Yun‐Wen Chen
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View article: Association between high polygenic risk scores and long-term exposure to air pollution in asthma development: a hospital-based case-control study
Association between high polygenic risk scores and long-term exposure to air pollution in asthma development: a hospital-based case-control study Open
View article: Reduction of Dietary Fat Rescues High-Fat Diet-Induced Depressive Phenotypes and the Associated Hippocampal Astrocytic Deficits in Mice
Reduction of Dietary Fat Rescues High-Fat Diet-Induced Depressive Phenotypes and the Associated Hippocampal Astrocytic Deficits in Mice Open
Background/Objectives: Depression is frequently comorbid with obesity. We previously showed that astrocyte-mediated hyperactive ventral hippocampal glutamatergic afferents to the nucleus accumbens determined the exhibition of depression-li…
View article: Comprehensive Exploration of Bromophenol Derivatives: Promising Antibacterial Agents against SA and MRSA
Comprehensive Exploration of Bromophenol Derivatives: Promising Antibacterial Agents against SA and MRSA Open
The incidence of treatment failure due to multidrug-resistant pathogens elevated over the years; the rate is much higher than new antibiotic drug discovery. Therefore, bromophenol derivatives as potential antibacterial agents on Staphyl…
View article: Dupilumab alleviates pruritus regardless of skin improvement in adults with atopic dermatitis: A cohort study
Dupilumab alleviates pruritus regardless of skin improvement in adults with atopic dermatitis: A cohort study Open
View article: Supplementary Data from <i>A20</i>, <i>ABIN-1/2</i>, and <i>CARD11</i> Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma
Supplementary Data from <i>A20</i>, <i>ABIN-1/2</i>, and <i>CARD11</i> Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma Open
Supplementary Figures S1-S2; Supplementary Tables S1-S2.
View article: Data from <i>A20</i>, <i>ABIN-1/2</i>, and <i>CARD11</i> Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma
Data from <i>A20</i>, <i>ABIN-1/2</i>, and <i>CARD11</i> Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma Open
Purpose: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of aggressive lymphomas with the activated B-cell–like subtype characterized by constitutive NF-κB activation. Activating mutations of CARD11 and inactiv…
View article: Data from <i>A20</i>, <i>ABIN-1/2</i>, and <i>CARD11</i> Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma
Data from <i>A20</i>, <i>ABIN-1/2</i>, and <i>CARD11</i> Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma Open
Purpose: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of aggressive lymphomas with the activated B-cell–like subtype characterized by constitutive NF-κB activation. Activating mutations of CARD11 and inactiv…
View article: Supplementary Data from <i>A20</i>, <i>ABIN-1/2</i>, and <i>CARD11</i> Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma
Supplementary Data from <i>A20</i>, <i>ABIN-1/2</i>, and <i>CARD11</i> Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma Open
Supplementary Figures S1-S2; Supplementary Tables S1-S2.
View article: Geographic distribution of the major clone of extended-spectrum beta-lactamase-producing Escherichia coli infection in a pediatric community in southern Taiwan
Geographic distribution of the major clone of extended-spectrum beta-lactamase-producing Escherichia coli infection in a pediatric community in southern Taiwan Open
ESBL-producing E. coli clones may be more challenging to treat clinically. Most infections were community-acquired, and there appeared to be major pulsotype clones, mainly in urban areas. This reinforces the necessity of environmental surv…
View article: Investigation of changes in ankylosing spondylitis disease activity through 2021 COVID-19 wave in Taiwan by using electronic medical record management system
Investigation of changes in ankylosing spondylitis disease activity through 2021 COVID-19 wave in Taiwan by using electronic medical record management system Open
View article: The Effectiveness of Multidisciplinary Team Huddles in Healthcare Hospital-Based Setting
The Effectiveness of Multidisciplinary Team Huddles in Healthcare Hospital-Based Setting Open
Implementing of multidisciplinary team huddle improved the accountability of issue identification, problem-solving and teamwork enhancement.
View article: High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens
High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens Open
Comorbidity exists between metabolic disorders and depressive syndrome with unclear mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet (HFD) to induce metabolic disorder and depressive phenotypes in mic…
View article: Association Between a History of Dengue Fever and the Risk of Systemic Autoimmune Rheumatic Diseases: A Nationwide, Population-Based Case-Control Study
Association Between a History of Dengue Fever and the Risk of Systemic Autoimmune Rheumatic Diseases: A Nationwide, Population-Based Case-Control Study Open
Purpose: To determine the association between a history of clinically diagnosed dengue infection and the risk of systemic autoimmune rheumatic diseases (SARDs). Methods: Using claims data from the 1997–2013 Taiwanese National Health Insura…
View article: Effects of Distal Mutations on Ligand-Binding Affinity in <i>E. coli</i> Dihydrofolate Reductase
Effects of Distal Mutations on Ligand-Binding Affinity in <i>E. coli</i> Dihydrofolate Reductase Open
Mutations far from the center of chemical activity in dihydrofolate reductase (DHFR) can affect several steps in the catalytic cycle. Mutations at highly conserved positions and the distal distance of the catalytic center (Met-42, Thr-113,…
View article: Association of the Risk of Childhood Asthma at Age 6 With Maternal Allergic or Immune-Mediated Inflammatory Diseases: A Nationwide Population-Based Study
Association of the Risk of Childhood Asthma at Age 6 With Maternal Allergic or Immune-Mediated Inflammatory Diseases: A Nationwide Population-Based Study Open
Objective: This study aimed to assess the associations of the risk of asthma diagnosed in children aged 6 years or younger and having maternal immune-mediated inflammatory diseases (IMIDs), including systemic lupus erythematosus (SLE), sys…
View article: Fluoxetine ameliorates high-fat diet-induced metabolic abnormalities partially via reduced adipose triglyceride lipase-mediated adipocyte lipolysis
Fluoxetine ameliorates high-fat diet-induced metabolic abnormalities partially via reduced adipose triglyceride lipase-mediated adipocyte lipolysis Open
Patients with type 2 diabetes mellitus have more risk to develop depression. Fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI), is drug for mood and anxiety disorders. Previous studies showed that FLX could induce weight lo…
View article: Pioglitazone rescues high-fat diet-induced depression-like phenotypes and hippocampal astrocytic deficits in mice
Pioglitazone rescues high-fat diet-induced depression-like phenotypes and hippocampal astrocytic deficits in mice Open
The prevalence of diabetes is rapidly increasing worldwide and is highly associated with the incidence of depression. Pioglitazone, a Peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, is widely used for treating patients w…
View article: Correlation Between Malpractice Litigation and Legislation Reform in Taiwan Over a 30-Year Period
Correlation Between Malpractice Litigation and Legislation Reform in Taiwan Over a 30-Year Period Open
Medical legislation reform has reduced the risk of malpractice litigation over time.
View article: Application of Supervised Machine Learning to Recognize Competent Level and Mixed Antinuclear Antibody Patterns Based on ICAP International Consensus
Application of Supervised Machine Learning to Recognize Competent Level and Mixed Antinuclear Antibody Patterns Based on ICAP International Consensus Open
Background: Antinuclear antibody pattern recognition is vital for autoimmune disease diagnosis but labor-intensive for manual interpretation. To develop an automated pattern recognition system, we established machine learning models based …
View article: Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli
Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli Open
View article: Hyperglycemia compromises the ischemia-provoked dedifferentiation of cerebral pericytes through p21–SOX2 signaling in high-fat diet-induced murine model
Hyperglycemia compromises the ischemia-provoked dedifferentiation of cerebral pericytes through p21–SOX2 signaling in high-fat diet-induced murine model Open
Aim: Diabetes-related cerebral small vessel disease (CSVD) causes neurological deficits. Patients with diabetes showed pericyte loss as a hallmark of retinopathy. Cerebral pericytes, which densely localize around brain capillaries, are qui…
View article: Loss of EGR-1 uncouples compensatory responses of pancreatic β cells
Loss of EGR-1 uncouples compensatory responses of pancreatic β cells Open
Rationale: Subjects unable to sustain β-cell compensation develop type 2 diabetes. Early growth response-1 protein (EGR-1), implicated in the regulation of cell differentiation, proliferation, and apoptosis, is induced by diverse me…
View article: Author Correction: STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion
Author Correction: STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Elevated Hedgehog-Interacting Protein Levels in Subjects with Prediabetes and Type 2 Diabetes
Elevated Hedgehog-Interacting Protein Levels in Subjects with Prediabetes and Type 2 Diabetes Open
Background: The prevalence of diabetes is rapidly increasing worldwide and is highly associated with the incidence of cancers. In order to prevent diabetes, early diagnosis of prediabetes is important. However, biomarkers for prediabetes d…
View article: Protein Glycation by Glyoxal Promotes Amyloid Formation by Islet Amyloid Polypeptide
Protein Glycation by Glyoxal Promotes Amyloid Formation by Islet Amyloid Polypeptide Open
View article: Quantitative Measurement of &#947;-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms Open
We have developed a pair of cell-based reporter gene assays to quantitatively measure γ-secretase cleavage of distinct substrates. This manuscript describes procedures that may be used to monitor γ-secretase-mediated cleavage of either APP…
View article: Effects of free fatty acids on serotonin 2C receptor and calcium homeostasis in pancreatic beta cells
Effects of free fatty acids on serotonin 2C receptor and calcium homeostasis in pancreatic beta cells Open
BACKGROUND:
View article: STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion
STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion Open
View article: ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease
ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease Open
Significance We demonstrate that ErbB2 can regulate autophagic flux through its direct interaction with Beclin-1, which effectively blocks autophagy initiation. Although the expression of ErbB2 becomes dormant during adulthood, it becomes …
View article: PrimerPooler: automated primer pooling to prepare library for targeted sequencing
PrimerPooler: automated primer pooling to prepare library for targeted sequencing Open
Targeted next-generation sequencing based on PCR amplification involves pooling of hundreds to thousands of primers, for preamplification and subsequent parallel single/multiplex PCR. It is often necessary to allocate the set of primers in…