Yumiko Matsuo
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View article: Adolescent and Current Exercise Habits in Chronic Obstructive Pulmonary Disease: Associations with Body Composition, Physical Activity, and Pulmonary Function
Adolescent and Current Exercise Habits in Chronic Obstructive Pulmonary Disease: Associations with Body Composition, Physical Activity, and Pulmonary Function Open
Exercise during adolescence may promote increased lung volume. However, even after the onset of COPD, especially if the disease has progressed, regular exercise routines can help maintain PA, better body composition, and pulmonary function.
View article: A Phase 1 Study of Ensitrelvir Fumaric Acid Tablets Evaluating the Safety, Pharmacokinetics and Food Effect in Healthy Adult Populations
A Phase 1 Study of Ensitrelvir Fumaric Acid Tablets Evaluating the Safety, Pharmacokinetics and Food Effect in Healthy Adult Populations Open
Japan Registry of Clinical Trials identifier: jRCT2031210202, registered on 16 July 2021.
View article: Pharmacokinetics, safety, and tolerability of single and multiple doses of zuranolone in Japanese and White healthy subjects: A phase 1 clinical trial
Pharmacokinetics, safety, and tolerability of single and multiple doses of zuranolone in Japanese and White healthy subjects: A phase 1 clinical trial Open
Aim This phase 1 study assessed the pharmacokinetics, safety, and tolerability of zuranolone in Japanese and White healthy adults, and Japanese healthy elderly subjects. Methods This single‐center study consisted of three parts. In Part A …
View article: Inspiratory and Expiratory Computed Tomography Imaging Clusters Reflect Functional Characteristics in Chronic Obstructive Pulmonary Disease
Inspiratory and Expiratory Computed Tomography Imaging Clusters Reflect Functional Characteristics in Chronic Obstructive Pulmonary Disease Open
Clusters using DPM parameters may reflect the characteristics of COPD and help understand the pathophysiology of the disease.
View article: Evaluation of the Drug–Drug Interaction Potential of Ensitrelvir Fumaric Acid with Cytochrome P450 3A Substrates in Healthy Japanese Adults
Evaluation of the Drug–Drug Interaction Potential of Ensitrelvir Fumaric Acid with Cytochrome P450 3A Substrates in Healthy Japanese Adults Open
View article: Safety, Tolerability, and Pharmacokinetics of the Novel Antiviral Agent Ensitrelvir Fumaric Acid, a SARS-CoV-2 3CL Protease Inhibitor, in Healthy Adults
Safety, Tolerability, and Pharmacokinetics of the Novel Antiviral Agent Ensitrelvir Fumaric Acid, a SARS-CoV-2 3CL Protease Inhibitor, in Healthy Adults Open
Ensitrelvir is a novel selective inhibitor of the 3C-like protease of SARS-CoV-2, which is essential for viral replication. This phase 1 study of ensitrelvir assessed its safety, tolerability, and pharmacokinetics of single (part 1, n = 50…
View article: Lobe Specific Disease Probability Measure and Pulmonary Function in COPD
Lobe Specific Disease Probability Measure and Pulmonary Function in COPD Open
Background: Disease Probability Measure (DPM) is a useful imaging assessment of gas-trapping and emphysema for chronic obstructive pulmonary disease (COPD).We hypothesized that the association between DPM data per lobe and pulmonary functi…
View article: Population pharmacokinetic and exposure-response analyses of d-amphetamine after administration of lisdexamfetamine dimesylate in Japanese pediatric ADHD patients
Population pharmacokinetic and exposure-response analyses of d-amphetamine after administration of lisdexamfetamine dimesylate in Japanese pediatric ADHD patients Open
Lisdexamfetamine dimesylate, a prodrug of d-amphetamine, has been approved for treatment of attention-deficit/hyperactivity disorder (ADHD). The purposes of this study were constructing a population pharmacokinetic model of d-amphetamine a…
View article: <p>Novel Respiratory Impedance-Based Phenotypes Reflect Different Pathophysiologies in Chronic Obstructive Pulmonary Disease Patients</p>
Novel Respiratory Impedance-Based Phenotypes Reflect Different Pathophysiologies in Chronic Obstructive Pulmonary Disease Patients Open
The FOT-based phenotyping may be useful to assess pathophysiological changes of COPD with CT assessments.
View article: A phase 1, randomized, double‐blind, placebo‐controlled study to evaluate the safety, tolerability, and pharmacokinetics of single and multiple doses of lisdexamfetamine dimesylate in Japanese and Caucasian healthy adult subjects
A phase 1, randomized, double‐blind, placebo‐controlled study to evaluate the safety, tolerability, and pharmacokinetics of single and multiple doses of lisdexamfetamine dimesylate in Japanese and Caucasian healthy adult subjects Open
Aim To assess safety, tolerability, and pharmacokinetics of lisdexamfetamine dimesylate in Japanese and Caucasian healthy adults. Methods A phase 1, double‐blind, randomized, placebo‐controlled, single‐ and multiple‐dose study in Japanese …
View article: Population pharmacokinetic and exposure-response analyses of guanfacine in Japanese pediatric ADHD patients
Population pharmacokinetic and exposure-response analyses of guanfacine in Japanese pediatric ADHD patients Open
Guanfacine hydrochloride extended-release tablet (GXR) is approved for child and adolescent patients with attention-deficit/hyperactivity disorder (ADHD). The aims of this study were to develop a population pharmacokinetic model of guanfac…
View article: Population Pharmacokinetics of Peramivir in Healthy Volunteers and Influenza Patients
Population Pharmacokinetics of Peramivir in Healthy Volunteers and Influenza Patients Open
Peramivir is an intravenous anti-influenza agent that inhibits viral growth by selectively inhibiting neuraminidase in human influenza A and B viruses. To characterize its pharmacokinetics, a population pharmacokinetic analysis of peramivi…
View article: Prediction of Pharmacokinetics and Pharmacodynamics of Doripenem in Pediatric Patients
Prediction of Pharmacokinetics and Pharmacodynamics of Doripenem in Pediatric Patients Open