Yumiko Ishii
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View article: Risk Factors for Cement Leakage in Cement-Augmented Pedicle Screw Fixation: A Multicenter Study of 140 Patients and 650 Screws
Risk Factors for Cement Leakage in Cement-Augmented Pedicle Screw Fixation: A Multicenter Study of 140 Patients and 650 Screws Open
Study Design Multicenter retrospective cohort study. Objectives Cement-augmented pedicle screws (CAPS) enhance fixation in osteoporotic patients, but carry a risk of cement leakage (CL), potentially leading to pulmonary embolism and neurol…
View article: Tezepelumab achieves improvement of severe uncontrolled asthma and rhinosinusitis: Case series
Tezepelumab achieves improvement of severe uncontrolled asthma and rhinosinusitis: Case series Open
Tezepelumab, a mAb targeting thymic stromal lymphopoietin (TSLP), reduces exacerbations in severe asthma. Four cases in which patients with severe asthma and chronic rhinosinusitis with nasal polyps showed improvements in both conditions a…
View article: Claudin-3 deficiency inhibits allergic responses in an ovalbumin-induced asthma mouse model
Claudin-3 deficiency inhibits allergic responses in an ovalbumin-induced asthma mouse model Open
View article: Lemborexant‐induced interstitial lung disease: A case report
Lemborexant‐induced interstitial lung disease: A case report Open
We report the first case of drug‐induced interstitial lung disease attributed to lemborexant. A 66‐year‐old man reported to our hospital with the acute onset of cough and breathlessness with ground‐glass opacity on radiological examination…
View article: Regulation of PD-L1 expression in non–small cell lung cancer by interleukin-1β
Regulation of PD-L1 expression in non–small cell lung cancer by interleukin-1β Open
Introduction Programmed cell death–ligand 1 (PD-L1) is a biomarker for prediction of the clinical efficacy of immune checkpoint inhibitors in various cancer types. The role of cytokines in regulation of PD-L1 expression in tumor cells has …
View article: Inhibition of PI3Kδ Differentially Regulates Poly I:C– and Human Metapneumovirus–Induced PD–L1 and PD–L2 Expression in Human Bronchial Epithelial Cells
Inhibition of PI3Kδ Differentially Regulates Poly I:C– and Human Metapneumovirus–Induced PD–L1 and PD–L2 Expression in Human Bronchial Epithelial Cells Open
Bronchial epithelial cells are front sentinels eliciting innate and adaptive immunity to respiratory viral pathogens. Recognition of viral double-stranded RNA induces antiviral interferon (IFN) responses in bronchial epithelial cells. Co-i…
View article: Airway compliance measurements in mouse models of respiratory diseases
Airway compliance measurements in mouse models of respiratory diseases Open
The quantification of airway compliance ( C aw ) is essential to the study of airway alterations in disease models. However, the required measurements of airway pressure and volume are difficult to acquire in mice. We hypothesized that the…
View article: Incense smoke-induced oxidative stress disrupts tight junctions and bronchial epithelial barrier integrity and induces airway hyperresponsiveness in mouse lungs
Incense smoke-induced oxidative stress disrupts tight junctions and bronchial epithelial barrier integrity and induces airway hyperresponsiveness in mouse lungs Open
View article: Radiocesium-bearing microparticles cause a large variation in 137Cs concentration in the aquatic insect, Stenopsyche marmorata, in the Ota River, Fukushima, Japan
Radiocesium-bearing microparticles cause a large variation in 137Cs concentration in the aquatic insect, Stenopsyche marmorata, in the Ota River, Fukushima, Japan Open
<p>Radiocesium-bearing microparticles (CsMPs), which are insoluble, Cs-bearing, silicate glass particles, have been found in terrestrial and freshwater environments after the TEPCO's Fukushima Daiichi Nuclear Power Plant (FDNPP) acci…
View article: Effects of Exposure to Incense Smoke on Airway Function: An in Vitro and in Vivo Study
Effects of Exposure to Incense Smoke on Airway Function: An in Vitro and in Vivo Study Open
Recent clinical studies have suggested that inhalation of incense smoke (IS) may result in impaired lung function and asthma. However, there is little experimental evidence to link IS with airway dysfunction. Using mouse and cell culture m…
View article: Effects of cigarette smoke on barrier function and tight junction proteins in the bronchial epithelium: protective role of cathelicidin LL-37
Effects of cigarette smoke on barrier function and tight junction proteins in the bronchial epithelium: protective role of cathelicidin LL-37 Open
View article: Frequency-dependent airway hyperresponsiveness in a mouse model of emphysema and allergic inflammation
Frequency-dependent airway hyperresponsiveness in a mouse model of emphysema and allergic inflammation Open
Asthma and chronic obstructive pulmonary disease (COPD), chronic airway inflammatory diseases characterized by airflow limitation, have different etiologies and pathophysiologies. Asthma-COPD Overlap (ACO) has recently been used for patien…
View article: Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury
Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury Open
Although pneumococcal infection is a serious problem worldwide and has a high mortality rate, the molecular mechanisms underlying the lethality caused by pneumococcus remain elusive. Here, we show that BLT2, a G protein-coupled receptor fo…
View article: Prevalence of Airflow Limitation Defined by Pre- and Post-Bronchodilator Spirometry in a Community-Based Health Checkup: The Hisayama Study
Prevalence of Airflow Limitation Defined by Pre- and Post-Bronchodilator Spirometry in a Community-Based Health Checkup: The Hisayama Study Open
Spirometry in health checkup may contribute to early diagnosis of chronic obstructive pulmonary disease (COPD) and asthma. Although post-bronchodilator airflow limitation is essential for definite diagnosis of COPD and post-bronchodilator …
View article: Efficacy of advice from healthcare professionals to pregnant women on avoiding constrictive clothing around the trunk: a study protocol for a randomised controlled trial
Efficacy of advice from healthcare professionals to pregnant women on avoiding constrictive clothing around the trunk: a study protocol for a randomised controlled trial Open
Introduction As a component of midwife care, eliminating clothing that constricts the trunk has been shown to markedly elevate the uterine fundus, soften the uterus and abdomen, and reduce the abdominal wall tension in women admitted to ho…