Yuan Qin
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View article: Coherence analysis of peripheral blood flow signals is a potential method for evaluating autonomic nervous system function
Coherence analysis of peripheral blood flow signals is a potential method for evaluating autonomic nervous system function Open
Introduction The autonomic nervous system (ANS) is crucial for maintaining homeostasis in the body and plays an important role in cardiovascular diseases. Although heart rate variability (HRV) is a commonly used non-invasive clinical tool …
View article: Outcomes of cosmetic suturing for facial trauma in medically underserved counties of western China: A retrospective observational cohort study
Outcomes of cosmetic suturing for facial trauma in medically underserved counties of western China: A retrospective observational cohort study Open
Facial trauma is frequent in medically underserved regions of western China, where lack of access to specialized surgical care contributes to infection, hypertrophic scarring, and psychosocial distress. Although cosmetic suturing is widely…
View article: FGF21-FGFR1 signaling protects against cardiac hypertrophy by regulating PINK1-mediated mitophagy pathway
FGF21-FGFR1 signaling protects against cardiac hypertrophy by regulating PINK1-mediated mitophagy pathway Open
FGF21 promotes PINK1-mediated mitophagy to attenuate cardiac hypertrophy, and mismatched FGFR1 expression may hamper the beneficial effect of FGF21 on cardiac hypertrophy.
View article: Prognostic impact of collateral circulation in direct thrombectomy versus bridging thrombectomy for acute ischemic stroke patients with anterior circulation large vessel occlusion: a retrospective comparative study
Prognostic impact of collateral circulation in direct thrombectomy versus bridging thrombectomy for acute ischemic stroke patients with anterior circulation large vessel occlusion: a retrospective comparative study Open
Objective To evaluate the prognostic impact of collateral circulation on outcomes of direct thrombectomy (DT) versus bridging thrombectomy (BT) for acute ischemic stroke (AIS) patients with anterior circulation large vessel occlusion (LVO)…
View article: Integrated metabolomic and microbiota analysis of semen: seasonal and morphological associations
Integrated metabolomic and microbiota analysis of semen: seasonal and morphological associations Open
Recent studies have begun to investigate the metabolic and microbiota profiles in semen, yet their association with abnormal sperm morphology, particularly in teratozoospermia, remains insufficiently characterized. Identifying specific met…
View article: Serum Krebs von den Lungen-6 as a potential biomarker for early diagnosis of silicosis: a case-control study
Serum Krebs von den Lungen-6 as a potential biomarker for early diagnosis of silicosis: a case-control study Open
Serum KL-6 may serve as a potential biomarker for early silicosis diagnosis. Its diagnostic performance is significantly improved when combined with CRP ad ACE, offering a potential multi-biomarker approach for enhanced detection in the ea…
View article: CT Radiomics-Clinical Model for Noninvasive Prediction of Tumor Mutation Burden and Survival in Locally Advanced Head and Neck Squamous Cell Carcinoma
CT Radiomics-Clinical Model for Noninvasive Prediction of Tumor Mutation Burden and Survival in Locally Advanced Head and Neck Squamous Cell Carcinoma Open
Purpose Tumor mutation burden (TMB) has emerged as a promising biomarker for predicting immunotherapy response. This study aimed to evaluate the potential of a CT-based radiomics model to predict TMB status and overall survival (OS) in pat…
View article: EGFR and CYP signaling disruption underlies 6PPD-quinone hepatotoxicity: Insights from a network and machine learning approach
EGFR and CYP signaling disruption underlies 6PPD-quinone hepatotoxicity: Insights from a network and machine learning approach Open
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPD-quinone), an emerging environmental contaminant derived from the common tire additive 6PPD, has been alarmingly detected in human biology samples and is associated with liver…
View article: Development, verification, and comparison of a risk stratification model to identify potential population benefiting from chemotherapy in non-metastatic male breast cancer
Development, verification, and comparison of a risk stratification model to identify potential population benefiting from chemotherapy in non-metastatic male breast cancer Open
To establish a prognostic stratification nomogram for non-metastatic male breast cancer to determine which patients can benefit from chemotherapy. A population-based study was conducted using data collected from the surveillance, epidemiol…
View article: Proteomic Landscape Uncovers Chemotherapy Resistance, Relapse Mechanisms, and Molecular Subtypes in Primary Central Nervous System Lymphoma for Precision Therapeutics
Proteomic Landscape Uncovers Chemotherapy Resistance, Relapse Mechanisms, and Molecular Subtypes in Primary Central Nervous System Lymphoma for Precision Therapeutics Open
Primary central nervous system lymphoma (PCNSL) is a rare and aggressive diffuse large B-cell lymphoma (DLBCL) subtype restricted to the CNS, with variable response to high-dose methotrexate and frequent relapse. We conducted the first com…
View article: Inhibition of Bif-1 confers cardio-protection in myocardial infarction
Inhibition of Bif-1 confers cardio-protection in myocardial infarction Open
Our study demonstrated that Bif-1 contributes to adverse cardiac remodeling and dysfunction following MI by promoting ER stress. Pharmacological inhibition of ER stress ameliorates cardiac remodeling and dysfunction. In addition, we identi…
View article: ARTEMIX: A community-boosting-based framework for airdrop hunter detection in the Web3 community
ARTEMIX: A community-boosting-based framework for airdrop hunter detection in the Web3 community Open
Airdrops represent a pivotal strategic instrument for Web3 projects, serving to distribute free tokens and motivate early adoption. However, the popularity of these tokens has fueled the emergence of airdrop hunters—individuals who exploit…
View article: Nodular-defect induced degradation of laser damage resistance of 532 nm high reflectivity coating after exposure to gamma rays
Nodular-defect induced degradation of laser damage resistance of 532 nm high reflectivity coating after exposure to gamma rays Open
The coupling effect of gamma-ray radiation and 532 nm nanosecond laser radiation on optical coatings and substrates was investigated. Fused silica and S-BSL7 glass with 532 nm high reflectivity (HR) coatings were irradiated using 60 Co gam…
View article: Empagliflozin improves pressure-overload-induced cardiac hypertrophy by inhibiting the canonical Wnt/β-catenin signaling pathway
Empagliflozin improves pressure-overload-induced cardiac hypertrophy by inhibiting the canonical Wnt/β-catenin signaling pathway Open
Background Empagliflozin (EMPA) is an SGLT-2 inhibitor that can control hyperglycemia. Clinical trials have indicated its cardio-protective effects against cardiac remodeling in diabetes or non-diabetes patients. However, the underlying mo…
View article: Acupuncture for the treatment of diabetic peripheral neuropathy in the elderly: a systematic review and meta-analysis
Acupuncture for the treatment of diabetic peripheral neuropathy in the elderly: a systematic review and meta-analysis Open
Background Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes mellitus, often causing pain or numbness in the patient’s limbs and even leading to amputation and death. Elderly patients with DPN usually…
View article: A Dynamic Online Nomogram Based on Gd-EOB-DTPA-Enhanced MRI and Inflammatory Biomarkers for Preoperative Prediction of Pathological Grade and Stratification in Solitary Hepatocellular Carcinoma: A Multicenter Study
A Dynamic Online Nomogram Based on Gd-EOB-DTPA-Enhanced MRI and Inflammatory Biomarkers for Preoperative Prediction of Pathological Grade and Stratification in Solitary Hepatocellular Carcinoma: A Multicenter Study Open
This easy-to-use dynamic online nomogram hold promise for use as a noninvasive tool in prediction HCC grade with high accuracy and robustness.
View article: Risk stratification of <scp>LA</scp>‐<scp>NPC</scp> during chemoradiotherapy based on clinical classification and <scp>TVRR</scp>
Risk stratification of <span>LA</span>‐<span>NPC</span> during chemoradiotherapy based on clinical classification and <span>TVRR</span> Open
Purpose To investigate the correlation between tumor volume reduction rate (TVRR) and prognosis in patients with diverse clinical types of nasopharyngeal carcinoma (NPC) undergoing chemoradiotherapy, thereby aptly categorizing risks and di…
View article: Multiple Machine-Learning Fusion Model Based on Gd-EOB-DTPA-Enhanced MRI and Aminotransferase-to-Platelet Ratio and Gamma-Glutamyl Transferase-to-Platelet Ratio to Predict Microvascular Invasion in Solitary Hepatocellular Carcinoma: A Multicenter Study
Multiple Machine-Learning Fusion Model Based on Gd-EOB-DTPA-Enhanced MRI and Aminotransferase-to-Platelet Ratio and Gamma-Glutamyl Transferase-to-Platelet Ratio to Predict Microvascular Invasion in Solitary Hepatocellular Carcinoma: A Multicenter Study Open
The APRI and GPR may be new potential biomarkers for predicting MVI of HCC. The ENS achieved optimal performance for predicting MVI in different sizes HCC and may aid in the individualized selection of surgical procedures.
View article: RETRACTED: Effect of radiation therapy during surgery on postoperative wound complications after breast reconstruction in patients with breast cancer: A meta‐analysis
RETRACTED: Effect of radiation therapy during surgery on postoperative wound complications after breast reconstruction in patients with breast cancer: A meta‐analysis Open
Breast remodelling is a major therapeutic choice in radical mastectomy. Breast reconstruction is regarded as a promising option for the treatment of breast cancer. The purpose of this meta‐analysis was to investigate the effect of Post mas…
View article: CcpA-Knockout Staphylococcus aureus Induces Abnormal Metabolic Phenotype via the Activation of Hepatic STAT5/PDK4 Signaling in Diabetic Mice
CcpA-Knockout Staphylococcus aureus Induces Abnormal Metabolic Phenotype via the Activation of Hepatic STAT5/PDK4 Signaling in Diabetic Mice Open
Catabolite control protein A (CcpA), an important global regulatory protein, is extensively found in S. aureus. Many studies have reported that CcpA plays a pivotal role in regulating the tricarboxylic acid cycle and pathogenicity. Moreove…
View article: NEAT1_2/RRAD/EHF Positive Feedback Loop Facilitates Aerobic Glycolysis in Papillary Thyroid Cancer Cells
NEAT1_2/RRAD/EHF Positive Feedback Loop Facilitates Aerobic Glycolysis in Papillary Thyroid Cancer Cells Open
Papillary thyroid carcinoma (PTC) is the most prevalent endocrine-related malignancy. In spite of the good prognosis, a more aggressive disease can develop in some PTC patients, leading to poor survival. Nuclear paraspeckle assembly transc…
View article: Peer Review #1 of "GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer (v0.1)"
Peer Review #1 of "GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer (v0.1)" Open
Objective: This study aimed to establish a prognostic model related to prostate cancer (PCa) recurrence-free survival (RFS) and identify biomarkers.Methods: The RFS prognostic model and key genes associated with PCa were established using …
View article: Peer Review #1 of "GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer (v0.2)"
Peer Review #1 of "GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer (v0.2)" Open
Objective: This study aimed to establish a prognostic model related to prostate cancer (PCa) recurrence-free survival (RFS) and identify biomarkers.Methods: The RFS prognostic model and key genes associated with PCa were established using …
View article: GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer
GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer Open
Objective This study aimed to establish a prognostic model related to prostate cancer (PCa) recurrence-free survival (RFS) and identify biomarkers. Methods The RFS prognostic model and key genes associated with PCa were established using L…