Yulia Timofeeva
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View article: A minimal presynaptic protein machinery mediating synchronous and asynchronous exocytosis and short-term plasticity
A minimal presynaptic protein machinery mediating synchronous and asynchronous exocytosis and short-term plasticity Open
Neurotransmitters are released from synaptic vesicles with remarkable precision in response to presynaptic Ca2+ influx but exhibit significant heterogeneity in exocytosis timing and efficacy based on the recent history of activity. This he…
View article: A minimal presynaptic protein machinery mediating synchronous and asynchronous exocytosis and short-term plasticity
A minimal presynaptic protein machinery mediating synchronous and asynchronous exocytosis and short-term plasticity Open
Neurotransmitters are released from synaptic vesicles with remarkable precision in response to presynaptic Ca 2+ influx but exhibit significant heterogeneity in exocytosis timing and efficacy based on the recent history of activity. This h…
View article: An exploratory computational analysis in mice brain networks of widespread epileptic seizure onset locations along with potential strategies for effective intervention and propagation control
An exploratory computational analysis in mice brain networks of widespread epileptic seizure onset locations along with potential strategies for effective intervention and propagation control Open
Mean-field models have been developed to replicate key features of epileptic seizure dynamics. However, the precise mechanisms and the role of the brain area responsible for seizure onset and propagation remain incompletely understood. In …
View article: An exploratory computational analysis in mice brain networks of widespread epileptic seizure onset locations along with potential strategies for effective intervention and propagation control
An exploratory computational analysis in mice brain networks of widespread epileptic seizure onset locations along with potential strategies for effective intervention and propagation control Open
Mean-field models have been developed to replicate key features of epileptic seizure dynamics. However, the precise mechanisms and the role of the brain area responsible for seizure onset and propagation remain incompletely understood. In …
View article: The release of inhibition model reproduces kinetics and plasticity of neurotransmitter release in central synapses
The release of inhibition model reproduces kinetics and plasticity of neurotransmitter release in central synapses Open
Calcium-evoked release of neurotransmitters from synaptic vesicles (SVs) is catalysed by SNARE proteins. The predominant view is that, at rest, complete assembly of SNARE complexes is inhibited (‘clamped’) by synaptotagmin and complexin mo…
View article: Asynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone
Asynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone Open
The balance between fast synchronous and delayed asynchronous release of neurotransmitters has a major role in defining computational properties of neuronal synapses and regulation of neuronal network activity. However, how it is tuned at …
View article: Asynchronous glutamate exocytosis is enhanced in low release probability synapses and is widely dispersed across the active zone.
Asynchronous glutamate exocytosis is enhanced in low release probability synapses and is widely dispersed across the active zone. Open
The balance between fast synchronous and delayed asynchronous release of neurotransmitters has a major role in defining computational properties of neuronal synapses and regulation of neuronal network activity. However, how it is tuned at …
View article: Asynchronous glutamate exocytosis is enhanced in low release probability synapses and is widely dispersed across the active zone
Asynchronous glutamate exocytosis is enhanced in low release probability synapses and is widely dispersed across the active zone Open
The balance between fast synchronous and delayed asynchronous release of neurotransmitters has a major role in defining computational properties of neuronal synapses and regulation of neuronal network activity. However, how it is tuned at …
View article: Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity
Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity Open
Renshaw cells (V1 R ) are excitable as soon as they reach their final location next to the spinal motoneurons and are functionally heterogeneous. Using multiple experimental approaches, in combination with biophysical modeling and dynamica…
View article: Slow‐decaying presynaptic calcium dynamics gate long‐lasting asynchronous release at the hippocampal mossy fiber to CA3 pyramidal cell synapse
Slow‐decaying presynaptic calcium dynamics gate long‐lasting asynchronous release at the hippocampal mossy fiber to CA3 pyramidal cell synapse Open
Action potentials trigger two modes of neurotransmitter release, with a fast synchronous component and a temporally delayed asynchronous release. Asynchronous release contributes to information transfer at synapses, including at the hippoc…
View article: Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity
Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity Open
Renshaw cells (V1 R ) are excitable as soon as they reach their final location next to the spinal motoneurons and are functionally heterogeneous. Using multiple experimental approaches, in combination with biophysical modeling and dynamica…
View article: Fluorescence lifetime imaging reveals regulation of presynaptic Ca<sup>2+</sup> by glutamate uptake and mGluRs, but not somatic voltage in cortical neurons
Fluorescence lifetime imaging reveals regulation of presynaptic Ca<sup>2+</sup> by glutamate uptake and mGluRs, but not somatic voltage in cortical neurons Open
Brain function relies on vesicular release of neurotransmitters at chemical synapses. The release probability depends on action potential‐evoked presynaptic Ca 2+ entry, but also on the resting Ca 2+ level. Whether these basic aspects of p…
View article: Low-rate firing limit for neurons with axon, soma and dendrites driven by spatially distributed stochastic synapses
Low-rate firing limit for neurons with axon, soma and dendrites driven by spatially distributed stochastic synapses Open
Analytical forms for neuronal firing rates are important theoretical tools for the analysis of network states. Since the 1960s, the majority of approaches have treated neurons as being electrically compact and therefore isopotential. These…
View article: Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release
Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release Open
Significance Release of neurotransmitters relies on submillisecond coupling of synaptic vesicle fusion to the triggering signal: AP-evoked presynaptic Ca 2+ influx. The key player that controls exocytosis of the synaptic vesicle is the Ca …
View article: Soil structure of sand quarries territory
Soil structure of sand quarries territory Open
Anthropogenic activities are one of the leading factors of soil differentiation. Significant changes in the soil cover occur as a result of the construction of quarries. The mining industry causes the complete degradation of soils in large…
View article: Low-rate firing limit for neurons with axon, soma and dendrites driven by spatially distributed stochastic synapses
Low-rate firing limit for neurons with axon, soma and dendrites driven by spatially distributed stochastic synapses Open
Analytical forms for neuronal firing rates are important theoretical tools for the analysis of network states. Since the 1960s, the majority of approaches have treated neurons as being electrically compact and therefore isopotential. These…
View article: PREVALENCE AND STRUCTURE OF DENTOALVEOLAR ANOMALIES IN ADOLESCENTS OF THE INDIGENOUS MINORITIES POPULATION OF THE KHANTY-MANSIYSK AUTONOMNIY OKRUG ― UGRA
PREVALENCE AND STRUCTURE OF DENTOALVEOLAR ANOMALIES IN ADOLESCENTS OF THE INDIGENOUS MINORITIES POPULATION OF THE KHANTY-MANSIYSK AUTONOMNIY OKRUG ― UGRA Open
Object. Dentoalveolar anomalies contribute to the development of morphological and functional disorders in the temporomandibular joint, and also lead to changes in aesthetics, chewing functions and speech formation. This report presents th…
View article: Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release
Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release Open
Synaptotagmin1 (Syt1) synchronises neurotransmitter release to action potentials acting as the fast Ca 2+ release sensor and as the inhibitor (clamp) of spontaneous and delayed asynchronous release. Whilst the Syt1 Ca 2+ activation mechani…
View article: Action potential counting at giant mossy fiber terminals gates information transfer in the hippocampus
Action potential counting at giant mossy fiber terminals gates information transfer in the hippocampus Open
Significance Neurons fire action potentials to transfer information through synaptic release of neurotransmitter. At presynaptic terminals, the pattern of action potential discharge is integrated through dynamic Ca 2+ signaling by the pres…
View article: Action potential counting at giant mossy fiber terminals gates information transfer in the hippocampus
Action potential counting at giant mossy fiber terminals gates information transfer in the hippocampus Open
Hippocampal mossy fibers have long been recognized as conditional detonators owing to prominent short-term facilitation, but the patterns of activity required to fire postsynaptic CA3 pyramidal neurons remain poorly understood. We show tha…
View article: Calmodulin as a major calcium buffer shaping vesicular release and short-term synaptic plasticity: facilitation through buffer dislocation
Calmodulin as a major calcium buffer shaping vesicular release and short-term synaptic plasticity: facilitation through buffer dislocation Open
Action potential-dependent release of synaptic vesicles and short-term synaptic plasticity are dynamically regulated by the endogenous Ca(2+) buffers that shape [Ca(2+)] profiles within a presynaptic bouton. Calmodulin is one of the most a…