Yumin Dai
YOU?
Author Swipe
View article: Chitosan scaffolds for bone applications: a detailed review of main types, features and multifaceted uses
Chitosan scaffolds for bone applications: a detailed review of main types, features and multifaceted uses Open
Chitosan scaffolds, derived from the exoskeletons of crustaceans, have become a foundational element in bone tissue engineering, celebrated for their exceptional biocompatibility, biodegradability, and inherent osteoconductive properties. …
View article: Roll‐To‐Roll Production of Smart Dressings for Wound Monitoring
Roll‐To‐Roll Production of Smart Dressings for Wound Monitoring Open
Chronic wounds require real‐time monitoring to assess wound status and prevent complications. While colorimetric sensors provide a user‐friendly, equipment‐free approach with visible feedback, their clinical adoption is hindered by limited…
View article: Toward satisfactory public accessibility: A crowdsourcing approach through online reviews to inclusive urban design
Toward satisfactory public accessibility: A crowdsourcing approach through online reviews to inclusive urban design Open
As urban populations grow, the need for accessible urban design has become urgent. Traditional survey methods for assessing public perceptions of accessibility are often limited in scope. Crowdsourcing via online reviews offers a valuable …
View article: <b>Liver-selective imidazolopyrazine mitochondrial uncoupler SHD865 reverses adiposity and glucose intolerance in mice</b>
<b>Liver-selective imidazolopyrazine mitochondrial uncoupler SHD865 reverses adiposity and glucose intolerance in mice</b> Open
Excess body fat is a risk factor for metabolic diseases and is a leading preventable cause of morbidity and mortality worldwide. There is a strong need to find new treatments that decrease the burden of obesity and lower the risk of obesit…
View article: <b>Liver-selective imidazolopyrazine mitochondrial uncoupler SHD865 reverses adiposity and glucose intolerance in mice</b>
<b>Liver-selective imidazolopyrazine mitochondrial uncoupler SHD865 reverses adiposity and glucose intolerance in mice</b> Open
Excess body fat is a risk factor for metabolic diseases and is a leading preventable cause of morbidity and mortality worldwide. There is a strong need to find new treatments that decrease the burden of obesity and lower the risk of obesit…
View article: Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice
Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice Open
Excess body fat is a risk factor for metabolic diseases and is a leading preventable cause of morbidity and mortality worldwide. There is a strong need to find new treatments that decrease the burden of obesity and lower the risk of obesit…
View article: Quantitative Determination of Water in Organic Liquids by Ambient Mass Spectrometry
Quantitative Determination of Water in Organic Liquids by Ambient Mass Spectrometry Open
This study uses a rapid tandem mass‐spectrometry method to determine water content in complex organic solutions. Emphasis is placed on trace‐water analysis by a fast and accurate alternative to the Karl–Fischer method. In this new method, …
View article: Data from Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance
Data from Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance Open
As a critical signaling node, ERK1/2 are attractive drug targets, particularly in tumors driven by activation of the MAPK pathway. Utility of targeting the MAPK pathway has been demonstrated by clinical responses to inhibitors of MEK1/2 or…
View article: Data from Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance
Data from Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance Open
As a critical signaling node, ERK1/2 are attractive drug targets, particularly in tumors driven by activation of the MAPK pathway. Utility of targeting the MAPK pathway has been demonstrated by clinical responses to inhibitors of MEK1/2 or…
View article: Supplementary Tables and Figures from Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance
Supplementary Tables and Figures from Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance Open
Table S1. Summary of CC-90003 specificity data resulting from cellular and biochemical assays. Table S2. Response of BRAF mutant cell lines to CC-90003 ERK 1/2 inhibition. Table S3. Summary of dose finding efficacy study in HCT-116 xenogra…
View article: Supplementary Tables and Figures from Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance
Supplementary Tables and Figures from Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance Open
Table S1. Summary of CC-90003 specificity data resulting from cellular and biochemical assays. Table S2. Response of BRAF mutant cell lines to CC-90003 ERK 1/2 inhibition. Table S3. Summary of dose finding efficacy study in HCT-116 xenogra…
View article: Supplementary figure legends and supplementary methods from Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance
Supplementary figure legends and supplementary methods from Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance Open
Supplementary figure legends and supplementary materials and methods
View article: Supplementary figure legends and supplementary methods from Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance
Supplementary figure legends and supplementary methods from Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance Open
Supplementary figure legends and supplementary materials and methods
View article: Data from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers
Data from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers Open
Purpose: PIM kinases have been shown to act as oncogenes in mice, with each family member being able to drive progression of hematologic cancers. Consistent with this, we found that PIMs are highly expressed in human hematologic cancers an…
View article: Supplementary Figures 1 - 5, Tables 1 - 2 from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers
Supplementary Figures 1 - 5, Tables 1 - 2 from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers Open
PDF file - 346KB, Supplementary Figure 1. Normal vs. Tumor expression of PIM kinases mRNA across 17 tissue types. Supplementary Figure 2. Comparison of LGB321 on-target activity vs. Previously described pan-PIM inhibitor. Supplementary Fig…
View article: Data from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers
Data from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers Open
Purpose: PIM kinases have been shown to act as oncogenes in mice, with each family member being able to drive progression of hematologic cancers. Consistent with this, we found that PIMs are highly expressed in human hematologic cancers an…
View article: Supplementary Figures 1 - 5, Tables 1 - 2 from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers
Supplementary Figures 1 - 5, Tables 1 - 2 from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers Open
PDF file - 346KB, Supplementary Figure 1. Normal vs. Tumor expression of PIM kinases mRNA across 17 tissue types. Supplementary Figure 2. Comparison of LGB321 on-target activity vs. Previously described pan-PIM inhibitor. Supplementary Fig…
View article: Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care
Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care Open
Continuous monitoring of intraocular pressure, particularly during sleep, remains a grand challenge in glaucoma care. Here we introduce a class of smart soft contact lenses, enabling the continuous 24-hour monitoring of intraocular pressur…
View article: Synthesis and Structure–Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases
Synthesis and Structure–Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases Open
Overexpression of PIM 1, 2, and 3 kinases is frequently observed in many malignancies. Previously, we discovered a potent and selective pan-PIM kinase inhibitor, compound 2, currently in phase I clinical trials. In this work, we were inter…
View article: [1,2,5]Oxadiazolo[3,4-<i>b</i>]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis
[1,2,5]Oxadiazolo[3,4-<i>b</i>]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis Open
Small molecule mitochondrial uncouplers are emerging as a new class of molecules for the treatment of nonalcoholic steatohepatitis. We utilized BAM15, a potent protonophore that uncouples the mitochondria without depolarizing the plasma me…
View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: Anibamine and Its Analogues: Potent Antiplasmodial Agents from <i>Aniba citrifolia</i>
Anibamine and Its Analogues: Potent Antiplasmodial Agents from <i>Aniba citrifolia</i> Open
In our continuing search for novel natural products with antiplasmodial activity, an extract of Aniba citrifolia was found to have good activity, with an IC50 value less than 1.25 μg/mL. After bioassay-directed fractionation, the known ind…
View article: Update on liquid biopsy in clinical management of non-small cell lung cancer
Update on liquid biopsy in clinical management of non-small cell lung cancer Open
Zhen Wu, Zhen Yang, Yu Dai, Qiang Zhu, Liang-An ChenRespiratory Department, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaAbstract: Lung cancer, a leading cause of cancer-related mortality, has a low rate of early …
View article: Discovery of a Branched Peptide That Recognizes the Rev Response Element (RRE) RNA and Blocks HIV-1 Replication
Discovery of a Branched Peptide That Recognizes the Rev Response Element (RRE) RNA and Blocks HIV-1 Replication Open
We synthesized and screened a unique 46 656-member library composed of unnatural amino acids that revealed several hits against RRE IIB RNA. Among the hit peptides identified, peptide 4A5 was found to be selective against competitor RNAs a…
View article: Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance
Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance Open
As a critical signaling node, ERK1/2 are attractive drug targets, particularly in tumors driven by activation of the MAPK pathway. Utility of targeting the MAPK pathway has been demonstrated by clinical responses to inhibitors of MEK1/2 or…
View article: Novel Bioactive Natural Products Isolated from Madagascar Plants and Marine Organisms (2009–2017)
Novel Bioactive Natural Products Isolated from Madagascar Plants and Marine Organisms (2009–2017) Open
Madagascar's rain forests and tropical dry forests are home to numerous endemic plant species and the island is considered a biodiversity hotspot. About 80% of the Madagascan (Malagasy) population relies on traditional medicines that have …
View article: Antiplasmodial Sesquiterpenoid Lactones from<i>Trichospira verticillata</i>: Structure Elucidation by Spectroscopic Methods and Comparison of Experimental and Calculated ECD Data
Antiplasmodial Sesquiterpenoid Lactones from<i>Trichospira verticillata</i>: Structure Elucidation by Spectroscopic Methods and Comparison of Experimental and Calculated ECD Data Open
A dichloromethane extract of Trichospira verticillata from the Natural Products Discovery Institute was discovered to have good antiplasmodial activity (IC50 ∼5 μg/mL). After purification by liquid-liquid partition and C18 reversed-phase H…