Wan‐Yu Lin
YOU?
Author Swipe
View article: Prevalence of seropositive occult hepatitis B virus infection among patients received chemotherapy in Taiwan: A retrospective study
Prevalence of seropositive occult hepatitis B virus infection among patients received chemotherapy in Taiwan: A retrospective study Open
OBI was identified in 3.4 % of patients with cancer in Taiwan, particularly among older people, those with hematologic malignancies, and individuals negative for anti-HBs. Thus, HBV DNA screening should be considered in high-risk patients …
View article: Longitudinal dynamics of humoral immune responses following serial COVID-19 vaccinations and breakthrough infections in dialysis patients
Longitudinal dynamics of humoral immune responses following serial COVID-19 vaccinations and breakthrough infections in dialysis patients Open
Patients with end-stage kidney disease (ESKD) undergoing dialysis have impaired vaccine responses. Many countries recommend extended primary series and regular COVID-19 boosters for this group, but data on long-term humoral responses after…
View article: Mining for gene-environment and gene-gene interactions: parametric and non-parametric tests for detecting variance quantitative trait loci
Mining for gene-environment and gene-gene interactions: parametric and non-parametric tests for detecting variance quantitative trait loci Open
Introduction Detection of variance quantitative trait loci (vQTL) can facilitate the discovery of gene-environment (GxE) and gene-gene interactions (GxG). Identifying vQTLs before direct GxE and GxG analyses can considerably reduce the num…
View article: Calcium ion-binding genes can predict tumor mutation burden and immune checkpoint blockade response in a pan-cancer model
Calcium ion-binding genes can predict tumor mutation burden and immune checkpoint blockade response in a pan-cancer model Open
View article: Three generations of epigenetic clocks in mediating the adverse effect of smoking on metabolic health
Three generations of epigenetic clocks in mediating the adverse effect of smoking on metabolic health Open
The GrimEAA-mediated proportions were approximately two times greater than the DunedinPACE-mediated proportions.
View article: The impact of healthy behaviors and physical activity on preventing cognitive impairment among older residents in Taipei
The impact of healthy behaviors and physical activity on preventing cognitive impairment among older residents in Taipei Open
View article: Associations between lifestyle factors, physiological conditions, and epigenetic age acceleration in an Asian population
Associations between lifestyle factors, physiological conditions, and epigenetic age acceleration in an Asian population Open
Epigenetic clocks use DNA methylation (DNAm) levels to predict an individual’s biological age. However, relationships between lifestyle/biomarkers and epigenetic age acceleration (EAA) in Asian populations remain unknown. We here explored …
View article: Causal effects of cardiovascular health on five epigenetic clocks
Causal effects of cardiovascular health on five epigenetic clocks Open
View article: Detecting gene–environment interactions from multiple continuous traits
Detecting gene–environment interactions from multiple continuous traits Open
Motivation Genetic variants present differential effects on humans according to various environmental exposures, the so-called “gene–environment interactions” (GxE). Many diseases can be diagnosed with multiple traits, such as obesity, dia…
View article: Gene‐Environment Interactions and Gene–Gene Interactions on Two Biological Age Measures: Evidence from Taiwan Biobank Participants
Gene‐Environment Interactions and Gene–Gene Interactions on Two Biological Age Measures: Evidence from Taiwan Biobank Participants Open
PhenoAge and BioAge are two commonly used biological age (BA) measures. The author here searched for gene‐environment interactions (GxE) and gene‐gene interactions (GxG) on PhenoAgeAccel (age‐adjusted PhenoAge) and BioAgeAccel (age‐adjuste…
View article: Searching for gene-gene interactions through variance quantitative trait loci of 29 continuous Taiwan Biobank phenotypes
Searching for gene-gene interactions through variance quantitative trait loci of 29 continuous Taiwan Biobank phenotypes Open
Introduction: After the era of genome-wide association studies (GWAS), thousands of genetic variants have been identified to exhibit main effects on human phenotypes. The next critical issue would be to explore the interplay between genes,…
View article: The emergence and successful elimination of SARS-CoV-2 dominant strains with increasing epidemic potential in Taiwan’s 2021 outbreak
The emergence and successful elimination of SARS-CoV-2 dominant strains with increasing epidemic potential in Taiwan’s 2021 outbreak Open
View article: Comparison of post-COVID-19 vaccination hypermetabolic lymphadenopathy on 18F-fluorodeoxyglucose PET/CT between virus-vector vaccine and mRNA vaccine
Comparison of post-COVID-19 vaccination hypermetabolic lymphadenopathy on 18F-fluorodeoxyglucose PET/CT between virus-vector vaccine and mRNA vaccine Open
Purpose We compared hypermetabolic lymphadenopathy (HLN) on 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) after virus-vector and mRNA vaccines for coronavirus disease 2019 (COVID-19). Methods Thi…
View article: Epigenetic age acceleration mediates the association between smoking and diabetes-related outcomes
Epigenetic age acceleration mediates the association between smoking and diabetes-related outcomes Open
View article: Epigenetic clocks derived from western samples differentially reflect Taiwanese health outcomes
Epigenetic clocks derived from western samples differentially reflect Taiwanese health outcomes Open
Introduction: Several epigenetic clocks have been developed, with five measures of epigenetic age acceleration (EAA) especially receiving extensive investigations: HannumEAA, IEAA, PhenoEAA, GrimEAA, and DunedinPACE. These epigenetic clock…
View article: Adverse events following the first, second and third doses of a COVID-19 vaccine in hemodialysis patients
Adverse events following the first, second and third doses of a COVID-19 vaccine in hemodialysis patients Open
COVID-19 vaccination was well tolerated in HD patients. Age, sex, dialysis vascular access and vaccine types were associated with postvaccination adverse events.
View article: Targeted next-generation sequencing for genetic variants of left ventricular mass status among community-based adults in Taiwan
Targeted next-generation sequencing for genetic variants of left ventricular mass status among community-based adults in Taiwan Open
Background: Left ventricular mass is a highly heritable disease. Previous studies have suggested common genetic variants to be associated with left ventricular mass; however, the roles of rare variants are still unknown. We performed targe…
View article: Associations of five obesity indicators with cognitive performance in 30,697 Taiwan Biobank participants
Associations of five obesity indicators with cognitive performance in 30,697 Taiwan Biobank participants Open
View article: The most effective exercise to prevent obesity: A longitudinal study of 33,731 Taiwan biobank participants
The most effective exercise to prevent obesity: A longitudinal study of 33,731 Taiwan biobank participants Open
Regular physical exercise is recommended to reduce the risk of obesity. However, it remains unclear which activities are more effective in preventing obesity. In this study, five obesity indices and lifestyle factors of 33,731 Taiwan Bioba…
View article: Cardiovascular health and four epigenetic clocks
Cardiovascular health and four epigenetic clocks Open
Background Cardiovascular health (CVH) was defined by the American Heart Association as an integrative idealness of seven clinical or lifestyle factors. Based on populations of European ancestry, recent studies have shown that ideal CVH is…
View article: Humoral antibody response to the first dose of the <scp>ChAdOx1 nCoV</scp>‐19 vaccine in Asian patients undergoing hemodialysis
Humoral antibody response to the first dose of the <span>ChAdOx1 nCoV</span>‐19 vaccine in Asian patients undergoing hemodialysis Open
Background and objectives The immunogenicity of vaccines is known to be attenuated in patients with end‐stage kidney disease due to uremia. Patients on dialysis were excluded from coronavirus disease 2019 (COVID‐19) vaccine trials; thus, t…
View article: Taiwan's Response to Influenza: A Seroepidemiological Evaluation of Policies and Implications for Pandemic Preparedness
Taiwan's Response to Influenza: A Seroepidemiological Evaluation of Policies and Implications for Pandemic Preparedness Open
This study is the first to show that exercise and preexisting immunity may affect antibody waning. Further investigation is needed to identify immune correlates of protection.
View article: Genome-wide association study for four measures of epigenetic age acceleration and two epigenetic surrogate markers using DNA methylation data from Taiwan Biobank
Genome-wide association study for four measures of epigenetic age acceleration and two epigenetic surrogate markers using DNA methylation data from Taiwan Biobank Open
To highlight the genetic architecture for epigenetic aging, McCartney et al. recently identified 137 significant single-nucleotide polymorphisms based on genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and two …
View article: Change of Renal Gallium Uptake Correlated with Change of Inflammation Activity in Renal Pathology in Lupus Nephritis Patients
Change of Renal Gallium Uptake Correlated with Change of Inflammation Activity in Renal Pathology in Lupus Nephritis Patients Open
Background: Lupus nephritis (LN) often lead to end-stage renal disease in systemic lupus erythematosus patients. This study aimed to investigate the clinical application of renal gallium-67 scans for determining renal histological paramete…
View article: An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population
An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population Open
View article: An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults: NCAM1, TTC12 and ZBTB20
An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults: NCAM1, TTC12 and ZBTB20 Open
The dopamine receptor-related loci have been suggested to be associated with cognitive functions and neurodegenerative diseases. It is unknown whether genetic variants such as single nucleotide polymorphisms (SNPs) in the dopamine receptor…
View article: Prediction of Probable Major Depressive Disorder in the Taiwan Biobank: An Integrated Machine Learning and Genome-Wide Analysis Approach
Prediction of Probable Major Depressive Disorder in the Taiwan Biobank: An Integrated Machine Learning and Genome-Wide Analysis Approach Open
In light of recent advancements in machine learning, personalized medicine using predictive algorithms serves as an essential paradigmatic methodology. Our goal was to explore an integrated machine learning and genome-wide analysis approac…
View article: NP-59 Adrenal Scintigraphy as an Imaging Biomarker to Predict KCNJ5 Mutation in Primary Aldosteronism Patients
NP-59 Adrenal Scintigraphy as an Imaging Biomarker to Predict KCNJ5 Mutation in Primary Aldosteronism Patients Open
Purpose Somatic KCNJ5 mutation occurs in half of unilateral primary aldosteronism (PA) and is associated with more severe phenotype. Mutation status can only be identified by tissue sample from adrenalectomy. NP-59 adrenal scintigraphy is …
View article: A large-scale observational study linking various kinds of physical exercise to lipoprotein-lipid profile
A large-scale observational study linking various kinds of physical exercise to lipoprotein-lipid profile Open
Regular jogging was not only associated with an increased level of HDL-C, but also the only one exercise associated with a decreased level of TG and TG/HDL-C ratio. Nonetheless, jogging may be difficult to engage in for subjects with limit…
View article: Acute effects of dietary phosphorus intake on markers of mineral metabolism in hemodialysis patients: post hoc analysis of a randomized crossover trial
Acute effects of dietary phosphorus intake on markers of mineral metabolism in hemodialysis patients: post hoc analysis of a randomized crossover trial Open
Increased dietary phosphorus intake acutely increases serum phosphate, iPTH, and iFGF23 levels and decreases serum calcium levels, highlighting the important role of daily fluctuations of dietary habits in disturbed mineral homeostasis in …