Yun‐Bi Ni
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View article: A Bioresponsive Genetically Encoded Antimicrobial Crystal for the Oral Treatment of <i>Helicobacter Pylori</i> Infection
A Bioresponsive Genetically Encoded Antimicrobial Crystal for the Oral Treatment of <i>Helicobacter Pylori</i> Infection Open
Helicobacter pylori ( H. pylori ) causes infection in the stomach and is a major factor for gastric carcinogenesis. The application of antimicrobial peptides (AMPs) as an alternative treatment to traditional antibiotics is limited by their…
View article: Spatial Distribution and Densities of CD103+ and FoxP3+ Tumor Infiltrating Lymphocytes by Digital Analysis for Outcome Prediction in Breast Cancer
Spatial Distribution and Densities of CD103+ and FoxP3+ Tumor Infiltrating Lymphocytes by Digital Analysis for Outcome Prediction in Breast Cancer Open
Background The evaluation of tumor-infiltrating lymphocytes (TILs) for breast cancer prognosis is now established. However, the clinical value for their spatial distributions of specific immune subsets, namely CD103+ tissue-resident memory…
View article: <i>Roseburia intestinalis</i> generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8 <sup>+</sup> T cells
<i>Roseburia intestinalis</i> generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8 <sup>+</sup> T cells Open
Objective Roseburia intestinalis is a probiotic species that can suppress intestinal inflammation by producing metabolites. We aimed to study the role of R. intestinalis in colorectal tumourigenesis and immunotherapy. Design R. intestinali…
View article: Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice
Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice Open
View article: Risk factors for sessile serrated lesions among Chinese patients undergoing colonoscopy
Risk factors for sessile serrated lesions among Chinese patients undergoing colonoscopy Open
Background and Aim Serrated polyps have been recognized as a premalignant lesion accounting for a significant proportion of colorectal cancer. Limited data are available regarding the risk factors for colorectal sessile serrated lesions (S…
View article: Spindle Cell Lesions of the Breast: A Diagnostic Algorithm
Spindle Cell Lesions of the Breast: A Diagnostic Algorithm Open
Context.— Spindle cell lesions of the breast represent a broad spectrum of entities, ranging from nonneoplastic reactive conditions to high-grade malignant tumors. The wide range makes breast spindle cell lesions a diagnostic pitfall. Obje…
View article: Combining Analysis of Tumor-infiltrating Lymphocytes (TIL) and PD-L1 Refined the Prognostication of Breast Cancer Subtypes
Combining Analysis of Tumor-infiltrating Lymphocytes (TIL) and PD-L1 Refined the Prognostication of Breast Cancer Subtypes Open
Background PD-L1 has been used as a biomarker to select patients for treatment of PD-1/PD-L1 inhibitors. Materials and Methods In this study, we assessed the clinicopathological features of breast cancers that are associated with PD-L1 exp…
View article: IDDF2021-ABS-0166 Transplantation of stool from obese patients promotes intestinal tumorigenesis in mice
IDDF2021-ABS-0166 Transplantation of stool from obese patients promotes intestinal tumorigenesis in mice Open
Background Epidemiological evidence supports a relationship between adiposity and elevated risk of colorectal cancer (CRC). Nevertheless, the role of gut microbiota in mediating the carcinogenic effect of adiposity is unknown. In this stud…
View article: Co-expression of HLA-I loci improved prognostication in HER2+ breast cancers
Co-expression of HLA-I loci improved prognostication in HER2+ breast cancers Open
View article: Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer
Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer Open
These results demonstrated the contributory role of APP cleavage on its oncogenic roles in breast cancer. ADAM10 was the key α-secretase. APP and ADAM10 co-expression was associated with worse survival in non-luminal breast cancers. Target…
View article: The Clinical Value of PELP1 for Breast Cancer: A Comparison with Multiple Cancers and Analysis in Breast Cancer Subtypes
The Clinical Value of PELP1 for Breast Cancer: A Comparison with Multiple Cancers and Analysis in Breast Cancer Subtypes Open
PELP1 is a sensitive marker for breast cancer, particularly non-luminal cases. However, its considerable expression in lung and ovarian cancers may limit its utility in differential diagnosis in some scenarios. PELP1 expression was associa…
View article: Amyloid Precursor Protein Is Associated with Aggressive Behavior in Nonluminal Breast Cancers
Amyloid Precursor Protein Is Associated with Aggressive Behavior in Nonluminal Breast Cancers Open
Background β-amyloid precursor protein (APP), a potential target for Alzheimer's disease treatment, has recently been shown to take part in carcinogenesis. Increased APP promotes migration, survival, and proliferation in breast cancer cell…
View article: Association of clinicopathological features and prognosis of TERT alterations in phyllodes tumor of breast
Association of clinicopathological features and prognosis of TERT alterations in phyllodes tumor of breast Open
View article: Amyloid Precursor Protein Underwent Proteolytic Cleavage by ADAM10 and Mediated Breast Cancer Growth and Migration
Amyloid Precursor Protein Underwent Proteolytic Cleavage by ADAM10 and Mediated Breast Cancer Growth and Migration Open
View article: Distinct Tertiary Lymphoid Structure Associations and Their Prognostic Relevance in HER2 Positive and Negative Breast Cancers
Distinct Tertiary Lymphoid Structure Associations and Their Prognostic Relevance in HER2 Positive and Negative Breast Cancers Open
Background The presence of tumor infiltrating lymphocytes (TIL) is associated with favorable prognosis. Recent evidence suggested that not only their density, but also the spatial organization as tertiary lymphoid structures (TLS), play a …
View article: Intratumoral Heterogeneity in Breast Cancer: A Comparison of Primary and Metastatic Breast Cancers
Intratumoral Heterogeneity in Breast Cancer: A Comparison of Primary and Metastatic Breast Cancers Open
Intratumoral heterogeneity presents challenges in the management of cancer. To gain deeper insight in intratumoral heterogeneity at different levels and tumor sites for common biomarkers in breast cancers, this report examines seven cases …
View article: FGFR1 is an adverse outcome indicator for luminal A breast cancers
FGFR1 is an adverse outcome indicator for luminal A breast cancers Open
Fibroblast growth factor receptor 1 (FGFR1) has been suggested to be the candidate gene for 8p11-12 amplification in breast cancer and its therapeutic/ prognostic value is explored. Most previous studies focused on FGFR1 gene amplification…
View article: Doublecortin-like kinase 1 expression associates with breast cancer with neuroendocrine differentiation
Doublecortin-like kinase 1 expression associates with breast cancer with neuroendocrine differentiation Open
Doublecortin-like kinase 1 (DCLK1), a microtubule associated kinase, has recently been proposed to be a putative marker for stemness and adverse prognosis in gastrointestinal cancers. However, it is not clear whether the protein also plays…