Yun Leng
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View article: A multi-omic analysis reveals a predictive value of tertiary lymphoid structures in improving the prognosis of colorectal cancer patients with BRAF mutation
A multi-omic analysis reveals a predictive value of tertiary lymphoid structures in improving the prognosis of colorectal cancer patients with BRAF mutation Open
Background BRAF mutations are prevalent in colorectal cancer (CRC) and generally confer a poor prognosis. Tertiary lymphoid structures (TLS), a critical component of the tumor immune microenvironment, exist in various malignancies and ofte…
View article: Emergence of extensively drug-resistant Salmonella Kentucky ST198 in Southwest China
Emergence of extensively drug-resistant Salmonella Kentucky ST198 in Southwest China Open
These findings highlight the emergence of extensively drug-resistant Salmonella Kentucky ST198 in Southwest China and underscore the urgent need for ongoing surveillance in this region due to its significant public health impact.
View article: Comparative genomic and antimicrobial resistance profiles of Salmonella strains isolated from pork and human sources in Sichuan, China
Comparative genomic and antimicrobial resistance profiles of Salmonella strains isolated from pork and human sources in Sichuan, China Open
Introduction Salmonella detection in retail pork is increasing, yet studies on its antimicrobial resistance (AMR) profiles and genomic characteristics remain limited. Moreover, it is still unclear whether certain Salmonella sequence types …
View article: High Efficacy of Adding G-CSF to Venetoclax Plus Azacitidine As Front-Line Treatment in Previously Untreated Acute Myeloid Leukaemia:a Pilot Study
High Efficacy of Adding G-CSF to Venetoclax Plus Azacitidine As Front-Line Treatment in Previously Untreated Acute Myeloid Leukaemia:a Pilot Study Open
Background: Venetoclax plus azacitidine (VA regimen) is recommended for treatment-naive patients with acute myeloid leukaemia (AML) who are unfit for intensive chemotherapy. However, the composite complete remission rate after one cycle of…
View article: Paired comparisons of venetoclax concentration in cerebrospinal fluid, bone marrow, and plasma in acute leukemia patients
Paired comparisons of venetoclax concentration in cerebrospinal fluid, bone marrow, and plasma in acute leukemia patients Open
Venetoclax, a small molecule inhibitor of BCL‐2, has demonstrated efficacy in treating acute leukemias and has been recommended as one of the first‐line anti‐leukemia therapies. Although venetoclax has been suggested to probably possess th…
View article: Gallic acid ameliorates colitis by modulating the Treg/Th17 balance <i>via</i> microbiota-derived secondary bile acids
Gallic acid ameliorates colitis by modulating the Treg/Th17 balance <i>via</i> microbiota-derived secondary bile acids Open
Gallic acid (GA), a plant phenol ubiquitously present in fruits and vegetables, has demonstrated efficacy in ameliorating ulcerative colitis (UC). Despite previous reports, the precise mechanism of GA's therapeutic action remains elusive. …
View article: [Comparison of etoposide combined with G-CSF and cyclophosphamide combined with G-CSF in the mobilization of autologous peripheral blood stem cells in patients with multiple myeloma].
[Comparison of etoposide combined with G-CSF and cyclophosphamide combined with G-CSF in the mobilization of autologous peripheral blood stem cells in patients with multiple myeloma]. Open
Objective: The effect and safety of etoposide combined with G-CSF were compared with those of cyclophosphamide combined with G-CSF in autologous peripheral blood mobilization in patients with multiple myeloma (MM) . Methods: Patients with …
View article: The complete mitochondrial genome and phylogenetic analysis of <i>Anabarilius duoyiheensis</i> Li, Mao & Lu, 2002 (Cypriniformes: Xenocyprididae)
The complete mitochondrial genome and phylogenetic analysis of <i>Anabarilius duoyiheensis</i> Li, Mao & Lu, 2002 (Cypriniformes: Xenocyprididae) Open
Anabarilius duoyiheensis is a native and rare fish in Yunnan. In this study, the complete mitochondrial genome of A. duoyiheensis was sequenced and published for a total of 16,614 bp, including 13 protein-coding genes, 22 transfer RNAs, tw…
View article: Characteristics and Risk Factors of Ultra-High-Risk Patients with Newly Diagnosed Multiple Myeloma
Characteristics and Risk Factors of Ultra-High-Risk Patients with Newly Diagnosed Multiple Myeloma Open
Objective: To investigate the clinical characteristics and risk factors of ultra-high-risk (UHR) patients with newly diagnosed multiple myeloma (MM). Methods: We screened UHR patients with a survival of less than 24 months and we selected …
View article: Prognostic value of t(4;14) translocation in newly diagnosed multiple myeloma patients in novel agent era
Prognostic value of t(4;14) translocation in newly diagnosed multiple myeloma patients in novel agent era Open
These results demonstrated that t(4; 14) alone may be not a poor prognostic factor patients with newly diagnosed MM in the novel agent era.
View article: The complete mitochondrial genome and phylogenetic analysis of <i>Anabarilius duoyiheensis</i> Li, Mao & Lu, 2002 (Cypriniformes: Xenocyprididae)
The complete mitochondrial genome and phylogenetic analysis of <i>Anabarilius duoyiheensis</i> Li, Mao & Lu, 2002 (Cypriniformes: Xenocyprididae) Open
Anabarilius duoyiheensis is a native and rare fish in Yunnan. In this study, the complete mitochondrial genome of A. duoyiheensis was sequenced and published for a total of 16,614 bp, including 13 protein-coding genes, 22 transfer RNAs, tw…
View article: Low Barthel index score is a poor prognostic factor for newly diagnosed multiple myeloma patients
Low Barthel index score is a poor prognostic factor for newly diagnosed multiple myeloma patients Open
Background: The basic activities of daily life may affect the prognosis of multiple myeloma (MM) patients and the Barthel index (BI) is currently the most widely used tool to evaluate basic activities of daily life, but few studies have ev…
View article: Development and validation of a new risk assessment model for immunomodulatory drug- associated venous thrombosis among Chinese patients with multiple myeloma
Development and validation of a new risk assessment model for immunomodulatory drug- associated venous thrombosis among Chinese patients with multiple myeloma Open
Background Venous thromboembolism (VTE) is a serious complication that can occur in individuals with multiple myeloma (MM) receiving immunomodulatory drugs (IMiDs). There is no available standard clinical model for predicting VTE in the Ch…
View article: Newly diagnosed multiple myeloma patients with CD56 expression benefit more from autologous stem cell transplantation
Newly diagnosed multiple myeloma patients with CD56 expression benefit more from autologous stem cell transplantation Open
Background Several studies showed that lack of CD56 expression was a poor prognostic factor for patients with newly diagnosed multiple myeloma (NDMM). However, other studies were not able to confirm the prognostic value of CD56 in NDMM. Th…
View article: Mechanisms underlying synergism between circularized tumor necrosis factor‐related apoptosis inducing ligand and bortezomib in bortezomib‐sensitive or ‐resistant myeloma cells
Mechanisms underlying synergism between circularized tumor necrosis factor‐related apoptosis inducing ligand and bortezomib in bortezomib‐sensitive or ‐resistant myeloma cells Open
Mechanisms underlying interactions between a novel, clinically relevant circularized tumor necrosis factor‐related apoptosis inducing ligand (TRAIL) agonist, circularly permuted TRAIL (CPT) have been examined in multiple myeloma (MM) cells…
View article: Ghrelin enhances cisplatin sensitivity in HO-8910 PM human ovarian cancer cells
Ghrelin enhances cisplatin sensitivity in HO-8910 PM human ovarian cancer cells Open
Background Resistance to platinum-based chemotherapy is one of the crucial problems in ovarian cancer treatment. Ghrelin, a widely distributed peptide hormone, participates in a series of cancer progression. The aim of this study is to det…
View article: The complete mitochondrial genome of <i>Silurus grahami</i> Regan, 1907 (Siluriformes: Siluridae), a native catfish in Fuxian Lake
The complete mitochondrial genome of <i>Silurus grahami</i> Regan, 1907 (Siluriformes: Siluridae), a native catfish in Fuxian Lake Open
In this study, the whole mitochondrial genome of Silurus grahami was reported to be 16,518 bp in length, including 13 protein-coding genes, two ribosomal RNAs, 22 transfer RNAs, and one control region. The phylogenetic analysis based on 13…
View article: The IAP antagonist birinapant potentiates bortezomib anti-myeloma activity in vitro and in vivo
The IAP antagonist birinapant potentiates bortezomib anti-myeloma activity in vitro and in vivo Open
Our data suggest that birinapant and bortezomib interact synergistically in MM cells, including those resistant to bortezomib, through inactivation of the non-canonical NF-κB and activation of the extrinsic apoptotic pathway both in vitro …
View article: Prevalence of HIV-1 Drug Resistance among Patients with Antiretroviral Therapy Failure in Sichuan, China, 2010-2016
Prevalence of HIV-1 Drug Resistance among Patients with Antiretroviral Therapy Failure in Sichuan, China, 2010-2016 Open
Antiretroviral therapy (ART) has been introduced recently and has significantly impacted morbidity and mortality, but can also engender drug resistance. To identify the prevalence of HIV-1 drug resistance (HIVDR) among patients with antire…
View article: Additional file 2: of The IAP antagonist birinapant potentiates bortezomib anti-myeloma activity in vitro and in vivo
Additional file 2: of The IAP antagonist birinapant potentiates bortezomib anti-myeloma activity in vitro and in vivo Open
Table S1. Analogous studies were performed on 43 primary MM samples. (XLSX 11 kb)
View article: Multi‐technical analysis on the antioxidative capacity and total phenol contents of 94 traditional Chinese dietary medicinal herbs
Multi‐technical analysis on the antioxidative capacity and total phenol contents of 94 traditional Chinese dietary medicinal herbs Open
Dietary medicinal herbs ( DMH s) are superior reservoirs for natural antioxidants and safe for long‐term consumption. Chinese government recently announced an official list of traditional Chinese DMH s to support civil health promotion. Ho…
View article: Recombinant human thrombopoietin improves the efficacy of intermediate-dose cyclophosphamide plus granulocyte colony-stimulating factor in mobilizing peripheral blood stem cells in patients with multiple myeloma
Recombinant human thrombopoietin improves the efficacy of intermediate-dose cyclophosphamide plus granulocyte colony-stimulating factor in mobilizing peripheral blood stem cells in patients with multiple myeloma Open
The combination of intermediate-dose cyclophosphamide (ID-CTX) and granulocyte colony-stimulating factor (G-CSF) fails to mobilize peripheral blood stem cells (PBSCs) in approximately 20% of treated patients with multiple myeloma (MM).In t…
View article: Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma
Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma Open
The role of the positive RNA Pol II regulator, P-TEFb (positive transcription elongation factor b), in maintenance of the anti-apoptotic protein Mcl-1 and bortezomib (btz) resistance was investigated in human multiple myeloma (MM) cells. M…
View article: Arsenic trioxide potentiates sensitivity of multiple myeloma cells to lenalidomide by upregulating cereblon expression levels
Arsenic trioxide potentiates sensitivity of multiple myeloma cells to lenalidomide by upregulating cereblon expression levels Open
The mechanism of the anti-myeloma effect of the immunomodulatory drug lenalidomide relies upon the binding of lenalidomide or an analogue to cereblon (CRBN) ubiquitin ligase, which inhibits it and results in the degradation of Ikaros-famil…
View article: Human iPSC-MSC-Derived Xenografts Modulate Immune Responses by Inhibiting the Cleavage of Caspases
Human iPSC-MSC-Derived Xenografts Modulate Immune Responses by Inhibiting the Cleavage of Caspases Open
Mesenchymal stem cells (MSCs) negatively modulate immune properties. Induced pluripotent stem cells (iPSCs)-derived MSCs are alternative source of MSCs. However, the effects of iPSC-MSCs on T cells phenotypes in vivo remain unclear. We est…