Yuna Hirohashi
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View article: Defective Microhomology-Mediated End-joining in SMARCB1-Deficient Tumors
Defective Microhomology-Mediated End-joining in SMARCB1-Deficient Tumors Open
Rhabdoid tumors (RTs) are highly aggressive cancers driven by biallelic mutation of SMARCB1, a core subunit of the BAF (SWI/SNF) complex. We found that SMARCB1-deficient tumors have a defect in the microhomology-mediated end-joining (MMEJ)…
View article: An actionable DNA repair defect in myeloid malignancies with U2AF1 S34 mutations
An actionable DNA repair defect in myeloid malignancies with U2AF1 S34 mutations Open
Mutations in the RNA splicing factor genes SRSF2, SF3B1, U2AF1 and ZRSR2 are present in >50% of patients with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and secondary acute myeloid leukemia (AML). Although r…
View article: Tumor-myeloid crosstalk drives therapy resistance in localized bladder cancer
Tumor-myeloid crosstalk drives therapy resistance in localized bladder cancer Open
Neoadjuvant cisplatin-based chemotherapy results in pathologic complete response for only a minority of patients with muscle-invasive bladder cancer (MIBC), and mechanisms of resistance and the effects of chemotherapy on the MIBC microenvi…
View article: Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma
Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma Open
Oncogene expression can cause replication stress (RS), leading to DNA double-strand breaks (DSBs) that require repair through pathways such as homologous recombination, nonhomologous end-joining, and microhomology-mediated end-joining (MME…
View article: Disruption of Microhomology-mediated End-joining in Ewing Sarcoma
Disruption of Microhomology-mediated End-joining in Ewing Sarcoma Open
SUMMARY Ewing sarcoma (EwS) is a group of bone and soft tissue cancers in children and young adults. Since EwS cells have pronounced sensitivity to radiation and chemotherapy-induced DNA damage, the role of the oncoprotein, EWS-FLI1, in DN…
View article: Tetracycline, an Appropriate Reagent for Measuring Bone-Formation Activity in the Murine Model of the Streptococcus mutans-Induced Bone Loss
Tetracycline, an Appropriate Reagent for Measuring Bone-Formation Activity in the Murine Model of the Streptococcus mutans-Induced Bone Loss Open
Tetracycline is used as a fluorescent reagent to measure bone formation activity in bone histomorphometric analyses. However, there is a possibility to lead a different conclusion when it is used in a bacteria-infected murine model since t…
View article: The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation
The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation Open
Receptor activator of NF-κB ligand (RANKL)-binding peptides inhibit bone resorption and were recently shown to activate bone formation. The stimulatory mechanism underlying bone formation associated with these peptides was explained as RAN…