Yu Tang
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View article: Long-term outcomes and prognostic predictors in patients with fibrosing mediastinitis associated pulmonary hypertension: a multicenter cohort study
Long-term outcomes and prognostic predictors in patients with fibrosing mediastinitis associated pulmonary hypertension: a multicenter cohort study Open
View article: A recurrence risk score model evaluating effects of postmastectomy radiotherapy in breast cancer patients with pathologically negative lymph nodes after neoadjuvant chemotherapy: a multicenter, retrospective study
A recurrence risk score model evaluating effects of postmastectomy radiotherapy in breast cancer patients with pathologically negative lymph nodes after neoadjuvant chemotherapy: a multicenter, retrospective study Open
Background: The role of postmastectomy radiotherapy (PMRT) in breast cancer patients achieving pathologically negative lymph nodes (ypN0) after neoadjuvant chemotherapy (NAC) remains controversial due to heterogeneous recurrence risks and …
View article: Luspatercept Treatment in a β-Thalassemia Patient with Pulmonary Arterial Hypertension: A Case Report
Luspatercept Treatment in a β-Thalassemia Patient with Pulmonary Arterial Hypertension: A Case Report Open
β-Thalassemia is associated with a range of complications, with pulmonary hypertension in affected individuals having a particularly high mortality rate. However, data on the use of pulmonary vasodilators in β-thalassemia are scarce. Here,…
View article: GOSU: Retrieval-Augmented Generation with Global-Level Optimized Semantic Unit-Centric Framework
GOSU: Retrieval-Augmented Generation with Global-Level Optimized Semantic Unit-Centric Framework Open
Building upon the standard graph-based Retrieval-Augmented Generation (RAG), the introduction of heterogeneous graphs and hypergraphs aims to enrich retrieval and generation by leveraging the relationships between multiple entities through…
View article: Xuanfei Baidu Formula Ameliorates Influenza A Virus-Induced Lung Inflammation by Repressing the NLRP3 Inflammasome in Macrophages
Xuanfei Baidu Formula Ameliorates Influenza A Virus-Induced Lung Inflammation by Repressing the NLRP3 Inflammasome in Macrophages Open
The NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome is an intracellular protein complex containing a nucleotide-binding oligomerization domain, leucine-rich repeats, and a pyrin domain. It is a key regulator…
View article: Development and Validation of a Headspace Gas Chromatography-Flame Ionization Detection Method for the Simultaneous Determination of 12 Residual Solvents in Avibactam Sodium Active Pharmaceutical Ingredient
Development and Validation of a Headspace Gas Chromatography-Flame Ionization Detection Method for the Simultaneous Determination of 12 Residual Solvents in Avibactam Sodium Active Pharmaceutical Ingredient Open
In the industrial production process of avibactam sodium, the quantitative determination of residual solvents from the manufacturing process is critical for ensuring product quality and safety. This study aimed to develop and validate a he…
View article: Piezo1 Knockdown Activates PI3K/AKT and Enhances SPP1 to Drive M2 Macrophage Polarization and Reduce Cardiac Inflammation
Piezo1 Knockdown Activates PI3K/AKT and Enhances SPP1 to Drive M2 Macrophage Polarization and Reduce Cardiac Inflammation Open
Piezo1 plays a key role in the immune response during sepsis. To date, our understanding of the role of Piezo1 in inflammatory diseases has mostly been limited to influencing vasomotor function and regulating inflammatory infiltration. Whe…
View article: Interpregnancy Weight Gain and Risks of Perinatal Death: A Systematic Review and Meta‐Analysis
Interpregnancy Weight Gain and Risks of Perinatal Death: A Systematic Review and Meta‐Analysis Open
The link between interpregnancy weight gain (IPWG) and perinatal death remains unclear. This meta‐analysis examines the impact of interpregnancy body mass index (BMI) increase on perinatal mortality. A comprehensive search was conducted in…
View article: Understanding the gap between expectations and reality in decentralized clinical trials
Understanding the gap between expectations and reality in decentralized clinical trials Open
View article: Causal Relationship Between Sex Hormone Binding Globulin and Obstetrical Disorders: A Two-Sample Bidirectional Mendelian Randomization Study
Causal Relationship Between Sex Hormone Binding Globulin and Obstetrical Disorders: A Two-Sample Bidirectional Mendelian Randomization Study Open
SHBG causally lowers risks of gestational diabetes, hypertension, hyperemesis, miscarriage, and preterm delivery, highlighting its clinical relevance in obstetrical pathophysiology.
View article: Depression and anxiety in patients with breast cancer receiving radiotherapy: a longitudinal study
Depression and anxiety in patients with breast cancer receiving radiotherapy: a longitudinal study Open
Background: Depression and anxiety are common among patients with breast cancer, but prospective studies of depression and anxiety after radiotherapy (RT) among these patients remain scarce. Objective: To evaluate the prevalence of and cha…
View article: Sodium Benzoate Inhibits Osteoblast Differentiation and Accelerates Bone Loss by Regulating the FGF2/p38/RUNX2 Pathway
Sodium Benzoate Inhibits Osteoblast Differentiation and Accelerates Bone Loss by Regulating the FGF2/p38/RUNX2 Pathway Open
Sodium benzoate (NaB) is a commonly used food ingredient that is also found in cosmetics and medicines. Previous studies have demonstrated that long-term NaB intake has detrimental effects on human health, while its effects on bone mass re…
View article: Causal relationships between four types of lipids and breast cancer risk with potential mediators: evidence from Mendelian randomization study and bioinformatics analysis
Causal relationships between four types of lipids and breast cancer risk with potential mediators: evidence from Mendelian randomization study and bioinformatics analysis Open
View article: Association between sphingomyelin levels and gut microbiota abundance in Alzheimer’s disease: a two-sample Mendelian randomization study
Association between sphingomyelin levels and gut microbiota abundance in Alzheimer’s disease: a two-sample Mendelian randomization study Open
View article: Comparison of simultaneous integrated tumor bed boost and sequential boost during hypofractionated whole-breast irradiation after breast-conserving surgery
Comparison of simultaneous integrated tumor bed boost and sequential boost during hypofractionated whole-breast irradiation after breast-conserving surgery Open
View article: Inhibiting glycolysis facilitated checkpoint blockade therapy for triple-negative breast cancer
Inhibiting glycolysis facilitated checkpoint blockade therapy for triple-negative breast cancer Open
Cancer cells are characterized by their altered energy metabolism. A hallmark of cancer metabolism is aerobic glycolysis, also called the Warburg effect. Hexokinase 2 (HK2), a crucial glycolytic enzyme converting glucose to glucose-6-phosp…
View article: Longitudinal Analyses and Predictive Factors of Radiation-Induced Lymphopenia After Postmastectomy Hypofractionated Radiation Therapy for Breast Cancer: A Pooled Cohort Study of 2 Prospective Trials
Longitudinal Analyses and Predictive Factors of Radiation-Induced Lymphopenia After Postmastectomy Hypofractionated Radiation Therapy for Breast Cancer: A Pooled Cohort Study of 2 Prospective Trials Open
View article: 20-Hydroxyecdysone Regulates the Expression of 30 Genes Specifically Expressed in Larval Digestive Tube of the Silkworm, Bombyx mori
20-Hydroxyecdysone Regulates the Expression of 30 Genes Specifically Expressed in Larval Digestive Tube of the Silkworm, Bombyx mori Open
Nutrients needed to fuel the processes of growth, development, and reproduction, and to form the proteins in the cocoon, are derived from the larval stage. The amount of leaf ingested in the fifth instar silkworm larvae accounted for about…
View article: FBXL3 serves as a suppressor of regenerative myogenesis.
FBXL3 serves as a suppressor of regenerative myogenesis. Open
Muscle regeneration hinges on the proliferation and differentiation of satellite cells. FBXL3, a member of the F-box protein family known for its role as a negative regulator of the circadian clock, is implicated in myogenesis. In this stu…
View article: RBM15-Mediated N6-Methyladenosine Modification of EMC6 Promotes Gastric Cancer Progression in Cag A+ Helicobacter pylori Infection
RBM15-Mediated N6-Methyladenosine Modification of EMC6 Promotes Gastric Cancer Progression in Cag A+ Helicobacter pylori Infection Open
View article: Right atrial metastasis after renal cell carcinoma operation: a case report
Right atrial metastasis after renal cell carcinoma operation: a case report Open
This case study highlights the rare clinical manifestations of cardiac metastasis from ccRCC. For patients who have the opportunity for surgery, surgical treatment is recommended as the preferred option. Early detection and treatment are t…
View article: Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-κB Pathway
Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-κB Pathway Open
SCU exhibited a dual impact by inhibiting TLR4 expression and disrupting TLR4-TRAF6 interaction, resulting in NF-κB inactivation, thereby blocking OS growth.
View article: Effectiveness and safety of hormone replacement therapy in the treatment of menopausal syndrome: a meta-analysis
Effectiveness and safety of hormone replacement therapy in the treatment of menopausal syndrome: a meta-analysis Open
HRT can enhance the quality of life and vaginal health in women experiencing menopausal symptoms, elevate estrogen levels, and improve bone density, while demonstrating a favorable safety profile with no significant increase in adverse eve…
View article: Holographic p-wave superconductor with spontaneously broken translation
Holographic p-wave superconductor with spontaneously broken translation Open
At the probe level, we investigate the holographic p-wave conductor/superconductor phase transition by both numerical and analytical methods. Especially, due to the nonlinear axion correction, the translational symmetry in superconductor i…
View article: Case Report: Zero-contrast balloon pulmonary angioplasty guided by real-time fusion of CT angiography with x-ray fluoroscopy
Case Report: Zero-contrast balloon pulmonary angioplasty guided by real-time fusion of CT angiography with x-ray fluoroscopy Open
Background Allergy to iodine contrast agents has long been a contraindication for balloon pulmonary angioplasty (BPA). We report the successful zero-contrast BPA procedure of a patient with inoperable chronic thromboembolic pulmonary hyper…
View article: Personalized neoantigen cancer vaccines: current progression, challenges and a bright future
Personalized neoantigen cancer vaccines: current progression, challenges and a bright future Open
View article: A Bioluminescence Resonance Energy Transfer-Based Approach for Determining Antibody-Receptor Occupancy In Vivo
A Bioluminescence Resonance Energy Transfer-Based Approach for Determining Antibody-Receptor Occupancy In Vivo Open
View article: Preoperative chemoradiotherapy in older patients with rectal cancer guided by comprehensive geriatric assessment within a multidisciplinary team—a multicenter phase II trial
Preoperative chemoradiotherapy in older patients with rectal cancer guided by comprehensive geriatric assessment within a multidisciplinary team—a multicenter phase II trial Open
View article: Quantitative evaluation of the impact of relaxing eligibility criteria on the risk–benefit profile of drugs for lung cancer based on real‐world data
Quantitative evaluation of the impact of relaxing eligibility criteria on the risk–benefit profile of drugs for lung cancer based on real‐world data Open
Introduction Restrictive eligibility criteria in cancer drug trials result in low enrollment rates and limited population diversity. Relaxed eligibility criteria (REC) based on solid evidence is becoming necessary for stakeholders worldwid…
View article: Adjuvant camrelizumab plus apatinib in resected hepatocellular carcinoma with microvascular invasion: a multi-center real world study
Adjuvant camrelizumab plus apatinib in resected hepatocellular carcinoma with microvascular invasion: a multi-center real world study Open
Postoperative adjuvant camrelizumab plus apatinib significantly improved the RFS benefits with acceptable toxicities in patients with HCC with MVI.