nagatomo, Midori Yukino-Iwashita, Yukinori Ikegami, Makoto Takei , et al. · 2023

Background Recently, patients with supra-normal left ventricular ejection fraction (snLVEF) are reported to have high risk of adverse outcomes, especially in women. We sought to evaluate sex-related differences in the association between L…

β1 Adrenergic Receptor Autoantibodies and IgG Subclasses: Current Status and Unsolved Issues Open

Akane Kawai, Yuji Nagatomo, Midori Yukino-Iwashita, Ryota Nakazawa, Akira Taruoka , et al. · 2023

A wide range of anti-myocardial autoantibodies have been reported since the 1970s. Among them, autoantibodies against the β1-adrenergic receptor (β1AR-AAb) have been the most thoroughly investigated, especially in dilated cardiomyopathy (D…

Coronary microvascular dysfunction in heart failure patients Open

Takumi Toya, Yuji Nagatomo, Yukinori Ikegami, Nobuyuki Masaki, Takeshi Adachi · 2023

Coronary microcirculation has multiple layers of autoregulatory function to maintain resting flow and augment hyperemic flow in response to myocardial demands. Functional or structural alterations in the coronary microvascular function are…

A Low Arginine/Ornithine Ratio is Associated with Long-Term Cardiovascular Mortality Open

Yuki Ishinoda, Nobuyuki Masaki, Yasuhiro Hitomi, Akira Taruoka, Akane Kawai , et al. · 2023

A low L-arginine/L-ornithine ratio may be associated with increased 10-year cardiac mortality.

D-Dimer beyond Diagnosis of Pulmonary Embolism: Its Implication for Long-Term Prognosis in Cardio-Oncology Era Open

Masafumi Himeno, Yuji Nagatomo, Akira Miyauchi, Aimi Sakamoto, Keita Kiyose , et al. · 2023

Venous thromboembolism (VTE) is a common comorbidity of cancer, often referred to as cancer-associated thrombosis (CAT). Even though its prevalence has been increasing, its clinical picture has not been thoroughly investigated. In this sin…

Short-Chain Fatty Acids in Gut–Heart Axis: Their Role in the Pathology of Heart Failure Open

Midori Yukino-Iwashita, Yuji Nagatomo, Akane Kawai, Akira Taruoka, Yusuke Yumita , et al. · 2022

Heart failure (HF) is a syndrome with global clinical and socioeconomic burden worldwide owing to its poor prognosis. Accumulating evidence has implicated the possible contribution of gut microbiota-derived metabolites, short-chain fatty a…

Potential association with malnutrition and allocation of combination medical therapies in hospitalized heart failure patients with reduced ejection fraction Open

Yumiko Kawakubo Ichihara, Yasuyuki Shiraishi, Shun Kohsaka, Takashi Kohno, Ayumi Goda , et al. · 2022

Impact of Left Ventricular Chamber Size on Outcome in Heart Failure with Preserved Ejection Fraction Open

S Ogawa, Yuji Nagatomo, Makoto Takei, Mike Saji, Ayumi Goda , et al. · 2022

Although heart failure with preserved ejection fraction (HFpEF) has a highly variable phenotype, heterogeneity in left ventricular chamber size (LVCS) and its association with long-term outcome have not been thoroughly investigated. The pr…

Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction Open

Yusuke Yumita, Yuji Nagatomo, Makoto Takei, Mike Saji, Ayumi Goda , et al. · 2022

The optimal heart rate (HR) in patients with heart failure with reduced ejection fraction (HFrEF) has been ill-defined. Recently, a formula was proposed for estimating the target heart rate (THR), which eliminates the overlap between the E…

Association between Plasma Follistatin-like Protein 1 Levels and the Presence and Severity of Coronary Artery Disease Open

Yurie Yamazaki, Yoshimi Kishimoto, Emi Saita, Masayuki Aoyama, Yukinori Ikegami , et al. · 2021

Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein known for its role in inflammation. However, plasma FSTL1 levels in patients with coronary artery disease (CAD) have not been fully elucidated. Thus, in this study, we investiga…

Association of Non-Invasive Positive Pressure Ventilation with Short-Term Clinical Outcomes in Patients Hospitalized for Acute Decompensated Heart Failure Open

Midori Yukino, Yuji Nagatomo, Ayumi Goda, Takashi Kohno, Makoto Takei , et al. · 2021

The real-world evidence has been sparse on the impact of non-invasive positive pressure ventilation (NPPV) on the outcomes in acute decompensated heart failure (ADHF) patients. We aim to explore this issue in the prospective multicenter WE…

“Target Heart Rate” calculated aiming at zero overlap of mitral E and A waves is useful for prediction of long-term outcome for patients with heart failure and reduced ejection fraction Open

Yusuke Yumita, Yuji Nagatomo, Makoto Takei, Mike Saji, Ayumi Goda , et al. · 2021

Background Lower heart rate (HR) is associated with more favourable long-term outcome in patients with heart failure with reduced ejection fraction (HFrEF). However, an optimal threshold of HR remains unclear. Targeted HR (THR), defined by…

Phenomapping in patients experiencing worsening renal function during hospitalization for acute heart failure Open

Ryuichiro Yagi, Makoto Takei, Shun Kohsaka, Yasuyuki Shiraishi, Nobuhiro Ikemura , et al. · 2021

Aims The impact of worsening renal function (WRF) on the prognosis of patients with acute heart failure (AHF) remains controversial. We aimed to identify phenotypically distinct subgroups among individuals with both AHF and WRF using clust…

Malnutrition in Hospitalized Heart Failure Patients with Reduced Ejection Fraction: Potential Association with Allocation of Guideline-Directed Medical Therapies Open

Yumiko Kawakubo Ichihara, Yasuyuki Shiraishi, Shun Kohsaka, Takashi Kohno, Ayumi Goda , et al. · 2021

Background: Malnutrition is common in patients with heart failure with reduced ejection fraction (HFrEF) and may influence the long-term prognosis and allocation of guideline-directed medical therapy (GDMT). Methods and Results: We reviewe…

Associations Between Plasma Kinin B1 Receptor Levels and the Presence and Severity of Coronary Artery Disease Open

Yoshimi Kishimoto, Masayuki Aoyama, Emi Saita, Yukinori Ikegami, Reiko Ohmori , et al. · 2020

Aim: Kinin B1 receptor (KB1R) was shown to be up-regulated in human carotid atherosclerotic lesions. Serum KB1R levels were also reported to be high in patients with stroke. However, KB1R deficiency increased atherosclerotic lesions. There…

Beta blockers versus calcium channel blockers for provocation of vasospastic angina after drug-eluting stent implantation: a multicentre prospective randomised trial Open

Mitsuaki Sawano, Toshiomi Katsuki, Takeshi Kitai, Koichi Tamita, Kotaro Obunai , et al. · 2020

Background Drug-eluting stent-induced vasospastic angina (DES-VSA) has emerged as a novel complication in the modern era of percutaneous coronary intervention (PCI). Although beta blockers (BBs) are generally recommended for coronary heart…

Association between Plasma Sestrin2 Levels and the Presence and Severity of Coronary Artery Disease Open

Yoshimi Kishimoto, Masayuki Aoyama, Emi Saita, Yukinori Ikegami, Reiko Ohmori , et al. · 2020

Aims . Atherosclerotic disease, such as coronary artery disease (CAD), is recognized to be associated with inflammation and oxidative stress. We investigated the association between CAD and plasma levels of sestrin2 which is one of the str…

Associations between Green Tea Consumption and Coffee Consumption and the Prevalence of Coronary Artery Disease Open

Yoshimi Kishimoto, Emi Saita, Chie Taguchi, Masayuki Aoyama, Yukinori Ikegami , et al. · 2020

Green tea and coffee contain various bioactive compounds (e.g., polyphenols), and their consumption has been proposed to decrease the risk of cardiovascular diseases. Here, we investigated the associations between the consumption of green …

High Plasma Levels of Soluble Talin-1 in Patients with Coronary Artery Disease Open

Masayuki Aoyama, Yoshimi Kishimoto, Emi Saita, Yukinori Ikegami, Reiko Ohmori , et al. · 2020

Aims. Talin-1 is a cytoskeletal protein that binds integrin, thereby leading to integrin activation and affecting focal adhesions. Recently, talin-1 expression was reported to be downregulated in human atherosclerotic plaques. However, blo…

High Plasma Levels of Legumain in Patients with Complex Coronary Lesions Open

Tomohiko Umei, Yoshimi Kishimoto, Masayuki Aoyama, Emi Saita, Hanako Niki , et al. · 2019

Plasma legumain levels were associated with the presence of complex coronary lesions.

Associations Between Plasma Betatrophin Levels and Coronary and Peripheral Artery Disease Open

Hanako Niki, Yoshimi Kishimoto, Susumu Ibe, Emi Saita, Kenji Sasaki , et al. · 2018

Plasma betatrophin levels were associated with the presence and severity of CAD and PAD, suggesting betatrophin has a role in atherosclerosis.

Plasma Heme Oxygenase-1 Levels in Patients with Coronary and Peripheral Artery Diseases Open

Yoshimi Kishimoto, Susumu Ibe, Emi Saita, Kenji Sasaki, Hanako Niki , et al. · 2018

Aims . Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate CO, biliverdin, and iron. Since these products have antiatherogenic properties, HO-1 may play a protective role against the progress…

P2275Are cholesterol crystals findings predictors for progression of non-culprit coronary plaque after acute myocardial infarction? (From optical coherence tomography study) Open

Kazuki Suruga, Kazuoki Dai, Yuhei Kobayashi, Yukinori Ikegami, Yasuhisa Nakao , et al. · 2018

Low Levels of Plasma Osteoglycin in Patients with Complex Coronary Lesions Open

Toshiki Seki, Emi Saita, Yoshimi Kishimoto, Susumu Ibe, Yoshichika Miyazaki , et al. · 2018

Although plasma osteoglycin levels were high in patients with CAD, they did not correlate with the severity of CAD and were not an independent factor for CAD. Notably, osteoglycin levels were low in patients with complex lesions and were a…

Low Plasma Levels of Fibroblast Growth Factor-21 in Patients with Peripheral Artery Disease Open

Yoshichika Miyazaki, Emi Saita, Yoshimi Kishimoto, Susumu Ibe, Toshiki Seki , et al. · 2018

No significant difference was found in the FGF-21 levels between patients with and without CAD. However, FGF-21 levels were low in patients with PAD, and were a factor for PAD independent of atherosclerotic risk factors.

Plasma interleukin-27 levels in patients with coronary artery disease Open

Kotaro Miura, Emi Saita, Norie Suzuki-Sugihara, Koutaro Miyata, Nobuhiro Ikemura , et al. · 2017

Interleukin (IL)-27, one of cytokines in the IL-12 family, is considered to have both pro- and anti-inflammatory properties. However, blood IL-27 levels in coronary artery disease (CAD) have not been fully elucidated yet. This cross-sectio…

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