Yuko Hino
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View article: Androgen receptors expressed in the primary sensory neurons regulate mechanical pain sensitivity
Androgen receptors expressed in the primary sensory neurons regulate mechanical pain sensitivity Open
Summary The expression of hormonal receptors in pain-processing regions complicates understanding the hormonal effects on pain mechanisms. This study investigates androgen receptor (AR) involvement in pain sensitivity and sex differences i…
View article: Citrate metabolism controls the senescent microenvironment via the remodeling of pro-inflammatory enhancers
Citrate metabolism controls the senescent microenvironment via the remodeling of pro-inflammatory enhancers Open
The senescent microenvironment and aged cells per se contribute to tissue remodeling, chronic inflammation, and age-associated dysfunction. However, the metabolic and epigenomic bases of the senescence-associated secretory phenotype (SASP)…
View article: Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone
Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone Open
In the adult mammalian brain, neurons are produced from neural stem cells (NSCs) residing in two niches—the subventricular zone (SVZ), which forms the lining of the lateral ventricles, and the subgranular zone in the hippocampus. Epigeneti…
View article: Author response: LSD1 defines the fiber type-selective responsiveness to environmental stress in skeletal muscle
Author response: LSD1 defines the fiber type-selective responsiveness to environmental stress in skeletal muscle Open
View article: LSD1 acts as an epigenetic barrier against glucocorticoid-induced atrophy and exercise-induced hypertrophy in skeletal muscle
LSD1 acts as an epigenetic barrier against glucocorticoid-induced atrophy and exercise-induced hypertrophy in skeletal muscle Open
Skeletal muscle exhibits remarkable plasticity in response to environmental cues, with stress-dependent effects on the fast-twitch and slow-twitch fibers. Although stress-induced gene expression underlies environmental adaptation, it is un…
View article: LSD1 defines erythroleukemia metabolism by controlling the lineage-specific transcription factors GATA1 and C/EBPα
LSD1 defines erythroleukemia metabolism by controlling the lineage-specific transcription factors GATA1 and C/EBPα Open
Acute myeloid leukemia (AML) is a heterogenous malignancy characterized by distinct lineage subtypes and various genetic/epigenetic alterations. As with other neoplasms, AML cells have well-known aerobic glycolysis, but metabolic variation…
View article: Additional file 1 of Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome
Additional file 1 of Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome Open
Generation of EpiEdit mice derived from ESCs via tetraploid complementation. Table S2. Generation of EpiEdit mice by transient expression of epigenome editing factors. Table S3. Generation of EpiEdit mice by stable expression of epigenome …
View article: Drinking Behavior and Mental Illness Among Evacuees in Fukushima Following the Great East Japan Earthquake: The Fukushima Health Management Survey
Drinking Behavior and Mental Illness Among Evacuees in Fukushima Following the Great East Japan Earthquake: The Fukushima Health Management Survey Open
The results of this study highlight that beginning drinkers have a high risk of serious mental illness. Thus, mental health professionals should pay attention to the drinking behaviors of evacuees, which might predict increased risk of ser…
View article: Explanatory Meetings on Thyroid Examination for the “Fukushima Health Management Survey” after the Great East Japan Earthquake: Reduction of Anxiety and Improvement of Comprehension
Explanatory Meetings on Thyroid Examination for the “Fukushima Health Management Survey” after the Great East Japan Earthquake: Reduction of Anxiety and Improvement of Comprehension Open
After the Fukushima Daiichi nuclear accident in 2011 and thyroid examinations of children in Fukushima, the Radiation Medical Science Center began "Explanatory meetings on thyroid examination" as a method of communication with residents su…