Yulia Shifrin
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View article: Three-Dimensional Organization of Telomeres: An Emerging Prognostic Biomarker in Multiple Myeloma
Three-Dimensional Organization of Telomeres: An Emerging Prognostic Biomarker in Multiple Myeloma Open
A crucial role of genome instability and telomeric dysfunction was demonstrated in multiple cancers, including multiple myeloma (MM). MM accounts for approximately 10% of all hematologic malignancies and includes asymptomatic pre-malignant…
View article: Novel method of minimal residual disease testing in myeloma: Liquid biopsies to enumerate and 3D telomere-profiling of circulating tumor cells
Novel method of minimal residual disease testing in myeloma: Liquid biopsies to enumerate and 3D telomere-profiling of circulating tumor cells Open
Introduction: Novel therapeutic approaches, especially cellular therapies, have significantly prolonged the survival of patients with multiple myeloma (MM). However, a cure is yet to be discovered, and the natural course of myeloma remains…
View article: Analysis by TeloView® Technology Predicts the Response of Hodgkin’s Lymphoma to First-Line ABVD Therapy
Analysis by TeloView® Technology Predicts the Response of Hodgkin’s Lymphoma to First-Line ABVD Therapy Open
Classic Hodgkin’s lymphoma (cHL) is a curable cancer with a disease-free survival rate of over 10 years. Over 80% of diagnosed patients respond favorably to first-line chemotherapy, but few biomarkers exist that can predict the 15–20% of p…
View article: Three‐dimensional telomere profiling predicts risk of progression in smoldering multiple myeloma
Three‐dimensional telomere profiling predicts risk of progression in smoldering multiple myeloma Open
Smoldering multiple myeloma (SMM) is a precursor stage that precedes multiple myeloma (MM). SMM is heterogenous with nearly 40% of patients progressing to MM in the first 5 years. The high rate of progression of SMM patients highlights the…
View article: Analysis by TeloView® Technology Predicts the Response of Hodgkin’s Lymphoma to first line ABVD Therapy
Analysis by TeloView® Technology Predicts the Response of Hodgkin’s Lymphoma to first line ABVD Therapy Open
Classic Hodgkin’s lymphoma (cHL) is a curable cancer with disease-free survival rate of over 10 years. Over 80% of diagnosed patients respond favorably to first line chemotherapy. However, 15-20% of patients experience refractory or early …
View article: Gastric and pyloric sphincter muscle function and the developmental-dependent regulation of gastric content emptying in the rat
Gastric and pyloric sphincter muscle function and the developmental-dependent regulation of gastric content emptying in the rat Open
Feeding intolerance is a common issue in the care of preterm neonates. The condition manifests as delayed emptying of gastric contents and represents a therapeutic challenge, since the factors accounting for its manifestations are unknown.…
View article: Maternal-pup interaction disturbances induce long-lasting changes in the newborn rat pulmonary vasculature
Maternal-pup interaction disturbances induce long-lasting changes in the newborn rat pulmonary vasculature Open
The factors accounting for the pathological maintenance of a high pulmonary vascular (PV) resistance postnatally remain elusive, but neonatal stressors may play a role in this process. Cross-fostering in the immediate neonatal period is as…