Yukti Khanna
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View article: The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation
The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation Open
The ability to sense and respond to osmotic fluctuations is critical for the maintenance of cellular integrity. We used gene co-essentiality analysis to identify an unappreciated relationship between TSC22D2, WNK1, and NRBP1 in regulating …
View article: <i>TSC22D</i>,<i>WNK</i>and<i>NRBP</i>gene families exhibit functional buffering and evolved with Metazoa for macromolecular crowd sensing
<i>TSC22D</i>,<i>WNK</i>and<i>NRBP</i>gene families exhibit functional buffering and evolved with Metazoa for macromolecular crowd sensing Open
SUMMARY The ability to sense and respond to osmotic fluctuations is critical for the maintenance of cellular integrity. Myriad redundancies have evolved across all facets of osmosensing in metazoans, including among water and ion transport…
View article: Disordered regions mediate the interaction of p53 and MRE11
Disordered regions mediate the interaction of p53 and MRE11 Open
The genome is frequently targeted by genotoxic agents, resulting in the formation of DNA scars. However, cells employ diverse repair mechanisms to restore DNA integrity. Among these processes, the Mre11-Rad50-Nbs1 complex detects double-st…
View article: EGCG Promotes FUS Condensate Formation in a Methylation-Dependent Manner
EGCG Promotes FUS Condensate Formation in a Methylation-Dependent Manner Open
Millions of people worldwide are affected by neurodegenerative diseases (NDs), and to date, no effective treatment has been reported. The hallmark of these diseases is the formation of pathological aggregates and fibrils in neural cells. M…
View article: Large scale changes in the transcriptome of Eisenia fetida during regeneration
Large scale changes in the transcriptome of Eisenia fetida during regeneration Open
Earthworms show a wide spectrum of regenerative potential with certain species like Eisenia fetida capable of regenerating more than two-thirds of their body while other closely related species, such as Paranais litoralis seem to have lost…