Yunfu Chen
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View article: Theoretical Mechanisms and Practical Paths for the Deep Integration of the Digital Economy and the Real Economy
Theoretical Mechanisms and Practical Paths for the Deep Integration of the Digital Economy and the Real Economy Open
The digital economy has become a core driver of economic development with its innovativeness and penetrability, and its integration with the real economy represents a central trend in global industrial transformation. However, academic res…
View article: Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial
Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial Open
The primary analysis at week 48 showed that the antiviral efficacy of GLS4/RTV with ETV was clearly superior to that of ETV monotherapy. GLS4/RTV with ETV was well tolerated; further studies evaluating its safety and efficacy are ongoing. …
View article: Vincristine Regulates C/EBP-β/TGF-β1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain
Vincristine Regulates C/EBP-β/TGF-β1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain Open
Vincristine induced spinal cord inflammation by promoting A1 polarization of astrocytes via upregulating the C/EBP-β/TGF-β1 signal pathway, thus leading to neuropathic pain. It was different from the traditional signal pathway, this study …
View article: Safety, Pharmacokinetics and Antiviral Efficacy of Capsid Assembly Modulator Freethiadine in Healthy Volunteers and Chronic Hepatitis B Patients
Safety, Pharmacokinetics and Antiviral Efficacy of Capsid Assembly Modulator Freethiadine in Healthy Volunteers and Chronic Hepatitis B Patients Open
Background and Aims Freethiadine is a novel hepatitis B virus capsid assembly modulator. Herein, we report the safety, tolerability, pharmacokinetics and 28‐day antiviral activities of freethiadine. Methods The study consisted of two parts…
View article: Morin Regulates M1/M2 Microglial Polarization via NF-κB p65 to Alleviate Vincristine-Induced Neuropathic Pain
Morin Regulates M1/M2 Microglial Polarization via NF-κB p65 to Alleviate Vincristine-Induced Neuropathic Pain Open
Our results demonstrate that morin inhibits neuroinflammation to alleviate vincristine-induced neuropathic pain via inhibiting the NF-κB signalling pathway to regulate M1/M2 microglial polarization.
View article: Droplet impacting dynamics on a thin liquid film on the rice-leaf microstructured surface
Droplet impacting dynamics on a thin liquid film on the rice-leaf microstructured surface Open
Although spraying pesticides onto stems and leaves is the most effective method to prevent plant pests and diseases, the splashing of the droplets upon impact with the leaf surface is one of the main ways that the liquid agent is lost duri…
View article: Computational fluid dynamics simulation analysis of the effect of curved rice leaves on the deposition behaviour of droplets
Computational fluid dynamics simulation analysis of the effect of curved rice leaves on the deposition behaviour of droplets Open
Background Although previous studies on the droplet deposition behaviour of rice leaves have modelled the leaves as flat surface structures, their curved surface structures actually have a significant effect on droplet deposition. Results …
View article: Design, Synthesis, and Biological Evaluation of Novel Thioureidobenzamide (TBA) Derivatives as HBV Capsid Assembly Modulators
Design, Synthesis, and Biological Evaluation of Novel Thioureidobenzamide (TBA) Derivatives as HBV Capsid Assembly Modulators Open
Hepatitis B virus (HBV) capsid assembly modulators (CAMs) represent a promising therapeutic approach for the treatment of HBV infection. In this study, we designed and synthesized five series of benzamide derivatives based on a multisite-b…
View article: Model construction and validation of airflow velocity attenuation through pear tree canopies
Model construction and validation of airflow velocity attenuation through pear tree canopies Open
To investigate the airflow velocity attenuation inside pear tree canopies and the factors that influence its effect on air-assisted spraying, the relationship between the resistance of the canopies to airflow and airflow velocity inside th…
View article: Design, Synthesis and Biological Evaluation of Novel Sulfonamides Benzamide Derivatives as HBV Capsid Protein Inhibitors
Design, Synthesis and Biological Evaluation of Novel Sulfonamides Benzamide Derivatives as HBV Capsid Protein Inhibitors Open
View article: Efficacy and safety of GLS4/ritonavir combined with entecavir in HBeAg-positive patients with chronic hepatitis B: interim results from phase 2b, multi-center study
Efficacy and safety of GLS4/ritonavir combined with entecavir in HBeAg-positive patients with chronic hepatitis B: interim results from phase 2b, multi-center study Open
View article: Antiviral Activity and Pharmacokinetics of the Hepatitis B Virus (HBV) Capsid Assembly Modulator GLS4 in Patients With Chronic HBV Infection
Antiviral Activity and Pharmacokinetics of the Hepatitis B Virus (HBV) Capsid Assembly Modulator GLS4 in Patients With Chronic HBV Infection Open
Background GLS4 is a first-in-class hepatitis B virus (HBV) capsid assembly modulator (class I) that can inhibit HBV replication by interfering with the assembly and disassembly of HBV nucleocapsid. Here, we evaluated its antiviral activit…
View article: CCDC 1963481: Experimental Crystal Structure Determination
CCDC 1963481: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: 3-((<i>R</i>)-4-(((<i>R</i>)-6-(2-Bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic Acid (HEC72702), a Novel Hepatitis B Virus Capsid Inhibitor Based on Clinical Candidate GLS4
3-((<i>R</i>)-4-(((<i>R</i>)-6-(2-Bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic Acid (HEC72702), a Novel Hepatitis B Virus Capsid Inhibitor Based on Clinical Candidate GLS4 Open
The inhibition of hepatitis B virus (HBV) capsid assembly is a novel strategy for the development of chronic hepatitis B (CHB) therapeutics. On the basis of the preclinical properties and clinical results of GLS4, we carried out further in…