Yukiyasu Ozawa
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View article: P1323: THE PROGNOSIS AND COMPLICATIONS OF PATIENTS WITH PRE-TRANSPLANT LIVER DYSFUNCTION
P1323: THE PROGNOSIS AND COMPLICATIONS OF PATIENTS WITH PRE-TRANSPLANT LIVER DYSFUNCTION Open
Topic: 22. Stem cell transplantation - Clinical Background: The hematopoietic cell transplantation comorbidity index (HCT-CI) score including hepatic dysfunction is known to be related to clinical outcomes after allogeneic hematopoietic ce…
View article: P1306: IMPACT OF HLA DISPARITY ON THE RISK OF OVERALL MORTALITY IN PATIENTS WITH EXTENSIVE CHRONIC GVHD
P1306: IMPACT OF HLA DISPARITY ON THE RISK OF OVERALL MORTALITY IN PATIENTS WITH EXTENSIVE CHRONIC GVHD Open
Topic: 22. Stem cell transplantation - Clinical Background: Chronic graft-versus-host disease (cGVHD) is a significant cause of morbidity and mortality in long-term survivors after allogeneic hematopoietic cell transplantation (allo-HCT). …
View article: Impact of <scp>MRD</scp> on clinical outcomes of unrelated hematopoietic stem cell transplantation in patients with Ph<sup>+</sup><scp>ALL</scp>: A retrospective nationwide study
Impact of <span>MRD</span> on clinical outcomes of unrelated hematopoietic stem cell transplantation in patients with Ph<sup>+</sup><span>ALL</span>: A retrospective nationwide study Open
Measurable residual disease (MRD) status before transplantation has been shown to be a strong prognostic factor in patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph + ALL). However, the outcomes of unrelated h…
View article: Poor outcome of allogeneic transplantation for therapy-related acute myeloid leukemia induced by prior chemoradiotherapy
Poor outcome of allogeneic transplantation for therapy-related acute myeloid leukemia induced by prior chemoradiotherapy Open
View article: Author Correction: A convolutional neural network-based model that predicts acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Author Correction: A convolutional neural network-based model that predicts acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation Open
View article: Prognostic impact of complex and/or monosomal karyotypes in post‐transplant poor cytogenetic acute myeloid leukaemia: A quantitative approach
Prognostic impact of complex and/or monosomal karyotypes in post‐transplant poor cytogenetic acute myeloid leukaemia: A quantitative approach Open
Summary To evaluate the prognostic impact of complex karyotype (CK) and/or monosomal karyotype (MK) in combination with various clinical factors on allogeneic stem cell transplantation (HSCT) outcomes of patients with acute myeloid leukaem…
View article: Should a matched sibling donor still be considered the primary option for allogeneic hematopoietic cell transplantation in patients over 50 years of age with myelodysplastic syndrome?
Should a matched sibling donor still be considered the primary option for allogeneic hematopoietic cell transplantation in patients over 50 years of age with myelodysplastic syndrome? Open
View article: Data from Differential Effect of Graft-versus-Host Disease on Survival in Acute Leukemia according to Donor Type
Data from Differential Effect of Graft-versus-Host Disease on Survival in Acute Leukemia according to Donor Type Open
Purpose:The anti-leukemic activity of allogeneic hematopoietic cell transplantation (HCT) depends on both the intensity of conditioning regimen and the strength of the graft-versus-leukemia (GVL) effect. However, it is unclear whether the …
View article: Data from Differential Effect of Graft-versus-Host Disease on Survival in Acute Leukemia according to Donor Type
Data from Differential Effect of Graft-versus-Host Disease on Survival in Acute Leukemia according to Donor Type Open
Purpose:The anti-leukemic activity of allogeneic hematopoietic cell transplantation (HCT) depends on both the intensity of conditioning regimen and the strength of the graft-versus-leukemia (GVL) effect. However, it is unclear whether the …
View article: Supplementary Data from Differential Effect of Graft-versus-Host Disease on Survival in Acute Leukemia according to Donor Type
Supplementary Data from Differential Effect of Graft-versus-Host Disease on Survival in Acute Leukemia according to Donor Type Open
Supplementary Data
View article: Supplementary Data from Differential Effect of Graft-versus-Host Disease on Survival in Acute Leukemia according to Donor Type
Supplementary Data from Differential Effect of Graft-versus-Host Disease on Survival in Acute Leukemia according to Donor Type Open
Supplementary Data
View article: CMV reactivation after allogeneic HCT is associated with a reduced risk of relapse in acute lymphoblastic leukemia
CMV reactivation after allogeneic HCT is associated with a reduced risk of relapse in acute lymphoblastic leukemia Open
Cytomegalovirus reactivation (CMVR) after allogeneic hematopoietic cell transplantation (HCT) is a frequent complication related to survival outcomes; however, its impact on relapse remains unclear, especially in acute lymphoblastic leukem…
View article: Post-hoc analysis of a clinical study on extracorporeal photopheresis in patients with chronic graft-versus-host disease in Japan
Post-hoc analysis of a clinical study on extracorporeal photopheresis in patients with chronic graft-versus-host disease in Japan Open
体外フォトフェレーシス(ECP)は,ステロイド抵抗性,依存性または不耐容の慢性移植片対宿主病(GVHD)患者を対象とした国内臨床試験の結果により,2020年12月に慢性GVHDに対する二次治療のための高度管理医療機器として薬事承認された。今回,この臨床試験に登録された15例を対象としてECP治療開始から36週までの治療効果や安全性をpost-hoc解析した。3例が試験を中止し,36週まで完了した患者は12例であった。ステロイド投与量はECP開始前より減量した患者は36週で1…
View article: Outcomes in Human T-Cell Leukemia Virus Type I Carriers after Hematopoietic Stem Cell Transplantation for Diseases Other than Adult T Cell Leukemia/Lymphoma
Outcomes in Human T-Cell Leukemia Virus Type I Carriers after Hematopoietic Stem Cell Transplantation for Diseases Other than Adult T Cell Leukemia/Lymphoma Open
View article: Effect of the COVID-19 pandemic on allogeneic stem cell transplantation in Japan
Effect of the COVID-19 pandemic on allogeneic stem cell transplantation in Japan Open
View article: Novel risk assessment for the intensity of conditioning regimen in older patients
Novel risk assessment for the intensity of conditioning regimen in older patients Open
Reduced-intensity conditioning (RIC) regimens have long-term outcomes that are generally comparable with those of myeloablative conditioning (MAC) because of a lower risk of nonrelapse mortality (NRM) but a higher risk of relapse. However,…
View article: Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10)
Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10) Open
The prognosis of acute myeloid leukemia (AML) patients with der(1;7)(q10;p10) who underwent allogeneic hematopoietic stem cell transplantation (allo‐SCT) is unclear due to its rarity. We retrospectively analyzed 151 AML patients with der(1…
View article: Impact of anti-thymocyte globulin on survival outcomes in female-to-male allogeneic hematopoietic stem cell transplantation
Impact of anti-thymocyte globulin on survival outcomes in female-to-male allogeneic hematopoietic stem cell transplantation Open
Allogeneic hematopoietic cell transplantation between female donors and male recipients (female-to-male allo-HCT) is a well-established risk factor for inferior survival outcomes due to a higher incidence of graft-versus-host disease (GVHD…
View article: Adult patients with Ph+ ALL benefit from conditioning regimen of medium‐dose VP16 plus CY/TBI
Adult patients with Ph+ ALL benefit from conditioning regimen of medium‐dose VP16 plus CY/TBI Open
The medium‐dose etoposide (VP16) added on cyclophosphamide (CY)/total body irradiation (TBI) is one of the intensified myeloablative conditioning regimens used in allogenic hematopoietic stem cell transplantation (allo‐HSCT) for acute lymp…
View article: Improvements in allogeneic hematopoietic cell transplantation outcomes for adults with ALL over the past 3 decades
Improvements in allogeneic hematopoietic cell transplantation outcomes for adults with ALL over the past 3 decades Open
Allogeneic hematopoietic cell transplantation (allo-HCT) is a promising treatment for adult acute lymphoblastic leukemia (ALL), an intractable hematological malignancy. The trends in allo-HCT outcomes over the past 30 years were examined t…
View article: Advantages of peripheral blood stem cells from unrelated donors versus bone marrow transplants in outcomes of adult acute myeloid leukemia patients
Advantages of peripheral blood stem cells from unrelated donors versus bone marrow transplants in outcomes of adult acute myeloid leukemia patients Open
The authors' results confirmed the overall safety of unrelated PBSC transplantation for adult AML patients and suggested an advantage of PBSCs, especially for those in CR1. Further optimization of the prophylactic strategy for cGVHD is req…
View article: Overcoming minimal residual disease using intensified conditioning with medium-dose etoposide, cyclophosphamide and total body irradiation in allogeneic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia in adults
Overcoming minimal residual disease using intensified conditioning with medium-dose etoposide, cyclophosphamide and total body irradiation in allogeneic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia in adults Open
This study demonstrated the benefits of the addition of VP16 in Ph+ ALL patients, especially those with positive MRD status. VP16/CY/TBI could be a potential strategy to overcome the survival risk of MRD positivity.
View article: Risk and Predictive Factors for Candidemia After Allogeneic Hematopoietic Cell Transplantation: JSTCT Transplant Complications Working Group
Risk and Predictive Factors for Candidemia After Allogeneic Hematopoietic Cell Transplantation: JSTCT Transplant Complications Working Group Open
Although antifungal prophylaxis that covers Candida species is a standard of care in allogeneic hematopoietic cell transplantation (HCT), candidemia mainly caused by non-albicans Candida species still occurs and is associated with a high m…
View article: Improvements in Allogeneic Hematopoietic Cell Transplantation Outcomes for Adults With ALL Over the Past Three Decades: A Nationwide Registry Analysis From the Adult ALL WG of the JSTCT
Improvements in Allogeneic Hematopoietic Cell Transplantation Outcomes for Adults With ALL Over the Past Three Decades: A Nationwide Registry Analysis From the Adult ALL WG of the JSTCT Open
View article: Antithymocyte Globulin Potentially Could Overcome an Adverse Effect of Acute Graft-versus-Host Disease in Matched-Related Peripheral Blood Stem Cell Transplantation
Antithymocyte Globulin Potentially Could Overcome an Adverse Effect of Acute Graft-versus-Host Disease in Matched-Related Peripheral Blood Stem Cell Transplantation Open
Previous Japanese studies have shown that bone marrow transplantation (BMT) is associated with better survival compared with peripheral blood stem cell transplantation (PBSCT) from a matched related donor (MRD). PBSCT recipients have shown…
View article: Decision Analysis for Unrelated Bone Marrow Transplantation or Immediate Cord Blood Transplantation for Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in First Complete Remission
Decision Analysis for Unrelated Bone Marrow Transplantation or Immediate Cord Blood Transplantation for Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in First Complete Remission Open
An HLA-matched relative is the first-choice donor for patients with Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL) in first complete remission (CR1). The most promising alternative donor is thought to be an HLA-ma…
View article: Syngeneic hematopoietic stem cell transplantation for acute myeloid leukemia: a propensity score-matched analysis
Syngeneic hematopoietic stem cell transplantation for acute myeloid leukemia: a propensity score-matched analysis Open
The present study evaluated outcomes and prognostic factors in adult patients with acute myeloid leukemia (AML) after syngeneic hematopoietic stem cell transplantation (HSCT). Among patients in first complete remission (CR1), outcomes of s…
View article: Dasatinib-based 2-step induction for adults with Philadelphia chromosome–positive acute lymphoblastic leukemia
Dasatinib-based 2-step induction for adults with Philadelphia chromosome–positive acute lymphoblastic leukemia Open
The standard treatment for adults with Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL) in Japan is imatinib-based chemotherapy followed by allogeneic hematopoietic stem cell transplantation (HSCT). However, ∼40% o…
View article: A case of sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance: long-term observation of neurological symptoms after autologous stem-cell transplantation.
A case of sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance: long-term observation of neurological symptoms after autologous stem-cell transplantation. Open
A 47-year-old woman presented with progressive limb weakness. A neurological examination revealed proximal dominant symmetrical muscle weakness in her limbs, and electromyography revealed complex repetitive discharges and short motor unit …
View article: Measurable residual disease affects allogeneic hematopoietic cell transplantation in Ph+ ALL during both CR1 and CR2
Measurable residual disease affects allogeneic hematopoietic cell transplantation in Ph+ ALL during both CR1 and CR2 Open
Although measurable residual disease (MRD) at the time of allogeneic hematopoietic cell transplantation (allo-HCT) has been reported to be an important prognostic factor for Philadelphia chromosome (Ph)–positive acute lymphoblastic leukemi…