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View article: Apathy, effort-based decisions and brain integrity in Alzheimer’s and Parkinson’s diseases
Apathy, effort-based decisions and brain integrity in Alzheimer’s and Parkinson’s diseases Open
Apathy, or loss of motivation, is a prominent syndrome accompanying both Alzheimer’s and Parkinson’s disease, in addition to other disorders. One approach to understanding motivational loss is to examine the processes underlying goal-direc…
View article: An open, longitudinal resource for mapping interindividual variation in the aging connectome
An open, longitudinal resource for mapping interindividual variation in the aging connectome Open
Trajectories of age-related neurocognitive decline are not uniform, and are impacted by numerous environmental and physiological factors. Earlier life phases set the stage for later life neurocognitive function, with midlife marking a crit…
View article: A transdiagnostic, multi-modal approach to understanding apathy: Methodological and analytical framework
A transdiagnostic, multi-modal approach to understanding apathy: Methodological and analytical framework Open
View article: cpCST: A New Continuous Performance Test for High-Precision Assessment of Attention Across the Lifespan
cpCST: A New Continuous Performance Test for High-Precision Assessment of Attention Across the Lifespan Open
Assessing sustained attention presents methodological challenges, particularly when spanning diverse populations whose baseline sensorimotor functioning may vary significantly. This study introduces the Continuous Performance Critical Stab…
View article: Neuropsychiatric and behavioral symptom clusters in frontotemporal dementia
Neuropsychiatric and behavioral symptom clusters in frontotemporal dementia Open
Background Non-Alzheimer's disease dementias, including frontotemporal dementia (FTD) can be difficult to characterize due to the predominance of distinct behavioral and neuropsychiatric symptoms. Widely used measurement tools lack structu…
View article: Network-based amyloid-beta pathology predicts subsequent cognitive decline in cognitively normal older adults
Network-based amyloid-beta pathology predicts subsequent cognitive decline in cognitively normal older adults Open
The deposition of amyloid-beta protein in the human brain is a hallmark of Alzheimer's disease and is related to cognitive decline. However, the relationship between early amyloid-beta deposition and future cognitive impairment remains poo…
View article: Heart rate variability and cardiorespiratory fitness associated with biological brain aging in a healthy adult lifespan sample
Heart rate variability and cardiorespiratory fitness associated with biological brain aging in a healthy adult lifespan sample Open
Background Measures of cardiovascular health have long been associated with brain health. For example, aerobic capacity (VO2max) is associated with preservation of functional and structural brain integrity in later life. Recent work has hi…
View article: Effort‐based decision making and white matter tracts associated with dimensions of apathy in Alzheimer’s and Parkinson’s disease
Effort‐based decision making and white matter tracts associated with dimensions of apathy in Alzheimer’s and Parkinson’s disease Open
Background Apathy is marked by diminished motivation and goal‐directed behavior, prevalent in neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD). Effort‐based decision‐making paradigms (EBDM), which requi…
View article: Brain reserve affects the expression of cognitive reserve networks
Brain reserve affects the expression of cognitive reserve networks Open
Cognitive reserve (CR) explains differential susceptibility of cognitive performance to neuropathology. However, as brain pathologies progress, cognitive decline occurs even in individuals with initially high CR. The interplay between the …
View article: Childhood engagement in cognitively stimulating activities moderates relationships between brain structure and cognitive function in adulthood
Childhood engagement in cognitively stimulating activities moderates relationships between brain structure and cognitive function in adulthood Open
View article: Exploring the Association between Amyloid-β and Memory Markers for Alzheimer's Disease in Cognitively Unimpaired Older Adults
Exploring the Association between Amyloid-β and Memory Markers for Alzheimer's Disease in Cognitively Unimpaired Older Adults Open
View article: Brain connectivity underlying apathy in Alzheimer’s and Parkinson’s diseases
Brain connectivity underlying apathy in Alzheimer’s and Parkinson’s diseases Open
Background Apathy, defined as a lack of motivation towards goal‐directed behavior, is a common neuropsychiatric symptom in Alzheimer’s (AD) and Parkinson’s (PD) disease. However, the mechanism underlying apathy is still unclear. Studies ha…
View article: In vivo tau is associated with retrospective change in memory and processing speed, but not reasoning, in cognitively unimpaired older adults.
In vivo tau is associated with retrospective change in memory and processing speed, but not reasoning, in cognitively unimpaired older adults. Open
Background The relationship between tau accumulation and cognitive decline in cognitively unimpaired older adults is still unclear. The tau PET tracer 18 F‐MK‐6240 has shown favorable imaging carachteristics to identify early tau accumulat…
View article: 63 In vivo Tau ([18F]-MK-6240) is Associated with Retrospective Change on Memory and Speed, but not Reasoning in Cognitively Healthy Older Adults
63 In vivo Tau ([18F]-MK-6240) is Associated with Retrospective Change on Memory and Speed, but not Reasoning in Cognitively Healthy Older Adults Open
Objective: Additional research is needed to better understand the relationship between early tau accumulation and cognitive decline in cognitively healthy (CH) older adults. The tau PET tracer 18F-MK-6240 has shown favorable imaging charac…
View article: 15 Socioeconomic Status in Association to Memory-Related Brain Activation in Middle-Aged Adults
15 Socioeconomic Status in Association to Memory-Related Brain Activation in Middle-Aged Adults Open
Objective: Socioeconomic status (SES) has been recognized as an important factor in psychological research within the last few decades. Past literature recognizes that having lower SES can have a negative impact on many aspects of one’s he…
View article: In vivo tau is associated with change in memory and processing speed, but not reasoning, in cognitively unimpaired older adults
In vivo tau is associated with change in memory and processing speed, but not reasoning, in cognitively unimpaired older adults Open
View article: Association of Cognitive Polygenic Index and Cognitive Performance with Age in Cognitively Healthy Adults
Association of Cognitive Polygenic Index and Cognitive Performance with Age in Cognitively Healthy Adults Open
Genome-wide association studies have discovered common genetic variants associated with cognitive performance. Polygenic scores that summarize these discoveries explain up to 10% of the variance in cognitive test performance in samples of …
View article: More youthful brain activations observed in older adults with better cognition
More youthful brain activations observed in older adults with better cognition Open
We investigated factors that influence the maintenance of youthful functional activation for a working memory task in healthy older adults. While task-related functional activation has been found to increase in extent and intensity in agin…
View article: Mediterranean diet and longitudinal change of white matter hyperintensity in cognitively intact young and older adults
Mediterranean diet and longitudinal change of white matter hyperintensity in cognitively intact young and older adults Open
Background A healthy dietary pattern, Mediterranean diet (MeDi), has been reported to be associated with better brain and cognition. White matter hyperintensities (WMHs), seen in brain magnetic resonance imaging, are considered to be due t…
View article: Older adults compensate for switch, but not mixing costs, relative to younger adults on an intrinsically cued task switching experiment
Older adults compensate for switch, but not mixing costs, relative to younger adults on an intrinsically cued task switching experiment Open
Introduction Aging negatively impacts the ability to rapidly and successfully switch between two or more tasks that have different rules or objectives. However, previous work has shown that the context impacts the extent of this age-relate…
View article: Effects of Brain Maintenance and Cognitive Reserve on Age-Related Decline in Three Cognitive Abilities
Effects of Brain Maintenance and Cognitive Reserve on Age-Related Decline in Three Cognitive Abilities Open
Objectives Age-related cognitive changes can be influenced by both brain maintenance (BM), which refers to the relative absence over time of changes in neural resources or neuropathologic changes, and cognitive reserve (CR), which encompas…
View article: Disruption of early visual processing in amyloid-positive healthy individuals and mild cognitive impairment
Disruption of early visual processing in amyloid-positive healthy individuals and mild cognitive impairment Open
Background Amyloid deposition is a primary predictor of Alzheimer’s disease (AD) and related neurodegenerative disorders. Retinal changes involving the structure and function of the ganglion cell layer are increasingly documented in both e…
View article: Longitudinal association between changes in resting-state network connectivity and cognition trajectories: The moderation role of a healthy diet
Longitudinal association between changes in resting-state network connectivity and cognition trajectories: The moderation role of a healthy diet Open
Introduction Healthy diet has been shown to alter brain structure and function and improve cognitive performance, and prior work from our group showed that Mediterranean diet (MeDi) moderates the effect of between-network resting-state fun…
View article: Physical activity moderates the association between white matter hyperintensity burden and cognitive change
Physical activity moderates the association between white matter hyperintensity burden and cognitive change Open
Objective Greater physical activity (PA) could delay cognitive decline, yet the underlying mechanisms remain unclear. White matter hyperintensity (WMH) burden is one of the key brain pathologies that have been shown to predict faster cogni…
View article: Diet moderates the effect of resting state functional connectivity on cognitive function
Diet moderates the effect of resting state functional connectivity on cognitive function Open
View article: Mediterranean Diet and White Matter Hyperintensity Change over Time in Cognitively Intact Adults
Mediterranean Diet and White Matter Hyperintensity Change over Time in Cognitively Intact Adults Open
Current evidence on the impact of Mediterranean diet (MeDi) on white matter hyperintensity (WMH) trajectory is scarce. This study aims to examine whether greater adherence to MeDi is associated with less accumulation of WMH. This populatio…
View article: Age-Specific Activation Patterns and Inter-Subject Similarity During Verbal Working Memory Maintenance and Cognitive Reserve
Age-Specific Activation Patterns and Inter-Subject Similarity During Verbal Working Memory Maintenance and Cognitive Reserve Open
Cognitive Reserve (CR), according to a recent consensus definition of the NIH-funded Reserve and Resilience collaboratory, 1 is constituted by any mechanism contributing to cognitive performance beyond, or interacting with, brain structure…
View article: Financial decision‐making and self‐awareness for financial decision‐making is associated with white matter integrity in older adults
Financial decision‐making and self‐awareness for financial decision‐making is associated with white matter integrity in older adults Open
Financial decision‐making (FDM) and awareness of the integrity of one's FDM abilities (or financial awareness) are both critical for preventing financial mistakes. We examined the white matter correlates of these constructs and hypothesize…
View article: Tracing Brain Amyloid-β in Asymptomatic Older Adults Relying on a Memory Marker for Alzheimer's Disease
Tracing Brain Amyloid-β in Asymptomatic Older Adults Relying on a Memory Marker for Alzheimer's Disease Open
View article: White matter fiber density for vocabulary better maintained than fluid abilities in aging
White matter fiber density for vocabulary better maintained than fluid abilities in aging Open
Background Aging research has repeatedly shown that crystallized abilities, cognitive processes reliant on learned knowledge, are well preserved well into old age. On the other hand, fluid abilities, processes that are not knowledge‐depend…