Yunhe An
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View article: C6orf223 promotes colorectal cancer growth and metastasis by facilitating PRMT5-MEP50 multiprotein complex assembling
C6orf223 promotes colorectal cancer growth and metastasis by facilitating PRMT5-MEP50 multiprotein complex assembling Open
Protein arginine methyltransferase 5 (PRMT5) complexes with methylosome protein 50 (MEP50) play crucial roles in tumor progress. However, the regulatory mechanism of governing the PRMT5-MEP50 hetero-octameric complex remains unclear. Here,…
View article: Magneto-photoelectrochemical 2D heterojunction platform for biosensing detection
Magneto-photoelectrochemical 2D heterojunction platform for biosensing detection Open
Photoelectrochemical (PEC) biosensors exhibit significant potential for biomolecule detection due to their high sensitivity and low background noise. However, their performance is severely constrained by the rapid recombination of photogen…
View article: Magneto-photoelectrochemical 2D heterojunction platform for biosensing detection
Magneto-photoelectrochemical 2D heterojunction platform for biosensing detection Open
Photoelectrochemical (PEC) biosensors exhibit significant potential for biomolecule detection due to their high sensitivity and low background noise. However, their performance is severely constrained by the rapid recombination of photogen…
View article: Knockdown of <scp>PRDX2</scp> Inhibits the Proliferation, Growth, Migration, Invasion, and <scp>MMP9</scp> Activity of Ewing's Sarcoma Cells Cultured In Vitro
Knockdown of <span>PRDX2</span> Inhibits the Proliferation, Growth, Migration, Invasion, and <span>MMP9</span> Activity of Ewing's Sarcoma Cells Cultured In Vitro Open
Background Ewing’s sarcoma (ES) is the second most common malignant primary bone tumor in children and adolescents. Peroxiredoxin 2 (PRDX2) is an antioxidant enzyme. Aims Here, we investigated the role and mechanism of PRDX2 in the develop…
View article: G9a/GLP inhibitor UNC0642 induces growth arrest in colorectal cancer via induction of ROS generation, coordinated overexpression of GADD genes, and the JNK/p38 MAPK pathway
G9a/GLP inhibitor UNC0642 induces growth arrest in colorectal cancer via induction of ROS generation, coordinated overexpression of GADD genes, and the JNK/p38 MAPK pathway Open
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer death worldwide. Hence, new therapeutic agents are urgently needed to manage colorectal cancer effectively. The epigenetic abnormalities of …
View article: Characteristics of Polycyclic Aromatic Hydrocarbons in Size-Resolved Particles in the Roadside Environment of Beijing: Seasonality, Source, and Toxicological Effects
Characteristics of Polycyclic Aromatic Hydrocarbons in Size-Resolved Particles in the Roadside Environment of Beijing: Seasonality, Source, and Toxicological Effects Open
The polycyclic aromatic hydrocarbons (PAHs) in size-resolved particles emitted from diverse sources are required for quantification to reduce the emissions in order to protect public health. Twenty-four PAHs in size-segregated particles in…
View article: Recent Advances in Fluorescent Nanoprobes for Food Safety Detection
Recent Advances in Fluorescent Nanoprobes for Food Safety Detection Open
Fluorescent nanoprobes show similar fluorescence properties to traditional organic dyes, but the addition of nanotechnology accurately controls the size, shape, chemical composition, and surface chemistry of the nanoprobes with unique char…
View article: A subpopulation of CD146+ macrophages enhances antitumor immunity by activating the NLRP3 inflammasome
A subpopulation of CD146+ macrophages enhances antitumor immunity by activating the NLRP3 inflammasome Open
View article: Transcriptome analysis of the effect of a novel human serine protease inhibitor SPINK13 on gene expression in MHCC97-H cells
Transcriptome analysis of the effect of a novel human serine protease inhibitor SPINK13 on gene expression in MHCC97-H cells Open
This study showed that SPINK13 inhibits hepatocellular carcinoma cell development by regulating the JNK, p53, and the IKK/NF-κB pathways, its potential targets for antitumor drugs may be JUN, GADD45A, GADD45B, TNFRS…
View article: Risk assessment of type 2 diabetes in northern China based on the logistic regression model
Risk assessment of type 2 diabetes in northern China based on the logistic regression model Open
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a complex disease with high incidence and serious harm associated with polygenic determination. This study aimed to develop a predictive model so as to assess the risk of T2DM and apply it to …
View article: miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6 Open
View article: miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6 Open
Background The aberrant expression of microRNA-454 (miR-454) has been confirmed to be involved in the development of cancers. However, the functional role of miR-454 in the progression of ovarian cancer remains unclear. Methods The express…
View article: miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6 Open
Background : It has been reported that hypoxia is closely related to the tumor malignancy and recurrence and regulates multiple hub genes in ovarian cancer. MicroRNA-454 (miR-454) has been confirmed to be involved in tumorigenesis and tumo…
View article: Abnormal overexpression of G9a in melanoma cells promotes cancer progression via upregulation of the Notch1 signaling pathway
Abnormal overexpression of G9a in melanoma cells promotes cancer progression via upregulation of the Notch1 signaling pathway Open
Malignant melanoma is a type of very dangerous skin cancer. Histone modifiers usually become dysregulated during the process of carcinoma development, thus there is potential for a histone modifier inhibitor as a useful drug for cancer the…
View article: <p>RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor</p>
RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor Open
This study revealed that RGS4 overexpression positively correlated with the development of NSCLC. TDownstream RGS4 targets (eg, miR-16 and BDNF) might be involved in the development of NSCLC and may serve as potential therapeutic ta…
View article: De novo Sequencing and Transcriptome Analysis Reveal Key Genes Regulating Steroid Metabolism in Leaves, Roots, Adventitious Roots and Calli of Periploca sepium Bunge
De novo Sequencing and Transcriptome Analysis Reveal Key Genes Regulating Steroid Metabolism in Leaves, Roots, Adventitious Roots and Calli of Periploca sepium Bunge Open
Periploca sepium Bunge is a traditional medicinal plant, whose root bark is important for Chinese herbal medicine. Its major bioactive compounds are C21 steroids and periplocin, a kind of cardiac glycoside, which are derived from th…
View article: Genome sequence of Plasmopara viticola and insight into the pathogenic mechanism
Genome sequence of Plasmopara viticola and insight into the pathogenic mechanism Open
View article: Autocrine activity of BDNF induced by the STAT3 signaling pathway causes prolonged TrkB activation and promotes human non-small-cell lung cancer proliferation
Autocrine activity of BDNF induced by the STAT3 signaling pathway causes prolonged TrkB activation and promotes human non-small-cell lung cancer proliferation Open