Yumiko Ishizawa
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View article: Similar destabilization of neural dynamics under different general anesthetics
Similar destabilization of neural dynamics under different general anesthetics Open
Different classes of anesthetics can induce unconsciousness despite acting through distinct biological mechanisms. This raises the possibility that they produce a convergent effect on the dynamics or temporal evolution of neural population…
View article: Preoperative Cognitive Optimization and Postoperative Cognitive Outcomes: A Narrative Review
Preoperative Cognitive Optimization and Postoperative Cognitive Outcomes: A Narrative Review Open
Evidence of the effect of preoperative cognitive optimization on postoperative cognitive functions in older adult surgical patients is still limited. Postoperative delirium was reduced by preoperative cognitive training. A limited number o…
View article: Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations
Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations Open
Many anesthetics cause loss of responsiveness despite having diverse underlying molecular and circuit actions. To explore the convergent effects of these drugs, we examined how anesthetic doses of ketamine and dexmedetomidine affected osci…
View article: Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders
Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders Open
Neuroinflammatory disorders preferentially impair the higher cognitive and executive functions of the prefrontal cortex (PFC). This includes such challenging disorders as delirium, perioperative neurocognitive disorder, and the sustained c…
View article: Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network
Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network Open
Delirium is a common, morbid, and costly syndrome that is closely linked to Alzheimer's disease (AD) and AD‐related dementias (ADRD) as a risk factor and outcome. Human studies of delirium have advanced our knowledge of delirium incidence …
View article: Does Preoperative Cognitive Optimization Improve Postoperative Outcomes in the Elderly?
Does Preoperative Cognitive Optimization Improve Postoperative Outcomes in the Elderly? Open
Perioperative neurocognitive disorder (PND) is a growing concern, affecting several million elderly patients each year in the United States, but strategies for its effective prevention have not yet been established. Humeidan et al. recentl…
View article: Neural signatures of α2-Adrenergic agonist-induced unconsciousness and awakening by antagonist
Neural signatures of α2-Adrenergic agonist-induced unconsciousness and awakening by antagonist Open
How the brain dynamics change during anesthetic-induced altered states of consciousness is not completely understood. The α2-adrenergic agonists are unique. They generate unconsciousness selectively through α2-adrenergic receptors and rela…
View article: Author response: Neural signatures of α2-Adrenergic agonist-induced unconsciousness and awakening by antagonist
Author response: Neural signatures of α2-Adrenergic agonist-induced unconsciousness and awakening by antagonist Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract How the brain dynamics change during anest…
View article: Neural Signatures of α2 Adrenergic Agonist-Induced Unconsciousness and Awakening by Antagonist
Neural Signatures of α2 Adrenergic Agonist-Induced Unconsciousness and Awakening by Antagonist Open
How the brain dynamics transition during anesthetic-induced altered states of consciousness is not completely understood. The α 2 adrenergic agonist is a unique anesthetic that generates unconsciousness selectively through α 2 adrenergic r…
View article: Dynamics of Ketamine-induced Loss and Return of Consciousness across Primate Neocortex
Dynamics of Ketamine-induced Loss and Return of Consciousness across Primate Neocortex Open
Background Ketamine is a noncompetitive N -methyl- d -aspartate antagonist and is known for unique electrophysiologic profiles in electroencephalography. However, the mechanisms of ketamine-induced unconsciousness are not clearly understoo…
View article: Dynamics of recovery from anaesthesia-induced unconsciousness across primate neocortex
Dynamics of recovery from anaesthesia-induced unconsciousness across primate neocortex Open
How the brain recovers from general anaesthesia is poorly understood. Neurocognitive problems during anaesthesia recovery are associated with an increase in morbidity and mortality in patients. We studied intracortical neuronal dynamics du…
View article: The neural computations for stimulus presence and modal identity diverge along a shared circuit
The neural computations for stimulus presence and modal identity diverge along a shared circuit Open
The brain is comprised of neural circuits that are able to flexibly represent the complexity of the external world. In accomplishing this feat, one of the first attributes the brain must code for is whether a stimulus is present and subseq…
View article: Leveraging Nonhuman Primate Multisensory Neurons and Circuits in Assessing Consciousness Theory
Leveraging Nonhuman Primate Multisensory Neurons and Circuits in Assessing Consciousness Theory Open
Both the global neuronal workspace (GNW) and integrated information theory (IIT) posit that highly complex and interconnected networks engender perceptual awareness. GNW specifies that activity recruiting frontoparietal networks will elici…
View article: Leveraging non-human primate multisensory neurons and circuits in assessing consciousness theory
Leveraging non-human primate multisensory neurons and circuits in assessing consciousness theory Open
Both the Global Neuronal Workspace (GNW) and Integrated Information Theory (IIT) posit that highly complex and interconnected networks engender perceptual awareness. GNW specifies that activity recruiting fronto-parietal networks will elic…
View article: Dynamics of Propofol-Induced Loss of Consciousness Across Primate Neocortex
Dynamics of Propofol-Induced Loss of Consciousness Across Primate Neocortex Open
How information is processed by the brain during awake and anesthetized states and, crucially, during the transition is not clearly understood. We demonstrate that neuronal dynamics are very different within an interconnecting cortical net…