Yimin Zhu
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View article: Chaihuang Qingfu Pills Protect Against Acute Pancreatitis—Associated Acute Lung Injury Through MMP9-NLRP3-Pyroptosis Pathway
Chaihuang Qingfu Pills Protect Against Acute Pancreatitis—Associated Acute Lung Injury Through MMP9-NLRP3-Pyroptosis Pathway Open
CHQF exerted a protective role in SAP-ALI by inhibiting macrophage pyroptosis through the MMP9-NLRP3 pathway, providing a novel therapeutic strategy for SAP-ALI.
View article: Puerarin ameliorates colitis by direct suppression of macrophage M1 polarization in DSS mice
Puerarin ameliorates colitis by direct suppression of macrophage M1 polarization in DSS mice Open
Our data suggest that the pathogenesis of DSS colitis is mediated by host cellular responses to toxic foreign molecules and the gut microbiota, and targeting specific cell populations, such as macrophages, with puerarin holds potential the…
View article: Zygotic Splicing Activation of the Transcriptome is a Crucial Aspect of Maternal‐to‐Zygotic Transition and Required for the Conversion from Totipotency to Pluripotency
Zygotic Splicing Activation of the Transcriptome is a Crucial Aspect of Maternal‐to‐Zygotic Transition and Required for the Conversion from Totipotency to Pluripotency Open
During maternal‐to‐zygotic transition (MZT) in the embryo, mRNA undergoes complex post‐transcriptional regulatory processes. However, it is unclear whether and how alternative splicing plays a functional role in MZT. By analyzing transcrip…
View article: Cullin‐associated and neddylation‐dissociated 1 regulate reprogramming of lipid metabolism through SKP1‐Cullin‐1‐F‐box<sup>FBXO11</sup>‐mediated heterogeneous nuclear ribonucleoprotein A2/B1 ubiquitination and promote hepatocellular carcinoma
Cullin‐associated and neddylation‐dissociated 1 regulate reprogramming of lipid metabolism through SKP1‐Cullin‐1‐F‐box<sup>FBXO11</sup>‐mediated heterogeneous nuclear ribonucleoprotein A2/B1 ubiquitination and promote hepatocellular carcinoma Open
Background Enhanced de novo lipogenesis is essential for hepatocellular carcinoma (HCC). Abnormally high cullin‐associated and neddylation‐dissociated 1 (CAND1) expression is associated with poor clinical prognosis in HCC. The SKP1‐Cullin‐…
View article: Loss of function NOG variant causes radiounlar synostosis
Loss of function NOG variant causes radiounlar synostosis Open
Background: Several NOG variants have been reported in patients with congenital joint fusion syndromes. Radioulnar synostosis (RUS) is the most common joint malformation of upper limbs. This study aims to explore NOG mutations in RUS. Meth…
View article: Dissecting the effects of paraquat-induced pulmonary injury in rats using UPLC-Q-TOF-MS/MS-based metabonomics
Dissecting the effects of paraquat-induced pulmonary injury in rats using UPLC-Q-TOF-MS/MS-based metabonomics Open
Objective Paraquat (PQ) is a toxic compound that selectively accumulates in the lungs, inducing severe pulmonary inflammation and fibrosis. However, data on the metabolomic changes induced by the PQ remain scant. This study aimed to determ…
View article: Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis
Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis Open
Importance Previous research has suggested that Xuebijing injection (XBJ), an herbal-based intravenous preparation, may reduce mortality among patients with sepsis. Objective To determine the effect of XBJ vs placebo on 28-day mortality am…
View article: Epidemiology and clinical characteristics of pediatric sepsis in PICUs of China: A national cross‐sectional study
Epidemiology and clinical characteristics of pediatric sepsis in PICUs of China: A national cross‐sectional study Open
Sepsis, defined as life-threatening organ failure induced by a dysregulated host response to infection, is a serious public health problem globally.1 Sepsis-related deaths represented 19.7% of deaths globally in 2017, accounting for nearly…
View article: Genome stability‑related lncRNA ZFPM2‑AS1 promotes tumor progression via miR‑3065‑5p/XRCC4 in hepatocellular carcinoma
Genome stability‑related lncRNA ZFPM2‑AS1 promotes tumor progression via miR‑3065‑5p/XRCC4 in hepatocellular carcinoma Open
Long noncoding RNAs (lncRNAs) have a certain link to genomic stability (GS). However, the regulatory relationship of lncRNAs and GS has not been thoroughly investigated in hepatocellular carcinoma (HCC). In the present study, samples were …
View article: The Genome Stability-Related lncRNA ZFPM2-AS1 Promotes Tumor Progression via miR-3065-5p/XRCC4 in Hepatocellular Carcinoma
The Genome Stability-Related lncRNA ZFPM2-AS1 Promotes Tumor Progression via miR-3065-5p/XRCC4 in Hepatocellular Carcinoma Open
Long noncoding RNAs (lncRNAs) have a certain link to genomic stability (GS). However, the regulatory relationship of lncRNAs and GS has not been thoroughly investigated in hepatocellular carcinoma (HCC). We retrieved the TCGA samples that …
View article: CAND1 drives lipid metabolism and hepatocellular carcinoma progression by regulating FBXO11-mediated hnRNPA2B1 ubiquitination
CAND1 drives lipid metabolism and hepatocellular carcinoma progression by regulating FBXO11-mediated hnRNPA2B1 ubiquitination Open
Background Aberrant lipid metabolism marks one of characteristic features of hepatocellular carcinoma (HCC). Here, we define the function and mechanism of CAND1 in lipid metabolism and progression of HCC in vitro and in vivo, and postulate…
View article: Mutant B3GALT6 in a Multiplex Family: A Dominant Variant Co-Segregated With Moderate Malformations
Mutant B3GALT6 in a Multiplex Family: A Dominant Variant Co-Segregated With Moderate Malformations Open
B3GALT6 is a well-documented disease-related gene. Several B3GALT6 -recessive variants have been reported to cause Ehlers–Danlos syndrome (EDS). To the best of our knowledge, no dominant B3GALT6 variant that causes human disease has been r…
View article: ENDOTHELIAL BIOMARKERS IN PATIENTS RECOVERED FROM COVID-19 ONE YEAR AFTER HOSPITAL DISCHARGE: A CROSS-SECTIONAL STUDY
ENDOTHELIAL BIOMARKERS IN PATIENTS RECOVERED FROM COVID-19 ONE YEAR AFTER HOSPITAL DISCHARGE: A CROSS-SECTIONAL STUDY Open
Background: COVID-19 is characterized by endothelial dysfunction and is presumed to have long-term cardiovascular sequelae. In this study, we aimed to explore the serum levels of endothelial biomarkers of COVID-19 recovers 1-year after hos…
View article: Elevated Expression of lncRNA MEG3 Induces Endothelial Dysfunction on HUVECs of IVF Born Offspring via Epigenetic Regulation
Elevated Expression of lncRNA MEG3 Induces Endothelial Dysfunction on HUVECs of IVF Born Offspring via Epigenetic Regulation Open
Cardiovascular dysfunction in children born after in vitro fertilization (IVF) has been of great concern, the potential molecular mechanisms for such long-term outcomes are still unknown. Here, we found that systolic blood pressure was a l…
View article: A genotype and phenotype analysis of <i>SMAD6</i> mutant patients with radioulnar synostosis
A genotype and phenotype analysis of <i>SMAD6</i> mutant patients with radioulnar synostosis Open
Background SMAD6 variants have been reported in patients with radioulnar synostosis (RUS). This study aimed to investigate the genotypes and phenotypes for a large cohort of patients with RUS having mutant SMAD6 . Methods Genomic DNA sampl…
View article: Identification of Glycolysis-Related lncRNAs and the Novel lncRNA WAC-AS1 Promotes Glycolysis and Tumor Progression in Hepatocellular Carcinoma
Identification of Glycolysis-Related lncRNAs and the Novel lncRNA WAC-AS1 Promotes Glycolysis and Tumor Progression in Hepatocellular Carcinoma Open
Background High glycolysis efficiency in tumor cells can promote tumor growth. lncRNAs play an important role in the proliferation, metabolism and migration of cancer cells, but their regulation of tumor glycolysis is currently not well re…
View article: Anti‐SARS‐CoV‐2 IgG levels in relation to disease severity of COVID‐19
Anti‐SARS‐CoV‐2 IgG levels in relation to disease severity of COVID‐19 Open
The durability of infection‐induced severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) immunity has crucial implications for reinfection and vaccine effectiveness. However, the relationship between coronavirus disease 2019 (COVID…
View article: Comment on: Cell Adhesion Molecules and Vascular Endothelial Growth Factor at the Systemic and Alveolar Level in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome
Comment on: Cell Adhesion Molecules and Vascular Endothelial Growth Factor at the Systemic and Alveolar Level in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Open
Indeed, at the alveolar level, cell adhesion molecules and VEGF-A may play a specific role in the pathogenesis of CARDS, and future studies should try to determine if and how these mediators mechanistically contribute to COVID-19 disease p…
View article: Xuebijing Injection Affects the Dynamic Change of Metabolism in CLP-Induced Septic Rats
Xuebijing Injection Affects the Dynamic Change of Metabolism in CLP-Induced Septic Rats Open
Xuebijing injection has been widely applied to treat sepsis. However, its roles in the dynamic change of metabolism in sepsis are still unknown. In our study, Gas chromatography-mass spectrometer (GC-MS) combined with multivariate statisti…
View article: Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency
Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency Open
Deficient maturations of mitochondrial transcripts are linked to clinical abnormalities but their pathophysiology remains elusive. Previous investigations showed that pathogenic variants in MTO1 for the biosynthesis of τm5U of tRNAGlu, tRN…