Explanipedia

Myelodysplastic Syndromes and Incident Cardiovascular Disease: A Nationwide, Real-World Cohort Study Open

Yuta Suzuki, Hidehiro Kaneko, Toshiyuki Ko, Akira Okada, Norifumi Takeda , et al. · 2025

MDS was independently associated with incident CVD, including IHD, stroke, HF, and AF. MDS should be recognized as an independent cardiovascular risk factor in both clinical practice and public health strategies.

Validation of a multi-video view-informed vision-language model for echocardiographic assessment in Japanese patients Open

Hiromasa Hayama, Xiaoming Zhou, J Kirigara, Yosuke Katayama, Koya Ozawa , et al. · 2025

Background Artificial intelligence (AI) has the potential to enhance echocardiographic interpretation; however, overfitting remains a major limitation, potentially reducing generalizability across diverse populations. EchoCLIP is a vision-…

Coronary artery stenosis in Japanese hemophiliacs living with HIV-1 progressed dramatically over two years Open

R Nagai, Hiroyuki Gatanaga, Haruka Uemura, Mikiko Ogata, Shuji Kubota , et al. · 2025

Patients with hemophilia living with HIV-1 are at increased risk for coronary artery disease (CAD) due to overlapping factors, including chronic vascular inflammation, antiretroviral therapy-associated dyslipidemia, and reduced physical ac…

Entrectinib-induced pericarditis with cardiac tamponade in a patient with neurotrophic tropomyosin receptor kinase 1 fusion-positive breast cancer Open

Aki Aoyama, Yutaro Yoshitomi, Akihiko Shimomura, Yukino Kawamura, Tomoko Taniyama , et al. · 2025

Introduction: Entrectinib is a multikinase inhibitor used to treat neurotrophic tropomyosin receptor kinase (NTRK) fusion-positive, locally advanced, or metastatic tumors. Cardiovascular events, such as congestive heart failure and myocard…

Utility and Limitations of Genetic Testing in the Routine Care of Cardiovascular Disease Patients in a General Hospital Open

Daiki Tomidokoro, Kotaro Mori, Masaya Yamamoto, Masato Isono, Kozue Takano , et al. · 2025

Genetic diagnosis is becoming more prevalent in the routine care of cardiovascular disease (CVD) but is still limited to specialized institutions. Therefore, general cardiologists are also expected to acquire fundamental knowledge for inco…

Prognostic impact of global longitudinal strain in patients hospitalized for acute heart failure with preserved ejection fraction and atrial fibrillation Open

Jennifer M. Yamamoto, Hiromasa Hayama, Yoshinari Enomoto, Masaya Yamamoto, Hidehiko Hara , et al. · 2025

Background In patients with atrial fibrillation (AF), heart failure (HF) with preserved ejection fraction (HFpEF) has a lower risk of cardiovascular death (CD) than HF with reduced ejection fraction (HFrEF). Therefore, there are few report…

Post-COVID-19 era trends in foreigners undergoing a complete medical examination in Japan: A single-center analysis of inbound medical care Open

Jun Lu, Sachiko Kubo, Makiko Hashimoto, Yuko Hayashi, Erika Masuda , et al. · 2025

In the post-COVID-19 era, inbound medical care in Japan adapted to the growing demand for high-quality and precise healthcare. One form of this care is a complete medical examination, which has gained significant popularity among foreign r…

Low-Density-Lipoprotein Cholesterol Control and Treatment Status 1 Year after the Initial Health Checkup in Individuals with Referral-Level LDL Cholesterol Open

Hiroyuki Aoki, Kaori Kitaoka, Yuta Suzuki, Hidehiro Kaneko, Akira Okada , et al. · 2025

Despite being classified as requiring early medical intervention, only half of individuals with LDL-C ≥ 180 mg/dL visited a physician within 3 months, and nearly half continued to have uncontrolled LDL-C at 1 year. Strategies to facilitate…

Treatment of Thrombotic Cardiovascular Diseases in People with Haemophilia: A Japanese Consensus Study [Secondary Publication] Open

Azusa Nagao, Yushi Chikasawa, Yukio Hiroi, Masahiro Ieko · 2025

Endothelial oestrogen–myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overload Open

Nobuaki Fukuma, Hiroyuki Tokiwa, Genri Numata, Kazutaka Ueda, Pang‐Yen Liu , et al. · 2024

Aims Oestrogen exerts beneficial cardiovascular effects by binding to specific receptors on various cells to activate nuclear and non-nuclear actions. Oestrogen receptor α (ERα) non-nuclear signalling confers protection against heart failu…

Simultaneous assessment of genetic and epigenetic contributions to plasma lipid levels with respect to cardiovascular risk Open

Fumihiko Takeuchi, Masaya Yamamoto, Masahiro Nakatochi, Kozue Takano, Atsuko Okazaki , et al. · 2024

Background This study aims to develop a model for simultaneously assessing genetic and epigenetic contributions to plasma lipid levels. Methods The predictive model was developed using two cardiovascular risk groups, i.e., individuals with…

A Surviving Case of Myocardial Infarction with Ventricular Septal Rupture and Ventricular Aneurysm following Gastrointestinal Bleeding Open

Misa Kusumoto, Jumpei Yamamoto, Sakura Kaneda, Takuya Matsushiro, Masaya Yamamoto , et al. · 2024

A 55-year-old man presented to the emergency department with worsening shortness of breath 1 month after a gastrointestinal bleed. He had congestive heart failure, and an electrocardiogram suggested ischemic heart disease involvement. Echo…

A Case of Ventricular Fibrillation in Masked Long-QT Syndrome Coexisting with Coronary Vasospasm Open

Atsumasa Kurozumi, Yoshinari Enomoto, Hisao Hara, Norihiro Kato, Yukio Hiroi · 2024

Although long-QT syndrome (LQTS) with a normal range QT interval at rest leads to fatal ventricular arrhythmias, it is difficult to diagnose. In this article, we present a rare case of a patient who suffered a cardiac arrest and was recent…

Difference in clinical courses and causes of COVID-19-related deaths in hospitalized patients infected with omicron and delta variants: A retrospective study in Japan Open

Ayana Sakurai, Shinichiro Morioka, Shinya Tsuzuki, Nobuaki Matsunaga, Sho Saito , et al. · 2024

Despite the lower rate of severe illness associated with the omicron variant than the delta variant, more deaths have occurred among patients with mild-to-moderate COVID-19 in Japan since the omicron variant surge during the sixth wave. Th…

Impact of left ventricular diastolic function and direct oral anticoagulant use for predicting embolic events in patients with heart failure and atrial fibrillation Open

Jumpei Yamamoto, Hiromasa Hayama, Yoshinari Enomoto, Masaya Yamamoto, Hisao Hara , et al. · 2024

Background Patients with atrial fibrillation (AF) and heart failure (HF) have high stroke risk owing to left atrial dysfunction. However, anticoagulation is a concern in patients with high bleeding risk. We aimed to identify independent pr…

DAPagliflozin for the attenuation of albuminuria in Patients with hEaRt failure and type 2 diabetes (DAPPER study): a multicentre, randomised, open-label, parallel-group, standard treatment-controlled trial Open

Fumiki Yoshihara, Miki Imazu, Ichiro Sakuma, Yukio Hiroi, Hisao Hara , et al. · 2023

Coronary artery stenosis in Japanese people living with HIV-1 with or without haemophilia Open

R Nagai, Mikiko Ogata, Shuji Kubota, Masaya Yamamoto, Haruka Uemura , et al. · 2023

An extremely high prevalence (12.2%) of moderate-to-severe coronary artery stenosis (CAS) was documented in asymptomatic Japanese haemophiliacs living with HIV-1 (JHLH) in our previous study. The cause of this phenomenon remains unknown. W…

Impact of left atrial dysfunction on mortality in patients with atrial fibrillation and heart failure Open

Jennifer M. Yamamoto, Hiromasa Hayama, Masaya Yamamoto, Hisao Hara, Yukio Hiroi · 2023

Background Patients with atrial fibrillation and heart failure have elevated left ventricular end-diastolic pressure in addition to decreased left atrial function, and there are few reports of useful prognostic indices on echocardiography.…

Impact of COVID-19 on Cardiovascular Disease Open

Yukio Hiroi · 2023

新型コロナウイルス感染症（COVID-19）は単なる呼吸器疾患に留まらず，全身の血管内皮細胞への感染やサイトカインストームにより，血栓症，脳卒中，心筋梗塞，不整脈などの心血管疾患を発症しやすくする。心血管疾患は基礎疾患としてCOVID-19の予後を悪化させ，診療体制にも大きな影響を与える。また，Long COVIDと呼ばれる後遺症，感染後の心血管疾患発症リスクの増加が問題である。

Septic Shock Associated with Severe Pelvic Organ Prolapse Open

Aki Aoyama, Jumpei Yamamoto, Yukio Hiroi · 2023

Prognostic Impact of Left Atrial Strain in Patients Hospitalized for Acute Heart Failure With Atrial Fibrillation Open

Jumpei Yamamoto, Masao Moroi, Hiromasa Hayama, Masaya Yamamoto, Hisao Hara , et al. · 2023

We found a significant association between LARS and death in patients with AF and HF. Patients with reduced LARS had poor prognosis, suggesting the need for aggressive therapy to improve their LA dysfunction.

Myocarditis With Ventricular Tachycardia Following Bivalent COVID-19 mRNA Vaccination Open

Jumpei Yamamoto, Toru Awaya, Takashi Nakagawa, Asuka Tamura, Yukio Hiroi · 2023

This report describes a case of probable myocarditis following bivalent COVID-19 vaccination. Although this was the patient's fifth COVID-19 vaccination, it was the first dose of bivalent vaccine. The myocarditis may have been due to direc…

Left atrial intramural haematoma: a fatal complication of cardiac amyloidosis—a case report Open

Rika Terashima, Takashi Nakagawa, Hisao Hara, Yukio Hiroi · 2023

Background Spontaneous left atrial intramural hematoma (LAIH) is extremely rare and there are only two cases of spontaneous LAIH involving cardiac amyloidosis (CA) reported in literature. In both cases, LAIH rapidly compromised hemodynamic…

Relation between laxative use and risk of major bleeding in patients with atrial fibrillation and heart failure Open

Jumpei Yamamoto, Masaya Yamamoto, Hisao Hara, Yukio Hiroi · 2023

Comparison of the clinical characteristics and outcomes of Japanese patients with COVID-19 treated in primary, secondary, and tertiary care facilities Open

Daiki Tomidokoro, Yusuke Asai, Kayoko Hayakawa, Satoshi Kutsuna, Mari Terada , et al. · 2022

Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury Open

Pang‐Yen Liu, Nobuaki Fukuma, Yukio Hiroi, Akiko Kunita, Hiroyuki Tokiwa , et al. · 2022

Acute myocardial infarction immediately after second vaccination for coronavirus disease 2019 Open

Atsumasa Kurozumi, Hisao Hara, R Nagai, Yukio Hiroi · 2022

We present a serious and rare case of acute myocardial infarction soon after the administration of second vaccination for coronavirus disease 2019. Patient's culprit lesion in the right coronary artery was identified and appropriately trea…

Cardiovascular considerations during the COVID-19 pandemic: A focused review for practice in Japan Open

Daiki Tomidokoro, Yukio Hiroi · 2022

The COVID-19 pandemic is continuing to have drastic consequences for patients, healthcare workers, and the health system. Its cardiovascular implications have been well described in previous studies, but original reports from Japan are spa…

Atherosclerotic Progression Is Related to Immune-Related Adverse Events Open

Atsumasa Kurozumi, Kayo Sakamoto, Takashi Nakagawa, Futoshi Matsunaga, Akihiko Shimomura , et al. · 2022

Immune checkpoint inhibitors (ICIs) are widely used in various types of cancers and patients. Recently, it has been reported that ICIs aggravate atherosclerosis. This study aimed to identify characteristics that are related to the progress…

Acute Myocardial Infarction Immediately after Second Vaccination for Coronavirus Disease 2019 Open

Atsumasa Kurozumi, Hisao Hara, R Nagai, Yukio Hiroi · 2022

We present a serious case of acute myocardial infarction soon after second vaccination for coronavirus disease 2019. Her pathological findings and intravascular imaging partly unveil how vaccine can cause acute coronary syndrome. It also s…

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