Yi Duan
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View article: Integrating Single‐Cell Transcriptome‐Wide Mendelian Randomization and Differentially Expressed Gene Analyses to Prioritize Dynamic Immune‐Related Drug Targets for Cancers
Integrating Single‐Cell Transcriptome‐Wide Mendelian Randomization and Differentially Expressed Gene Analyses to Prioritize Dynamic Immune‐Related Drug Targets for Cancers Open
Single‐cell expression quantitative trait loci data offer promising opportunities to inform immune‐related drug development in cancer. However, pleiotropy can complicate causal inference. We introduce MR‐DEG, a framework that integrates Me…
View article: Delayed-onset tracheal rupture after prone-position surgery: a case report of conservative management without bronchoscopy and literature review
Delayed-onset tracheal rupture after prone-position surgery: a case report of conservative management without bronchoscopy and literature review Open
Tracheobronchial injury, while rare, carries a significant risk of mortality, with iatrogenic causes being predominant. This article presents a singular case of delayed tracheal rupture following percutaneous nephrolithotomy conducted unde…
View article: Multivariable risk prediction models for postoperative cardiac injury in adults undergoing non-cardiac surgery: a systematic review and meta-analysis protocol
Multivariable risk prediction models for postoperative cardiac injury in adults undergoing non-cardiac surgery: a systematic review and meta-analysis protocol Open
Introduction Postoperative cardiac injury, encompassing myocardial infarction (MI) and myocardial injury after non-cardiac surgery (MINS), is a major perioperative complication associated with substantial morbidity and mortality. While num…
View article: Comparing the pericapsular nerve group block and fascia iliaca block for acute pain management in patients with hip fracture
Comparing the pericapsular nerve group block and fascia iliaca block for acute pain management in patients with hip fracture Open
View article: The genetic diversity and populational specificity of the human gut virome at single-nucleotide resolution
The genetic diversity and populational specificity of the human gut virome at single-nucleotide resolution Open
Here, we introduce the Chinese Gut Viral Reference (CGVR) set, consisting of 120,568 viral genomes from 3234 deeply sequenced fecal samples collected nationwide, covering 72,751 viral operational taxonomic units (vOTUs), nearly 90% of whic…
View article: Machine learning prediction and explanation of high intraoperative blood pressure variability for noncardiac surgery using preoperative factors
Machine learning prediction and explanation of high intraoperative blood pressure variability for noncardiac surgery using preoperative factors Open
View article: Identifying patterns of high intraoperative blood pressure variability in noncardiac surgery using explainable machine learning: a retrospective cohort study
Identifying patterns of high intraoperative blood pressure variability in noncardiac surgery using explainable machine learning: a retrospective cohort study Open
The models enabled accurate classification of HIBPV cases and highlighted key discriminative perioperative variables through SHAP-based interpretation. Intraoperative HR and BIS were significant contributing factors. Moreover, interactions…
View article: Artificial intelligence in anesthesia: insights from the 2024 Nobel Prize in Physics
Artificial intelligence in anesthesia: insights from the 2024 Nobel Prize in Physics Open
View article: Assessing the effectiveness of continuous glucose monitoring compared with conventional monitoring in enhancing surgical outcomes for patients with diabetes: protocol for a multicentre, parallel-arm, randomised, pragmatic trial in China
Assessing the effectiveness of continuous glucose monitoring compared with conventional monitoring in enhancing surgical outcomes for patients with diabetes: protocol for a multicentre, parallel-arm, randomised, pragmatic trial in China Open
Introduction The Comprehensive Complication Index (CCI) is an internationally recognised indicator of postoperative complications. During the perioperative period, patients with diabetes mellitus (DM) or impaired glucose tolerance (IGT) ma…
View article: Applications of bacteriophages in precision engineering of the human gut microbiome
Applications of bacteriophages in precision engineering of the human gut microbiome Open
As our understanding of the role of the gut microbiome in human diseases deepens, precision engineering of the gut microbiome using bacteriophages has gained significant attention. Herein, we review the recent advances in bacteriophage-med…
View article: Gut microbiota in treating inflammatory digestive diseases: Current challenges and therapeutic opportunities
Gut microbiota in treating inflammatory digestive diseases: Current challenges and therapeutic opportunities Open
Accumulating evidence indicates that the gut microbiota is intricately involved in the initiation and progression of human diseases, forming a multidirectional regulatory axis centered on intestinal microbiota. This article illustrates the…
View article: <i>iMeta</i> Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health
<i>iMeta</i> Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health Open
The iMeta Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and …
View article: MdEval: Massively Multilingual Code Debugging
MdEval: Massively Multilingual Code Debugging Open
Code large language models (LLMs) have made significant progress in code debugging by directly generating the correct code based on the buggy code snippet. Programming benchmarks, typically consisting of buggy code snippet and their associ…
View article: Bacteriophages and their potential for treatment of metabolic diseases
Bacteriophages and their potential for treatment of metabolic diseases Open
Recent advances highlight the role of gut virome, particularly phageome, in metabolic disorders such as obesity, type 2 diabetes mellitus, metabolic dysfunction‐associated fatty liver disease, and cardiovascular diseases, including hyperte…
View article: Retraction Note: Optical medical equipment application and observing the occurrence of hypotension in elderly patients after general anesthesia induction through arteriovenous ultrasound parameters
Retraction Note: Optical medical equipment application and observing the occurrence of hypotension in elderly patients after general anesthesia induction through arteriovenous ultrasound parameters Open
View article: The Application of Remimazolam Toluene Sulfonate with Propofol in Orthotopic Liver Transplantation
The Application of Remimazolam Toluene Sulfonate with Propofol in Orthotopic Liver Transplantation Open
The objective of the study is to explore the application value of remimazolam toluene sulfonate in orthotopic liver transplantation. A total of 120 patients who underwent orthotopic liver transplantation in our hospital from March 2021 to …
View article: <i>Bacillus subtilis</i> YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization
<i>Bacillus subtilis</i> YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization Open
YisK is an uncharacterized protein in Bacillus subtilis previously shown to interact genetically with the elongasome protein Mbl. YisK overexpression leads to cell widening and lysis, phenotypes that are dependent on mbl and suppressed by …
View article: Co-teaching in medicine and nursing in training nurse anesthetists: a before-and-after controlled study
Co-teaching in medicine and nursing in training nurse anesthetists: a before-and-after controlled study Open
View article: <i>Bacillus subtilis</i>YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization
<i>Bacillus subtilis</i>YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization Open
YisK is an uncharacterized protein in Bacillus subtilis previously shown to interact genetically with the elongasome protein Mbl. YisK overexpression leads to cell widening and lysis, phenotypes that are dependent on mbl and suppressed by …
View article: miR-21-5p prevents doxorubicin-induced cardiomyopathy by downregulating BTG2
miR-21-5p prevents doxorubicin-induced cardiomyopathy by downregulating BTG2 Open
Cardiomyocyte apoptosis has been characterized as one of the major mechanisms underlying doxorubicin (DOX)-induced cardiomyopathy. MicroRNA-21-5p (miR-21-5p) was reported to mitigate ischemia-induced cardiomyocyte apoptosis and cardiac inj…
View article: Supplementary Table S4 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Supplementary Table S4 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma Open
Predicted risk group (BRBarray)_LMedits
View article: Supplementary Table S3 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Supplementary Table S3 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma Open
TLR4 signature genes
View article: Supplementary Table S7 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Supplementary Table S7 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma Open
Control and cirrhosis patients
View article: Supplementary Table S2 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Supplementary Table S2 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma Open
Key Resources Table
View article: Supplementary Table S6 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Supplementary Table S6 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma Open
MDSC signiture genes
View article: Supplementary table S8 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Supplementary table S8 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma Open
16s rRNA sequencing of PSC patients
View article: Supplementary Table S6 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Supplementary Table S6 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma Open
MDSC signiture genes
View article: Supplementary Table S3 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Supplementary Table S3 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma Open
TLR4 signature genes
View article: Data from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Data from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma Open
Gut dysbiosis is commonly observed in patients with cirrhosis and chronic gastrointestinal disorders; however, its effect on antitumor immunity in the liver is largely unknown. Here we studied how the gut microbiome affects antitumor immun…
View article: Supplementary Table S5 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Supplementary Table S5 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma Open
PSC patients information