Yuko Oda
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View article: MON-271 Vitamin D Receptor with Calcium Sensing Receptor Control Epidermal Tumorigenesis Through Oxidative Stress And DNA Repair Genes With Tumor Suppressor P53 Signaling
MON-271 Vitamin D Receptor with Calcium Sensing Receptor Control Epidermal Tumorigenesis Through Oxidative Stress And DNA Repair Genes With Tumor Suppressor P53 Signaling Open
Disclosure: M.B. Meyer: None. I. Yeh: None. Z. Lin: None. C.T. Wong: None. D.H. Oh: None. D.D. Bikle: None. The vitamin D receptor (VDR) with calcium sensing receptor (CASR) regulates epidermal proliferation and differentiation. Deletion o…
View article: Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics
Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics Open
Postnatal cell fate is postulated to be primarily determined by the local tissue microenvironment. Here, we find that Mediator 1 ( Med1 ) dependent epigenetic mechanisms dictate tissue-specific lineage commitment and progression of dental …
View article: Mediator 1 ablation induces enamel-to-hair lineage conversion through enhancer dynamics
Mediator 1 ablation induces enamel-to-hair lineage conversion through enhancer dynamics Open
Postnatal cell fate has been postulated to be primarily determined by the local tissue microenvironment. Here, we found that Mediator 1 ( Med1 ) dependent epigenetic mechanisms dictate tissue-specific lineage commitment and progression of …
View article: Transcriptional Regulation of Dental Epithelial Cell Fate
Transcriptional Regulation of Dental Epithelial Cell Fate Open
Dental enamel is hardest tissue in the body and is produced by dental epithelial cells residing in the tooth. Their cell fates are tightly controlled by transcriptional programs that are facilitated by fate determining transcription factor…
View article: Deletion of Mediator 1 suppresses TGFβ signaling leading to changes in epidermal lineages and regeneration
Deletion of Mediator 1 suppresses TGFβ signaling leading to changes in epidermal lineages and regeneration Open
Epidermal lineages and injury induced regeneration are controlled by transcriptional programs coordinating cellular signaling and epigenetic regulators, but the mechanism remains unclear. Previous studies showed that conditional deletion o…
View article: Vitamin D and calcium signaling in epidermal stem cells and their regeneration
Vitamin D and calcium signaling in epidermal stem cells and their regeneration Open
Epidermal stem cells (SCs) residing in the skin play an essential role for epidermal regeneration during cutaneous wound healing. Upon injury, distinct epidermal SCs residing in the interfollicular epidermis and/or hair follicles are activ…
View article: Neuroanatomical substrate of chronic psychosis in epilepsy: an MRI study
Neuroanatomical substrate of chronic psychosis in epilepsy: an MRI study Open
There may be different neural bases between subjects with epilepsy only (EP) and interictal chronic epilepsy psychosis (EPS). However, there have been few structural MRI studies of EPS. The current study was conducted to investigate the ne…
View article: Role of Vitamin D and Calcium in Epidermal Wound Repair
Role of Vitamin D and Calcium in Epidermal Wound Repair Open
Wound repair is critical for good health. Lack of vitamin D and calcium or their receptors (VDR, Casr, respectively) results in delayed wound healing. The mechanisms involved include a reduction in stem cell numbers and their activation by…
View article: Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization
Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization Open
When the skin is injured, keratinocytes proliferate, migrate, and differentiate to regenerate the epidermis. We recently showed that ablation of the vitamin D receptor (Vdr) in keratinocytes delays wound re-epithelialization in mice also f…
View article: Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer
Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer Open
1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone rec…