Cheng Peng
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View article: Catalyst-Controlled Divergent Synthesis of Bicyclo[2.1.1]hexanes and Cyclobutenes: The Unique Effect of Au(I)
Catalyst-Controlled Divergent Synthesis of Bicyclo[2.1.1]hexanes and Cyclobutenes: The Unique Effect of Au(I) Open
Catalyst-controlled chemodivergent synthesis is a powerful strategy for exploring the chemical space. We report a Cu-(I)/Au-(I)-catalyzed chemodivergent reaction of bicyclo[1.1.0]-butane amides with azadienes, enabling access to two valuab…
View article: Effect of modified subcostal anterior quadratus lumborum block on perioperative opioid consumption in patients undergoing gynecologic endoscopic surgery
Effect of modified subcostal anterior quadratus lumborum block on perioperative opioid consumption in patients undergoing gynecologic endoscopic surgery Open
Objective To assess the impact of ultrasound-guided multimodal anesthesia utilizing a modified subcostal anterior quadratus lumborum block (QLB) in conjunction with general anesthesia on perioperative opioid consumption among patients unde…
View article: Development and application of a triplex real-time PCR method for the detection of <i>Lawsonia intracellularis</i> , <i>Brachyspira hyodysenteriae</i> , and <i>Clostridium perfringens</i>
Development and application of a triplex real-time PCR method for the detection of <i>Lawsonia intracellularis</i> , <i>Brachyspira hyodysenteriae</i> , and <i>Clostridium perfringens</i> Open
Lawsonia intracellularis (LI), Brachyspira hyodysenteriae (Bhy), and Clostridium perfringens (Cp) are three common swine enteric pathogens widespread worldwide, leading to huge economic losses to the pig industry. LI, Bhy, and Cp are co-in…
View article: Nitroreductase-mediated cell ablation uncovers the pivotal role of ependymoglial cells in entire cortex regeneration in axolotls
Nitroreductase-mediated cell ablation uncovers the pivotal role of ependymoglial cells in entire cortex regeneration in axolotls Open
Developing precise targeted cell ablation in the axolotl (Ambystoma mexicanum) is crucial for elucidating the roles or interactions of specific cell types in regeneration and modeling diseases. Here we establish a Nitroreductase (NTR)-base…
View article: Synergistic Recruitment of Symbiotic Fungi by Potting and Scleroderma bovista Inoculation Suppresses Pathogens in Hazel Rhizosphere Microbiomes
Synergistic Recruitment of Symbiotic Fungi by Potting and Scleroderma bovista Inoculation Suppresses Pathogens in Hazel Rhizosphere Microbiomes Open
This study explored how potted treatments (with and without Scleroderma bovista inoculation) shape rhizosphere microbial diversity in hazel across five soils using split-root cultivation. Three treatments (control, split-root, split-root w…
View article: Co-design protein sequence and structure in discrete space via generative flow
Co-design protein sequence and structure in discrete space via generative flow Open
Motivation Generative models have demonstrated considerable promise in de novo protein design. Traditional approaches typically focus on either sequence or structure in isolation, limiting the capacity to explore the intricate sequence–str…
View article: Combination of Sodium Butyrate and Immunotherapy in Glioma: regulation of immunologically hot and cold tumors via gut microbiota and metabolites
Combination of Sodium Butyrate and Immunotherapy in Glioma: regulation of immunologically hot and cold tumors via gut microbiota and metabolites Open
Background Recent studies have highlighted the importance of cross-talk along the gut-brain axis in regulating inflammatory nociception, inflammatory responses, and immune homeostasis. The gut microbiota, particularly its bacterial composi…
View article: Angle-constrained distributed formation control with disturbance rejection
Angle-constrained distributed formation control with disturbance rejection Open
View article: Coadministration of ribavirin and arenaviral entry inhibitor LHF-535 enhances antiviral benefit against authentic lassa virus
Coadministration of ribavirin and arenaviral entry inhibitor LHF-535 enhances antiviral benefit against authentic lassa virus Open
View article: Fed-DFA: Federated Distillation for Heterogeneous Model Fusion Through the Adversarial Lens
Fed-DFA: Federated Distillation for Heterogeneous Model Fusion Through the Adversarial Lens Open
Most of the federated learning techniques are limited to homogeneous model fusion. With the rapid growth of smart applications on resource-constrained edge devices, it becomes a barrier to accommodate their heterogeneous computing power an…
View article: Symptom networks and working memory in schizophrenia: a multi-methodological cross-sectional study from phenotype to endophenotype
Symptom networks and working memory in schizophrenia: a multi-methodological cross-sectional study from phenotype to endophenotype Open
View article: Catalyst-controlled regiodivergence and stereodivergence in formal cross-[4+2] cycloadditions: The unique effect of bismuth(III)
Catalyst-controlled regiodivergence and stereodivergence in formal cross-[4+2] cycloadditions: The unique effect of bismuth(III) Open
The [4+2] cycloaddition is crucial for constructing six-membered rings in pharmaceuticals and natural products. Cross-[4+2] cycloadditions offer greater product diversity than traditional diene-dienophile reactions due to multiple possible…
View article: A Novel Quantification Method for Gene-Edited Animal Detection Based on ddPCR
A Novel Quantification Method for Gene-Edited Animal Detection Based on ddPCR Open
As gene-editing technologies continue to evolve, gene-edited products are making significant strides. These products have already been commercialized in the United States and Japan, prompting global attention to their safety and regulatory…
View article: Comparative analysis of the effects of gender on lower extremity kinematics following a 5 km running time trial in collegiate recreational runners
Comparative analysis of the effects of gender on lower extremity kinematics following a 5 km running time trial in collegiate recreational runners Open
View article: Dual‐Responsive Multi‐Functional Silica Nanoparticles With Repaired Mitochondrial Functions for Efficient Alleviation of Spinal Cord Injury
Dual‐Responsive Multi‐Functional Silica Nanoparticles With Repaired Mitochondrial Functions for Efficient Alleviation of Spinal Cord Injury Open
Preserved/rescued mitochondrial functions have a significant effect on maintaining neurogenesis, axonal carriage, and synaptic plasticity following spinal cord injury (SCI). We fabricated an ingenious redox‐responsive strategy for commande…
View article: Epigenome and transcriptome changes in <i>KMT2D</i>-related Kabuki syndrome Type 1 iPSCs, neuronal progenitors and cortical neurons
Epigenome and transcriptome changes in <i>KMT2D</i>-related Kabuki syndrome Type 1 iPSCs, neuronal progenitors and cortical neurons Open
Kabuki syndrome type 1 (KS1) is a neurodevelopmental disorder caused by loss-of-function variants in KMT2D which encodes a H3K4 methyltransferase. The mechanisms underlying neurodevelopmental problems in KS1 are still largely unknown. Here…
View article: Discovery of viruses and bacteria associated with swine respiratory disease on farms at a nationwide scale in China using metatranscriptomic and metagenomic sequencing
Discovery of viruses and bacteria associated with swine respiratory disease on farms at a nationwide scale in China using metatranscriptomic and metagenomic sequencing Open
Respiratory disease (RD) is a worldwide leading threat to the pig industry, but there is still limited understanding of the pathogens associated with swine RD. In this study, we conducted a nationwide genomic surveillance on identifying vi…
View article: GiantHunter: Accurate detection of giant virus in metagenomic data using reinforcement-learning and Monte Carlo tree search
GiantHunter: Accurate detection of giant virus in metagenomic data using reinforcement-learning and Monte Carlo tree search Open
Motivation: Nucleocytoplasmic large DNA viruses (NCLDVs) are notable for their large genomes and extensive gene repertoires, which contribute to their widespread environmental presence and critical roles in processes such as host metabolic…
View article: Immediate and long-term effects of zero-drop running shoes on lower extremity biomechanics
Immediate and long-term effects of zero-drop running shoes on lower extremity biomechanics Open
Objective The purpose of the study was to investigate the immediate and long-term effects of zero-drop running shoes on lower extremity joint biomechanics. Methods Seven male runners participated in this study (height: 1.74 ± 0.03 m, weigh…
View article: Identification and validation of a T cell receptor targeting KRAS G12V in HLA-A*11:01 pancreatic cancer patients
Identification and validation of a T cell receptor targeting KRAS G12V in HLA-A*11:01 pancreatic cancer patients Open
T cells targeting a KRAS mutation can induce durable tumor regression in some patients with metastatic epithelial cancer. It is unknown whether T cells targeting mutant KRAS that are capable of killing tumor cells can be identified from pe…
View article: Age-related trends in trabecular bone scores and bone mineral density in Chinese men with type 2 diabetes mellitus: a cross-sectional study
Age-related trends in trabecular bone scores and bone mineral density in Chinese men with type 2 diabetes mellitus: a cross-sectional study Open
View article: Predicting high-quality ecologically suitable areas of Astragalus mongholicus Bunge based on secondary metabolites content using Biomod2 model
Predicting high-quality ecologically suitable areas of Astragalus mongholicus Bunge based on secondary metabolites content using Biomod2 model Open
View article: Gallic acid: a dietary metabolite’s therapeutic potential in the management of atherosclerotic cardiovascular disease
Gallic acid: a dietary metabolite’s therapeutic potential in the management of atherosclerotic cardiovascular disease Open
Atherosclerotic cardiovascular disease (ASCVD) causes significant morbidity and mortality globally. Most of the chemicals specifically target certain pathways and minimally impact other diseases associated with ASCVD. Moreover, interaction…
View article: Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020
Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020 Open
RAS proteins, as pivotal signal transduction molecules, are frequently mutated and hyperactivated in various human cancers, closely associated with tumor cell proliferation, survival, and metastasis. Despite extensive research on RAS targe…
View article: The Metabolome Characteristics of Aerobic Endurance Development in Adolescent Male Rowers Using Polarized and Threshold Model: An Original Research
The Metabolome Characteristics of Aerobic Endurance Development in Adolescent Male Rowers Using Polarized and Threshold Model: An Original Research Open
Objective: This study aimed to explore the molecular response mechanisms of differential blood metabolites before and after 8 weeks of threshold and polarized training models using metabolomics technology combined with changes in athletic …
View article: Dynamic Characteristics of Angular Contact Ball Bearings with Mild Defect on Outer Raceway
Dynamic Characteristics of Angular Contact Ball Bearings with Mild Defect on Outer Raceway Open
View article: Integrated Tandem Ultrafiltration Membrane Technology for Separating Polysaccharides from Curcuma Longa: Structure Characterization, Separation Mechanisms, and Protective Effects on Huvecs
Integrated Tandem Ultrafiltration Membrane Technology for Separating Polysaccharides from Curcuma Longa: Structure Characterization, Separation Mechanisms, and Protective Effects on Huvecs Open
View article: New Generation Flat-Plate Oscillating Heat Pipes Characterized by Topological Channel Layouts Applicable for Multi-Heat Source Cooling
New Generation Flat-Plate Oscillating Heat Pipes Characterized by Topological Channel Layouts Applicable for Multi-Heat Source Cooling Open
View article: Structure, Attachment and Transmembrane Internalisation of Peste Des Petits Ruminants Virus
Structure, Attachment and Transmembrane Internalisation of Peste Des Petits Ruminants Virus Open
Peste des petits ruminants virus (PPRV), a single‐stranded negative‐sense RNA virus with an envelope, belongs to the Morbillivirus in the Paramyxoviridae family and is prevalent worldwide. PPRV infection causes fever, stomatitis, diarrhoea…
View article: Spatial transcriptomics in breast cancer: providing insight into tumor heterogeneity and promoting individualized therapy
Spatial transcriptomics in breast cancer: providing insight into tumor heterogeneity and promoting individualized therapy Open
A comprehensive understanding of tumor heterogeneity, tumor microenvironment and the mechanisms of drug resistance is fundamental to advancing breast cancer research. While single-cell RNA sequencing has resolved the issue of “temporal dyn…