Yunkou Wu
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View article: Bradykinin measurement by liquid chromatography tandem mass spectrometry in subjects with hereditary angioedema enhanced by cold activation
Bradykinin measurement by liquid chromatography tandem mass spectrometry in subjects with hereditary angioedema enhanced by cold activation Open
Whole blood under cold activation showed striking elevation of BK levels in subjects with HAE-C1INH, while minimally affecting healthy volunteers. The assay has been assessed for accuracy, precision and stability. It may serve as a reliabl…
View article: Exploring the potential of the novel imidazole‐4,5‐dicarboxyamide chemical exchange saturation transfer scaffold for pH and perfusion imaging
Exploring the potential of the novel imidazole‐4,5‐dicarboxyamide chemical exchange saturation transfer scaffold for pH and perfusion imaging Open
Here, we describe and assess the potential of 14 newly synthesized imidazole‐4,5‐dicarboxyamides ( I45DCs ) for pH and perfusion imaging. A number of these aromatic compounds possess large labile proton chemical shifts (up to 7.7 ppm from …
View article: First-in-human use of 11C-CPPC with positron emission tomography for imaging the macrophage colony-stimulating factor 1 receptor
First-in-human use of 11C-CPPC with positron emission tomography for imaging the macrophage colony-stimulating factor 1 receptor Open
Purpose Study of the contribution of microglia to onset and course of several neuropsychiatric conditions is challenged by the fact that these resident immune cells often take on different phenotypes and functions outside the living brain.…
View article: First-in-human use of 11C-CPPC with positron emission tomography for imaging the macrophage colony stimulating factor 1 receptor
First-in-human use of 11C-CPPC with positron emission tomography for imaging the macrophage colony stimulating factor 1 receptor Open
Purpose: Study of the contribution of microglia to onset and course of several neuropsychiatric conditions is challenged by the fact that these resident immune cells often take on different phenotypes and functions outside the intact livin…
View article: PET Imaging of the cannabinoid receptor type 2 in humans using [11C]MDTC
PET Imaging of the cannabinoid receptor type 2 in humans using [11C]MDTC Open
Purpose: We report findings from the first-in-human study of [ 11 C]MDTC, a radiotracer developed to image the cannabinoid receptor type 2 (CB2R) with positron emission tomography (PET). Methods: Ten healthy adults were imaged according to…
View article: Amino Acid‐Derived Sensors for Specific Zn<sup>2+</sup> Detection Using Hyperpolarized <sup>13</sup>C Magnetic Resonance Spectroscopy
Amino Acid‐Derived Sensors for Specific Zn<sup>2+</sup> Detection Using Hyperpolarized <sup>13</sup>C Magnetic Resonance Spectroscopy Open
Alterations in Zn 2+ concentration are seen in normal tissues and in disease states, and for this reason imaging of Zn 2+ is an area of active investigation. Herein, enriched [1‐ 13 C]cysteine and [1‐ 13 C 2 ]iminodiacetic acid were develo…
View article: PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)
PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R) Open
Significance [ 11 C]CPPC [5-cyano- N -(4-(4-[ 11 C]methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide] is a PET radiotracer specific for CSF1R, a microglia-specific marker. This compound can be used as a noninvasive tool fo…
View article: Lanthanide‐Based <i>T<sub>2ex</sub></i> and CEST Complexes Provide Insights into the Design of pH Sensitive MRI Agents
Lanthanide‐Based <i>T<sub>2ex</sub></i> and CEST Complexes Provide Insights into the Design of pH Sensitive MRI Agents Open
The CEST and T 1 / T 2 relaxation properties of a series of Eu 3+ and Dy 3+ DOTA‐tetraamide complexes with four appended primary amine groups are measured as a function of pH. The CEST signals in the Eu 3+ complexes show a strong CEST sign…
View article: Imaging Extracellular Lactate In Vitro and In Vivo Using CEST MRI and a Paramagnetic Shift Reagent
Imaging Extracellular Lactate In Vitro and In Vivo Using CEST MRI and a Paramagnetic Shift Reagent Open
Overproduction of lactate is a hallmark of cancer, yet a method to quantitatively measure lactate production by cancer cells is not straight‐forward. Chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) can potential…