Yulia Zinchenko
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View article: Ways to Enhance the Diagnosis of Pulmonary Sarcoidosis (Literature Review)
Ways to Enhance the Diagnosis of Pulmonary Sarcoidosis (Literature Review) Open
The article analyzes 50 publications devoted to diagnostic approaches to detection of sarcoidosis. It highlights that currently diagnosis of this disease is not standardized and thus errors are highly possible to occur. Improved approaches…
View article: A Key Role of CD8+ T Cells in Controlling of Tuberculosis Infection
A Key Role of CD8+ T Cells in Controlling of Tuberculosis Infection Open
The main role in the control of tuberculosis infection is played by macrophages and Th1 and CD8+ T cells. The study aimed to identify the most diagnostically significant CD8+ T cell subsets in tuberculosis patients. Methods: Peripheral blo…
View article: Molecular Markers of Early Immune Response in Tuberculosis: Prospects of Application in Predictive Medicine
Molecular Markers of Early Immune Response in Tuberculosis: Prospects of Application in Predictive Medicine Open
Tuberculosis (TB) remains an important public health problem and one of the leading causes of death. Individuals with latent tuberculosis infection (LTBI) have an increased risk of developing active TB. The problem of the diagnosis of the …
View article: Pulmonary Sarcoidosis: Experimental Models and Perspectives of Molecular Diagnostics Using Quantum Dots
Pulmonary Sarcoidosis: Experimental Models and Perspectives of Molecular Diagnostics Using Quantum Dots Open
Sarcoidosis is a complex inflammatory multisystem disease of unknown etiology that is characterised by epithelioid cell granulomatous lesions affecting various organs, mainly the lungs. In general, sarcoidosis is asymptomatic, but some cas…
View article: Sarcoidosis and Autoimmune Inflammatory Syndrome Induced by Adjuvants
Sarcoidosis and Autoimmune Inflammatory Syndrome Induced by Adjuvants Open
Currently, sarcoidosis remains one of the diseases with unknown etiology, which significantly complicates its diagnosis and treatment. Various causes of sarcoidosis have been studied for many years. Both organic and inorganic trigger facto…
View article: Identification of autoimmune markers in pulmonary tuberculosis
Identification of autoimmune markers in pulmonary tuberculosis Open
Introduction Pathogenesis of many autoimmune diseases is mainly promoted by poorly regulated and/or wrong targeted immune response to pathogens including M. tuberculosis . Autoimmunity is one of the processes with are characteristics of tu…
View article: Tuberculosis in the Russian Federation: Dynamics of the Epidemic Indicators before and after COVID-19 Pandemic
Tuberculosis in the Russian Federation: Dynamics of the Epidemic Indicators before and after COVID-19 Pandemic Open
The measures taken against tuberculosis (TB) in recent years in the Russian Federation have been highly effective. Unfortunately, the COVID-19 pandemic may seriously undermine the progress that has been made in the fight against TB. The ai…
View article: Sarcoidosis: Progression to the chronic stage and pathogenic based treatment (narrative review)
Sarcoidosis: Progression to the chronic stage and pathogenic based treatment (narrative review) Open
Many factors confirm the autoimmune nature of sarcoidosis and help in determining the strategy of patient management and treatment initiation. However, the causes and the mechanisms of disease progression that result in fibrosis and insuff…
View article: Detection of Anti-Vimentin Antibodies in Patients with Sarcoidosis
Detection of Anti-Vimentin Antibodies in Patients with Sarcoidosis Open
There is a need to further characterize the antibody response to vimentin in relation to its possible involvement in pathogenicity of sarcoidosis and other lung disorders. Objectives: We investigated serum samples from patients with sarcoi…
View article: Detection of Antibodies in Patients with Sarcoidosis
Detection of Antibodies in Patients with Sarcoidosis Open
There is a need to further characterize the antibody response to vimentin in relation to it possible involvement in pathogenicity of sarcoidosis, and other lung disorders. Objectives: We investigated serum samples from patients with sarcoi…
View article: Features of management of sarcoidosis patients with autoimmune inflammation
Features of management of sarcoidosis patients with autoimmune inflammation Open
Introduction : Currently, the theory of the autoimmune nature of sarcoidosis is increasingly attracting attention. However, there are no clear criteria for autoimmune inflammation in this granulomatous disease, which makes it possible to d…
View article: Molecular and Cellular Mechanisms of M. tuberculosis and SARS-CoV-2 Infections—Unexpected Similarities of Pathogenesis and What to Expect from Co-Infection
Molecular and Cellular Mechanisms of M. tuberculosis and SARS-CoV-2 Infections—Unexpected Similarities of Pathogenesis and What to Expect from Co-Infection Open
Tuberculosis is still an important medical and social problem. In recent years, great strides have been made in the fight against M. tuberculosis, especially in the Russian Federation. However, the emergence of a new coronavirus infection …
View article: The Effectiveness of Autologous Composition Based on Dendritic Cells in the Treatment of Pulmonary Tuberculosis with Extremely Drug Resistance After an Ineffective Course of Polychemotherapy
The Effectiveness of Autologous Composition Based on Dendritic Cells in the Treatment of Pulmonary Tuberculosis with Extremely Drug Resistance After an Ineffective Course of Polychemotherapy Open
Despite the introduction of new anti-tuberculosis drugs, the problem of treating tuberculosis patients with a broad drug-resistant pathogen (XDR MBT) remains relevant. Aim of the study . Тo increase the effectiveness of treatment of this c…
View article: Small Fiber Neuropathy in Sarcoidosis
Small Fiber Neuropathy in Sarcoidosis Open
Sarcoidosis (SC) is a granulomatous disease of an unknown origin. The most common SC-related neurological complication is a small fiber neuropathy (SFN) that is often considered to be the result of chronic inflammation and remains signific…
View article: Post COVID-19 Syndrome in Patients with Asymptomatic/Mild Form
Post COVID-19 Syndrome in Patients with Asymptomatic/Mild Form Open
Post COVID-19 Syndrome (PCS) is a complex of various symptoms developing a month or more after the acute phase of the disease. The cases of PCS development among patients with asymptomatic/mild forms are frequently reported; however, the p…
View article: Immunotherapy in the Treatment of COVID-19
Immunotherapy in the Treatment of COVID-19 Open
The high mortality rate in COVID-19 can be explained by the development of a hyperinflammatory syndrome, characterized by a cytokine storm and extensive thrombus formation. The main direction for preventing the development of hyperinflamma…
View article: Efficacy of Different Types of Therapy for COVID-19: A Comprehensive Review
Efficacy of Different Types of Therapy for COVID-19: A Comprehensive Review Open
A new coronavirus disease (COVID-19) has already affected millions of people in 213 countries. The possibilities of treatment have been reviewed in recent publications but there are many controversial results and conclusions. An analysis o…
View article: Diagnostics and management of tuberculosis and COVID-19 in a patient with pneumothorax (clinical case)
Diagnostics and management of tuberculosis and COVID-19 in a patient with pneumothorax (clinical case) Open
The spread of COVID-19 in countries with high and medium incidence of tuberculosis has led to an increased risk of COVID-19 and tuberculosis co-infection, introducing new diagnostic and therapeutic challenges for the clinician. Hereby we d…
View article: Features of tuberculosis diagnosis in the COVID-19
Features of tuberculosis diagnosis in the COVID-19 Open
2020 began with the most significant pandemic COVID-19 in the history of this century. The epidemiology indicators are growing every day. The spread of COVID-19 may affect an increase in the incidence of tuberculosis, despite a decrease in…
View article: The opposite effect of human leukocyte antigen genotypes in sarcoidosis and tuberculosis: a narrative review of the literature
The opposite effect of human leukocyte antigen genotypes in sarcoidosis and tuberculosis: a narrative review of the literature Open
Sarcoidosis and tuberculosis share several similar clinical and pathogenic characteristics that make some researchers consider a common pathogenesis for these diseases. Human leukocyte antigen (HLA) genotypes are studied both in sarcoidosi…
View article: Autoimmune component in the etiology of sarcoidosis
Autoimmune component in the etiology of sarcoidosis Open
The article presents a review of 60 publications from international and Russian databases (PubMed, Web of Science, and Elsevier) from 1960 to 2018 with the keywords "sarcoidosis," "autoimmune reactions," "antibodies," and "HLA-genotype" ch…
View article: New Laboratory Criterion for the Differential Diagnosis of Sarcoidosis and Pulmonary Tuberculosis
New Laboratory Criterion for the Differential Diagnosis of Sarcoidosis and Pulmonary Tuberculosis Open
Take-Home Message. This study provides a new diagnostic index based on the antibodies to mutated citrullinated vimentin concentration and the level of different B subsets. Determination of index over 5 Units proved to be characteristic of …
View article: Imbalance in B cell and T Follicular Helper Cell Subsets in Pulmonary Sarcoidosis
Imbalance in B cell and T Follicular Helper Cell Subsets in Pulmonary Sarcoidosis Open
Sarcoidosis is a systemic granulomatous disease that develops due to the Th1, Th17 and Treg lymphocytes disturbance. There is an assumption, that B cells and follicular T-helper (Tfh) cells may play an important role in this disorder, as w…
View article: Sarcoidosis as an Autoimmune Disease
Sarcoidosis as an Autoimmune Disease Open
Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease. This review attempts an integra…
View article: Recombinant tuberculosis allergen (Diaskintest<sup>®</sup>) in tuberculosis diagnostic in Russia (meta-analysis)
Recombinant tuberculosis allergen (Diaskintest<sup>®</sup>) in tuberculosis diagnostic in Russia (meta-analysis) Open
Immunological testing for tuberculosis has been one of the most rapidly developing areas in the last decade. A new-generation immunological skin test, Diaskintest (DST), has been developed in the Russian Federation and successfully impleme…
View article: CHARACTERISTICS OF AUTOIMMUNE INFLAMMATION IN THE PATIENTS WITH LUNG TUBERCULOSIS
CHARACTERISTICS OF AUTOIMMUNE INFLAMMATION IN THE PATIENTS WITH LUNG TUBERCULOSIS Open
Tuberculosis is a granulomatous disease caused by Mycobacterium tuberculosis , being characterized by the development of caseous granulomas in various organs, mainly in lungs. M. tuberculosis is known to be a trigger for autoimmune inflamm…
View article: Diagnosis of Latent Tuberculosis Infection in Personnel of Various Institutions and Determination of the Risk Group for Tuberculosis
Diagnosis of Latent Tuberculosis Infection in Personnel of Various Institutions and Determination of the Risk Group for Tuberculosis Open
Early diagnosis of tuberculosis remains essential for the prevention of the disease and control of its incidence. The diagnosis of latent tuberculosis infection (LTBI) has significantly improved over the last years due to the use of new im…
View article: AUTOIMMUNE ORIGIN OF SARCOIDOSIS: DETERMINATION OF SPECIFIC IMMUNE COMPLEXES IN PATIENTS WITH RESPIRATORY SARCOIDOSIS
AUTOIMMUNE ORIGIN OF SARCOIDOSIS: DETERMINATION OF SPECIFIC IMMUNE COMPLEXES IN PATIENTS WITH RESPIRATORY SARCOIDOSIS Open
The etiology of sarcoidosis is not completely understood. A hypothesis exists about the relationship between sarcoidosis and a complex of pathological autoimmune reactions that occur under the influence of triggering factors. In this study…
View article: Altered peripheral blood Th17 and follicular T-helper subsets in patients with pulmonary tuberculosis
Altered peripheral blood Th17 and follicular T-helper subsets in patients with pulmonary tuberculosis Open
Tuberculosis (TB) is one of the most common infections worldwide. Eradication of an intracellular pathogen M. tuberculosis requires to induce a Th1 response by activating IFNγ-producing tissue macrophages. Along with Th1 cells, various sub…